GREMLIN Database
NUPC - Pyrimidine nucleoside transport protein
UniProt: P39141 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (390)
Sequences: 1639 (937)
Seq/√Len: 47.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_Y267_G4.9951.00
298_E329_S4.5641.00
296_W299_A4.1841.00
363_Q366_V3.8291.00
266_N278_Q3.7611.00
97_I251_V3.6981.00
278_Q320_S3.6731.00
23_G26_R3.6531.00
320_S323_Q3.5981.00
167_T205_F3.3501.00
302_A336_V3.3291.00
22_S373_K3.2131.00
162_Q369_R2.9801.00
153_L160_L2.9361.00
12_V291_L2.8561.00
302_A332_T2.8051.00
20_A376_Y2.7511.00
77_V256_I2.7421.00
10_L384_L2.7081.00
115_F119_Y2.6201.00
292_V383_F2.5861.00
245_F249_V2.5591.00
22_S212_N2.5161.00
372_L376_Y2.4941.00
35_M206_I2.4701.00
106_I233_F2.4611.00
203_G381_V2.3961.00
18_W24_K2.3741.00
57_G61_K2.3441.00
157_L360_N2.3311.00
158_G362_K2.3181.00
241_I257_G2.2571.00
308_T320_S2.2381.00
346_F372_L2.1911.00
17_A210_I2.1431.00
66_L103_L2.0911.00
22_S162_Q2.0491.00
106_I237_L2.0441.00
321_L331_R2.0300.99
110_W233_F2.0300.99
242_L250_V2.0200.99
109_K230_K2.0020.99
140_A152_S1.9780.99
192_Y338_V1.9750.99
17_A207_I1.9610.99
286_A303_G1.9470.99
237_L261_I1.9260.99
292_V387_A1.9240.99
51_I55_L1.8930.99
247_V250_V1.8500.99
338_V385_S1.8310.99
200_N385_S1.8290.99
71_A92_N1.8200.99
72_E75_N1.8070.99
344_A382_S1.8010.99
134_E209_S1.7890.99
211_I377_G1.7880.99
279_G283_Y1.7740.99
7_I11_I1.7730.99
162_Q366_V1.7440.98
130_M135_S1.7060.98
161_N214_Y1.6930.98
246_K249_V1.6880.98
146_Q348_S1.6710.98
211_I376_Y1.6630.98
45_I49_T1.6370.98
310_M379_T1.6330.98
147_S247_V1.6310.98
119_Y122_L1.6280.98
200_N203_G1.6240.98
20_A211_I1.6210.97
123_A127_V1.6100.97
44_Y392_I1.5940.97
105_G109_K1.5920.97
32_I206_I1.5890.97
163_Q214_Y1.5820.97
290_F296_W1.5780.97
121_G132_R1.5740.97
5_I290_F1.5730.97
277_F281_L1.5580.97
33_V37_I1.5400.97
264_L268_I1.5320.96
4_L8_I1.5240.96
94_L252_A1.5140.96
17_A380_L1.5120.96
111_K114_P1.5020.96
115_F118_R1.4890.96
100_I144_L1.4740.96
165_L366_V1.4580.95
146_Q352_I1.4520.95
344_A379_T1.4440.95
275_I280_I1.4420.95
166_Y377_G1.4310.95
18_W27_I1.4250.95
55_L58_G1.4160.94
260_A347_S1.4060.94
250_V254_M1.4010.94
70_A74_I1.3990.94
248_A252_A1.3920.94
64_G68_E1.3840.94
311_V346_F1.3820.94
23_G215_E1.3810.94
372_L375_L1.3720.93
27_I210_I1.3660.93
8_I290_F1.3610.93
70_A260_A1.3550.93
233_F237_L1.3440.93
286_A296_W1.3420.93
173_M352_I1.3360.93
149_V171_S1.3310.92
65_Y68_E1.3240.92
157_L359_L1.3210.92
