SUA5 - BACSU - GREMLIN Contacts

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SUA5 - Threonylcarbamoyl-AMP synthase

UniProt:	P39153	Sequences: MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGLGANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGALTLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTKAEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIHVDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTEEKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMNRLMKAAGGRVIR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	346 (317)
Sequences:	2305 (1784)
Seq/√Len:	100.2

BACSU - SUA5
SULSO - Q7LXP3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
27_L	32_E	4.846	1.00
47_N	50_N	4.395	1.00
36_F	45_G	4.241	1.00
32_E	173_A	4.014	1.00
48_A	71_V	3.687	1.00
165_A	175_I	3.119	1.00
189_V	232_S	3.061	1.00
26_A	30_E	2.632	1.00
75_D	139_R	2.489	1.00
22_A	140_E	2.442	1.00
207_K	211_E	2.432	1.00
83_T	106_L	2.412	1.00
45_G	145_I	2.371	1.00
36_F	137_L	2.295	1.00
137_L	176_V	2.266	1.00
58_Y	65_S	2.252	1.00
51_T	114_S	2.183	1.00
47_N	143_L	2.182	1.00
152_L	171_R	2.176	1.00
67_N	153_S	2.171	1.00
136_A	139_R	2.166	1.00
271_G	310_F	2.139	1.00
21_I	140_E	2.138	1.00
183_I	204_G	2.114	1.00
94_M	104_L	2.064	1.00
36_F	134_A	2.028	1.00
51_T	116_R	2.020	1.00
73_I	79_L	2.016	1.00
199_L	207_K	1.971	1.00
57_I	146_A	1.954	1.00
97_F	213_V	1.942	1.00
80_E	91_K	1.927	1.00
74_A	138_I	1.922	1.00
162_E	166_H	1.903	1.00
206_T	209_Q	1.886	1.00
165_A	169_D	1.873	1.00
109_K	112_A	1.872	1.00
268_R	316_D	1.864	1.00
269_R	316_D	1.857	1.00
46_A	53_A	1.844	1.00
85_P	107_P	1.834	1.00
160_K	180_P	1.813	1.00
209_Q	212_A	1.811	1.00
32_E	56_K	1.794	1.00
73_I	128_M	1.785	1.00
82_L	126_I	1.767	1.00
185_V	331_A	1.762	1.00
325_D	337_M	1.734	1.00
55_K	116_R	1.714	1.00
89_K	214_I	1.702	1.00
27_L	174_G	1.701	1.00
244_A	311_D	1.698	1.00
161_A	177_D	1.696	1.00
232_S	235_M	1.692	1.00
55_K	59_E	1.680	1.00
84_G	107_P	1.676	1.00
31_N	50_N	1.671	1.00
25_A	140_E	1.668	1.00
136_A	140_E	1.664	1.00
74_A	78_Q	1.657	1.00
17_N	20_Q	1.647	1.00
35_A	172_I	1.614	1.00
78_Q	81_D	1.613	1.00
60_A	168_L	1.587	1.00
296_L	332_I	1.582	1.00
130_D	135_L	1.581	1.00
108_C	115_P	1.581	1.00
152_L	167_D	1.570	1.00
248_I	322_S	1.568	1.00
167_D	308_R	1.551	1.00
56_K	59_E	1.551	1.00
78_Q	138_I	1.508	1.00
25_A	141_S	1.502	1.00
28_L	137_L	1.490	1.00
87_P	90_A	1.473	1.00
288_K	306_A	1.436	1.00
