GREMLIN Database
GLYA - Serine hydroxymethyltransferase
UniProt: P39148 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 415 (407)
Sequences: 4084 (1815)
Seq/√Len: 90.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_R188_D4.4261.00
156_R189_E4.3711.00
72_D76_D3.3181.00
160_L189_E3.2261.00
105_I219_F3.1271.00
177_T211_P2.9291.00
287_S370_G2.9281.00
148_Q302_Q2.9041.00
150_I155_V2.8981.00
111_T137_N2.8691.00
154_D157_E2.8531.00
78_A235_M2.8361.00
222_T235_M2.7311.00
144_D147_T2.6521.00
156_R182_K2.6351.00
17_N69_V2.6241.00
375_E399_R2.6021.00
156_R160_L2.5991.00
327_A384_L2.5671.00
382_L399_R2.5291.00
369_D372_A2.5151.00
26_I363_V2.5091.00
157_E161_A2.4141.00
284_N369_D2.4071.00
271_G275_Q2.3891.00
181_K185_E2.3881.00
158_K162_H2.3661.00
111_T162_H2.3041.00
207_A282_A2.2991.00
283_Q287_S2.2761.00
284_N370_G2.2501.00
209_L286_I2.2481.00
294_E298_K2.2051.00
14_A69_V2.1901.00
87_V237_L2.1771.00
78_A222_T2.0901.00
368_F376_V2.0551.00
295_A377_G2.0521.00
383_A396_A2.0271.00
176_R309_D2.0211.00
299_E378_A2.0081.00
196_V217_A2.0041.00
155_V183_F2.0031.00
338_S358_L1.9831.00
175_P303_L1.9691.00
72_D75_R1.9681.00
379_I396_A1.9671.00
295_A298_K1.9401.00
301_I381_A1.9351.00
299_E381_A1.9301.00
139_V162_H1.9301.00
363_V373_L1.9291.00
86_H238_C1.9241.00
112_V138_F1.8821.00
43_Q262_V1.8581.00
86_H247_D1.8381.00
14_A70_V1.8351.00
295_A378_A1.8191.00
76_D80_E1.7991.00
295_A374_E1.7951.00
106_L166_L1.7881.00
201_I210_H1.7781.00
238_C243_G1.7261.00
321_G348_E1.7181.00
111_T139_V1.7021.00
386_N389_D1.6881.00
284_N287_S1.6721.00
34_F409_L1.6481.00
372_A407_F1.6381.00
154_D158_K1.6341.00
95_A124_T1.6171.00
17_N66_H1.6131.00
28_L363_V1.6121.00
291_R295_A1.6081.00
36_S272_E1.6041.00
169_A183_F1.5821.00
86_H243_G1.5811.00
66_H69_V1.5621.00
292_L373_L1.5481.00
11_V70_V1.5431.00
152_Y182_K1.5381.00
318_R348_E1.5351.00
288_N364_T1.5351.00
183_F194_F1.5241.00
43_Q265_A1.5171.00
80_E274_L1.4991.00
289_A308_T1.4941.00
209_L282_A1.4911.00
218_D239_R1.4911.00
375_E379_I1.4851.00
292_L377_G1.4781.00
102_Y168_V1.4761.00
279_K283_Q1.4530.99
395_E399_R1.4300.99
19_R23_Q1.4220.99
243_G247_D1.4210.99
371_D374_E1.4120.99
47_L70_V1.4050.99
11_V268_V1.4030.99
292_L296_L1.3980.99
118_S342_A1.3910.99
293_A313_I1.3910.99
99_M131_F1.3860.99
381_A385_K1.3800.99
333_E393_L1.3570.99
85_E239_R1.3560.99
166_L195_M1.3520.99
201_I310_N1.3500.99
209_L283_Q1.3400.99
87_V235_M1.3380.99
330_V387_H1.3370.99
295_A299_E1.3340.99
14_A66_H1.3330.99
84_A214_V1.3330.99
334_I383_A1.3320.99
81_I273_V1.3310.99
78_A270_F1.3240.99
198_M237_L1.3110.99