102_A237_L1.3180.92
72_E263_A1.3090.92
147_S355_A1.3080.92
245_F253_A1.3030.92
147_S250_V1.2940.91
15_G19_I1.2730.91
89_F347_S1.2630.90
28_K31_P1.2620.90
78_F90_F1.2590.90
119_Y123_A1.2570.90
298_E328_F1.2540.90
65_Y69_Y1.2510.90
283_Y300_V1.2510.90
49_T52_G1.2490.90
277_F311_V1.2410.89
161_N216_V1.2390.89
247_V251_V1.2380.89
74_I91_M1.2360.89
146_Q347_S1.2340.89
235_E364_G1.2240.89
235_E239_E1.2180.89
80_G88_T1.2090.88
236_V240_Y1.1840.87
102_A241_I1.1760.87
137_N149_V1.1760.87
286_A300_V1.1750.87
265_I277_F1.1730.87
389_V392_I1.1710.86
140_A144_L1.1640.86
161_N164_R1.1620.86
382_S385_S1.1610.86
297_N301_N1.1410.85
331_R335_I1.1330.85
80_G84_A1.1310.85
200_N338_V1.1290.84
321_L336_V1.1220.84
61_K64_G1.1200.84
81_L88_T1.1190.84
289_A306_M1.1190.84
96_P179_S1.1180.84
16_L288_F1.1150.84
16_L376_Y1.1130.84
324_N327_H1.1130.84
304_S308_T1.1130.84
19_I24_K1.1080.83
356_V367_V1.0980.83
278_Q308_T1.0950.83
375_L379_T1.0910.82
262_I312_S1.0850.82
167_T171_S1.0830.82
150_F172_A1.0790.82
318_M341_V1.0680.81
44_Y48_N1.0670.81
38_L127_V1.0660.81
257_G350_G1.0620.81
312_S316_V1.0590.80
42_L203_G1.0520.80
187_M319_T1.0520.80
185_M190_P1.0490.80
268_I271_A1.0460.80
313_N347_S1.0420.79
381_V385_S1.0400.79
183_A315_F1.0370.79
45_I51_I1.0330.79
296_W303_G1.0290.78
59_F62_G1.0240.78
275_I279_G1.0220.78
179_S247_V1.0180.78
137_N171_S1.0180.78
157_L168_L1.0170.78
294_I302_A1.0120.77
14_L210_I1.0110.77
18_W210_I0.9990.76
120_I142_A0.9910.76
83_N88_T0.9880.76
364_G378_A0.9870.75
146_Q351_I0.9860.75
40_F388_I0.9860.75
346_F375_L0.9750.75
250_V355_A0.9750.75
146_Q310_M0.9730.74
309_K315_F0.9720.74
98_V244_G0.9500.73
67_L182_G0.9480.72
6_G331_R0.9460.72
21_S210_I0.9440.72
110_W113_L0.9430.72
35_M128_N0.9430.72
349_I352_I0.9390.72
141_S175_T0.9390.72
55_L59_F0.9380.72
207_I377_G0.9380.72
124_L128_N0.9360.71
16_L359_L0.9330.71
14_L32_I0.9310.71
28_K33_V0.9310.71
62_G65_Y0.9270.71
130_M205_F0.9220.70
43_G303_G0.9170.70
375_L378_A0.9150.70
30_R34_V0.9130.70
152_S251_V0.9100.69
161_N215_E0.9060.69
13_F207_I0.9040.69
180_I347_S0.9030.69
117_I156_E0.9020.69
181_V193_V0.9010.69
43_G332_T0.9000.68
276_S279_G0.8990.68
74_I260_A0.8980.68
269_F275_I0.8940.68
187_M349_I0.8880.67
254_M346_F0.8870.67
349_I371_G0.8870.67
144_L152_S0.8860.67
171_S201_L0.8850.67
297_N329_S0.8850.67
197_L200_N0.8800.67
349_I367_V0.8780.67
112_V330_G0.8700.66
6_G194_V0.8580.65
328_F333_T0.8540.64
93_V248_A0.8530.64
