GREMLIN Database
COMFA - ComF operon protein 1
UniProt: P39145 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (376)
Sequences: 14455 (9300)
Seq/√Len: 479.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_I170_V3.3621.00
157_F187_L3.2741.00
158_P161_E3.1261.00
297_P301_W3.1201.00
215_S220_L3.0481.00
174_T183_L2.9681.00
298_R301_W2.9421.00
368_E372_Q2.9161.00
132_L261_V2.8151.00
187_L212_L2.7611.00
336_V342_L2.7421.00
336_V345_A2.7291.00
346_A382_I2.5701.00
346_A350_K2.5261.00
343_E358_S2.5201.00
296_E299_F2.4971.00
398_T432_I2.4341.00
186_R189_A2.3881.00
184_A188_K2.3681.00
235_V262_Y2.3601.00
159_G163_A2.3551.00
336_V382_I2.2201.00
371_Q375_D2.2131.00
158_P163_A2.1831.00
357_A378_L2.1721.00
157_F161_E2.0951.00
319_K352_V2.0941.00
296_E301_W2.0811.00
372_Q377_Q2.0761.00
296_E300_V1.9851.00
173_A215_S1.9791.00
330_R397_Q1.9791.00
297_P300_V1.9591.00
354_C380_L1.9411.00
417_A431_V1.9031.00
124_G144_I1.9021.00
198_A201_G1.8971.00
102_W105_E1.8891.00
357_A372_Q1.8831.00
158_P162_S1.8791.00
442_M445_A1.8671.00
204_D207_G1.8311.00
243_D247_Q1.8221.00
346_A356_T1.8201.00
100_Y103_K1.8041.00
243_D246_L1.8031.00
184_A196_I1.7921.00
401_L433_Y1.7781.00
195_D211_P1.7561.00
63_C66_T1.7511.00
66_T69_R1.7491.00
128_A155_M1.7471.00
442_M446_R1.7091.00
185_P189_A1.6931.00
295_P299_F1.6831.00
367_K371_Q1.6801.00
112_S116_T1.6561.00
92_R95_E1.6551.00
321_W432_I1.6551.00
110_W113_I1.6201.00
318_V322_I1.6191.00
159_G162_S1.6061.00
68_Q71_F1.6051.00
161_E165_N1.6031.00
88_V92_R1.5991.00
61_N64_G1.5901.00
362_E365_H1.5771.00
294_L297_P1.5551.00
153_T183_L1.5501.00
61_N65_Q1.5491.00
92_R96_E1.5481.00
83_Y86_S1.5471.00
197_S210_S1.5361.00
65_Q68_Q1.5301.00
132_L142_L1.5271.00
317_A320_R1.5011.00
159_G165_N1.4991.00
181_L367_K1.4931.00
82_L86_S1.4841.00
383_T387_L1.4761.00
76_S79_K1.4661.00
405_S433_Y1.4661.00
349_F382_I1.4601.00
79_K82_L1.4581.00
106_N162_S1.4471.00
297_P302_C1.4461.00
77_S81_K1.4361.00
346_A358_S1.4321.00
179_V390_G1.4221.00
210_S213_M1.4141.00
71_F75_H1.4131.00
314_I318_V1.4071.00
314_I321_W1.4031.00
169_R211_P1.3981.00
355_R379_D1.3931.00
62_R66_T1.3761.00
91_G95_E1.3671.00
443_L447_K1.3581.00
78_G82_L1.3571.00
387_L391_V1.3481.00
84_C87_C1.3421.00
118_D154_E1.3361.00
184_A198_A1.3331.00
79_K83_Y1.3331.00
88_V91_G1.3321.00
83_Y87_C1.3281.00
64_G68_Q1.3211.00
126_Q130_N1.3111.00
