GREMLIN Database
SUA5 - Threonylcarbamoyl-AMP synthase
UniProt: P39153 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (317)
Sequences: 2305 (1784)
Seq/√Len: 100.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_L32_E4.8461.00
47_N50_N4.3951.00
36_F45_G4.2411.00
32_E173_A4.0141.00
48_A71_V3.6871.00
165_A175_I3.1191.00
189_V232_S3.0611.00
26_A30_E2.6321.00
75_D139_R2.4891.00
22_A140_E2.4421.00
207_K211_E2.4321.00
83_T106_L2.4121.00
45_G145_I2.3711.00
36_F137_L2.2951.00
137_L176_V2.2661.00
58_Y65_S2.2521.00
51_T114_S2.1831.00
47_N143_L2.1821.00
152_L171_R2.1761.00
67_N153_S2.1711.00
136_A139_R2.1661.00
271_G310_F2.1391.00
21_I140_E2.1381.00
183_I204_G2.1141.00
94_M104_L2.0641.00
36_F134_A2.0281.00
51_T116_R2.0201.00
73_I79_L2.0161.00
199_L207_K1.9711.00
57_I146_A1.9541.00
97_F213_V1.9421.00
80_E91_K1.9271.00
74_A138_I1.9221.00
162_E166_H1.9031.00
206_T209_Q1.8861.00
165_A169_D1.8731.00
109_K112_A1.8721.00
268_R316_D1.8641.00
269_R316_D1.8571.00
46_A53_A1.8441.00
85_P107_P1.8341.00
160_K180_P1.8131.00
209_Q212_A1.8111.00
32_E56_K1.7941.00
73_I128_M1.7851.00
82_L126_I1.7671.00
185_V331_A1.7621.00
325_D337_M1.7341.00
55_K116_R1.7141.00
89_K214_I1.7021.00
27_L174_G1.7011.00
244_A311_D1.6981.00
161_A177_D1.6961.00
232_S235_M1.6921.00
55_K59_E1.6801.00
84_G107_P1.6761.00
31_N50_N1.6711.00
25_A140_E1.6681.00
136_A140_E1.6641.00
74_A78_Q1.6571.00
17_N20_Q1.6471.00
35_A172_I1.6141.00
78_Q81_D1.6131.00
60_A168_L1.5871.00
296_L332_I1.5821.00
130_D135_L1.5811.00
108_C115_P1.5811.00
152_L167_D1.5701.00
248_I322_S1.5681.00
167_D308_R1.5511.00
56_K59_E1.5511.00
78_Q138_I1.5081.00
25_A141_S1.5021.00
28_L137_L1.4901.00
87_P90_A1.4731.00
288_K306_A1.4361.00
76_I95_K1.4321.00
156_P308_R1.4311.00
91_K95_K1.4301.00
295_Q298_T1.4261.00
28_L141_S1.4261.00
27_L173_A1.4141.00
276_E289_S1.3921.00
271_G315_V1.3901.00
71_V117_V1.3780.99
128_M135_L1.3770.99
211_E216_P1.3710.99
76_I91_K1.3700.99
28_L143_L1.3600.99
191_S231_I1.3540.99
207_K330_L1.3400.99
26_A29_R1.3310.99
49_K114_S1.3270.99
130_D182_G1.3260.99
217_I220_D1.3250.99
305_D309_S1.3090.99
108_C118_T1.2980.99
160_K305_D1.2930.99
138_I141_S1.2930.99
75_D78_Q1.2920.99
35_A164_V1.2890.99
274_T278_K1.2820.99
79_L126_I1.2770.99
133_L178_G1.2710.99
288_K309_S1.2650.99
107_P122_E1.2640.99
23_Q26_A1.2620.99
84_G110_P1.2420.99
210_I214_I1.2370.99
49_K143_L1.2320.99
93_L102_L1.2320.99
76_I94_M1.2290.99
92_T96_R1.2260.99
82_L113_L1.2250.99
66_D237_Y1.2180.99
273_L306_A1.2160.99
192_C197_P1.2140.99
66_D236_K1.2120.99
