GREMLIN Database
PDP - Pyrimidine-nucleoside phosphorylase
UniProt: P39142 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (421)
Sequences: 2202 (1404)
Seq/√Len: 68.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_L45_I4.7761.00
15_E51_S4.2191.00
215_A429_T3.8311.00
13_G48_Q3.6061.00
381_R396_T3.5011.00
9_K20_E3.3321.00
24_F38_A3.3131.00
18_T57_D3.2981.00
308_K311_D3.2461.00
131_H138_E3.1991.00
141_K145_R3.0851.00
343_A389_E2.8591.00
101_A299_V2.8391.00
53_R57_D2.8161.00
210_T213_D2.7721.00
347_S418_A2.7591.00
15_E53_R2.6751.00
202_T236_I2.5861.00
382_K392_E2.5631.00
102_L299_V2.5601.00
341_K412_Y2.5301.00
247_I354_I2.4201.00
298_E302_N2.4151.00
299_V302_N2.3751.00
246_A379_M2.3611.00
92_T150_V2.2831.00
343_A390_K2.2701.00
67_E156_N2.2601.00
135_T138_E2.2341.00
342_E419_A2.2191.00
98_L296_L2.1941.00
6_I24_F2.1331.00
121_I132_V2.1281.00
354_I411_V2.1101.00
52_D223_R2.1101.00
209_K352_D2.1101.00
286_A292_A2.1061.00
276_G296_L2.0991.00
219_K223_R2.0961.00
24_F41_L2.0851.00
258_D263_E2.0661.00
142_L146_D2.0521.00
339_P393_P2.0321.00
56_A227_N2.0161.00
277_S292_A2.0151.00
213_D216_E1.9891.00
337_D396_T1.9791.00
273_L296_L1.9671.00
350_V353_E1.9561.00
367_T370_D1.9491.00
18_T53_R1.9481.00
99_V279_M1.9381.00
63_V189_I1.9201.00
146_D315_N1.8881.00
26_N30_D1.8821.00
18_T22_Q1.8751.00
104_V285_K1.8701.00
358_A363_A1.8691.00
338_V411_V1.8671.00
259_T269_H1.8641.00
75_E144_N1.8471.00
9_K14_K1.8371.00
297_E301_K1.8271.00
138_E141_K1.8231.00
6_I41_L1.8131.00
93_L253_V1.7881.00
321_S328_K1.7881.00
278_Q430_L1.7631.00
346_V349_I1.7451.00
366_A370_D1.7361.00
373_D400_N1.7351.00
28_Y38_A1.7251.00
202_T214_A1.6760.99
64_N68_T1.6710.99
27_G32_S1.6650.99
251_L379_M1.6580.99
335_Q396_T1.6480.99
345_V421_A1.6420.99
94_V268_L1.6280.99
299_V304_K1.6130.99
225_G232_T1.6120.99
12_N46_F1.6010.99
349_I415_I1.5960.99
298_E304_K1.5900.99
63_V68_T1.5900.99
293_R297_E1.5820.99
56_A228_V1.5700.99
127_I313_L1.5550.99
79_V195_A1.5060.99
98_L276_G1.4980.99
91_T268_L1.4800.99
8_I12_N1.4690.99
307_E311_D1.4570.99
181_A220_A1.4560.99
376_V399_A1.4510.98
102_L280_V1.4490.98
98_L299_V1.4480.98
142_L315_N1.4450.98
198_L221_M1.4330.98
269_H297_E1.4210.98
336_I408_I1.4210.98
134_L142_L1.4170.98
189_I228_V1.4130.98
253_V256_A1.4080.98
50_M178_P1.4060.98
42_A164_L1.4060.98
251_L398_Y1.4050.98
269_H301_K1.4000.98
408_I412_Y1.3970.98
261_K306_L1.3930.98
379_M398_Y1.3900.98
389_E392_E1.3900.98
90_T244_G1.3790.98
333_A400_N1.3660.98
338_V395_V1.3590.98
337_D393_P1.3550.98
378_I395_V1.3510.98
95_L276_G1.3490.98
285_K295_K1.3410.97
55_R220_A1.3370.97
210_T214_A1.3320.97
8_I172_G1.3200.97
226_N232_T1.3200.97
