GREMLIN Database
UPP - Uracil phosphoribosyltransferase
UniProt: P39149 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (204)
Sequences: 3063 (1610)
Seq/√Len: 112.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E56_N4.3221.00
109_L192_G4.1221.00
168_E172_K3.9501.00
162_A181_I3.5491.00
140_A157_F2.9601.00
52_E63_K2.8941.00
167_V184_L2.8791.00
34_D90_K2.8681.00
141_V173_H2.6761.00
141_V169_E2.6531.00
54_D61_A2.5611.00
60_Q186_E2.5451.00
144_I170_L2.5171.00
27_K31_E2.4611.00
17_T64_S2.3891.00
74_V130_V2.3081.00
145_H149_K2.2681.00
169_E173_H2.2491.00
164_P168_E2.2251.00
52_E65_K2.2091.00
41_A88_I2.2031.00
88_I158_M1.9841.00
54_D63_K1.9611.00
157_F170_L1.9411.00
148_K174_H1.9221.00
25_G28_D1.9081.00
103_Y112_V1.8731.00
19_I33_V1.8491.00
59_V195_V1.8431.00
34_D86_D1.8311.00
145_H173_H1.8191.00
60_Q195_V1.7631.00
12_I36_V1.7231.00
126_E154_N1.6871.00
105_D112_V1.6861.00
164_P186_E1.6641.00
13_Q65_K1.6621.00
189_N195_V1.6601.00
56_N61_A1.6421.00
168_E171_Q1.6341.00
47_D156_R1.6261.00
167_V179_I1.6191.00
75_V98_G1.5911.00
147_L152_A1.5781.00
43_E46_R1.5471.00
76_P82_L1.5441.00
37_A84_M1.5331.00
111_P138_G1.4971.00
38_T90_K1.4861.00
89_L97_V1.4781.00
15_K35_E1.4771.00
142_E145_H1.4661.00
6_V184_L1.4401.00
51_E66_V1.4181.00
16_L182_A1.4171.00
148_K176_D1.4091.00
51_E68_S1.3661.00
53_V66_V1.3521.00
33_V160_L1.3361.00
74_V88_I1.3301.00
141_V145_H1.3251.00
44_I158_M1.3211.00
159_C181_I1.3201.00
186_E195_V1.3161.00
146_S150_R1.3091.00
45_T92_I1.2640.99
156_R178_D1.2640.99
40_M44_I1.2630.99
187_K195_V1.2470.99
144_I155_I1.2410.99
30_R89_L1.2410.99
24_T204_R1.2390.99
48_L72_L1.2320.99
116_V146_S1.2030.99
100_V143_A1.1920.99
102_L139_S1.1860.99
116_V150_R1.1820.99
98_G119_P1.1820.99
19_I32_L1.1720.99
145_H174_H1.1550.99
127_F152_A1.1380.99
153_K176_D1.1360.99
98_G118_L1.1330.99
106_P191_K1.1060.98
40_M158_M1.0980.98
7_F12_I1.0910.98
71_K125_R1.0880.98
146_S149_K1.0870.98
19_I36_V1.0830.98
170_L179_I1.0770.98
72_L125_R1.0700.98
165_E187_K1.0700.98
73_G122_V1.0690.98
73_G127_F1.0630.98
164_P187_K1.0600.98
36_V182_A1.0420.98
113_E146_S1.0260.97
28_D31_E1.0230.97
185_D194_I1.0190.97
75_V118_L1.0110.97
110_K169_E0.9920.97
49_P68_S0.9890.97
129_V147_L0.9850.97
41_A87_G0.9750.96
41_A74_V0.9740.96
5_Y180_Y0.9740.96
45_T48_L0.9660.96
82_L99_H0.9640.96
12_I39_L0.9580.96
126_E156_R0.9540.96
122_V152_A0.9430.96
55_I62_A0.9270.95
187_K190_E0.9260.95
21_N55_I0.9220.95
156_R180_Y0.9200.95
154_N178_D0.8970.94
38_T91_L0.8950.94
8_D13_Q0.8860.94
121_D125_R0.8790.93
141_V170_L0.8790.93
15_K32_L0.8750.93
63_K67_I0.8730.93
108_T111_P0.8730.93
111_P114_Y0.8720.93
83_G205_M0.8680.93
165_E168_E0.8530.92
144_I177_V0.8410.92
142_E146_S0.8360.92
74_V92_I0.8320.91
129_V144_I0.8250.91
18_Y66_V0.8230.91
105_D110_K0.8220.91
26_T96_K0.8200.91
7_F40_M0.8200.91
16_L161_V0.8160.91
41_A91_L0.8130.91
53_V67_I0.8130.91
85_V99_H0.8080.90
54_D62_A0.8070.90
17_T66_V0.7980.90
33_V36_V0.7830.89
44_I128_I0.7800.89
18_Y28_D0.7790.89
169_E172_K0.7770.88
133_M194_I0.7740.88
104_R133_M0.7730.88
103_Y115_Y0.7710.88
171_Q178_D0.7710.88
122_V127_F0.7700.88
73_G98_G0.7620.87
170_L177_V0.7610.87
104_R202_G0.7580.87
34_D38_T0.7510.87
171_Q179_I0.7480.87
8_D46_R0.7470.86
128_I156_R0.7390.86
80_A133_M0.7390.86
105_D108_T0.7380.86
127_F147_L0.7310.85
16_L183_A0.7280.85