300_A328_V1.2090.99
46_A57_I1.2090.99
320_A336_L1.2050.99
299_V323_F1.2030.99
166_H312_E1.1950.98
123_T193_A1.1860.98
83_T124_V1.1840.98
128_M138_I1.1780.98
93_L210_I1.1770.98
141_S144_P1.1580.98
334_N338_K1.1460.98
102_L190_L1.1180.98
185_V204_G1.1150.98
244_A315_V1.1130.98
302_G306_A1.1120.98
22_A26_A1.1010.97
35_A161_A1.1010.97
163_H305_D1.0970.97
54_V117_V1.0900.97
270_V275_T1.0890.97
79_L86_A1.0880.97
74_A139_R1.0820.97
88_E91_K1.0790.97
104_L190_L1.0710.97
96_R213_V1.0700.97
67_N119_A1.0700.97
306_A310_F1.0560.97
192_C214_I1.0530.97
202_P334_N1.0490.97
60_A171_R1.0490.97
199_L217_I1.0430.96
197_P215_G1.0340.96
33_V60_A1.0330.96
153_S236_K1.0300.96
138_I145_I1.0290.96
134_A147_A1.0270.96
83_T126_I1.0190.96
155_K167_D1.0190.96
76_I128_M1.0170.96
299_V332_I1.0160.96
83_T109_K1.0130.96
135_L139_R1.0110.96
191_S197_P1.0100.96
154_G238_T1.0020.96
263_Y319_I1.0000.95
185_V300_A0.9920.95
277_E291_G0.9870.95
89_K92_T0.9830.95
333_M338_K0.9830.95
96_R212_A0.9810.95
25_A29_R0.9770.95
155_K243_T0.9720.95
271_G274_T0.9660.95
277_E292_R0.9630.94
298_T302_G0.9610.94
214_I217_I0.9600.94
190_L214_I0.9570.94
141_S145_I0.9560.94
296_L329_G0.9540.94
105_I125_A0.9450.94
230_P236_K0.9440.94
302_G305_D0.9430.94
79_L106_L0.9340.93
168_L172_I0.9300.93
133_L176_V0.9280.93
80_E86_A0.9250.93
86_A94_M0.9170.93
246_L320_A0.9130.93
245_P317_F0.9130.93
156_P246_L0.9120.93
248_I340_A0.9110.93
97_F205_I0.9100.93
45_G134_A0.9090.93
208_E327_G0.9040.92
98_W102_L0.8970.92
29_R143_L0.8940.92
58_Y119_A0.8940.92
244_A310_F0.8930.92
49_K112_A0.8910.92
211_E218_H0.8890.92
81_D142_G0.8890.92
244_A314_K0.8880.92
67_N237_Y0.8880.92
35_A45_G0.8880.92
278_K321_E0.8810.91
238_T341_G0.8770.91
291_G299_V0.8730.91
193_A196_I0.8710.91
168_L171_R0.8680.91
306_A309_S0.8670.91
152_L155_K0.8650.91
298_T301_A0.8630.90
236_K334_N0.8510.90
333_M337_M0.8510.90
94_M128_M0.8450.90
78_Q128_M0.8400.89
115_P122_E0.8390.89
62_G171_R0.8380.89
118_T124_V0.8350.89
18_D136_A0.8330.89
47_N144_P0.8310.89
270_V317_F0.8300.89
141_S189_V0.8300.89
161_A179_G0.8270.89
57_I147_A0.8250.88
260_I272_V0.8230.88
322_S333_M0.8210.88
47_N141_S0.8180.88
160_K163_H0.8170.88
89_K195_D0.8120.88
89_K192_C0.8110.88
21_I176_V0.8100.87
161_A164_V0.8090.87
197_P214_I0.8080.87
105_I200_L0.8040.87
323_F332_I0.8030.87
246_L336_L0.8030.87
21_I137_L0.8030.87
244_A318_I0.8020.87
92_T95_K0.8000.87
108_C113_L0.8000.87
278_K282_Y0.7970.87
275_T323_F0.7970.87
270_V273_L0.7970.87
71_V82_L0.7960.87
50_N53_A0.7940.86
153_S237_Y0.7920.86
103_T125_A0.7900.86
