GREMLIN Database
GUTR - Transcription activator GutR
UniProt: P39143 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 829 (652)
Sequences: 3896 (3443)
Seq/√Len: 134.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
675_Q678_K5.8411.00
632_D635_G5.7441.00
751_Q754_K5.6011.00
712_Y715_E5.2401.00
790_E793_K4.5821.00
198_I334_L3.7881.00
128_D134_P3.4801.00
667_A683_L3.4011.00
435_N474_Q3.2151.00
408_L412_L3.0401.00
424_E504_Q2.9271.00
624_G640_I2.8501.00
182_M213_A2.8171.00
592_L595_R2.7971.00
619_R639_Q2.7181.00
408_L415_A2.7071.00
412_L415_A2.6921.00
648_E659_K2.6851.00
186_R216_S2.6851.00
782_A798_N2.6691.00
704_G720_Y2.6541.00
743_G759_F2.5961.00
727_S732_G2.5841.00
295_R298_H2.5401.00
408_L411_E2.5321.00
380_F409_I2.5111.00
338_D341_D2.4471.00
228_N232_W2.4171.00
441_L461_A2.4111.00
759_F780_G2.3881.00
647_L658_L2.3781.00
150_R153_Q2.3731.00
746_Y758_A2.3551.00
230_I235_A2.3321.00
556_E559_N2.3091.00
607_H642_A2.2971.00
767_H774_L2.2861.00
607_H615_E2.2631.00
379_E413_G2.2311.00
739_Y758_A2.2291.00
756_E781_M2.2061.00
691_I696_Q2.1991.00
778_H797_S2.1531.00
656_Y692_S2.1531.00
663_H682_I2.1311.00
229_S232_W2.1101.00
728_S732_G2.0841.00
717_I742_L2.0831.00
717_I745_A2.0591.00
438_T474_Q2.0481.00
278_T283_I2.0281.00
405_A412_L1.9981.00
518_N522_H1.9841.00
232_W235_A1.9731.00
795_V799_Q1.9311.00
186_R213_A1.9311.00
228_N245_F1.9261.00
756_E788_K1.9051.00
124_I127_K1.8991.00
210_A313_T1.8811.00
198_I210_A1.8521.00
573_K608_H1.8491.00
229_S235_A1.8471.00
656_Y659_K1.8331.00
290_I312_L1.8271.00
274_L278_T1.8021.00
411_E415_A1.7961.00
563_V579_L1.7931.00
240_L245_F1.7801.00
342_A391_M1.7531.00
612_H649_Q1.7501.00
513_E517_R1.7351.00
128_D131_F1.7341.00
129_G134_P1.7281.00
228_N235_A1.7241.00
126_R130_L1.7151.00
690_P695_I1.7031.00
611_Q614_R1.7031.00
171_W212_E1.6941.00
228_N231_I1.6921.00
185_I213_A1.6881.00
648_E685_E1.6801.00
745_A749_C1.6791.00
431_W443_Q1.6771.00
596_I600_R1.6731.00
554_K590_I1.6701.00
464_D467_R1.6601.00
680_E710_R1.6601.00
368_Q373_S1.6591.00
212_E216_S1.6591.00
405_A408_L1.6571.00
346_F377_K1.6491.00
724_N727_S1.6401.00
530_T534_R1.6391.00
724_N728_S1.6281.00
127_K132_G1.6261.00
775_I805_I1.6201.00
410_H415_A1.6061.00
142_V146_L1.6041.00
637_L673_D1.6041.00
410_H414_K1.5931.00
245_F249_I1.5891.00
739_Y761_Q1.5871.00
144_K148_H1.5741.00
583_I587_L1.5721.00
129_G132_G1.5681.00
802_I818_V1.5631.00
207_T289_S1.5501.00
723_A727_S1.5501.00
728_S735_T1.5501.00
406_Q410_H1.5431.00
728_S731_G1.5431.00
442_W498_V1.5401.00
680_E684_N1.5401.00
141_N144_K1.5381.00
746_Y754_K1.5351.00
228_N249_I1.5351.00
717_I749_C1.5351.00
721_E742_L1.5321.00
616_A647_L1.5271.00
728_S761_Q1.5211.00
127_K131_F1.5141.00
602_A618_F1.5131.00
