GREMLIN Database
YWLB - Uncharacterized protein YwlB
UniProt: P39152 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (133)
Sequences: 324 (278)
Seq/√Len: 24.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_E114_F6.6501.00
23_A67_V4.5031.00
51_L84_M4.4521.00
51_L66_L3.4751.00
85_E96_V2.9231.00
61_G93_I2.7690.99
6_R41_E2.6980.99
124_L127_S2.4020.98
29_G133_S2.3560.98
97_Y141_L2.0630.95
66_L81_F1.8120.91
122_E126_S1.6880.87
6_R12_D1.6340.86
72_L77_I1.6280.85
120_V141_L1.6190.85
49_G55_K1.6070.85
29_G124_L1.5950.84
19_F69_S1.5780.83
99_V130_F1.5740.83
125_F130_F1.5730.83
37_F52_G1.5680.83
100_A109_L1.5610.83
134_R139_A1.5470.82
134_R137_E1.4820.79
20_L26_S1.4780.79
81_F112_M1.4430.77
8_A39_M1.3840.74
96_V100_A1.3750.74
16_L19_F1.3560.73
60_Q123_E1.3440.72
96_V114_F1.3340.72
8_A50_C1.3170.71
25_T54_E1.3170.71
62_L124_L1.2860.69
99_V109_L1.2810.68
78_V112_M1.2720.68
104_S129_H1.2410.66
29_G114_F1.2320.65
8_A16_L1.1870.62
50_C108_F1.1860.62
104_S135_Q1.1720.61
39_M47_I1.1610.61
68_I73_H1.1520.60
81_F108_F1.1440.59
85_E112_M1.1400.59
120_V130_F1.1350.59
26_S29_G1.1150.57
114_F125_F1.1080.57
63_L96_V1.1050.57
16_L50_C1.1030.57
64_R98_L1.0910.56
26_S134_R1.0910.56
19_F50_C1.0900.56
92_Q95_T1.0660.54
37_F118_E1.0630.54
40_L49_G1.0620.54
51_L99_V1.0590.53
26_S73_H1.0500.53
55_K61_G1.0480.53
108_F111_A1.0470.53
55_K124_L1.0390.52
16_L61_G1.0360.52
24_K128_D1.0310.51
50_C67_V1.0280.51
20_L65_S0.9960.49
16_L39_M0.9800.48
16_L33_G0.9780.48
82_Q117_A0.9710.47
11_K32_E0.9680.47
42_D77_I0.9670.47
117_A129_H0.9610.46
22_Q42_D0.9600.46
97_Y124_L0.9600.46
73_H92_Q0.9370.45
98_L142_M0.9270.44
99_V120_V0.9250.44
20_L136_T0.9220.44
101_N105_S0.9200.44
18_A39_M0.9120.43
73_H76_H0.9110.43
67_V81_F0.9030.42
104_S137_E0.8880.41
105_S135_Q0.8820.41
26_S99_V0.8780.41
56_I127_S0.8770.41
24_K88_C0.8700.40
25_T105_S0.8670.40
61_G96_V0.8660.40
44_E60_Q0.8640.40
21_K75_G0.8640.40
53_I77_I0.8600.39
53_I107_D0.8600.39
15_V92_Q0.8560.39
135_Q139_A0.8500.39
18_A42_D0.8440.38
10_E82_Q0.8410.38
109_L121_P0.8390.38
97_Y126_S0.8370.38
62_L129_H0.8240.37
88_C133_S0.8050.36
17_E95_T0.8020.36
56_I61_G0.7910.35
25_T135_Q0.7880.35
39_M141_L0.7840.34
68_I108_F0.7740.34
16_L34_F0.7650.33
20_L73_H0.7610.33
16_L40_L0.7610.33
20_L25_T0.7570.33
21_K119_S0.7560.33
129_H134_R0.7520.32
40_L84_M0.7440.32
23_A78_V0.7340.31
72_L89_E0.7320.31
12_D16_L0.7220.31
97_Y143_K0.7190.30
42_D82_Q0.7180.30
67_V108_F0.7160.30
38_L50_C0.7160.30
78_V81_F0.7150.30
28_E122_E0.7140.30
109_L130_F0.7110.30
26_S139_A0.7100.30
16_L35_T0.7070.30
23_A50_C0.7030.29
23_A41_E0.7010.29
69_S132_E0.6980.29
100_A134_R0.6970.29
66_L88_C0.6860.28
25_T98_L0.6790.28
50_C97_Y0.6750.28
20_L127_S0.6740.28
120_V124_L0.6660.27
80_L142_M0.6640.27
40_L111_A0.6600.27
87_L101_N0.6590.27
85_E130_F0.6570.27
25_T113_G0.6560.27
68_I80_L0.6550.27
26_S101_N0.6540.27
79_T86_V0.6530.27
63_L85_E0.6530.27
40_L141_L0.6520.26
127_S137_E0.6520.26
95_T141_L0.6510.26
14_D22_Q0.6510.26
20_L105_S0.6490.26
21_K142_M0.6450.26
53_I71_K0.6430.26
49_G124_L0.6410.26
40_L51_L0.6400.26
66_L80_L0.6390.26
16_L21_K0.6320.25
49_G106_A0.6320.25
42_D94_K0.6310.25
44_E123_E0.6290.25
100_A121_P0.6230.25
126_S129_H0.6200.25
104_S134_R0.6150.24
8_A40_L0.6150.24
95_T117_A0.6140.24
53_I62_L0.6090.24
65_S98_L0.6040.24
48_A77_I0.6030.24
57_S122_E0.6000.24
51_L67_V0.5920.23
31_K117_A0.5920.23
18_A22_Q0.5860.23
100_A135_Q0.5860.23
71_K107_D0.5840.23
38_L84_M0.5840.23
105_S134_R0.5810.23
45_K86_V0.5800.23
50_C88_C0.5750.22
98_L105_S0.5730.22
25_T73_H0.5730.22
15_V117_A0.5710.22
90_K94_K0.5690.22
23_A81_F0.5670.22
18_A119_S0.5670.22
12_D32_E0.5640.22
56_I124_L0.5640.22
26_S135_Q0.5580.22
26_S100_A0.5540.21
17_E31_K0.5530.21
31_K36_Q0.5520.21
48_A72_L0.5480.21
36_Q91_H0.5370.21
33_G123_E0.5280.20
129_H139_A0.5280.20
11_K30_V0.5270.20
36_Q93_I0.5190.20
37_F74_Q0.5160.20
8_A30_V0.5140.20
49_G109_L0.5100.19
110_T142_M0.5090.19
95_T120_V0.5080.19
50_C123_E0.5010.19
109_L124_L0.5010.19
70_D75_G0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e0kA 2 0.9252 99.6 0.661 Contact Map
3d2mA 5 0.9524 99.5 0.672 Contact Map
1y9kA 1 0.9796 99.5 0.673 Contact Map
3te4A 1 0.9864 99.5 0.676 Contact Map
2g3aA 2 0.8912 99.5 0.678 Contact Map
3fixA 2 0.8707 99.5 0.68 Contact Map
3gy9A 3 0.8639 99.5 0.681 Contact Map
2j8mA 2 0.9524 99.5 0.682 Contact Map
3d8pA 1 0.9524 99.5 0.683 Contact Map
2r7hA 2 0.9184 99.5 0.683 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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