90_A192_C0.7790.85
90_A104_L0.7790.85
105_I123_T0.7780.85
84_G109_K0.7770.85
20_Q174_G0.7740.85
249_C319_I0.7690.85
246_L318_I0.7680.85
77_S80_E0.7640.84
309_S313_N0.7620.84
193_A197_P0.7600.84
156_P236_K0.7590.84
35_A44_L0.7580.84
153_S156_P0.7560.84
204_G209_Q0.7520.83
238_T342_G0.7490.83
164_V172_I0.7480.83
81_D112_A0.7480.83
307_L336_L0.7450.83
191_S194_D0.7450.83
273_L310_F0.7410.82
166_H308_R0.7390.82
137_L141_S0.7380.82
28_L176_V0.7370.82
89_K216_P0.7360.82
185_V332_I0.7310.82
246_L340_A0.7290.81
193_A231_I0.7290.81
62_G65_S0.7290.81
52_D55_K0.7280.81
320_A323_F0.7280.81
73_I78_Q0.7270.81
24_A135_L0.7270.81
131_H178_G0.7260.81
28_L145_I0.7260.81
156_P237_Y0.7250.81
158_P163_H0.7230.81
323_F333_M0.7210.81
237_Y334_N0.7190.80
98_W104_L0.7160.80
275_T299_V0.7140.80
98_W128_M0.7140.80
107_P193_A0.7130.80
224_S228_E0.7120.80
49_K113_L0.7110.80
232_S338_K0.7100.80
155_K166_H0.7100.80
310_F315_V0.7090.80
194_D198_V0.7070.79
165_A172_I0.7060.79
46_A125_A0.7050.79
46_A54_V0.7040.79
28_L138_I0.6990.79
86_A91_K0.6930.78
138_I142_G0.6920.78
296_L324_P0.6900.78
293_R321_E0.6890.78
246_L307_L0.6890.78
247_A317_F0.6860.77
324_P329_G0.6850.77
172_I175_I0.6840.77
117_V146_A0.6840.77
207_K210_I0.6820.77
245_P311_D0.6810.77
275_T278_K0.6810.77
150_A164_V0.6810.77
75_D135_L0.6810.77
274_T277_E0.6800.77
163_H167_D0.6790.77
268_R317_F0.6760.76
24_A174_G0.6740.76
36_F145_I0.6700.76
121_L232_S0.6690.76
67_N236_K0.6680.75
79_L94_M0.6680.75
93_L190_L0.6660.75
261_Q265_Q0.6660.75
44_L158_P0.6650.75
243_T311_D0.6650.75
206_T211_E0.6640.75
71_V124_V0.6620.75
207_K220_D0.6610.75
34_V174_G0.6600.75
250_E322_S0.6590.74
66_D123_T0.6560.74
125_A146_A0.6530.74
244_A316_D0.6490.73
168_L173_A0.6480.73
71_V113_L0.6450.73
31_N47_N0.6440.73
62_G153_S0.6410.72
66_D156_P0.6400.72
93_L104_L0.6390.72
156_P167_D0.6380.72
154_G236_K0.6370.72
248_I332_I0.6370.72
263_Y266_G0.6370.72
90_A191_S0.6370.72
86_A106_L0.6370.72
211_E215_G0.6340.72
88_E92_T0.6340.72
161_A180_P0.6300.71
247_A319_I0.6300.71
275_T293_R0.6270.71
269_R273_L0.6260.71
169_D172_I0.6240.70
214_I218_H0.6230.70
231_I338_K0.6200.70
54_V189_V0.6190.70
54_V58_Y0.6190.70
154_G241_A0.6180.70
180_P301_A0.6140.69
90_A197_P0.6140.69
310_F318_I0.6120.69
290_C298_T0.6110.69
25_A145_I0.6110.69
66_D230_P0.6090.69
73_I80_E0.6090.69
72_H189_V0.6050.68
76_I80_E0.6030.68
49_K141_S0.6020.68
296_L299_V0.6020.68
132_P136_A0.6010.68
276_E298_T0.6010.68
209_Q297_E0.6000.67
260_I267_G0.5980.67
67_N233_P0.5970.67
67_N167_D0.5960.67
300_A332_I0.5960.67