20_E24_T1.3110.99
25_K332_D1.3050.99
368_F373_L1.3030.99
145_K345_Y1.3020.99
301_I320_L1.3020.99
212_N215_P1.2960.99
138_F168_V1.2950.99
105_I242_F1.2840.99
222_T270_F1.2790.99
210_H310_N1.2730.99
302_Q316_D1.2710.99
144_D151_D1.2660.99
320_L385_K1.2620.98
335_G401_A1.2530.98
52_A260_M1.2500.98
280_T283_Q1.2470.98
379_I399_R1.2370.98
392_K396_A1.2340.98
208_G279_K1.2290.98
242_F245_K1.2290.98
106_L110_D1.2180.98
334_I396_A1.2100.98
139_V158_K1.1950.98
13_N17_N1.1920.98
101_V219_F1.1840.98
25_K335_G1.1840.98
293_A303_L1.1840.98
383_A393_L1.1820.98
143_V345_Y1.1770.98
322_L384_L1.1740.98
57_G72_D1.1690.98
294_E374_E1.1670.97
100_A250_I1.1670.97
47_L67_V1.1660.97
35_V40_M1.1630.97
153_D182_K1.1610.97
27_E337_T1.1590.97
363_V376_V1.1570.97
302_Q319_S1.1560.97
342_A346_D1.1560.97
180_F210_H1.1520.97
299_E382_L1.1470.97
107_E110_D1.1430.97
169_A196_V1.1390.97
7_Q271_G1.1350.97
110_D165_K1.1340.97
195_M221_T1.1280.97
24_T401_A1.1240.97
188_D218_D1.1220.97
193_Y242_F1.1200.97
74_A267_A1.1060.97
156_R185_E1.1030.96
182_K185_E1.1000.96
144_D154_D1.0990.96
26_I368_F1.0950.96
86_H246_I1.0950.96
375_E406_K1.0940.96
338_S356_I1.0930.96
86_H239_R1.0900.96
218_D240_E1.0880.96
318_R347_P1.0870.96
299_E374_E1.0870.96
19_R410_Y1.0860.96
290_K294_E1.0820.96
218_D242_F1.0730.96
12_F16_K1.0730.96
105_I193_Y1.0700.96
378_A382_L1.0650.96
62_G328_E1.0650.96
171_A178_I1.0580.95
287_S369_D1.0540.95
5_P12_F1.0500.95
11_V14_A1.0500.95
67_V260_M1.0480.95
107_E165_K1.0460.95
296_L381_A1.0460.95
297_T306_G1.0450.95
152_Y155_V1.0440.95
115_M142_G1.0430.95
291_R374_E1.0330.95
333_E390_E1.0300.95
85_E240_E1.0300.95
184_R218_D1.0290.95
114_G124_T1.0240.95
379_I403_L1.0200.95
177_T210_H1.0170.94
198_M205_V1.0130.94
52_A64_C1.0110.94
239_R242_F1.0100.94
181_K216_Y1.0070.94
375_E378_A1.0040.94
335_G397_R0.9980.94
302_Q306_G0.9930.94
348_E352_V0.9910.94
334_I393_L0.9910.94
113_L139_V0.9870.93
169_A194_F0.9870.93
137_N162_H0.9810.93
231_P265_A0.9780.93
382_L395_E0.9770.93
116_N140_E0.9750.93
299_E385_K0.9750.93
330_V383_A0.9740.93
323_T348_E0.9700.93
398_Q402_A0.9700.93
19_R46_V0.9690.93
320_L381_A0.9670.93
171_A201_I0.9670.93
372_A403_L0.9640.93
152_Y183_F0.9610.93
84_A237_L0.9570.92
173_A314_L0.9570.92
8_D77_R0.9560.92
250_I254_I0.9550.92
331_L338_S0.9530.92
99_M254_I0.9530.92
104_T249_S0.9490.92
11_V47_L0.9480.92
85_E238_C0.9420.92
144_D345_Y0.9410.92
171_A310_N0.9390.92
289_A361_A0.9370.92
116_N119_H0.9350.92
334_I379_I0.9340.91
313_I358_L0.9330.91
229_R365_S0.9290.91
114_G140_E0.9260.91
369_D407_F0.9240.91