76_I	95_K	1.432	1.00
156_P	308_R	1.431	1.00
91_K	95_K	1.430	1.00
295_Q	298_T	1.426	1.00
28_L	141_S	1.426	1.00
27_L	173_A	1.414	1.00
276_E	289_S	1.392	1.00
271_G	315_V	1.390	1.00
71_V	117_V	1.378	0.99
128_M	135_L	1.377	0.99
211_E	216_P	1.371	0.99
76_I	91_K	1.370	0.99
28_L	143_L	1.360	0.99
191_S	231_I	1.354	0.99
207_K	330_L	1.340	0.99
26_A	29_R	1.331	0.99
49_K	114_S	1.327	0.99
130_D	182_G	1.326	0.99
217_I	220_D	1.325	0.99
305_D	309_S	1.309	0.99
108_C	118_T	1.298	0.99
160_K	305_D	1.293	0.99
138_I	141_S	1.293	0.99
75_D	78_Q	1.292	0.99
35_A	164_V	1.289	0.99
274_T	278_K	1.282	0.99
79_L	126_I	1.277	0.99
133_L	178_G	1.271	0.99
288_K	309_S	1.265	0.99
107_P	122_E	1.264	0.99
23_Q	26_A	1.262	0.99
84_G	110_P	1.242	0.99
210_I	214_I	1.237	0.99
49_K	143_L	1.232	0.99
93_L	102_L	1.232	0.99
76_I	94_M	1.229	0.99
92_T	96_R	1.226	0.99
82_L	113_L	1.225	0.99
66_D	237_Y	1.218	0.99
273_L	306_A	1.216	0.99
192_C	197_P	1.214	0.99
66_D	236_K	1.212	0.99
300_A	328_V	1.209	0.99
46_A	57_I	1.209	0.99
320_A	336_L	1.205	0.99
299_V	323_F	1.203	0.99
166_H	312_E	1.195	0.98
123_T	193_A	1.186	0.98
83_T	124_V	1.184	0.98
128_M	138_I	1.178	0.98
93_L	210_I	1.177	0.98
141_S	144_P	1.158	0.98
334_N	338_K	1.146	0.98
102_L	190_L	1.118	0.98
185_V	204_G	1.115	0.98
244_A	315_V	1.113	0.98
302_G	306_A	1.112	0.98
22_A	26_A	1.101	0.97
35_A	161_A	1.101	0.97
163_H	305_D	1.097	0.97
54_V	117_V	1.090	0.97
270_V	275_T	1.089	0.97
79_L	86_A	1.088	0.97
74_A	139_R	1.082	0.97
88_E	91_K	1.079	0.97
104_L	190_L	1.071	0.97
96_R	213_V	1.070	0.97
67_N	119_A	1.070	0.97
306_A	310_F	1.056	0.97
192_C	214_I	1.053	0.97
202_P	334_N	1.049	0.97
60_A	171_R	1.049	0.97
199_L	217_I	1.043	0.96
197_P	215_G	1.034	0.96
33_V	60_A	1.033	0.96
153_S	236_K	1.030	0.96
138_I	145_I	1.029	0.96
134_A	147_A	1.027	0.96
83_T	126_I	1.019	0.96
155_K	167_D	1.019	0.96
76_I	128_M	1.017	0.96
299_V	332_I	1.016	0.96
83_T	109_K	1.013	0.96
135_L	139_R	1.011	0.96
191_S	197_P	1.010	0.96
154_G	238_T	1.002	0.96
263_Y	319_I	1.000	0.95
185_V	300_A	0.992	0.95
277_E	291_G	0.987	0.95
89_K	92_T	0.983	0.95
333_M	338_K	0.983	0.95
96_R	212_A	0.981	0.95
25_A	29_R	0.977	0.95
155_K	243_T	0.972	0.95
271_G	274_T	0.966	0.95
277_E	292_R	0.963	0.94
298_T	302_G	0.961	0.94
214_I	217_I	0.960	0.94
190_L	214_I	0.957	0.94
141_S	145_I	0.956	0.94
296_L	329_G	0.954	0.94
105_I	125_A	0.945	0.94
230_P	236_K	0.944	0.94
302_G	305_D	0.943	0.94
79_L	106_L	0.934	0.93
168_L	172_I	0.930	0.93
