GREMLIN Database
PAP - Protein-arginine-phosphatase
UniProt: P39155 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (144)
Sequences: 4713 (3565)
Seq/√Len: 297.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_I139_R3.3861.00
23_S27_R3.2631.00
18_E22_K2.9471.00
69_L91_I2.8861.00
82_A91_I2.4231.00
117_L133_E2.4091.00
2_D33_N2.3811.00
55_L62_L2.1301.00
16_M51_A2.1201.00
8_T87_H2.0881.00
85_H115_D2.0621.00
57_E128_K1.9021.00
122_G126_I1.8391.00
5_F21_F1.8091.00
4_I37_A1.7691.00
35_R67_S1.7601.00
54_A128_K1.7301.00
105_L138_L1.6481.00
88_K92_A1.5931.00
16_M55_L1.5711.00
103_F108_Y1.5441.00
58_K135_E1.5241.00
72_E76_S1.5081.00
3_I21_F1.5061.00
33_N76_S1.5011.00
47_A64_H1.4931.00
82_A88_K1.4781.00
25_A34_V1.4771.00
24_I135_E1.4591.00
35_R77_A1.4581.00
54_A57_E1.4521.00
58_K131_R1.4511.00
8_T40_F1.4201.00
39_V90_I1.3971.00
20_L131_R1.3821.00
20_L134_L1.3781.00
67_S73_L1.3781.00
24_I138_L1.3781.00
46_K52_V1.3641.00
129_Q133_E1.3631.00
25_A32_V1.3631.00
54_A131_R1.3591.00
21_F34_V1.3501.00
105_L134_L1.3251.00
85_H104_T1.3171.00
58_K132_D1.3121.00
47_A52_V1.2831.00
20_L138_L1.2801.00
19_A62_L1.2681.00
53_E124_I1.2301.00
103_F107_E1.2231.00
106_K109_V1.1941.00
47_A62_L1.1921.00
52_V62_L1.1841.00
60_I135_E1.1801.00
106_K133_E1.1791.00
22_K34_V1.1561.00
88_K102_V1.1481.00
92_A102_V1.1431.00
104_T115_D1.1291.00
41_A68_P1.1261.00
37_A67_S1.1131.00
23_S26_E1.1091.00
19_A60_I1.1031.00
123_S126_I1.0971.00
28_E143_K1.0951.00
52_V56_F1.0781.00
74_M80_V1.0761.00
17_A83_M1.0621.00
21_F138_L1.0621.00
54_A58_K1.0461.00
19_A64_H1.0351.00
84_T87_H1.0201.00
51_A54_A1.0131.00
135_E139_R1.0091.00
140_Q143_K1.0071.00
90_I93_S1.0011.00
2_D76_S0.9991.00
82_A104_T0.9961.00
53_E57_E0.9921.00
74_M98_Y0.9851.00
86_Q90_I0.9821.00
71_E94_Q0.9811.00
69_L74_M0.9801.00
108_Y141_L0.9791.00
83_M105_L0.9651.00
124_I128_K0.9631.00
79_L141_L0.9621.00
79_L103_F0.9501.00
91_I102_V0.9501.00
75_E97_R0.9441.00
19_A22_K0.9351.00
108_Y144_Q0.9341.00
24_I27_R0.9311.00
81_L141_L0.9271.00
57_E124_I0.9251.00
90_I94_Q0.9241.00
88_K104_T0.9221.00
105_L137_L0.9111.00
81_L103_F0.9081.00
98_Y101_K0.9041.00
109_V136_E0.9031.00
8_T86_Q0.8991.00
128_K132_D0.8971.00
130_T134_L0.8951.00
16_M131_R0.8931.00
49_P53_E0.8871.00
19_A61_A0.8761.00
95_F102_V0.8701.00
83_M116_V0.8671.00
4_I77_A0.8651.00
5_F17_A0.8601.00
48_T127_Y0.8601.00
81_L108_Y0.8541.00
106_K137_L0.8501.00
19_A47_A0.8471.00