107_E134_V0.9150.91
42_A268_V0.9130.91
382_L392_K0.9110.90
39_V269_S0.9090.90
303_L313_I0.9080.90
10_Q271_G0.9040.90
241_E245_K0.9020.90
103_F136_Y0.9000.90
16_K19_R0.8980.90
271_G274_L0.8970.90
51_Y225_H0.8970.90
235_M270_F0.8970.90
193_Y219_F0.8920.89
294_E297_T0.8890.89
176_R307_G0.8860.89
74_A89_V0.8860.89
219_F242_F0.8850.89
159_A167_I0.8820.89
106_L112_V0.8810.89
302_Q343_I0.8810.89
131_F135_Q0.8780.89
382_L396_A0.8770.89
401_A405_D0.8710.88
102_Y112_V0.8670.88
9_E12_F0.8650.88
14_A17_N0.8630.88
372_A406_K0.8620.88
387_H393_L0.8600.88
181_K184_R0.8600.88
329_H333_E0.8600.88
160_L163_K0.8580.88
83_G208_G0.8580.88
15_I42_A0.8560.87
282_A285_V0.8550.87
394_E398_Q0.8420.87
10_Q13_N0.8380.86
96_Q99_M0.8380.86
9_E13_N0.8340.86
392_K395_E0.8340.86
326_V330_V0.8340.86
160_L190_V0.8330.86
297_T303_L0.8330.86
169_A198_M0.8330.86
314_L341_N0.8320.86
368_F403_L0.8320.86
375_E402_A0.8310.86
102_Y138_F0.8270.86
178_I183_F0.8260.86
118_S346_D0.8240.85
301_I315_V0.8230.85
167_I183_F0.8160.85
221_T236_I0.8160.85
61_Y225_H0.8150.85
11_V73_I0.8150.85
282_A361_A0.8140.85
92_H96_Q0.8090.84
158_K161_A0.8090.84
289_A313_I0.8070.84
169_A217_A0.8050.84
323_T326_V0.8040.84
368_F407_F0.8040.84
78_A237_L0.8030.84
128_P138_F0.8030.84
175_P313_I0.8020.84
150_I178_I0.7950.83
398_Q401_A0.7940.83
396_A399_R0.7870.83
51_Y61_Y0.7860.83
238_C247_D0.7850.83
37_E41_E0.7840.82
24_T405_D0.7820.82
386_N393_L0.7800.82
76_D79_K0.7760.82
4_L15_I0.7760.82
298_K374_E0.7750.82
11_V271_G0.7750.82
397_R401_A0.7730.82
229_R281_Y0.7720.81
291_R370_G0.7670.81
346_D349_K0.7660.81
101_V195_M0.7660.81
386_N392_K0.7660.81
296_L377_G0.7660.81
101_V106_L0.7650.81
383_A392_K0.7650.81
273_V278_F0.7630.81
69_V72_D0.7610.81
238_C246_I0.7600.80
15_I47_L0.7600.80
184_R194_F0.7590.80
116_N142_G0.7570.80
368_F372_A0.7560.80
360_T373_L0.7520.80
326_V388_E0.7520.80
181_K215_P0.7470.79
155_V186_I0.7450.79
157_E160_L0.7450.79
299_E377_G0.7450.79
215_P220_V0.7430.79
377_G381_A0.7430.79
75_R79_K0.7430.79
278_F285_V0.7420.79
201_I205_V0.7410.79
78_A87_V0.7370.78
113_L140_E0.7360.78
280_T284_N0.7300.78
95_A250_I0.7280.78
106_L195_M0.7260.77
295_A381_A0.7190.77
4_L41_E0.7180.77
24_T335_G0.7170.76
238_C242_F0.7150.76
79_K87_V0.7150.76
9_E38_A0.7110.76
101_V221_T0.7110.76
84_A220_V0.7080.76
115_M178_I0.7080.76
85_E242_F0.7070.75
245_K248_K0.7070.75
131_F136_Y0.7060.75
322_L326_V0.7050.75
326_V348_E0.7030.75
330_V393_L0.7010.75
92_H259_L0.7000.75
390_E394_E0.7000.75
75_R247_D0.6970.74
194_F217_A0.6970.74
70_V260_M0.6960.74
113_L162_H0.6950.74
383_A387_H0.6950.74