245_F386_D1.3100.97
267_D383_K1.3050.97
211_E215_A1.3050.97
353_E410_K1.2970.97
139_F149_A1.2960.97
292_A296_L1.2920.97
348_E416_R1.2870.97
383_K386_D1.2810.97
8_I175_N1.2810.97
22_Q64_N1.2780.97
314_K320_S1.2750.97
254_K327_S1.2730.97
287_D291_E1.2590.96
76_G105_P1.2590.96
90_T255_E1.2570.96
125_E132_V1.2560.96
181_A224_I1.2560.96
60_M63_V1.2520.96
94_V259_T1.2520.96
235_V430_L1.2340.96
55_R178_P1.2260.96
73_A140_I1.2260.96
375_A400_N1.2250.96
22_Q57_D1.2220.96
106_V279_M1.2220.96
6_I38_A1.2210.96
22_Q26_N1.2140.95
215_A219_K1.2100.95
395_V411_V1.2090.95
254_K258_D1.2050.95
185_M225_G1.2010.95
331_Q375_A1.1990.95
38_A164_L1.1940.95
96_A148_V1.1930.95
331_Q398_Y1.1860.95
74_I78_K1.1760.95
376_V397_L1.1650.94
280_V292_A1.1630.94
250_A254_K1.1620.94
172_G175_N1.1610.94
62_M186_S1.1560.94
306_L310_K1.1550.94
335_Q398_Y1.1460.94
16_L41_L1.1420.94
78_K194_D1.1400.94
52_D227_N1.1300.93
304_K307_E1.1270.93
195_A231_Q1.1260.93
294_A297_E1.1200.93
270_E293_R1.1130.93
204_A350_V1.1120.93
345_V387_K1.1070.93
259_T265_P1.1040.92
247_I380_L1.1040.92
202_T428_H1.0990.92
12_N175_N1.0930.92
143_V149_A1.0880.92
60_M64_N1.0870.92
330_P375_A1.0870.92
251_L332_A1.0840.92
49_D178_P1.0800.92
354_I378_I1.0800.92
22_Q61_A1.0780.92
357_A407_V1.0610.91
226_N231_Q1.0480.90
373_D401_R1.0460.90
92_T108_K1.0450.90
273_L293_R1.0390.90
238_D424_P1.0270.89
60_M228_V1.0260.89
379_M396_T1.0260.89
334_Y399_A1.0250.89
409_A413_D1.0240.89
222_V234_A1.0190.89
404_V407_V1.0180.89
130_F316_Q1.0170.89
150_V312_F1.0150.89
18_T60_M1.0150.89
334_Y402_E1.0120.89
405_D408_I1.0120.89
91_T272_V1.0070.89
259_T264_G1.0000.88
204_A240_S0.9940.88
27_G30_D0.9930.88
67_E136_K0.9870.87
424_P428_H0.9840.87
138_E142_L0.9840.87
128_M319_D0.9830.87
98_L305_A0.9820.87
231_Q284_K0.9780.87
340_A343_A0.9770.87
246_A251_L0.9770.87
91_T271_L0.9770.87
353_E414_N0.9750.87
79_V283_A0.9740.87
360_L410_K0.9730.87
49_D55_R0.9710.87
357_A411_V0.9700.87
233_M278_Q0.9660.86
17_T20_E0.9640.86
336_I405_D0.9630.86
233_M282_L0.9610.86
148_V312_F0.9610.86
99_V283_A0.9600.86
341_K390_K0.9560.86
342_E417_I0.9530.86
266_E270_E0.9450.85
341_K392_E0.9370.85
381_R393_P0.9370.85
24_F45_I0.9350.85
98_L101_A0.9330.84
277_S296_L0.9320.84
107_A196_I0.9320.84
204_A348_E0.9320.84
286_A295_K0.9320.84
193_A196_I0.9320.84
71_L78_K0.9270.84
269_H273_L0.9240.84
235_V274_T0.9230.84
108_K196_I0.9220.84
261_K303_G0.9210.84
95_L272_V0.9210.84
250_A330_P0.9200.84
10_K54_E0.9180.83
121_I196_I0.9180.83
306_L320_S0.9180.83
109_M193_A0.9150.83
35_D368_K0.9110.83
281_V286_A0.9070.83
91_T275_L0.9050.83
319_D328_K0.9040.82
63_V228_V0.9020.82
195_A282_L0.8990.82