42_L104_I0.8470.64
162_Q212_N0.8440.63
70_A96_P0.8430.63
76_F89_F0.8400.63
72_E266_N0.8390.63
165_L363_Q0.8380.63
349_I375_L0.8370.63
138_A205_F0.8360.63
278_Q323_Q0.8350.63
173_M378_A0.8340.62
330_G334_A0.8340.62
80_G86_Q0.8330.62
139_V183_A0.8320.62
175_T189_K0.8320.62
108_Q155_K0.8310.62
206_I382_S0.8300.62
54_F57_G0.8290.62
141_S181_V0.8260.62
13_F384_L0.8260.62
248_A303_G0.8240.62
224_R227_E0.8220.61
104_I144_L0.8220.61
243_D246_K0.8210.61
162_Q370_F0.8190.61
28_K129_G0.8190.61
167_T208_A0.8190.61
113_L155_K0.8180.61
282_G304_S0.8180.61
262_I304_S0.8180.61
210_I291_L0.8160.61
91_M95_L0.8130.61
121_G135_S0.8130.61
117_I176_V0.8130.61
38_L242_L0.8120.60
8_I154_K0.8080.60
68_E71_A0.8070.60
181_V185_M0.8030.60
58_G62_G0.8020.59
80_G83_N0.8020.59
34_V128_N0.7980.59
14_L391_L0.7960.59
121_G124_L0.7950.59
37_I291_L0.7940.59
338_V389_V0.7910.58
40_F392_I0.7910.58
232_S275_I0.7880.58
156_E378_A0.7870.58
75_N80_G0.7830.58
113_L117_I0.7800.57
10_L385_S0.7790.57
147_S180_I0.7790.57
282_G303_G0.7790.57
181_V197_L0.7770.57
41_I44_Y0.7770.57
194_V198_V0.7760.57
90_F252_A0.7750.57
325_G328_F0.7720.57
10_L203_G0.7720.57
238_G242_L0.7710.56
35_M48_N0.7700.56
200_N382_S0.7680.56
49_T53_N0.7670.56
270_N296_W0.7670.56
203_G385_S0.7670.56
113_L188_L0.7610.55
39_Q203_G0.7570.55
53_N57_G0.7560.55
231_Q369_R0.7550.55
163_Q201_L0.7550.55
133_L149_V0.7520.55
146_Q248_A0.7500.54
176_V180_I0.7480.54
288_F383_F0.7480.54
13_F292_V0.7460.54
27_I59_F0.7460.54
193_V209_S0.7460.54
255_L259_V0.7440.54
345_N348_S0.7430.54
263_A267_G0.7420.54
332_T336_V0.7420.54
133_L160_L0.7400.53
5_I8_I0.7380.53
256_I271_A0.7380.53
330_G333_T0.7370.53
292_V335_I0.7340.53
104_I175_T0.7340.53
214_Y218_K0.7340.53
273_F276_S0.7310.52
313_N316_V0.7310.52
78_F95_L0.7290.52
335_I373_K0.7290.52
34_V37_I0.7290.52
83_N86_Q0.7270.52
128_N168_L0.7270.52
77_V255_L0.7270.52
163_Q209_S0.7260.52
86_Q92_N0.7250.52
301_N328_F0.7230.52
104_I113_L0.7230.52
141_S171_S0.7230.52
170_A284_V0.7200.51
177_S180_I0.7200.51
365_N369_R0.7180.51
58_G61_K0.7170.51
43_G296_W0.7160.51
171_S331_R0.7160.51
351_I354_G0.7160.51
15_G18_W0.7140.51
338_V382_S0.7130.51
69_Y264_L0.7090.50
160_L168_L0.7080.50
134_E167_T0.7060.50
100_I258_F0.7040.50
105_G230_K0.7030.50
159_L278_Q0.7030.50
106_I261_I0.6980.49
137_N168_L0.6980.49
310_M344_A0.6970.49
82_V91_M0.6960.49
36_L388_I0.6940.49
254_M351_I0.6920.49
379_T382_S0.6910.48
103_L253_A0.6860.48
71_A75_N0.6850.48