288_K291_G0.5960.67
325_D329_G0.5960.67
72_H147_A0.5950.67
274_T279_A0.5950.67
21_I136_A0.5930.66
156_P334_N0.5890.66
73_I82_L0.5880.66
196_I218_H0.5870.66
273_L320_A0.5860.66
163_H308_R0.5850.65
116_R119_A0.5830.65
167_D237_Y0.5830.65
91_K94_M0.5800.65
51_T115_P0.5790.65
62_G119_A0.5780.65
264_Q285_D0.5780.65
190_L218_H0.5780.65
329_G333_M0.5770.64
152_L168_L0.5760.64
241_A246_L0.5750.64
208_E329_G0.5750.64
123_T230_P0.5740.64
288_K313_N0.5730.64
278_K293_R0.5720.64
156_P238_T0.5710.64
191_S198_V0.5700.63
52_D165_A0.5690.63
36_F147_A0.5670.63
155_K338_K0.5660.63
58_Y116_R0.5660.63
18_D140_E0.5660.63
74_A135_L0.5650.63
238_T241_A0.5650.63
161_A175_I0.5640.63
113_L124_V0.5640.63
208_E330_L0.5620.62
46_A116_R0.5600.62
250_E337_M0.5590.62
18_D22_A0.5580.62
119_A204_G0.5560.62
158_P164_V0.5540.61
60_A173_A0.5530.61
275_T321_E0.5530.61
246_L339_A0.5520.61
33_V145_I0.5510.61
104_L192_C0.5500.61
49_K144_P0.5470.60
81_D109_K0.5460.60
102_L210_I0.5460.60
33_V173_A0.5450.60
96_R209_Q0.5440.60
25_A28_L0.5440.60
294_A298_T0.5440.60
248_I342_G0.5390.59
291_G295_Q0.5380.59
74_A128_M0.5350.59
101_A210_I0.5340.58
315_V318_I0.5330.58
211_E217_I0.5330.58
54_V116_R0.5320.58
27_L172_I0.5310.58
73_I94_M0.5300.58
93_L97_F0.5300.58
67_N156_P0.5290.58
204_G329_G0.5270.57
90_A106_L0.5270.57
33_V56_K0.5240.57
67_N232_S0.5240.57
45_G147_A0.5230.57
269_R286_Y0.5230.57
94_M98_W0.5220.57
199_L221_K0.5220.57
165_A174_G0.5220.57
23_Q174_G0.5210.57
20_Q176_V0.5200.56
108_C114_S0.5200.56
57_I125_A0.5170.56
46_A168_L0.5160.56
66_D334_N0.5160.56
131_H138_I0.5150.56
57_I204_G0.5150.56
48_A54_V0.5150.56
272_V275_T0.5130.55
37_P178_G0.5130.55
35_A167_D0.5120.55
82_L128_M0.5120.55
299_V302_G0.5110.55
267_G270_V0.5100.55
191_S338_K0.5090.55
326_T329_G0.5090.55
65_S116_R0.5070.55
205_I209_Q0.5070.55
199_L209_Q0.5060.54
46_A312_E0.5050.54
23_Q27_L0.5050.54
70_I234_G0.5040.54
78_Q144_P0.5030.54
106_L192_C0.5030.54
60_A170_G0.5030.54
309_S312_E0.5010.54
204_G244_A0.5010.54
289_S292_R0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eqaA 1 0.9249 100 0.21 Contact Map
3l7vA 1 0.6098 100 0.516 Contact Map
1jcuA 1 0.6012 100 0.532 Contact Map
1k7jA 1 0.5896 100 0.535 Contact Map
3vthA 1 0.8497 100 0.567 Contact Map
1hruA 2 0.5318 100 0.572 Contact Map
4g9iA 1 0.974 100 0.59 Contact Map
3ttcA 1 0.9653 100 0.602 Contact Map
2yv4A 1 0.2803 99.8 0.843 Contact Map
1xgsA 2 0.4277 46.3 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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