533_K536_Q1.5061.00
437_D467_R1.5001.00
480_L498_V1.4891.00
660_V690_P1.4831.00
126_R129_G1.4751.00
680_E703_R1.4751.00
664_A702_V1.4681.00
691_I722_A1.4671.00
765_D768_N1.4631.00
183_E187_Q1.4601.00
370_L377_K1.4581.00
785_L797_S1.4581.00
296_D302_T1.4551.00
175_F212_E1.4541.00
670_F678_K1.4541.00
707_S715_E1.4531.00
707_S712_Y1.4521.00
296_D300_F1.4481.00
700_L719_L1.4461.00
767_H800_K1.4421.00
623_S627_L1.4391.00
369_L373_S1.4361.00
644_L659_K1.4241.00
627_L635_G1.4231.00
379_E383_A1.4131.00
717_I721_E1.4121.00
727_S731_G1.4071.00
339_Q378_N1.4041.00
463_L468_F1.4001.00
179_S341_D1.4001.00
127_K130_L1.3961.00
746_Y751_Q1.3901.00
136_E140_E1.3861.00
691_I700_L1.3861.00
778_H800_K1.3861.00
230_I233_V1.3841.00
229_S234_S1.3811.00
612_H615_E1.3801.00
792_T800_K1.3791.00
682_I685_E1.3761.00
181_D209_I1.3721.00
697_H727_S1.3721.00
722_A725_E1.3621.00
707_S719_L1.3591.00
441_L471_A1.3561.00
724_N738_A1.3551.00
446_C503_E1.3541.00
141_N145_R1.3531.00
753_E788_K1.3491.00
408_L414_K1.3491.00
344_E348_Q1.3461.00
596_I623_S1.3421.00
619_R642_A1.3411.00
623_S639_Q1.3401.00
744_V747_V1.3321.00
231_I235_A1.3241.00
756_E784_L1.3221.00
531_H534_R1.3181.00
199_T333_Q1.3171.00
703_R708_F1.3141.00
627_L632_D1.3121.00
663_H685_E1.3061.00
670_F682_I1.3041.00
342_A386_G1.3021.00
143_V147_F1.2971.00
406_Q412_L1.2911.00
760_E781_M1.2881.00
681_T685_E1.2851.00
132_G135_S1.2841.00
793_K796_E1.2831.00
481_I494_A1.2791.00
708_F720_Y1.2781.00
733_E768_N1.2761.00
522_H575_I1.2751.00
756_E785_L1.2711.00
654_D659_K1.2621.00
806_D818_V1.2611.00
446_C502_G1.2581.00
274_L285_L1.2551.00
427_F498_V1.2551.00
448_F520_W1.2551.00
131_F134_P1.2531.00
685_E688_N1.2521.00
705_D708_F1.2461.00
724_N732_G1.2461.00
172_S211_L1.2451.00
693_P729_T1.2421.00
127_K135_S1.2421.00
249_I252_Q1.2401.00
706_L710_R1.2391.00
213_A217_C1.2391.00
124_I128_D1.2371.00
572_Q575_I1.2361.00
621_D665_L1.2351.00
720_Y741_N1.2351.00
405_A415_A1.2341.00
343_H381_I1.2301.00
228_N233_V1.2231.00
411_E414_K1.2221.00
723_A728_S1.2211.00
128_D132_G1.2171.00
644_L663_H1.2151.00
701_L741_N1.2151.00
717_I746_Y1.2121.00
412_L416_G1.2121.00
660_V689_Q1.2041.00
408_L416_G1.2031.00
814_I818_V1.1991.00
202_A426_L1.1951.00
600_R623_S1.1921.00
703_R707_S1.1921.00
635_G638_Q1.1910.99
410_H413_G1.1900.99
135_S147_F1.1890.99
815_R818_V1.1890.99
785_L793_K1.1880.99
642_A645_K1.1880.99
343_H377_K1.1860.99
577_I614_R1.1860.99
438_T475_M1.1850.99
771_Q774_L1.1850.99
405_A410_H1.1840.99
339_Q382_S1.1800.99
186_R217_C1.1800.99
724_N731_G1.1800.99
619_R646_I1.1740.99
406_Q415_A1.1710.99
684_N703_R1.1680.99
295_R302_T1.1640.99
445_L452_P1.1640.99
142_V153_Q1.1630.99
440_K444_T1.1560.99
532_L536_Q1.1560.99
520_W524_Y1.1550.99
780_G783_Q1.1540.99