133_L	176_V	0.928	0.93
80_E	86_A	0.925	0.93
86_A	94_M	0.917	0.93
246_L	320_A	0.913	0.93
245_P	317_F	0.913	0.93
156_P	246_L	0.912	0.93
248_I	340_A	0.911	0.93
97_F	205_I	0.910	0.93
45_G	134_A	0.909	0.93
208_E	327_G	0.904	0.92
98_W	102_L	0.897	0.92
29_R	143_L	0.894	0.92
58_Y	119_A	0.894	0.92
244_A	310_F	0.893	0.92
49_K	112_A	0.891	0.92
211_E	218_H	0.889	0.92
81_D	142_G	0.889	0.92
244_A	314_K	0.888	0.92
67_N	237_Y	0.888	0.92
35_A	45_G	0.888	0.92
278_K	321_E	0.881	0.91
238_T	341_G	0.877	0.91
291_G	299_V	0.873	0.91
193_A	196_I	0.871	0.91
168_L	171_R	0.868	0.91
306_A	309_S	0.867	0.91
152_L	155_K	0.865	0.91
298_T	301_A	0.863	0.90
236_K	334_N	0.851	0.90
333_M	337_M	0.851	0.90
94_M	128_M	0.845	0.90
78_Q	128_M	0.840	0.89
115_P	122_E	0.839	0.89
62_G	171_R	0.838	0.89
118_T	124_V	0.835	0.89
18_D	136_A	0.833	0.89
47_N	144_P	0.831	0.89
270_V	317_F	0.830	0.89
141_S	189_V	0.830	0.89
161_A	179_G	0.827	0.89
57_I	147_A	0.825	0.88
260_I	272_V	0.823	0.88
322_S	333_M	0.821	0.88
47_N	141_S	0.818	0.88
160_K	163_H	0.817	0.88
89_K	195_D	0.812	0.88
89_K	192_C	0.811	0.88
21_I	176_V	0.810	0.87
161_A	164_V	0.809	0.87
197_P	214_I	0.808	0.87
105_I	200_L	0.804	0.87
323_F	332_I	0.803	0.87
246_L	336_L	0.803	0.87
21_I	137_L	0.803	0.87
244_A	318_I	0.802	0.87
92_T	95_K	0.800	0.87
108_C	113_L	0.800	0.87
278_K	282_Y	0.797	0.87
275_T	323_F	0.797	0.87
270_V	273_L	0.797	0.87
71_V	82_L	0.796	0.87
50_N	53_A	0.794	0.86
153_S	237_Y	0.792	0.86
103_T	125_A	0.790	0.86
90_A	192_C	0.779	0.85
90_A	104_L	0.779	0.85
105_I	123_T	0.778	0.85
84_G	109_K	0.777	0.85
20_Q	174_G	0.774	0.85
249_C	319_I	0.769	0.85
246_L	318_I	0.768	0.85
77_S	80_E	0.764	0.84
309_S	313_N	0.762	0.84
193_A	197_P	0.760	0.84
156_P	236_K	0.759	0.84
35_A	44_L	0.758	0.84
153_S	156_P	0.756	0.84
204_G	209_Q	0.752	0.83
238_T	342_G	0.749	0.83
164_V	172_I	0.748	0.83
81_D	112_A	0.748	0.83
307_L	336_L	0.745	0.83
191_S	194_D	0.745	0.83
273_L	310_F	0.741	0.82
166_H	308_R	0.739	0.82
137_L	141_S	0.738	0.82
28_L	176_V	0.737	0.82
89_K	216_P	0.736	0.82
185_V	332_I	0.731	0.82
246_L	340_A	0.729	0.81
193_A	231_I	0.729	0.81
62_G	65_S	0.729	0.81
52_D	55_K	0.728	0.81
320_A	323_F	0.728	0.81
73_I	78_Q	0.727	0.81
24_A	135_L	0.727	0.81
131_H	178_G	0.726	0.81
28_L	145_I	0.726	0.81
156_P	237_Y	0.725	0.81
158_P	163_H	0.723	0.81
323_F	333_M	0.721	0.81
237_Y	334_N	0.719	0.80
98_W	104_L	0.716	0.80
275_T	299_V	0.714	0.80
98_W	128_M	0.714	0.80