313_L318_G0.8970.82
11_Q175_N0.8970.82
254_K379_M0.8950.82
202_T211_E0.8910.82
25_V160_A0.8910.82
360_L366_A0.8890.81
196_I230_R0.8870.81
109_M153_Q0.8860.81
342_E390_K0.8840.81
238_D241_Q0.8830.81
79_V104_V0.8830.81
211_E428_H0.8820.81
332_A375_A0.8810.81
102_L295_K0.8810.81
105_P147_K0.8790.81
16_L21_I0.8790.81
240_S348_E0.8760.80
277_S289_L0.8760.80
250_A375_A0.8720.80
237_S271_L0.8690.80
121_I130_F0.8600.79
345_V418_A0.8550.79
241_Q384_V0.8540.79
77_I195_A0.8530.79
93_L97_P0.8510.78
336_I402_E0.8470.78
387_K421_A0.8440.78
244_G255_E0.8420.78
96_A312_F0.8400.78
4_V172_G0.8390.77
235_V278_Q0.8390.77
356_V360_L0.8390.77
76_G194_D0.8340.77
137_D141_K0.8320.77
57_D60_M0.8320.77
281_V292_A0.8300.77
283_A286_A0.8240.76
250_A329_L0.8230.76
49_D176_S0.8220.76
370_D374_L0.8220.76
38_A41_L0.8210.76
359_M366_A0.8130.75
146_D311_D0.8120.75
211_E214_A0.8120.75
104_V280_V0.8030.74
185_M224_I0.8000.74
272_V276_G0.7990.74
185_M198_L0.7980.74
21_I61_A0.7970.74
201_K271_L0.7960.74
21_I25_V0.7940.73
67_E155_G0.7880.73
274_T278_Q0.7850.73
8_I11_Q0.7830.72
259_T268_L0.7820.72
211_E429_T0.7820.72
10_K50_M0.7810.72
363_A376_V0.7780.72
90_T383_K0.7740.72
23_F27_G0.7730.71
382_K386_D0.7730.71
346_V415_I0.7720.71
343_A416_R0.7710.71
121_I312_F0.7710.71
269_H300_M0.7690.71
25_V29_T0.7670.71
274_T293_R0.7670.71
295_K299_V0.7650.71
95_L275_L0.7640.71
180_I208_M0.7640.71
346_V384_V0.7620.70
40_A172_G0.7620.70
340_A391_G0.7600.70
75_E78_K0.7600.70
99_V276_G0.7600.70
247_I358_A0.7580.70
98_L300_M0.7570.70
104_V283_A0.7570.70
52_D216_E0.7520.69
304_K308_K0.7490.69
336_I404_V0.7490.69
212_E215_A0.7460.69
90_T246_A0.7440.69
226_N229_G0.7440.69
406_E409_A0.7430.68
21_I50_M0.7400.68
108_K193_A0.7400.68
107_A272_V0.7380.68
11_Q46_F0.7380.68
126_A374_L0.7370.68
31_G163_K0.7360.68
307_E310_K0.7340.68
338_V412_Y0.7310.67
331_Q335_Q0.7300.67
99_V104_V0.7300.67
98_L292_A0.7280.67
209_K213_D0.7270.67
286_A291_E0.7240.66
375_A398_Y0.7230.66
332_A398_Y0.7220.66
289_L292_A0.7220.66
28_Y167_L0.7210.66
246_A254_K0.7190.66
218_A234_A0.7190.66
100_A308_K0.7160.66
181_A185_M0.7160.66
254_K329_L0.7160.66
384_V424_P0.7160.66
133_E154_S0.7150.65
387_K417_I0.7100.65
94_V256_A0.7080.65
195_A283_A0.7080.65
55_R58_L0.7060.65
382_K388_V0.7060.65
29_T61_A0.7050.64
240_S428_H0.7040.64
94_V272_V0.7030.64
6_I23_F0.7020.64
247_I378_I0.7020.64
277_S293_R0.7010.64
277_S281_V0.6990.64
155_G162_K0.6980.64
47_F55_R0.6980.64
46_F175_N0.6980.64
266_E269_H0.6980.64
71_L139_F0.6950.63
344_G417_I0.6950.63
73_A144_N0.6940.63
291_E294_A0.6930.63
200_V234_A0.6920.63
63_V230_R0.6890.63
273_L277_S0.6870.62
337_D381_R0.6870.62
393_P396_T0.6870.62