47_A55_L0.8391.00
6_V80_V0.8381.00
24_I142_A0.8361.00
72_E75_E0.8341.00
92_A95_F0.8191.00
24_I28_E0.8161.00
28_E139_R0.8131.00
39_V91_I0.8001.00
107_E113_H0.7971.00
60_I131_R0.7840.99
141_L145_L0.7780.99
113_H129_Q0.7740.99
6_V91_I0.7730.99
110_T136_E0.7680.99
25_A142_A0.7670.99
37_A69_L0.7650.99
20_L60_I0.7590.99
131_R135_E0.7550.99
50_H124_I0.7460.99
56_F62_L0.7430.99
54_A124_I0.7370.99
74_M95_F0.7370.99
2_D77_A0.7200.99
46_K64_H0.7190.99
46_K65_V0.7170.99
40_F68_P0.7110.99
16_M54_A0.7090.99
74_M91_I0.7070.99
108_Y140_Q0.7060.99
41_A45_G0.7050.99
4_I67_S0.7010.99
81_L105_L0.7010.99
42_S45_G0.7000.99
8_T84_T0.7000.99
21_F24_I0.6960.99
22_K26_E0.6930.99
25_A30_L0.6900.99
126_I129_Q0.6880.99
58_K128_K0.6760.98
103_F144_Q0.6730.98
73_L77_A0.6660.98
4_I80_V0.6610.98
80_V91_I0.6610.98
50_H122_G0.6600.98
95_F98_Y0.6590.98
104_T107_E0.6580.98
71_E75_E0.6530.98
109_V140_Q0.6520.98
70_T73_L0.6490.98
17_A105_L0.6370.98
95_F100_D0.6350.98
79_L108_Y0.6340.98
74_M96_G0.6320.97
17_A134_L0.6230.97
130_T133_E0.6170.97
40_F90_I0.6160.97
79_L145_L0.6110.97
56_F61_A0.6080.97
16_M130_T0.6020.97
83_M87_H0.5950.96
70_T76_S0.5940.96
10_N14_S0.5890.96
28_E142_A0.5820.96
51_A55_L0.5820.96
50_H123_S0.5790.96
11_T127_Y0.5790.96
37_A73_L0.5750.96
121_G126_I0.5740.96
75_E98_Y0.5720.95
22_K63_N0.5700.95
134_L138_L0.5650.95
55_L60_I0.5630.95
67_S77_A0.5610.95
35_R76_S0.5600.95
106_K115_D0.5560.95
2_D35_R0.5560.95
18_E64_H0.5520.95
8_T90_I0.5510.94
116_V133_E0.5500.94
109_V141_L0.5500.94
45_G66_S0.5490.94
21_F141_L0.5470.94
48_T120_F0.5460.94
95_F101_K0.5450.94
126_I130_T0.5440.94
19_A63_N0.5390.94
20_L135_E0.5390.94
116_V137_L0.5360.94
5_F138_L0.5340.94
98_Y102_V0.5340.94
105_L141_L0.5290.93
141_L144_Q0.5270.93
3_I79_L0.5220.93
43_P68_P0.5160.92
20_L24_I0.5150.92
107_E114_G0.5100.92
48_T51_A0.5070.92
11_T48_T0.5050.92
22_K64_H0.5030.91
41_A121_G0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4etnA 1 0.98 100 0.13 Contact Map
3jviA 1 0.9867 100 0.153 Contact Map
3n8iA 1 0.9733 100 0.158 Contact Map
1d1qA 1 0.9733 100 0.16 Contact Map
4egsA 2 0.96 100 0.16 Contact Map
4picA 2 0.98 100 0.16 Contact Map
4lrqA 2 0.9733 100 0.162 Contact Map
2cwdA 1 0.96 100 0.164 Contact Map
2gi4A 1 0.9867 100 0.171 Contact Map
1u2pA 1 0.9867 100 0.171 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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