292_L358_L0.6950.74
328_E332_D0.6930.74
286_I360_T0.6920.74
214_V220_V0.6900.74
84_A212_N0.6900.74
393_L396_A0.6900.74
145_K148_Q0.6890.74
325_K351_F0.6880.73
231_P269_S0.6860.73
7_Q38_A0.6860.73
374_E378_A0.6830.73
113_L138_F0.6820.73
286_I290_K0.6790.72
103_F249_S0.6770.72
23_Q410_Y0.6770.72
111_T158_K0.6760.72
155_V158_K0.6760.72
402_A406_K0.6750.72
103_F254_I0.6750.72
112_V166_L0.6750.72
399_R402_A0.6720.72
205_V210_H0.6720.72
86_H240_E0.6710.72
202_A227_T0.6710.72
393_L397_R0.6710.72
177_T212_N0.6710.72
207_A283_Q0.6700.71
180_F201_I0.6690.71
102_Y166_L0.6690.71
198_M206_A0.6690.71
128_P351_F0.6670.71
129_V248_K0.6600.70
313_I360_T0.6590.70
34_F362_A0.6590.70
40_M49_N0.6590.70
323_T352_V0.6570.70
12_F41_E0.6560.70
330_V386_N0.6550.70
317_L320_L0.6550.70
78_A82_F0.6540.70
113_L159_A0.6520.69
155_V169_A0.6490.69
330_V333_E0.6490.69
187_A194_F0.6440.68
278_F282_A0.6430.68
291_R294_E0.6410.68
371_D407_F0.6400.68
330_V334_I0.6400.68
107_E137_N0.6400.68
317_L343_I0.6400.68
40_M410_Y0.6390.68
402_A405_D0.6380.68
332_D335_G0.6380.68
187_A192_A0.6380.68
395_E398_Q0.6370.68
239_R243_G0.6370.68
59_R68_D0.6360.68
342_A349_K0.6350.67
168_V195_M0.6330.67
108_Q135_Q0.6330.67
80_E83_G0.6310.67
4_L38_A0.6290.67
32_E51_Y0.6280.67
154_D162_H0.6280.67
269_S273_V0.6270.66
326_V387_H0.6270.66
51_Y257_G0.6270.66
115_M152_Y0.6260.66
272_E281_Y0.6250.66
304_V317_L0.6240.66
114_G138_F0.6230.66
315_V338_S0.6220.66
282_A286_I0.6200.66
395_E402_A0.6180.65
169_A178_I0.6170.65
329_H332_D0.6170.65
240_E244_K0.6160.65
79_K84_A0.6140.65
91_P250_I0.6140.65
151_D154_D0.6140.65
84_A239_R0.6130.65
25_K404_T0.6120.65
379_I383_A0.6120.65
101_V166_L0.6110.64
23_Q409_L0.6100.64
35_V39_V0.6090.64
175_P305_S0.6080.64
390_E393_L0.6070.64
296_L303_L0.6050.64
284_N364_T0.6040.64
204_L286_I0.6040.64
249_S254_I0.6030.63
65_E332_D0.6020.63
386_N390_E0.6010.63
295_A373_L0.6000.63
317_L321_G0.5980.63
73_I271_G0.5980.63
7_Q275_Q0.5960.63
301_I385_K0.5960.63
229_R272_E0.5950.62
17_N20_E0.5950.62
181_K188_D0.5950.62
135_Q249_S0.5940.62
332_D337_T0.5940.62
378_A399_R0.5930.62
291_R373_L0.5920.62
379_I382_L0.5920.62
153_D157_E0.5920.62
119_H142_G0.5910.62
215_P239_R0.5900.62
153_D156_R0.5900.62
276_D280_T0.5900.62
72_D260_M0.5890.62
277_D280_T0.5890.62
230_G269_S0.5870.61
11_V66_H0.5850.61
349_K352_V0.5850.61
244_K248_K0.5830.61
358_L380_I0.5830.61
175_P312_L0.5830.61
153_D189_E0.5820.61
119_H145_K0.5790.60
98_N221_T0.5790.60
242_F246_I0.5780.60
303_L315_V0.5780.60
207_A279_K0.5770.60
105_I166_L0.5760.60
20_E23_Q0.5760.60