743_G758_A1.1530.99
532_L535_E1.1520.99
603_A615_E1.1460.99
414_K417_Y1.1420.99
708_F713_H1.1420.99
727_S730_Y1.1400.99
723_A731_G1.1400.99
260_D264_N1.1380.99
431_W439_R1.1350.99
212_E215_Y1.1320.99
267_R270_V1.1320.99
554_K586_F1.1270.99
584_S599_G1.1260.99
736_I739_Y1.1250.99
519_R522_H1.1230.99
680_E706_L1.1230.99
377_K405_A1.1230.99
747_V784_L1.1190.99
531_H535_E1.1170.99
124_I130_L1.1170.99
671_L679_A1.1160.99
530_T535_E1.1140.99
458_A468_F1.1140.99
637_L669_L1.1120.99
786_Y798_N1.1060.99
775_I801_A1.1060.99
341_D344_E1.1040.99
229_S289_S1.1010.99
295_R300_F1.0940.99
142_V150_R1.0910.99
137_G141_N1.0900.99
189_M217_C1.0900.99
717_I720_Y1.0890.99
756_E760_E1.0880.99
696_Q700_L1.0860.99
779_Y805_I1.0830.99
700_L722_A1.0820.99
641_E666_K1.0790.99
670_F675_Q1.0790.99
640_I665_L1.0780.99
763_L777_Y1.0720.99
648_E663_H1.0720.99
627_L639_Q1.0710.99
637_L641_E1.0690.99
405_A414_K1.0680.99
428_G501_Y1.0650.99
528_A533_K1.0610.99
696_Q703_R1.0600.99
703_R719_L1.0600.99
693_P696_Q1.0590.99
534_R537_P1.0590.99
655_A658_L1.0570.99
125_L128_D1.0560.99
181_D335_S1.0560.99
441_L468_F1.0550.99
602_A605_A1.0550.99
740_F744_V1.0540.99
700_L707_S1.0540.99
757_E761_Q1.0520.99
435_N438_T1.0460.99
342_A381_I1.0450.99
346_F395_I1.0440.99
813_G816_G1.0400.99
436_E439_R1.0390.99
370_L373_S1.0390.99
659_K663_H1.0370.99
369_L374_S1.0330.99
527_Y533_K1.0330.99
124_I129_G1.0310.99
407_Q410_H1.0310.99
680_E683_L1.0310.99
680_E707_S1.0300.99
615_E619_R1.0280.99
669_L673_D1.0270.98
442_W501_Y1.0260.98
725_E729_T1.0240.98
125_L129_G1.0180.98
463_L471_A1.0170.98
683_L702_V1.0150.98
130_L135_S1.0130.98
529_E533_K1.0120.98
557_W592_L1.0110.98
616_A658_L1.0100.98
190_L220_D1.0090.98
406_Q414_K1.0080.98
766_K777_Y1.0070.98
343_H378_N1.0060.98
607_H619_R1.0050.98
793_K797_S1.0040.98
759_F777_Y1.0020.98
713_H745_A1.0010.98
229_S233_V1.0010.98
231_I234_S0.9980.98
230_I234_S0.9970.98
519_R524_Y0.9930.98
574_E578_E0.9900.98
233_V236_D0.9880.98
189_M309_K0.9840.98
458_A465_A0.9840.98
232_W236_D0.9820.98
295_R299_E0.9810.98
247_N270_V0.9810.98
702_V706_L0.9810.98
230_I236_D0.9790.98
684_N688_N0.9780.98
742_L746_Y0.9770.98
728_S739_Y0.9710.98
406_Q411_E0.9710.98
131_F135_S0.9700.98
802_I806_D0.9680.98
271_R274_L0.9670.98
549_N552_Q0.9670.98
698_R701_L0.9660.98
792_T796_E0.9650.98
654_D662_G0.9620.98
146_L149_D0.9610.98
576_L580_I0.9610.98
687_E696_Q0.9600.98
637_L670_F0.9590.98
701_L705_D0.9590.98
527_Y530_T0.9570.98
742_L758_A0.9570.98
296_D299_E0.9560.98
126_R131_F0.9560.98
214_A286_I0.9530.98
381_I391_M0.9520.98
270_V277_Y0.9520.98
136_E143_V0.9510.98
743_G780_G0.9510.98
666_K682_I0.9490.97
615_E646_I0.9470.97
452_P457_L0.9430.97
135_S143_V0.9420.97
654_D666_K0.9400.97
