GREMLIN Database
SP2R - Stage II sporulation protein R
UniProt: P39151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (184)
Sequences: 441 (381)
Seq/√Len: 28.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_V141_I7.0851.00
85_R137_E5.7471.00
142_T146_G5.6721.00
91_K94_E4.3761.00
59_L103_M4.0281.00
99_A112_I3.9881.00
62_H106_E3.2841.00
59_L143_L3.0881.00
81_I85_R3.0191.00
81_I137_E2.7221.00
103_M143_L2.6561.00
101_E105_K2.3050.99
103_M108_A2.2020.98
43_I85_R2.1850.98
43_I88_I2.1350.98
48_L142_T2.1200.97
100_K112_I2.1160.97
43_I116_F1.9760.96
45_L84_A1.9690.96
103_M112_I1.9250.95
125_L130_V1.8280.94
46_R131_Y1.8110.94
66_A69_K1.8040.94
42_A131_Y1.7600.93
112_I143_L1.7570.93
61_R64_R1.7440.92
42_A46_R1.7390.92
178_A182_Q1.7100.92
103_M110_Q1.6730.91
64_R68_N1.6130.89
102_T105_K1.5260.86
92_L114_V1.4580.83
50_N56_D1.4400.83
66_A102_T1.4260.82
15_L23_A1.4210.82
58_Q62_H1.4200.82
92_L139_I1.4060.81
67_V95_I1.3820.80
78_I87_V1.3810.80
63_I102_T1.3610.79
119_I131_Y1.3560.79
128_N175_D1.3350.78
128_N171_K1.3160.77
127_G161_F1.3060.76
96_K114_V1.2900.75
59_L108_A1.2810.75
48_L115_D1.2780.74
68_N164_F1.2640.74
68_N71_I1.2590.73
96_K100_K1.2550.73
41_Q135_E1.2510.73
118_K135_E1.2500.73
182_Q187_L1.2300.71
71_I88_I1.2270.71
9_I13_L1.2010.70
53_S58_Q1.1940.69
43_I137_E1.1920.69
99_A103_M1.1890.69
71_I149_A1.1850.69
183_T186_V1.1790.68
115_D142_T1.1770.68
95_I114_V1.1730.68
71_I124_K1.1530.66
133_A166_N1.1500.66
68_N162_L1.1470.66
120_S135_E1.1360.65
52_D149_A1.1330.65
183_T187_L1.1130.64
143_L146_G1.1060.63
182_Q186_V1.0860.62
149_A162_L1.0790.61
159_L163_D1.0700.60
110_Q143_L1.0450.59
47_I75_V1.0370.58
119_I140_L1.0340.58
114_V139_I1.0320.58
54_D58_Q1.0310.58
122_P163_D1.0240.57
45_L73_T1.0200.57
124_K161_F1.0100.56
43_I124_K1.0080.56
123_T133_A1.0070.56
153_C160_C0.9990.55
85_R116_F0.9970.55
39_P42_A0.9970.55
63_I108_A0.9940.55
68_N140_L0.9930.55
170_V173_Q0.9820.54
158_P163_D0.9750.53
15_L29_Q0.9600.52
42_A146_G0.9400.51
87_V91_K0.9350.50
133_A139_I0.9330.50
46_R119_I0.9310.50
64_R133_A0.9310.50
21_G25_E0.9250.49
35_P39_P0.9000.48
13_L21_G0.8960.47
64_R156_F0.8940.47
131_Y164_F0.8910.47
38_I129_M0.8900.47
58_Q143_L0.8800.46
93_P97_A0.8780.46
50_N59_L0.8740.46
46_R74_W0.8730.45
66_A105_K0.8710.45
135_E184_E0.8690.45
39_P46_R0.8560.44
42_A119_I0.8500.44
71_I139_I0.8410.43
78_I84_A0.8410.43
80_S145_N0.8400.43
40_D156_F0.8400.43
43_I84_A0.8360.43
47_I141_I0.8360.43
96_K103_M0.8350.43
127_G169_A0.8350.43
24_K27_T0.8170.41
42_A158_P0.8150.41
102_T107_G0.8050.40
45_L75_V0.8010.40
21_G24_K0.7960.40
175_D178_A0.7930.39
182_Q190_V0.7880.39
88_I116_F0.7860.39
65_D98_I0.7860.39
51_S56_D0.7830.39
53_S156_F0.7800.39
92_L96_K0.7770.38
96_K99_A0.7730.38
68_N124_K0.7690.38
100_K103_M0.7680.38
42_A142_T0.7640.37
100_K141_I0.7600.37
22_L25_E0.7600.37
64_R129_M0.7600.37
105_K176_K0.7540.37
88_I146_G0.7510.36
102_T114_V0.7390.36
85_R124_K0.7370.35
119_I142_T0.7350.35
155_L161_F0.7310.35
25_E130_V0.7300.35
22_L27_T0.7300.35
120_S155_L0.7280.35
