GREMLIN Database
COMFB - ComF operon protein 2
UniProt: P39146 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 98 (86)
Sequences: 160 (136)
Seq/√Len: 14.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_D31_Q4.5501.00
11_K35_L3.9301.00
2_L32_N3.0940.98
22_H26_T3.0580.98
64_Q68_A2.6470.95
9_V69_M2.6300.95
21_L77_A2.4260.92
14_L81_S2.3980.92
61_V65_K2.1960.88
52_K86_D2.1240.86
61_V68_A1.8010.74
70_L73_L1.7680.73
65_K68_A1.7350.72
6_K64_Q1.7260.71
42_V49_D1.7160.71
59_E79_V1.6780.69
31_Q35_L1.5990.65
5_S47_V1.5240.61
34_V49_D1.4580.58
34_V54_A1.4390.57
37_L79_V1.4300.56
27_C84_P1.4180.56
2_L51_K1.3450.51
37_L41_K1.3080.49
56_T81_S1.2870.48
28_Q31_Q1.2640.47
23_M72_I1.2390.46
55_Y73_L1.2350.45
2_L35_L1.2120.44
20_Q41_K1.2080.44
51_K75_E1.1300.40
16_R70_L1.0430.35
14_L35_L1.0350.35
43_S71_V1.0280.34
49_D86_D1.0260.34
12_E76_S1.0070.33
70_L85_S1.0010.33
45_S53_I0.9910.33
10_M35_L0.9880.32
15_D24_A0.9860.32
55_Y64_Q0.9810.32
15_D35_L0.9620.31
6_K42_V0.9420.30
20_Q77_A0.9280.30
50_F78_A0.9270.30
3_V73_L0.9240.29
67_T74_A0.9070.29
37_L74_A0.8980.28
67_T85_S0.8940.28
29_V75_E0.8910.28
70_L74_A0.8840.28
32_N47_V0.8580.27
2_L50_F0.8510.26
72_I86_D0.8500.26
67_T72_I0.8380.26
67_T73_L0.8310.25
70_L77_A0.8200.25
58_A71_V0.8190.25
42_V52_K0.8100.24
13_L58_A0.8080.24
68_A76_S0.7900.24
38_S78_A0.7850.23
26_T83_S0.7790.23
16_R54_A0.7790.23
47_V71_V0.7670.23
72_I75_E0.7640.23
24_A43_S0.7470.22
41_K72_I0.7410.22
79_V82_E0.7390.22
22_H58_A0.7380.22
10_M52_K0.7220.21
27_C36_A0.6970.20
51_K74_A0.6960.20
11_K31_Q0.6890.20
62_D87_L0.6840.20
3_V14_L0.6840.20
55_Y60_L0.6820.20
34_V73_L0.6810.20
3_V21_L0.6790.20
28_Q75_E0.6760.19
10_M86_D0.6740.19
55_Y71_V0.6640.19
48_T76_S0.6620.19
45_S59_E0.6560.19
49_D65_K0.6550.19
9_V62_D0.6500.19
38_S76_S0.6480.18
8_I72_I0.6470.18
6_K61_V0.6460.18
32_N54_A0.6370.18
82_E86_D0.6350.18
36_A48_T0.6300.18
8_I58_A0.6230.18
60_L74_A0.6110.17
6_K65_K0.6030.17
29_V76_S0.6010.17
3_V78_A0.6010.17
29_V48_T0.6000.17
21_L55_Y0.5960.17
6_K28_Q0.5940.17
21_L34_V0.5910.17
11_K15_D0.5900.17
57_K68_A0.5790.16
32_N66_N0.5760.16
41_K56_T0.5740.16
13_L28_Q0.5730.16
14_L45_S0.5690.16
11_K60_L0.5680.16
23_M54_A0.5650.16
53_I63_K0.5550.16
42_V63_K0.5470.15
19_D74_A0.5470.15
49_D52_K0.5380.15
3_V53_I0.5280.15
18_M34_V0.5260.15
62_D83_S0.5240.15
34_V77_A0.5220.15
15_D79_V0.5170.14
24_A67_T0.5160.14
22_H67_T0.5160.14
47_V80_V0.5140.14
16_R32_N0.5070.14
47_V84_P0.5030.14
7_E30_C0.5000.14
7_E33_D0.5000.14
30_C33_D0.5000.14
30_C46_Y0.5000.14
33_D46_Y0.5000.14
7_E46_Y0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4waiA 2 0.9184 100 0.254 Contact Map
4mfuA 2 0.8776 15.2 0.929 Contact Map
4cb9A 1 0.8776 13.1 0.931 Contact Map
4bkwA 1 0.3367 11.3 0.933 Contact Map
4fakA 2 0.8878 7.7 0.938 Contact Map
1ns5A 2 0.898 5.8 0.941 Contact Map
1to0A 2 0.8673 5.6 0.942 Contact Map
3qwpA 1 0.9796 5.3 0.942 Contact Map
4ouaA 1 0.5612 4.3 0.945 Contact Map
3l3uA 2 0.8673 4.1 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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