413_G416_G0.9350.97
785_L790_E0.9350.97
600_R604_D0.9330.97
738_A742_L0.9320.97
697_H700_L0.9320.97
702_V705_D0.9300.97
176_I348_Q0.9300.97
349_E392_A0.9270.97
640_I666_K0.9260.97
181_D184_A0.9240.97
185_I196_C0.9230.97
273_A277_Y0.9220.97
552_Q556_E0.9210.97
724_N742_L0.9210.97
777_Y780_G0.9200.97
426_L429_R0.9190.97
577_I602_A0.9150.97
814_I817_E0.9110.97
404_P408_L0.9110.97
637_L666_K0.9100.97
671_L709_A0.9090.97
763_L767_H0.9060.97
666_K671_L0.9060.97
298_H327_G0.9060.97
759_F784_L0.9040.97
698_R702_V0.9040.97
130_L134_P0.9020.97
650_S654_D0.9010.97
687_E691_I0.9010.97
380_F405_A0.9000.97
740_F777_Y0.9000.97
587_L592_L0.8980.96
596_I627_L0.8970.96
453_D456_S0.8950.96
811_A815_R0.8910.96
195_V301_I0.8890.96
697_H703_R0.8880.96
146_L153_Q0.8880.96
577_I618_F0.8870.96
704_G742_L0.8870.96
339_Q343_H0.8850.96
247_N251_Y0.8840.96
339_Q386_G0.8810.96
557_W595_R0.8790.96
802_I814_I0.8790.96
139_I143_V0.8770.96
270_V273_A0.8760.96
535_E538_N0.8740.96
723_A730_Y0.8700.96
700_L706_L0.8690.96
124_I132_G0.8650.96
293_A320_Q0.8640.96
460_A516_A0.8640.96
490_T493_L0.8640.96
719_L722_A0.8630.96
667_A682_I0.8600.96
456_S523_Y0.8570.95
760_E785_L0.8540.95
766_K773_E0.8540.95
770_N773_E0.8540.95
688_N692_S0.8530.95
580_I598_Y0.8530.95
145_R150_R0.8520.95
760_E793_K0.8510.95
660_V686_I0.8490.95
704_G723_A0.8470.95
199_T331_A0.8470.95
561_L595_R0.8460.95
374_S378_N0.8460.95
404_P407_Q0.8440.95
637_L675_Q0.8440.95
659_K666_K0.8440.95
444_T516_A0.8430.95
544_Y560_I0.8420.95
440_K512_Y0.8410.95
670_F673_D0.8410.95
666_K670_F0.8390.95
398_M405_A0.8390.95
763_L774_L0.8380.95
762_M777_Y0.8370.95
457_L460_A0.8360.95
531_H536_Q0.8340.95
270_V274_L0.8300.95
650_S655_A0.8300.95
446_C506_L0.8290.95
442_W502_G0.8290.95
268_F271_R0.8290.95
727_S734_K0.8290.95
126_R132_G0.8290.95
210_A286_I0.8290.95
518_N572_Q0.8280.94
380_F391_M0.8280.94
131_F147_F0.8270.94
599_G622_T0.8260.94
747_V787_R0.8250.94
663_H689_Q0.8240.94
771_Q807_S0.8240.94
174_R348_Q0.8230.94
752_F784_L0.8230.94
548_R582_R0.8230.94
704_G708_F0.8220.94
743_G762_M0.8190.94
586_F590_I0.8190.94
531_H549_N0.8190.94
739_Y765_D0.8170.94
516_A519_R0.8170.94
740_F780_G0.8150.94
718_Q722_A0.8140.94
596_I626_A0.8120.94
231_I236_D0.8110.94
667_A686_I0.8110.94
437_D471_A0.8110.94
314_A318_V0.8100.94
132_G136_E0.8100.94
805_I813_G0.8070.94
149_D153_Q0.8070.94
683_L699_V0.8060.94
659_K685_E0.8040.94
426_L431_W0.8030.94
723_A726_I0.8030.94
704_G741_N0.8030.94
667_A679_A0.8020.94
136_E147_F0.8010.93
697_H701_L0.8000.93
140_E144_K0.8000.93
447_F520_W0.8000.93
208_T212_E0.7990.93
778_H792_T0.7980.93
641_E678_K0.7980.93
267_R271_R0.7970.93
251_Y269_V0.7970.93
538_N544_Y0.7960.93
676_Q706_L0.7950.93
744_V780_G0.7940.93
350_V395_I0.7910.93