108_A143_L0.7250.35
19_L22_L0.7220.34
59_L63_I0.7190.34
40_D162_L0.7190.34
124_K137_E0.7160.34
20_V23_A0.7140.34
16_S104_E0.7140.34
69_K135_E0.7130.34
47_I131_Y0.7110.34
35_P40_D0.7040.33
61_R149_A0.7030.33
122_P161_F0.7010.33
8_C13_L0.7000.33
61_R65_D0.6970.33
110_Q162_L0.6900.32
164_F167_G0.6890.32
14_L102_T0.6840.32
59_L110_Q0.6830.32
116_F140_L0.6820.32
82_E124_K0.6780.31
170_V175_D0.6730.31
41_Q155_L0.6710.31
10_Y20_V0.6680.31
78_I88_I0.6670.31
48_L119_I0.6670.31
46_R125_L0.6650.31
70_E98_I0.6640.31
45_L131_Y0.6640.31
181_K186_V0.6570.30
90_S176_K0.6550.30
75_V131_Y0.6550.30
14_L17_G0.6540.30
181_K184_E0.6530.30
109_N189_D0.6470.29
86_R113_S0.6440.29
130_V169_A0.6360.29
153_C157_P0.6360.29
157_P160_C0.6360.29
81_I91_K0.6350.29
39_P155_L0.6320.28
68_N166_N0.6320.28
131_Y156_F0.6300.28
45_L133_A0.6290.28
63_I103_M0.6290.28
163_D167_G0.6290.28
50_N53_S0.6260.28
48_L156_F0.6230.28
14_L79_T0.6200.28
111_S143_L0.6180.28
116_F169_A0.6130.27
95_I182_Q0.6130.27
19_L97_A0.6120.27
46_R68_N0.6080.27
55_Q113_S0.6060.27
85_R135_E0.6050.27
68_N110_Q0.6020.27
48_L116_F0.6000.26
176_K182_Q0.5970.26
49_A56_D0.5940.26
52_D115_D0.5900.26
43_I158_P0.5870.26
119_I133_A0.5850.26
42_A140_L0.5830.25
64_R184_E0.5820.25
77_D101_E0.5810.25
11_I19_L0.5800.25
68_N129_M0.5790.25
131_Y142_T0.5780.25
38_I142_T0.5770.25
96_K113_S0.5760.25
123_T169_A0.5720.25
18_A29_Q0.5700.25
46_R140_L0.5680.25
80_S109_N0.5680.25
97_A184_E0.5670.25
65_D154_V0.5660.25
13_L25_E0.5660.25
25_E145_N0.5650.24
23_A26_E0.5610.24
9_I89_R0.5590.24
97_A177_E0.5590.24
90_S177_E0.5580.24
122_P162_L0.5550.24
9_I185_K0.5540.24
43_I81_I0.5530.24
46_R142_T0.5510.24
64_R151_W0.5490.24
48_L140_L0.5480.24
88_I163_D0.5460.23
18_A26_E0.5450.23
14_L92_L0.5450.23
82_E97_A0.5440.23
83_E176_K0.5430.23
86_R89_R0.5420.23
89_R104_E0.5410.23
171_K175_D0.5390.23
43_I74_W0.5380.23
38_I137_E0.5380.23
12_F20_V0.5360.23
70_E169_A0.5340.23
110_Q114_V0.5340.23
178_A181_K0.5280.22
108_A169_A0.5270.22
15_L54_D0.5250.22
47_I142_T0.5240.22
120_S140_L0.5240.22
155_L170_V0.5230.22
186_V190_V0.5230.22
116_F119_I0.5220.22
114_V186_V0.5190.22
74_W131_Y0.5190.22
64_R139_I0.5190.22
46_R112_I0.5180.22
45_L119_I0.5180.22
17_G21_G0.5170.22
122_P131_Y0.5170.22
12_F180_K0.5160.22
14_L18_A0.5160.22
114_V133_A0.5160.22
89_R177_E0.5120.22
46_R99_A0.5110.22
35_P95_I0.5110.22
123_T167_G0.5090.21
86_R180_K0.5090.21
149_A164_F0.5080.21
14_L23_A0.5070.21
98_I141_I0.5060.21
8_C90_S0.5020.21
86_R90_S0.5010.21
9_I33_N0.5000.21
16_S27_T0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1usuB 1 0.375 22.5 0.963 Contact Map
3ekiA 1 0.7768 13.8 0.966 Contact Map
3ldzA 1 0.3973 9.9 0.968 Contact Map
3layA 5 0.2589 9.7 0.969 Contact Map
1elkA 1 0.4152 7.2 0.97 Contact Map
4pj0U 1 0.3795 7.1 0.97 Contact Map
2ak5A 3 0.2857 7 0.971 Contact Map
2ew3A 1 0.2679 6.5 0.971 Contact Map
1pfsA 2 0.3259 6.2 0.971 Contact Map
2f95B 2 0.0893 5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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