GREMLIN Database
MNTP - Putative manganese efflux pump MntP
UniProt: P39154 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (175)
Sequences: 1918 (1571)
Seq/√Len: 118.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_G182_L4.9641.00
52_V141_G4.2231.00
87_Q90_M3.5011.00
90_M94_K3.4651.00
46_I112_A3.4341.00
24_F151_G3.3661.00
92_S168_A2.5621.00
52_V137_I2.5551.00
46_I108_L2.4631.00
79_A83_V2.3171.00
56_L137_I2.1871.00
172_I176_V2.1301.00
139_L143_F2.1101.00
85_G171_G2.1031.00
86_V90_M2.0211.00
46_I105_G2.0031.00
38_K42_Y1.9161.00
16_A139_L1.8921.00
95_Q100_F1.8851.00
23_A144_S1.8531.00
30_M111_F1.8391.00
132_H135_L1.8341.00
85_G175_I1.8091.00
89_L171_G1.8061.00
13_S139_L1.8031.00
28_L154_V1.7841.00
19_L118_D1.7711.00
28_L151_G1.7641.00
147_L151_G1.7221.00
43_I108_L1.7061.00
27_G148_T1.6651.00
13_S143_F1.6611.00
12_L139_L1.6101.00
87_Q91_A1.6071.00
35_L40_I1.5981.00
12_L136_T1.5891.00
17_F147_L1.5591.00
42_Y105_G1.5451.00
175_I178_G1.5311.00
40_I44_G1.4891.00
45_F49_L1.4821.00
154_V158_V1.4631.00
83_V87_Q1.4361.00
20_G147_L1.4181.00
12_L16_A1.3911.00
16_A143_F1.3671.00
51_H115_V1.3551.00
69_L73_A1.3301.00
179_L183_L1.3261.00
85_G178_G1.3221.00
92_S96_S1.3111.00
50_F141_G1.3001.00
48_G141_G1.2961.00
119_S140_F1.2941.00
23_A55_P1.2831.00
55_P140_F1.2791.00
35_L39_Q1.2751.00
82_F86_V1.2721.00
20_G47_I1.2670.99
154_V162_L1.2440.99
39_Q103_P1.2420.99
24_F125_S1.2230.99
40_I152_L1.2140.99
49_L53_I1.2080.99
39_Q42_Y1.1860.99
20_G144_S1.1840.99
15_M177_F1.1770.99
47_I51_H1.1770.99
50_F54_M1.1760.99
153_L157_Q1.1750.99
68_L71_V1.1720.99
54_M116_S1.1660.99
158_V162_L1.1630.99
20_G143_F1.1450.99
51_H119_S1.1430.99
73_A77_G1.1290.99
51_H140_F1.1190.99
95_Q98_E1.1170.99
70_G73_A1.1020.99
77_G181_L1.0990.99
48_G145_M1.0750.98
10_I71_V1.0680.98
15_M126_L1.0410.98
157_Q160_S1.0360.98
38_K43_I1.0220.98
155_G159_Q1.0100.97
164_T168_A1.0090.97
23_A48_G1.0010.97
57_A120_F0.9960.97
42_Y104_A0.9890.97
123_G155_G0.9850.97
36_R39_Q0.9820.97
144_S148_T0.9780.97
66_S70_G0.9770.97
77_G115_V0.9730.97
133_P137_I0.9690.97
18_A21_M0.9600.97
92_S95_Q0.9550.96
96_S101_M0.9550.96
11_T28_L0.9510.96
89_L168_A0.9400.96
161_W165_Y0.9280.96
80_L181_L0.9190.96
47_I115_V0.9130.95
17_F173_I0.9120.95
18_A170_G0.9110.95
90_M93_F0.9080.95
44_G149_W0.9010.95
44_G55_P0.8840.94
44_G145_M0.8800.94
30_M124_L0.8790.94
43_I103_P0.8660.94
98_E101_M0.8640.94
138_T142_L0.8610.94
32_M158_V0.8570.94
30_M107_G0.8530.93
118_D122_V0.8470.93
29_G32_M0.8470.93
29_G44_G0.8420.93
21_M148_T0.8370.93
26_V74_V0.8370.93
104_A107_G0.8360.93
105_G108_L0.8320.93
82_F178_G0.8250.92
16_A20_G0.8150.92
149_W153_L0.8130.92
78_G82_F0.8060.91
60_A134_L0.7940.91
138_T180_K0.7920.91
18_A148_T0.7840.90
20_G23_A0.7800.90
77_G81_L0.7780.90
76_I110_L0.7780.90
30_M103_P0.7650.89
135_L139_L0.7620.89
54_M58_G0.7620.89
58_G181_L0.7380.87
79_A100_F0.7310.87