107_P	193_A	0.713	0.80
224_S	228_E	0.712	0.80
49_K	113_L	0.711	0.80
232_S	338_K	0.710	0.80
155_K	166_H	0.710	0.80
310_F	315_V	0.709	0.80
194_D	198_V	0.707	0.79
165_A	172_I	0.706	0.79
46_A	125_A	0.705	0.79
46_A	54_V	0.704	0.79
28_L	138_I	0.699	0.79
86_A	91_K	0.693	0.78
138_I	142_G	0.692	0.78
296_L	324_P	0.690	0.78
293_R	321_E	0.689	0.78
246_L	307_L	0.689	0.78
247_A	317_F	0.686	0.77
324_P	329_G	0.685	0.77
172_I	175_I	0.684	0.77
117_V	146_A	0.684	0.77
207_K	210_I	0.682	0.77
245_P	311_D	0.681	0.77
275_T	278_K	0.681	0.77
150_A	164_V	0.681	0.77
75_D	135_L	0.681	0.77
274_T	277_E	0.680	0.77
163_H	167_D	0.679	0.77
268_R	317_F	0.676	0.76
24_A	174_G	0.674	0.76
36_F	145_I	0.670	0.76
121_L	232_S	0.669	0.76
67_N	236_K	0.668	0.75
79_L	94_M	0.668	0.75
93_L	190_L	0.666	0.75
261_Q	265_Q	0.666	0.75
44_L	158_P	0.665	0.75
243_T	311_D	0.665	0.75
206_T	211_E	0.664	0.75
71_V	124_V	0.662	0.75
207_K	220_D	0.661	0.75
34_V	174_G	0.660	0.75
250_E	322_S	0.659	0.74
66_D	123_T	0.656	0.74
125_A	146_A	0.653	0.74
244_A	316_D	0.649	0.73
168_L	173_A	0.648	0.73
71_V	113_L	0.645	0.73
31_N	47_N	0.644	0.73
62_G	153_S	0.641	0.72
66_D	156_P	0.640	0.72
93_L	104_L	0.639	0.72
156_P	167_D	0.638	0.72
154_G	236_K	0.637	0.72
248_I	332_I	0.637	0.72
263_Y	266_G	0.637	0.72
90_A	191_S	0.637	0.72
86_A	106_L	0.637	0.72
211_E	215_G	0.634	0.72
88_E	92_T	0.634	0.72
161_A	180_P	0.630	0.71
247_A	319_I	0.630	0.71
275_T	293_R	0.627	0.71
269_R	273_L	0.626	0.71
169_D	172_I	0.624	0.70
214_I	218_H	0.623	0.70
231_I	338_K	0.620	0.70
54_V	189_V	0.619	0.70
54_V	58_Y	0.619	0.70
154_G	241_A	0.618	0.70
180_P	301_A	0.614	0.69
90_A	197_P	0.614	0.69
310_F	318_I	0.612	0.69
290_C	298_T	0.611	0.69
25_A	145_I	0.611	0.69
66_D	230_P	0.609	0.69
73_I	80_E	0.609	0.69
72_H	189_V	0.605	0.68
76_I	80_E	0.603	0.68
49_K	141_S	0.602	0.68
296_L	299_V	0.602	0.68
132_P	136_A	0.601	0.68
276_E	298_T	0.601	0.68
209_Q	297_E	0.600	0.67
260_I	267_G	0.598	0.67
67_N	233_P	0.597	0.67
67_N	167_D	0.596	0.67
300_A	332_I	0.596	0.67
288_K	291_G	0.596	0.67
325_D	329_G	0.596	0.67
72_H	147_A	0.595	0.67
274_T	279_A	0.595	0.67
21_I	136_A	0.593	0.66
156_P	334_N	0.589	0.66
73_I	82_L	0.588	0.66
196_I	218_H	0.587	0.66
273_L	320_A	0.586	0.66
163_H	308_R	0.585	0.65
116_R	119_A	0.583	0.65
167_D	237_Y	0.583	0.65
91_K	94_M	0.580	0.65
51_T	115_P	0.579	0.65
62_G	119_A	0.578	0.65
264_Q	285_D	0.578	0.65
190_L	218_H	0.578	0.65
329_G	333_M	0.577	0.64