124_T138_F0.5750.60
270_F274_L0.5730.60
366_R408_P0.5730.60
10_Q80_E0.5730.60
297_T302_Q0.5720.59
231_P262_V0.5710.59
363_V368_F0.5710.59
394_E397_R0.5660.59
95_A130_N0.5650.58
95_A99_M0.5640.58
266_K270_F0.5620.58
85_E243_G0.5610.58
148_Q343_I0.5600.58
152_Y178_I0.5600.58
196_V237_L0.5600.58
81_I270_F0.5600.58
60_Y129_V0.5600.58
214_V237_L0.5590.58
103_F131_F0.5570.57
346_D351_F0.5570.57
301_I380_I0.5540.57
99_M135_Q0.5510.57
14_A47_L0.5510.57
196_V201_I0.5510.57
331_L356_I0.5500.56
205_V310_N0.5500.56
36_S281_Y0.5500.56
322_L327_A0.5500.56
371_D378_A0.5490.56
342_A351_F0.5490.56
240_E243_G0.5480.56
99_M130_N0.5470.56
180_F205_V0.5470.56
74_A270_F0.5470.56
62_G337_T0.5460.56
95_A102_Y0.5450.56
35_V265_A0.5450.56
372_A375_E0.5440.56
156_R186_I0.5440.56
286_I289_A0.5440.56
179_D182_K0.5430.55
73_I77_R0.5430.55
185_E189_E0.5420.55
53_E59_R0.5410.55
224_T233_G0.5400.55
218_D243_G0.5400.55
43_Q261_H0.5390.55
92_H95_A0.5380.55
106_L165_K0.5370.55
15_I46_V0.5360.55
148_Q301_I0.5350.54
285_V360_T0.5340.54
331_L380_I0.5340.54
290_K309_D0.5340.54
33_N281_Y0.5340.54
177_T286_I0.5320.54
172_S199_A0.5320.54
99_M103_F0.5310.54
66_H70_V0.5310.54
64_C259_L0.5300.54
140_E158_K0.5300.54
58_K351_F0.5300.54
112_V165_K0.5290.54
372_A376_V0.5290.54
64_C266_K0.5270.53
239_R245_K0.5270.53
40_M46_V0.5260.53
373_L376_V0.5250.53
328_E338_S0.5250.53
99_M136_Y0.5250.53
403_L410_Y0.5240.53
27_E362_A0.5240.53
35_V48_T0.5240.53
259_L262_V0.5230.53
301_I343_I0.5230.53
273_V282_A0.5230.53
285_V289_A0.5220.53
77_R268_V0.5210.52
287_S290_K0.5200.52
327_A356_I0.5190.52
209_L279_K0.5190.52
260_M263_I0.5180.52
207_A286_I0.5180.52
301_I319_S0.5180.52
296_L315_V0.5180.52
144_D149_Y0.5170.52
315_V320_L0.5160.52
25_K65_E0.5150.52
129_V349_K0.5120.51
32_E225_H0.5120.51
92_H266_K0.5110.51
199_A221_T0.5100.51
159_A186_I0.5090.51
225_H257_G0.5090.51
323_T353_T0.5090.51
103_F135_Q0.5080.51
301_I377_G0.5080.51
207_A212_N0.5080.51
31_S61_Y0.5070.51
287_S291_R0.5060.50
83_G214_V0.5050.50
44_G48_T0.5050.50
96_Q259_L0.5040.50
202_A222_T0.5020.50
292_L295_A0.5010.50
284_N288_N0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rv3A 3 0.9976 100 0.461 Contact Map
3ou5A 2 0.9157 100 0.489 Contact Map
3h7fA 2 0.9976 100 0.577 Contact Map
4wxgA 2 0.9831 100 0.593 Contact Map
3n0lA 2 0.959 100 0.619 Contact Map
3gbxA 2 0.9181 100 0.628 Contact Map
3ecdA 2 0.9108 100 0.628 Contact Map
2dkjA 2 0.9663 100 0.631 Contact Map
2vi8A 2 0.9759 100 0.637 Contact Map
4msoA 2 0.9253 100 0.641 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0126 seconds.