GREMLIN Database
COMFC - ComF operon protein 3
UniProt: P39147 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (188)
Sequences: 3996 (3346)
Seq/√Len: 244.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_L223_S4.1211.00
127_I208_A3.5671.00
157_L208_A3.3201.00
165_Q176_S3.1931.00
74_R213_L2.9381.00
169_K172_E2.8121.00
80_Y86_M2.7061.00
199_Y225_T2.6931.00
78_S225_T2.6341.00
182_T211_C2.5841.00
191_N220_S2.5351.00
121_H193_I2.1121.00
129_L141_Q2.0811.00
170_K174_L1.9991.00
124_L193_I1.9931.00
207_F210_R1.9841.00
95_F166_S1.9511.00
160_L181_D1.9371.00
153_S156_P1.9071.00
106_K110_S1.8571.00
194_L208_A1.8351.00
93_F102_I1.8281.00
143_H147_E1.8281.00
125_V156_P1.8141.00
132_E161_N1.7731.00
123_V192_I1.7461.00
74_R220_S1.7161.00
213_L221_V1.7151.00
92_R98_D1.6711.00
158_I181_D1.6671.00
191_N222_S1.6631.00
168_K176_S1.6611.00
193_I224_F1.6451.00
124_L150_D1.6441.00
131_K135_E1.6121.00
46_L56_V1.5941.00
84_D87_K1.5561.00
129_L133_R1.5341.00
105_F226_L1.5261.00
212_L218_A1.5191.00
123_V153_S1.5171.00
133_R159_R1.4861.00
124_L149_L1.4841.00
205_L225_T1.4801.00
129_L140_N1.4681.00
203_A207_F1.4601.00
109_F226_L1.4521.00
89_T105_F1.4021.00
144_L147_E1.3901.00
99_A144_L1.3801.00
211_C214_E1.3791.00
162_N179_I1.3701.00
122_F191_N1.3621.00
75_Q222_S1.3611.00
82_Y91_S1.3441.00
86_M227_I1.3441.00
87_K91_S1.3121.00
129_L134_E1.3061.00
142_A146_A1.2981.00
130_S161_N1.2871.00
192_I218_A1.2691.00
76_N223_S1.2671.00
158_I183_K1.2601.00
109_F224_F1.2481.00
133_R136_E1.2331.00
110_S152_P1.2001.00
103_N148_C1.2001.00
106_K148_C1.2001.00
76_N225_T1.1951.00
122_F193_I1.1931.00
191_N219_A1.1711.00
199_Y205_L1.1661.00
126_P143_H1.1621.00
73_L209_A1.1511.00
66_R206_H1.1431.00
93_F145_L1.1321.00
127_I204_T1.1311.00
187_A190_M1.1261.00
93_F101_I1.1181.00
102_I144_L1.1171.00
218_A221_V1.1161.00
107_S152_P1.1141.00
189_G218_A1.1001.00
159_R162_N1.0961.00
113_F224_F1.0951.00
106_K149_L1.0901.00
91_S95_F1.0871.00
208_A211_C1.0741.00
123_V189_G1.0681.00
142_A195_I1.0661.00
146_A149_L1.0621.00
209_A213_L1.0551.00
182_T215_K1.0521.00
207_F211_C1.0451.00
133_R164_K1.0391.00
76_N199_Y1.0371.00
142_A145_L1.0351.00
178_C207_F1.0161.00
124_L146_A1.0111.00
134_E143_H1.0031.00
163_E168_K1.0001.00
130_S133_R0.9861.00
122_F190_M0.9841.00
49_R59_D0.9801.00
109_F145_L0.9711.00
92_R96_R0.9651.00
93_F105_F0.9611.00
90_L226_L0.9561.00
148_C152_P0.9361.00
73_L223_S0.9351.00
177_E207_F0.9311.00
149_L195_I0.9181.00
101_I104_A0.9181.00
129_L159_R0.9101.00
93_F144_L0.9061.00
133_R141_Q0.8991.00
80_Y226_L0.8780.99
187_A218_A0.8770.99
166_S198_L0.8750.99
174_L206_H0.8690.99
131_K134_E0.8690.99
206_H209_A0.8590.99
91_S96_R0.8490.99
132_E136_E0.8470.99
216_G219_A0.8460.99
165_Q198_L0.8450.99
143_H154_H0.8440.99
146_A150_D0.8400.99
132_E135_E0.8380.99
176_S179_I0.8370.99
146_A195_I0.8300.99
159_R180_F0.8300.99
88_E92_R0.8240.99
80_Y108_D0.8160.99
212_L216_G0.8120.99
73_L76_N0.8090.99
123_V190_M0.8060.99
145_L226_L0.8030.99
126_P140_N0.8000.99
129_L142_A0.7990.99
93_F139_F0.7980.99
195_I224_F0.7970.99
209_A223_S0.7970.99
179_I207_F0.7960.99
213_L218_A0.7930.99
121_H191_N0.7920.99
73_L205_L0.7850.99
121_H222_S0.7790.99