118_L150_R0.7270.85
24_T28_D0.7250.85
41_A44_I0.7220.85
72_L126_E0.7210.84
39_L42_F0.7210.84
128_I158_M0.7160.84
74_V85_V0.7150.84
166_G188_L0.7140.84
181_I184_L0.7130.84
18_Y24_T0.7130.84
85_V97_V0.7120.84
69_G125_R0.7070.83
185_D196_P0.7040.83
37_A87_G0.6980.82
126_E153_K0.6980.82
76_P130_V0.6980.82
174_H177_V0.6960.82
55_I61_A0.6870.81
104_R132_P0.6840.81
138_G169_E0.6820.81
129_V143_A0.6800.81
104_R135_A0.6800.81
104_R139_S0.6770.81
17_T55_I0.6740.80
133_M139_S0.6730.80
104_R200_D0.6710.80
101_G114_Y0.6700.80
161_V183_A0.6670.80
96_K125_R0.6660.79
133_M193_Y0.6650.79
20_R185_D0.6630.79
159_C162_A0.6620.79
52_E64_S0.6620.79
72_L92_I0.6580.79
34_D37_A0.6560.78
65_K68_S0.6510.78
60_Q187_K0.6470.77
51_E67_I0.6470.77
57_T62_A0.6450.77
82_L85_V0.6420.77
133_M198_L0.6380.77
7_F181_I0.6380.77
33_V205_M0.6330.76
5_Y8_D0.6310.76
18_Y32_L0.6280.75
53_V64_S0.6270.75
144_I148_K0.6270.75
21_N53_V0.6260.75
165_E186_E0.6220.75
109_L191_K0.6210.75
129_V170_L0.6200.74
73_G118_L0.6180.74
102_L142_E0.6160.74
50_L65_K0.6160.74
33_V37_A0.6140.74
11_L39_L0.6130.74
49_P70_K0.6080.73
20_R196_P0.6050.73
33_V201_A0.6040.73
102_L146_S0.6020.72
167_V171_Q0.6000.72
64_S67_I0.5990.72
39_L91_L0.5980.72
145_H148_K0.5950.71
85_V130_V0.5950.71
185_D197_G0.5920.71
147_L151_G0.5900.71
193_Y201_A0.5900.71
35_E42_F0.5870.70
100_V116_V0.5870.70
26_T30_R0.5850.70
167_V181_I0.5830.70
25_G94_A0.5820.70
58_P204_R0.5810.70
110_K142_E0.5800.70
44_I127_F0.5780.69
196_P199_G0.5740.69
24_T58_P0.5710.68
47_D178_D0.5700.68
15_K39_L0.5700.68
141_V174_H0.5690.68
113_E150_R0.5680.68
80_A193_Y0.5680.68
28_D156_R0.5670.68
91_L94_A0.5630.67
102_L113_E0.5590.67
32_L35_E0.5540.66
38_T41_A0.5530.66
19_I44_I0.5520.66
5_Y178_D0.5520.66
194_I198_L0.5510.66
111_P142_E0.5510.66
85_V88_I0.5500.65
25_G96_K0.5480.65
12_I182_A0.5470.65
14_H67_I0.5470.65
139_S142_E0.5470.65
31_E90_K0.5470.65
17_T33_V0.5450.65
17_T21_N0.5450.65
106_P138_G0.5440.65
155_I177_V0.5430.64
29_F58_P0.5420.64
80_A202_G0.5420.64
148_K177_V0.5420.64
34_D205_M0.5410.64
194_I200_D0.5400.64
86_D90_K0.5400.64
34_D41_A0.5400.64
11_L91_L0.5380.64
42_F87_G0.5350.63
140_A179_I0.5340.63
14_H18_Y0.5340.63
22_E61_A0.5330.63
159_C167_V0.5330.63
58_P119_P0.5310.63
111_P139_S0.5300.63
140_A159_C0.5280.62
84_M160_L0.5250.62
132_P135_A0.5250.62
47_D180_Y0.5240.62
13_Q50_L0.5230.62
100_V129_V0.5210.61
80_A194_I0.5190.61
174_H179_I0.5190.61
13_Q183_A0.5190.61
41_A158_M0.5190.61
23_N56_N0.5170.61
165_E192_G0.5150.60
160_L182_A0.5140.60
14_H35_E0.5110.60
178_D181_I0.5110.60
62_A65_K0.5110.60
20_R197_G0.5100.60
143_A208_T0.5080.59
51_E69_G0.5080.59
17_T65_K0.5060.59
104_R203_D0.5060.59
113_E142_E0.5060.59
29_F201_A0.5050.59
80_A201_A0.5050.59
132_P139_S0.5040.59
148_K153_K0.5040.59
27_K84_M0.5030.59
73_G125_R0.5010.58
33_V84_M0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xttA 3 0.9809 100 0.236 Contact Map
1o5oA 3 1 100 0.26 Contact Map
1bd3D 3 1 100 0.266 Contact Map
2ehjA 3 0.9904 100 0.269 Contact Map
3dmpA 4 0.9761 100 0.27 Contact Map
1v9sA 3 0.9952 100 0.284 Contact Map
2e55A 3 0.9809 100 0.296 Contact Map
1i5eA 2 0.9904 100 0.348 Contact Map
3s5jB 2 0.9426 99.8 0.733 Contact Map
1qb7A 2 0.9187 99.7 0.761 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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