215_A236_I0.6870.62
397_L411_V0.6850.62
273_L297_E0.6840.62
339_P412_Y0.6830.62
45_I58_L0.6830.62
237_S274_T0.6820.62
339_P391_G0.6810.62
271_L426_L0.6800.62
411_V415_I0.6780.61
246_A255_E0.6780.61
333_A402_E0.6770.61
264_G269_H0.6760.61
94_V98_L0.6760.61
397_L404_V0.6750.61
29_T160_A0.6750.61
108_K121_I0.6740.61
74_I105_P0.6740.61
101_A302_N0.6730.61
339_P390_K0.6730.61
353_E413_D0.6730.61
198_L232_T0.6720.61
177_I216_E0.6720.61
143_V192_G0.6720.61
254_K398_Y0.6720.61
278_Q289_L0.6710.61
274_T277_S0.6710.61
270_E274_T0.6700.60
339_P392_E0.6700.60
240_S424_P0.6690.60
310_K320_S0.6680.60
36_Y39_S0.6670.60
126_A331_Q0.6660.60
235_V275_L0.6660.60
107_A312_F0.6640.60
291_E295_K0.6630.60
38_A167_L0.6620.60
334_Y404_V0.6620.60
34_P39_S0.6610.59
340_A417_I0.6580.59
140_I144_N0.6580.59
211_E236_I0.6570.59
367_T371_E0.6560.59
242_P246_A0.6560.59
134_L316_Q0.6540.59
9_K17_T0.6530.58
399_A404_V0.6520.58
101_A308_K0.6510.58
25_V232_T0.6500.58
68_T230_R0.6490.58
45_I50_M0.6480.58
56_A60_M0.6470.58
143_V191_A0.6470.58
96_A214_A0.6460.58
107_A143_V0.6460.58
245_F379_M0.6450.58
28_Y163_K0.6450.58
143_V157_L0.6420.57
350_V414_N0.6410.57
395_V415_I0.6400.57
349_I384_V0.6370.57
153_Q157_L0.6370.57
52_D220_A0.6360.57
238_D428_H0.6350.56
380_L383_K0.6320.56
6_I16_L0.6320.56
92_T184_I0.6310.56
37_Q43_M0.6310.56
109_M221_M0.6280.56
131_H134_L0.6270.55
354_I407_V0.6270.55
109_M196_I0.6260.55
71_L74_I0.6240.55
254_K331_Q0.6240.55
72_S78_K0.6220.55
27_G33_I0.6210.55
109_M151_I0.6180.54
96_A150_V0.6170.54
68_T158_T0.6170.54
34_P47_F0.6140.54
134_L138_E0.6130.54
259_T267_D0.6130.54
52_D56_A0.6120.54
69_I363_A0.6120.54
240_S384_V0.6120.54
298_E301_K0.6110.54
29_T158_T0.6110.54
276_G279_M0.6100.53
87_V116_H0.6080.53
102_L312_F0.6070.53
209_K214_A0.6040.53
273_L300_M0.6030.53
121_I152_G0.6030.53
74_I144_N0.6020.52
294_A298_E0.6020.52
352_D356_V0.6010.52
388_V394_L0.6000.52
401_R404_V0.5990.52
107_A191_A0.5980.52
154_S240_S0.5980.52
75_E105_P0.5970.52
39_S42_A0.5970.52
258_D261_K0.5960.52
245_F381_R0.5960.52
389_E417_I0.5940.52
408_I411_V0.5910.51
4_V366_A0.5890.51
150_V363_A0.5870.51
25_V28_Y0.5870.51
134_L151_I0.5860.51
110_S121_I0.5860.51
4_V8_I0.5860.51
107_A230_R0.5830.50
71_L193_A0.5830.50
281_V296_L0.5820.50
58_L182_S0.5810.50
19_E22_Q0.5810.50
145_R311_D0.5800.50
19_E23_F0.5770.49
53_R227_N0.5770.49
28_Y32_S0.5760.49
102_L296_L0.5740.49
29_T163_K0.5730.49
108_K191_A0.5720.49
5_D356_V0.5720.49
191_A196_I0.5720.49
13_G47_F0.5720.49
112_R125_E0.5690.49
372_I376_V0.5670.48
257_I306_L0.5670.48
277_S286_A0.5670.48
94_V309_F0.5670.48
336_I399_A0.5660.48
380_L386_D0.5650.48
7_I50_M0.5650.48