152_L	168_L	0.576	0.64
241_A	246_L	0.575	0.64
208_E	329_G	0.575	0.64
123_T	230_P	0.574	0.64
288_K	313_N	0.573	0.64
278_K	293_R	0.572	0.64
156_P	238_T	0.571	0.64
191_S	198_V	0.570	0.63
52_D	165_A	0.569	0.63
36_F	147_A	0.567	0.63
155_K	338_K	0.566	0.63
58_Y	116_R	0.566	0.63
18_D	140_E	0.566	0.63
74_A	135_L	0.565	0.63
238_T	241_A	0.565	0.63
161_A	175_I	0.564	0.63
113_L	124_V	0.564	0.63
208_E	330_L	0.562	0.62
46_A	116_R	0.560	0.62
250_E	337_M	0.559	0.62
18_D	22_A	0.558	0.62
119_A	204_G	0.556	0.62
158_P	164_V	0.554	0.61
60_A	173_A	0.553	0.61
275_T	321_E	0.553	0.61
246_L	339_A	0.552	0.61
33_V	145_I	0.551	0.61
104_L	192_C	0.550	0.61
49_K	144_P	0.547	0.60
81_D	109_K	0.546	0.60
102_L	210_I	0.546	0.60
33_V	173_A	0.545	0.60
96_R	209_Q	0.544	0.60
25_A	28_L	0.544	0.60
294_A	298_T	0.544	0.60
248_I	342_G	0.539	0.59
291_G	295_Q	0.538	0.59
74_A	128_M	0.535	0.59
101_A	210_I	0.534	0.58
315_V	318_I	0.533	0.58
211_E	217_I	0.533	0.58
54_V	116_R	0.532	0.58
27_L	172_I	0.531	0.58
73_I	94_M	0.530	0.58
93_L	97_F	0.530	0.58
67_N	156_P	0.529	0.58
204_G	329_G	0.527	0.57
90_A	106_L	0.527	0.57
33_V	56_K	0.524	0.57
67_N	232_S	0.524	0.57
45_G	147_A	0.523	0.57
269_R	286_Y	0.523	0.57
94_M	98_W	0.522	0.57
199_L	221_K	0.522	0.57
165_A	174_G	0.522	0.57
23_Q	174_G	0.521	0.57
20_Q	176_V	0.520	0.56
108_C	114_S	0.520	0.56
57_I	125_A	0.517	0.56
46_A	168_L	0.516	0.56
66_D	334_N	0.516	0.56
131_H	138_I	0.515	0.56
57_I	204_G	0.515	0.56
48_A	54_V	0.515	0.56
272_V	275_T	0.513	0.55
37_P	178_G	0.513	0.55
35_A	167_D	0.512	0.55
82_L	128_M	0.512	0.55
299_V	302_G	0.511	0.55
267_G	270_V	0.510	0.55
191_S	338_K	0.509	0.55
326_T	329_G	0.509	0.55
65_S	116_R	0.507	0.55
205_I	209_Q	0.507	0.55
199_L	209_Q	0.506	0.54
46_A	312_E	0.505	0.54
23_Q	27_L	0.505	0.54
70_I	234_G	0.504	0.54
78_Q	144_P	0.503	0.54
106_L	192_C	0.503	0.54
60_A	170_G	0.503	0.54
309_S	312_E	0.501	0.54
204_G	244_A	0.501	0.54
289_S	292_R	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2eqaA	1	0.9249	100	0.21	Contact Map
3l7vA	1	0.6098	100	0.516	Contact Map
1jcuA	1	0.6012	100	0.532	Contact Map
1k7jA	1	0.5896	100	0.535	Contact Map
3vthA	1	0.8497	100	0.567	Contact Map
1hruA	2	0.5318	100	0.572	Contact Map
4g9iA	1	0.974	100	0.59	Contact Map
3ttcA	1	0.9653	100	0.602	Contact Map
2yv4A	1	0.2803	99.8	0.843	Contact Map
1xgsA	2	0.4277	46.3	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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