74_Y77_S1.3111.00
299_F302_C1.3091.00
185_P371_Q1.3021.00
399_G420_T1.2931.00
111_K115_L1.2901.00
342_L358_S1.2881.00
68_Q72_S1.2871.00
442_M447_K1.2761.00
121_L125_Q1.2731.00
86_S90_M1.2701.00
236_D389_R1.2691.00
446_R449_I1.2641.00
319_K323_E1.2641.00
357_A369_K1.2621.00
71_F74_Y1.2591.00
69_R72_S1.2511.00
187_L214_I1.2461.00
90_M94_S1.2381.00
291_R294_L1.2371.00
442_M449_I1.2361.00
64_G67_D1.2361.00
444_D447_K1.2361.00
180_V198_A1.2351.00
76_S80_N1.2321.00
66_T70_Y1.2211.00
341_I404_E1.2171.00
111_K114_K1.2141.00
289_H295_P1.2111.00
295_P298_R1.2101.00
440_K443_L1.2081.00
65_Q69_R1.2071.00
67_D70_Y1.2051.00
172_I187_L1.2011.00
315_P348_C1.1941.00
83_Y89_M1.1801.00
345_A402_G1.1761.00
282_S285_I1.1691.00
345_A382_I1.1651.00
160_I187_L1.1571.00
101_S104_E1.1531.00
144_I263_L1.1471.00
70_Y74_Y1.1441.00
243_D248_F1.1411.00
80_N84_C1.1401.00
169_R226_A1.1291.00
290_H293_P1.1271.00
106_N109_N1.1241.00
65_Q70_Y1.1171.00
86_S89_M1.1121.00
339_V343_E1.1111.00
171_C227_I1.1081.00
107_E111_K1.1051.00
158_P165_N1.1011.00
77_S80_N1.0991.00
332_V398_T1.0961.00
157_F160_I1.0911.00
162_S165_N1.0881.00
406_S413_L1.0801.00
67_D71_F1.0771.00
81_K84_C1.0751.00
63_C67_D1.0731.00
78_G81_K1.0731.00
440_K444_D1.0721.00
160_I231_I1.0711.00
443_L446_R1.0671.00
289_H292_K1.0661.00
112_S193_G1.0631.00
94_S97_V1.0561.00
314_I322_I1.0551.00
91_G94_S1.0511.00
272_K276_L1.0441.00
310_N313_K1.0381.00
94_S98_P1.0311.00
385_T416_I1.0311.00
110_W114_K1.0271.00
332_V400_V1.0271.00
73_F76_S1.0261.00
323_E352_V1.0251.00
82_L85_R1.0241.00
174_T180_V1.0221.00
187_L196_I1.0171.00
131_V142_L1.0121.00
72_S76_S1.0121.00
113_I116_T1.0121.00
170_V229_V1.0051.00
359_V387_L1.0051.00
440_K447_K0.9991.00
89_M93_V0.9981.00
342_L360_H0.9971.00
77_S83_Y0.9941.00
319_K348_C0.9941.00
184_A214_I0.9881.00
75_H78_G0.9841.00
368_E371_Q0.9821.00
198_A203_S0.9801.00
64_G69_R0.9801.00
317_A324_F0.9771.00
89_M94_S0.9751.00
73_F79_K0.9741.00
156_L263_L0.9731.00
93_V97_V0.9701.00
119_G125_Q0.9701.00
244_Q248_F0.9701.00
316_P320_R0.9691.00
292_K295_P0.9671.00
199_L202_G0.9661.00
83_Y88_V0.9651.00
163_A229_V0.9651.00
109_N113_I0.9651.00
95_E98_P0.9641.00
115_L192_Q0.9621.00
284_R287_A0.9601.00
338_S341_I0.9581.00
90_M96_E0.9541.00
96_E99_L0.9531.00
87_C90_M0.9521.00
444_D449_I0.9511.00
205_D208_R0.9501.00
113_I154_E0.9491.00
62_R65_Q0.9491.00
66_T71_F0.9441.00