116_H201_K0.5640.48
98_L273_L0.5630.48
345_V420_E0.5610.48
208_M214_A0.5600.47
327_S331_Q0.5590.47
67_E392_E0.5580.47
158_T228_V0.5570.47
387_K405_D0.5570.47
289_L293_R0.5570.47
90_T267_D0.5560.47
124_L253_V0.5550.47
130_F312_F0.5550.47
282_L363_A0.5550.47
394_L415_I0.5550.47
204_A352_D0.5530.47
197_V280_V0.5530.47
21_I270_E0.5530.47
343_A387_K0.5510.46
25_V164_L0.5490.46
387_K419_A0.5490.46
92_T109_M0.5490.46
241_Q376_V0.5470.46
360_L406_E0.5460.46
250_A292_A0.5450.46
62_M164_L0.5440.46
108_K221_M0.5440.46
151_I191_A0.5430.45
46_F172_G0.5410.45
95_L296_L0.5400.45
141_K144_N0.5390.45
419_A427_I0.5390.45
347_S416_R0.5390.45
214_A219_K0.5360.45
52_D178_P0.5350.44
342_E387_K0.5350.44
147_K308_K0.5350.44
179_L182_S0.5350.44
71_L224_I0.5340.44
397_L408_I0.5340.44
127_I309_F0.5330.44
275_L282_L0.5320.44
300_M416_R0.5320.44
309_F313_L0.5320.44
402_E405_D0.5320.44
264_G267_D0.5310.44
416_R421_A0.5300.44
37_Q40_A0.5300.44
119_G122_D0.5290.44
127_I312_F0.5290.44
95_L98_L0.5290.44
254_K330_P0.5290.44
132_V391_G0.5290.44
156_N162_K0.5270.44
141_K387_K0.5270.44
103_D285_K0.5270.44
18_T61_A0.5260.43
28_Y368_K0.5260.43
216_E220_A0.5250.43
413_D425_K0.5240.43
126_A250_A0.5240.43
260_L305_A0.5240.43
418_A421_A0.5240.43
380_L395_V0.5230.43
108_K256_A0.5220.43
77_I284_K0.5220.43
130_F149_A0.5220.43
423_A427_I0.5210.43
15_E18_T0.5210.43
158_T363_A0.5200.43
35_D39_S0.5200.43
138_E145_R0.5200.43
62_M161_D0.5200.43
94_V276_G0.5180.42
108_K368_K0.5160.42
425_K428_H0.5160.42
245_F266_E0.5160.42
167_L368_K0.5150.42
123_K179_L0.5150.42
72_S76_G0.5150.42
90_T256_A0.5140.42
10_K49_D0.5140.42
121_I151_I0.5120.42
223_R227_N0.5120.42
101_A304_K0.5120.42
197_V282_L0.5120.42
16_L54_E0.5110.42
287_D294_A0.5100.42
338_V408_I0.5090.41
92_T363_A0.5090.41
164_L167_L0.5090.41
204_A351_A0.5080.41
272_V426_L0.5070.41
146_D312_F0.5060.41
193_A230_R0.5060.41
89_D179_L0.5050.41
107_A221_M0.5040.41
96_A151_I0.5040.41
311_D314_K0.5030.41
258_D327_S0.5020.41
12_N48_Q0.5010.40
161_D377_G0.5010.40
222_V232_T0.5010.40
185_M355_G0.5010.40
113_G170_V0.5010.40
336_I403_N0.5010.40
291_E304_K0.5000.40
202_T238_D0.5000.40
56_A220_A0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h5qA 2 1 100 0.271 Contact Map
1brwA 2 0.9977 100 0.272 Contact Map
4eadA 2 1 100 0.282 Contact Map
2dsjA 2 0.9769 100 0.284 Contact Map
1uouA 2 0.9769 100 0.297 Contact Map
4ga6A 2 0.9307 100 0.385 Contact Map
1vquA 2 0.6905 100 0.601 Contact Map
2elcA 4 0.6859 100 0.613 Contact Map
4giuA 2 0.6882 100 0.613 Contact Map
1khdA 2 0.6744 100 0.618 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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