132_H136_T0.7310.87
31_G151_G0.7250.86
50_F120_F0.7160.86
41_F49_L0.7150.86
107_G114_G0.7150.86
29_G144_S0.7090.85
44_G118_D0.7060.85
88_M170_G0.7050.85
21_M25_S0.7030.85
40_I103_P0.7000.84
50_F55_P0.6990.84
51_H58_G0.6950.84
75_Y89_L0.6900.83
52_V133_P0.6880.83
34_K100_F0.6880.83
46_I109_L0.6870.83
104_A139_L0.6870.83
48_G144_S0.6850.83
69_L76_I0.6850.83
115_V119_S0.6740.82
134_L138_T0.6730.82
86_V93_F0.6690.82
79_A138_T0.6680.81
114_G177_F0.6660.81
54_M140_F0.6600.81
10_I14_I0.6550.80
14_I177_F0.6540.80
23_A119_S0.6540.80
110_L173_I0.6530.80
103_P107_G0.6520.80
39_Q107_G0.6500.80
23_A118_D0.6490.80
144_S181_L0.6480.79
36_R172_I0.6460.79
73_A81_L0.6450.79
106_P109_L0.6400.79
80_L162_L0.6370.78
130_G138_T0.6350.78
84_L136_T0.6340.78
41_F149_W0.6220.77
13_S76_I0.6210.77
19_L23_A0.6200.76
97_E101_M0.6150.76
51_H180_K0.6140.76
166_S173_I0.6110.75
170_G178_G0.6100.75
78_G178_G0.6090.75
40_I149_W0.6070.75
125_S128_I0.6040.75
73_A182_L0.6040.75
92_S98_E0.6030.74
36_R43_I0.6010.74
57_A97_E0.6000.74
54_M113_I0.5990.74
37_K149_W0.5950.73
60_A142_L0.5950.73
39_Q49_L0.5920.73
51_H111_F0.5890.73
96_S100_F0.5880.73
117_L121_S0.5860.72
10_I135_L0.5860.72
27_G152_L0.5810.72
175_I179_L0.5790.71
47_I111_F0.5750.71
60_A83_V0.5730.71
101_M176_V0.5730.71
80_L88_M0.5730.71
162_L165_Y0.5730.71
47_I148_T0.5710.70
20_G51_H0.5700.70
174_L178_G0.5700.70
95_Q99_R0.5680.70
42_Y150_L0.5670.70
120_F124_L0.5660.70
55_P167_E0.5640.69
62_G163_G0.5640.69
48_G113_I0.5640.69
89_L92_S0.5570.68
78_G115_V0.5540.68
88_M159_Q0.5520.68
97_E100_F0.5510.68
25_S84_L0.5440.67
28_L43_I0.5440.67
16_A26_V0.5430.67
99_R169_L0.5400.66
40_I45_F0.5380.66
51_H170_G0.5360.66
41_F60_A0.5360.66
124_L133_P0.5360.66
67_G142_L0.5340.65
16_A148_T0.5340.65
136_T140_F0.5330.65
104_A111_F0.5330.65
44_G48_G0.5320.65
25_S165_Y0.5300.65
119_S170_G0.5300.65
30_M33_V0.5300.65
63_N127_G0.5300.65
58_G141_G0.5290.65
77_G87_Q0.5280.64
51_H143_F0.5270.64
26_V84_L0.5260.64
57_A150_L0.5260.64
89_L105_G0.5250.64
93_F168_A0.5250.64
50_F122_V0.5240.64
16_A147_L0.5220.64
31_G111_F0.5210.63
23_A170_G0.5210.63
49_L159_Q0.5190.63
10_I86_V0.5170.63
54_M115_V0.5160.63
156_K169_L0.5160.63
13_S20_G0.5150.62
83_V102_S0.5140.62
30_M127_G0.5120.62
97_E146_M0.5080.61
14_I84_L0.5080.61
78_G170_G0.5070.61
36_R138_T0.5050.61
90_M97_E0.5020.61
17_F67_G0.5020.61
112_A137_I0.5000.60
87_Q115_V0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.5135 18.4 0.934 Contact Map
4p6vD 1 0.7784 16.3 0.936 Contact Map
1pw4A 1 0.9514 11.9 0.94 Contact Map
3wdoA 1 0.4757 10.6 0.941 Contact Map
4bemJ 1 0.7243 7.9 0.944 Contact Map
4w6vA 1 0.5027 7.9 0.944 Contact Map
2wswA 3 0.4973 7 0.946 Contact Map
4n7wA 2 0.8054 6.9 0.946 Contact Map
4xnjA 1 0.4703 6.7 0.946 Contact Map
4pypA 1 0.4324 5.9 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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