200_Y203_S0.9431.00
93_V96_E0.9411.00
309_L313_K0.9401.00
293_P296_E0.9381.00
321_W324_F0.9371.00
244_Q247_Q0.9331.00
90_M93_V0.9321.00
323_E327_K0.9241.00
133_I162_S0.9221.00
317_A321_W0.9211.00
156_L231_I0.9201.00
109_N112_S0.9201.00
290_H294_L0.9191.00
230_M260_L0.9191.00
75_H79_K0.9181.00
86_S92_R0.9161.00
370_V393_V0.9161.00
106_N113_I0.9141.00
331_P395_K0.9131.00
87_C96_E0.9111.00
322_I332_V0.9101.00
91_G99_L0.9081.00
361_A386_I0.9021.00
395_K425_E0.9021.00
157_F163_A0.9001.00
82_L88_V0.8981.00
321_W325_H0.8941.00
85_R89_M0.8921.00
115_L193_G0.8901.00
298_R302_C0.8901.00
70_Y73_F0.8891.00
67_D74_Y0.8881.00
61_N66_T0.8871.00
63_C68_Q0.8871.00
67_D73_F0.8861.00
168_L228_D0.8851.00
112_S115_L0.8821.00
295_P301_W0.8811.00
270_E274_K0.8801.00
95_E99_L0.8771.00
322_I326_V0.8741.00
296_E302_C0.8741.00
79_K88_V0.8731.00
443_L448_H0.8721.00
443_L449_I0.8721.00
96_E100_Y0.8681.00
230_M250_V0.8681.00
74_Y78_G0.8681.00
87_C91_G0.8631.00
218_H223_Y0.8611.00
120_K126_Q0.8601.00
401_L417_A0.8561.00
146_A150_A0.8531.00
374_R395_K0.8501.00
81_K85_R0.8451.00
107_E110_W0.8431.00
440_K445_A0.8391.00
92_R98_P0.8361.00
343_E360_H0.8341.00
444_D448_H0.8341.00
197_S213_M0.8341.00
350_K356_T0.8331.00
331_P379_D0.8321.00
179_V182_E0.8261.00
365_H368_E0.8241.00
314_I325_H0.8231.00
445_A448_H0.8221.00
69_R73_F0.8221.00
123_S126_Q0.8221.00
65_Q71_F0.8201.00
129_A158_P0.8191.00
293_P300_V0.8191.00
341_I345_A0.8171.00
80_N83_Y0.8151.00
313_K317_A0.8141.00
325_H330_R0.8141.00
199_L223_Y0.8121.00
401_L416_I0.8111.00
401_L405_S0.8101.00
78_G83_Y0.8101.00
294_L298_R0.8061.00
203_S207_G0.8041.00
364_K368_E0.8001.00
63_C70_Y0.7991.00
169_R228_D0.7991.00
201_G204_D0.7981.00
88_V95_E0.7981.00
89_M92_R0.7941.00
250_V253_A0.7941.00
314_I404_E0.7931.00
72_S75_H0.7921.00
264_S267_P0.7881.00
322_I354_C0.7851.00
64_G70_Y0.7821.00
445_A449_I0.7781.00
185_P188_K0.7751.00
164_L211_P0.7741.00
61_N67_D0.7731.00
80_N86_S0.7701.00
92_R99_L0.7691.00
333_F396_V0.7681.00
108_S111_K0.7671.00
294_L299_F0.7631.00
73_F77_S0.7621.00
77_S84_C0.7611.00
229_V261_V0.7611.00
349_F356_T0.7601.00
173_A220_L0.7601.00
128_A132_L0.7581.00
62_R68_Q0.7571.00
419_R422_R0.7561.00
293_P297_P0.7531.00
441_S444_D0.7521.00
89_M95_E0.7521.00
181_L185_P0.7501.00
436_F439_T0.7481.00
81_K89_M0.7461.00
247_Q277_N0.7411.00
94_S99_L0.7411.00
85_R88_V0.7411.00