445_L457_L0.7900.93
373_S376_L0.7900.93
774_L804_L0.7900.93
724_N730_Y0.7890.93
411_E416_G0.7890.93
214_A284_L0.7890.93
752_F756_E0.7890.93
405_A416_G0.7880.93
367_E373_S0.7870.93
438_T471_A0.7850.93
743_G781_M0.7850.93
662_G666_K0.7840.93
677_E681_T0.7840.93
129_G135_S0.7840.93
615_E642_A0.7840.93
601_K604_D0.7830.93
208_T392_A0.7820.93
140_E143_V0.7810.93
699_V702_V0.7800.93
404_P412_L0.7800.93
713_H717_I0.7800.93
744_V759_F0.7780.92
714_V749_C0.7770.92
143_V146_L0.7770.92
197_L312_L0.7770.92
703_R710_R0.7760.92
298_H302_T0.7760.92
210_A311_L0.7750.92
292_T295_R0.7740.92
245_F252_Q0.7720.92
695_I699_V0.7720.92
568_S571_E0.7720.92
337_L345_F0.7710.92
644_L648_E0.7690.92
204_M336_G0.7650.92
557_W587_L0.7640.92
720_Y724_N0.7640.92
718_Q721_E0.7640.92
563_V567_A0.7640.92
756_E790_E0.7640.92
183_E186_R0.7640.92
127_K134_P0.7640.92
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295_R303_S0.7630.92
752_F788_K0.7620.92
296_D301_I0.7620.92
565_Q597_E0.7610.92
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144_K147_F0.7510.91
774_L800_K0.7500.91
521_A575_I0.7500.91
528_A534_R0.7470.91
721_E754_K0.7470.91
644_L666_K0.7460.91
796_E800_K0.7460.91
246_L254_G0.7460.91
596_I630_V0.7450.91
204_M335_S0.7430.91
696_Q708_F0.7420.91
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761_Q764_Y0.7400.90
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641_E645_K0.7340.90
533_K537_P0.7340.90
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410_H416_G0.7230.89
667_A701_L0.7200.89
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714_V717_I0.7180.89
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527_Y531_H0.7160.89
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159_T162_P0.5830.77
571_E576_L0.5830.77
517_R566_W0.5820.77
723_A738_A0.5820.77
384_T393_L0.5810.76
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289_S390_A0.5800.76
613_T655_A0.5770.76
533_K538_N0.5770.76
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427_F442_W0.5680.75
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413_G417_Y0.5680.75
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519_R523_Y0.5670.75
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213_A311_L0.5660.75
577_I584_S0.5650.74
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646_I649_Q0.5640.74
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659_K689_Q0.5620.74
367_E370_L0.5620.74
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297_I300_F0.5610.74
165_H218_V0.5610.74
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645_K649_Q0.5600.74
606_A615_E0.5600.74
681_T684_N0.5600.74
634_D673_D0.5590.74
494_A498_V0.5580.74
764_Y768_N0.5580.74
204_M334_L0.5580.74