209_A221_V0.7760.99
89_T101_I0.7750.99
90_L227_I0.7740.99
157_L212_L0.7740.99
35_K41_G0.7730.99
211_C215_K0.7720.99
82_Y87_K0.7690.99
98_D101_I0.7530.98
57_C60_C0.7530.98
95_F141_Q0.7520.98
77_R222_S0.7520.98
171_T175_L0.7500.98
148_C151_R0.7470.98
102_I106_K0.7450.98
35_K64_R0.7430.98
193_I222_S0.7420.98
162_N176_S0.7370.98
163_E167_K0.7350.98
35_K40_T0.7330.98
178_C211_C0.7300.98
106_K152_P0.7280.98
47_C60_C0.7270.98
95_F164_K0.7260.98
78_S228_R0.7220.98
182_T185_N0.7200.98
155_H183_K0.7190.98
82_Y227_I0.7140.98
180_F208_A0.7090.98
215_K218_A0.7030.98
109_F149_L0.7000.97
146_A151_R0.6970.97
130_S162_N0.6920.97
101_I105_F0.6890.97
95_F133_R0.6870.97
58_R62_V0.6810.97
79_V112_T0.6740.97
93_F226_L0.6730.97
43_I77_R0.6720.97
187_A192_I0.6690.97
108_D111_S0.6670.97
77_R112_T0.6670.97
95_F139_F0.6630.97
37_K40_T0.6570.96
77_R116_V0.6550.96
45_P51_Q0.6550.96
174_L203_A0.6540.96
124_L195_I0.6540.96
38_K41_G0.6540.96
47_C57_C0.6500.96
127_I180_F0.6490.96
90_L198_L0.6480.96
104_A108_D0.6450.96
157_L194_L0.6440.96
97_G138_G0.6410.96
97_G100_E0.6390.96
88_E96_R0.6390.96
110_S149_L0.6380.96
190_M219_A0.6370.96
44_C47_C0.6360.96
73_L206_H0.6360.96
46_L64_R0.6290.95
58_R61_E0.6270.95
107_S148_C0.6240.95
168_K201_T0.6240.95
99_A139_F0.6230.95
40_T64_R0.6190.95
93_F141_Q0.6170.95
143_H155_H0.6150.95
188_E216_G0.6130.95
35_K38_K0.6120.95
190_M218_A0.6100.94
182_T187_A0.6090.94
74_R206_H0.6060.94
187_A219_A0.6040.94
77_R81_T0.6010.94
93_F106_K0.5950.94
41_G45_P0.5940.94
194_L209_A0.5910.94
79_V109_F0.5900.93
159_R179_I0.5890.93
194_L205_L0.5890.93
49_R199_Y0.5820.93
164_K167_K0.5750.93
82_Y95_F0.5730.92
154_H158_I0.5720.92
43_I48_G0.5720.92
81_T228_R0.5710.92
165_Q180_F0.5690.92
126_P153_S0.5660.92
155_H158_I0.5630.92
41_G64_R0.5620.92
156_P187_A0.5520.91
91_S166_S0.5470.91
187_A215_K0.5450.90
127_I157_L0.5430.90
216_G221_V0.5410.90
168_K172_E0.5400.90
110_S224_F0.5390.90
86_M90_L0.5380.90
176_S207_F0.5370.90
61_E64_R0.5350.90
156_P160_L0.5350.90
153_S186_S0.5350.90
142_A149_L0.5340.90
74_R222_S0.5320.89
174_L198_L0.5320.89
134_E140_N0.5320.89
66_R73_L0.5320.89
114_S117_Y0.5300.89
93_F140_N0.5300.89
56_V64_R0.5300.89
137_R140_N0.5290.89
45_P56_V0.5290.89
80_Y227_I0.5280.89
164_K168_K0.5280.89
113_F117_Y0.5270.89
95_F180_F0.5240.89
186_S189_G0.5200.88
43_I81_T0.5200.88
89_T198_L0.5190.88
162_N180_F0.5160.88
171_T174_L0.5160.88
140_N143_H0.5140.88
199_Y228_R0.5140.88
130_S141_Q0.5130.88
36_L80_Y0.5120.88
194_L223_S0.5120.88
113_F149_L0.5100.87
172_E175_L0.5080.87
123_V156_P0.5080.87
160_L183_K0.5070.87
194_L218_A0.5070.87
165_Q170_K0.5000.86
65_T206_H0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zn8A 2 0.6812 99.8 0.655 Contact Map
1vchA 5 0.6594 99.8 0.672 Contact Map
2dy0A 2 0.6725 99.8 0.672 Contact Map
1wd5A 1 0.5328 99.8 0.68 Contact Map
1ecfA 4 0.9127 99.8 0.681 Contact Map
1y0bA 2 0.6638 99.8 0.682 Contact Map
1g2qA 2 0.6943 99.8 0.686 Contact Map
1l1qA 2 0.6638 99.8 0.686 Contact Map
4lzaA 2 0.655 99.8 0.687 Contact Map
1yfzA 3 0.5502 99.7 0.692 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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