75_H80_N0.7411.00
314_I317_A0.7401.00
74_Y81_K0.7371.00
322_I349_F0.7361.00
361_A366_R0.7351.00
365_H369_K0.7321.00
217_T232_I0.7301.00
398_T430_D0.7281.00
129_A133_I0.7281.00
291_R295_P0.7231.00
120_K125_Q0.7231.00
218_H237_A0.7221.00
103_K114_K0.7201.00
108_S112_S0.7171.00
61_N69_R0.7161.00
121_L129_A0.7131.00
160_I163_A0.7071.00
69_R74_Y0.7071.00
286_P289_H0.7071.00
213_M227_I0.7061.00
294_L302_C0.7061.00
107_E114_K0.7041.00
330_R398_T0.7031.00
315_P319_K0.7021.00
325_H398_T0.7001.00
76_S81_K0.7001.00
195_D209_L0.6991.00
84_C88_V0.6991.00
62_R72_S0.6981.00
310_N316_P0.6941.00
283_V286_P0.6941.00
82_L99_L0.6901.00
245_T248_F0.6891.00
398_T401_L0.6861.00
62_R67_D0.6811.00
139_K259_T0.6791.00
161_E191_F0.6781.00
164_L194_A0.6781.00
147_V150_A0.6781.00
141_E260_L0.6741.00
66_T72_S0.6731.00
292_K296_E0.6701.00
81_K87_C0.6701.00
310_N314_I0.6701.00
293_P299_F0.6691.00
345_A349_F0.6681.00
91_G96_E0.6671.00
293_P298_R0.6641.00
287_A291_R0.6641.00
68_Q73_F0.6641.00
122_S125_Q0.6601.00
79_K86_S0.6601.00
183_L186_R0.6581.00
294_L300_V0.6581.00
293_P301_W0.6561.00
237_A240_Y0.6561.00
79_K85_R0.6551.00
74_Y80_N0.6521.00
287_A290_H0.6511.00
383_T391_V0.6511.00
79_K84_C0.6501.00
294_L301_W0.6491.00
309_L316_P0.6491.00
409_T412_A0.6481.00
314_I326_V0.6431.00
316_P319_K0.6421.00
420_T429_G0.6411.00
53_I64_G0.6411.00
318_V400_V0.6381.00
347_A351_G0.6381.00
176_R218_H0.6371.00
69_R75_H0.6371.00
100_Y104_E0.6361.00
97_V100_Y0.6341.00
156_L183_L0.6341.00
141_E280_L0.6331.00
157_F164_L0.6331.00
76_S85_R0.6331.00
277_N281_H0.6321.00
240_Y244_Q0.6291.00
291_R297_P0.6291.00
76_S86_S0.6281.00
221_L245_T0.6271.00
369_K372_Q0.6271.00
140_E283_V0.6271.00
288_R293_P0.6251.00
74_Y79_K0.6251.00
117_W122_S0.6230.99
229_V259_T0.6200.99
333_F383_T0.6180.99
385_T412_A0.6180.99
292_K299_F0.6170.99
326_V378_L0.6150.99
348_C352_V0.6150.99
91_G98_P0.6130.99
157_F162_S0.6100.99
418_G421_G0.6090.99
179_V391_V0.6080.99
142_L261_V0.6070.99
74_Y100_Y0.6070.99
113_I118_D0.6050.99
64_G72_S0.6050.99
90_M98_P0.6050.99
83_Y98_P0.6030.99
224_K227_I0.6020.99
121_L124_G0.6010.99
321_W400_V0.6000.99
296_E428_D0.5980.99
353_H356_T0.5970.99
295_P300_V0.5970.99
341_I344_K0.5960.99
86_S91_G0.5950.99
130_N138_K0.5950.99
236_D415_Q0.5940.99
83_Y96_E0.5920.99
72_S77_S0.5910.99
289_H293_P0.5910.99
80_N87_C0.5910.99
66_T77_S0.5900.99
186_R190_A0.5900.99