684_N712_Y0.5570.73
624_G639_Q0.5560.73
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402_D416_G0.5560.73
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466_R512_Y0.5520.73
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451_P489_R0.5430.72
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142_V152_G0.5420.71
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666_K672_K0.5410.71
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443_Q512_Y0.5380.71
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455_K465_A0.5380.71
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280_E307_G0.5320.70
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676_Q709_A0.5320.70
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298_H303_S0.5310.70
267_R277_Y0.5300.70
553_M557_W0.5290.70
661_W665_L0.5290.70
667_A702_V0.5290.70
656_Y689_Q0.5290.70
551_D555_Q0.5270.69
704_G710_R0.5270.69
667_A703_R0.5260.69
724_N733_E0.5260.69
407_Q414_K0.5250.69
407_Q416_G0.5250.69
772_V805_I0.5250.69
666_K687_E0.5240.69
296_D303_S0.5230.69
736_I743_G0.5230.69
288_D496_Q0.5230.69
685_E692_S0.5220.69
381_I394_S0.5210.68
517_R524_Y0.5210.68
245_F254_G0.5200.68
654_D660_V0.5200.68
339_Q381_I0.5190.68
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407_Q412_L0.5180.68
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469_H473_E0.5170.68
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744_V783_Q0.5160.68
401_D416_G0.5150.68
662_G667_A0.5150.68
202_A288_D0.5150.68
687_E700_L0.5140.67
269_V272_N0.5140.67
741_N780_G0.5130.67
700_L726_I0.5130.67
446_C524_Y0.5120.67
442_W446_C0.5110.67
684_N707_S0.5110.67
550_L590_I0.5110.67
662_G668_R0.5110.67
174_R392_A0.5110.67
662_G683_L0.5100.67
555_Q558_P0.5090.67
612_H646_I0.5080.67
559_N563_V0.5080.67
650_S658_L0.5070.66
518_N575_I0.5070.66
404_P413_G0.5070.66
708_F744_V0.5070.66
135_S139_I0.5060.66
609_L612_H0.5060.66
202_A317_N0.5060.66
179_S183_E0.5060.66
207_T288_D0.5060.66
454_E468_F0.5060.66
482_Q493_L0.5050.66
647_L662_G0.5050.66
124_I137_G0.5050.66
302_T310_V0.5040.66
378_N382_S0.5040.66
401_D405_A0.5030.66
639_Q642_A0.5030.66
633_L673_D0.5020.66
813_G818_V0.5020.66
606_A614_R0.5000.65
404_P411_E0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z6tA 1 0.6828 100 0.698 Contact Map
2a5yB 2 0.5609 100 0.72 Contact Map
3sfzA 1 0.6864 100 0.72 Contact Map
1vt4I 4 0.6526 100 0.748 Contact Map
2qenA 1 0.3691 100 0.807 Contact Map
4jhrA 2 0.2799 99.9 0.815 Contact Map
2fnaA 1 0.3643 99.9 0.817 Contact Map
3sf4A 1 0.3993 99.9 0.822 Contact Map
4a1sA 1 0.3703 99.9 0.824 Contact Map
3ulqA 1 0.3534 99.9 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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