62_R69_R0.5880.99
171_C215_S0.5860.99
73_F83_Y0.5860.99
76_S82_L0.5840.99
218_H221_L0.5810.99
82_L87_C0.5800.99
75_H83_Y0.5800.99
83_Y93_V0.5750.99
185_P374_R0.5740.99
85_R92_R0.5730.99
331_P397_Q0.5710.99
72_S78_G0.5700.99
228_D258_S0.5670.99
168_L226_A0.5670.99
288_R291_R0.5650.99
110_W115_L0.5650.99
167_G226_A0.5650.99
187_L191_F0.5640.99
336_V402_G0.5620.99
65_Q79_K0.5620.99
70_Y80_N0.5610.99
61_N71_F0.5600.99
83_Y92_R0.5580.99
194_A201_G0.5580.99
335_F416_I0.5550.99
289_H294_L0.5540.99
194_A211_P0.5530.99
84_C95_E0.5520.99
90_M97_V0.5490.99
344_K348_C0.5490.99
76_S88_V0.5490.99
199_L204_D0.5480.99
53_I63_C0.5480.99
81_K86_S0.5460.99
347_A350_K0.5440.99
70_Y75_H0.5440.99
174_T216_T0.5420.99
125_Q128_A0.5420.99
219_Q222_R0.5420.99
369_K378_L0.5410.99
182_E392_T0.5400.99
196_I201_G0.5400.99
199_L213_M0.5390.99
81_K88_V0.5380.99
397_Q425_E0.5380.99
92_R97_V0.5380.99
85_R91_G0.5360.98
63_C74_Y0.5360.98
317_A434_F0.5350.98
53_I68_Q0.5340.98
73_F78_G0.5330.98
131_V283_V0.5320.98
71_F77_S0.5320.98
67_D75_H0.5310.98
310_N317_A0.5310.98
315_P321_W0.5300.98
71_F79_K0.5300.98
405_S442_M0.5300.98
63_C69_R0.5290.98
425_E428_D0.5290.98
77_S82_L0.5270.98
91_G100_Y0.5260.98
318_V345_A0.5250.98
372_Q378_L0.5250.98
61_N70_Y0.5240.98
288_R292_K0.5240.98
90_M95_E0.5240.98
65_Q76_S0.5230.98
93_V100_Y0.5230.98
323_E353_H0.5220.98
61_N68_Q0.5210.98
79_K97_V0.5190.98
79_K90_M0.5190.98
131_V285_I0.5180.98
313_K325_H0.5180.98
130_N133_I0.5170.98
331_P396_V0.5140.98
269_K272_K0.5120.98
129_A132_L0.5120.98
202_G205_D0.5120.98
84_C94_S0.5100.98
161_E164_L0.5070.98
72_S79_K0.5060.98
334_L402_G0.5060.98
283_V287_A0.5060.98
285_I289_H0.5050.98
80_N85_R0.5040.98
321_W434_F0.5040.98
111_K193_G0.5040.98
315_P402_G0.5030.98
124_G128_A0.5030.98
85_R90_M0.5020.98
282_S308_K0.5020.98
68_Q75_H0.5000.98
154_E158_P0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nhoA 1 0.8164 100 0.352 Contact Map
3fmpB 1 0.4428 100 0.355 Contact Map
4c9bA 1 0.7905 100 0.358 Contact Map
4pxaA 1 0.8531 100 0.358 Contact Map
2db3A 1 0.8423 100 0.365 Contact Map
4ljyA 1 0.8488 100 0.367 Contact Map
4w7sA 2 0.8337 100 0.367 Contact Map
3eiqA 1 0.7387 100 0.368 Contact Map
4d25A 1 0.8445 100 0.372 Contact Map
4qu4A 1 0.8035 100 0.374 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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