294_I336_V0.6850.48
137_N204_G0.6830.48
335_I384_L0.6820.48
104_I306_M0.6800.47
192_Y385_S0.6790.47
350_G371_G0.6770.47
93_V183_A0.6760.47
212_N297_N0.6750.47
84_A211_I0.6750.47
12_V15_G0.6740.47
177_S308_T0.6720.47
45_I279_G0.6710.46
313_N317_A0.6690.46
300_V303_G0.6690.46
176_V285_F0.6680.46
139_V142_A0.6660.46
314_E317_A0.6640.46
305_I317_A0.6620.46
133_L136_Y0.6610.45
93_V315_F0.6560.45
35_M139_V0.6550.45
218_K221_D0.6550.45
157_L323_Q0.6530.45
268_I274_G0.6520.45
352_I356_V0.6500.44
25_K126_K0.6490.44
10_L275_I0.6480.44
59_F194_V0.6470.44
170_A342_S0.6440.44
101_S175_T0.6440.44
28_K128_N0.6430.44
207_I350_G0.6410.44
266_N276_S0.6410.44
103_L261_I0.6400.43
327_H330_G0.6400.43
222_M268_I0.6400.43
121_G160_L0.6390.43
14_L206_I0.6380.43
124_L375_L0.6360.43
18_W22_S0.6350.43
313_N345_N0.6350.43
41_I45_I0.6340.43
65_Y267_G0.6330.43
353_A388_I0.6310.43
8_I291_L0.6310.43
29_I33_V0.6300.42
112_V115_F0.6290.42
225_V294_I0.6280.42
332_T337_S0.6280.42
112_V284_V0.6270.42
54_F58_G0.6260.42
52_G134_E0.6260.42
14_L27_I0.6260.42
355_A367_V0.6250.42
111_K115_F0.6240.42
251_V368_A0.6230.42
383_F386_A0.6220.42
111_K254_M0.6210.42
108_Q114_P0.6190.41
56_V121_G0.6180.41
115_F386_A0.6180.41
43_G334_A0.6180.41
45_I335_I0.6160.41
14_L36_L0.6150.41
173_M374_L0.6140.41
188_L340_L0.6140.41
54_F98_V0.6140.41
19_I249_V0.6140.41
138_A313_N0.6130.41
245_F252_A0.6120.41
218_K256_I0.6120.41
29_I144_L0.6100.41
40_F44_Y0.6090.40
140_A200_N0.6090.40
265_I354_G0.6090.40
350_G382_S0.6090.40
309_K345_N0.6060.40
42_L45_I0.6030.40
62_G106_I0.6010.40
230_K239_E0.6010.40
151_I247_V0.6000.40
113_L200_N0.5990.39
169_C352_I0.5990.39
97_I315_F0.5920.39
216_V219_E0.5910.39
288_F291_L0.5900.39
141_S201_L0.5900.39
94_L248_A0.5890.39
301_N327_H0.5890.39
130_M163_Q0.5850.38
344_A348_S0.5850.38
7_I391_L0.5830.38
162_Q363_Q0.5830.38
135_S145_G0.5830.38
62_G66_L0.5820.38
18_W389_V0.5820.38
252_A255_L0.5820.38
51_I54_F0.5820.38
243_D251_V0.5810.38
288_F369_R0.5810.38
122_L127_V0.5800.38
77_V252_A0.5800.38
34_V154_K0.5790.38
169_C178_M0.5790.38
30_R129_G0.5780.37
131_G164_R0.5770.37
244_G248_A0.5760.37
7_I365_N0.5760.37
64_G346_F0.5740.37
112_V365_N0.5730.37
192_Y203_G0.5730.37
45_I55_L0.5730.37
154_K294_I0.5720.37
138_A200_N0.5720.37
37_I41_I0.5710.37
319_T322_T0.5710.37
278_Q283_Y0.5700.37
15_G210_I0.5690.37
335_I379_T0.5680.37
236_V307_A0.5680.37
118_R325_G0.5680.37
217_A221_D0.5660.36
14_L29_I0.5660.36
106_I110_W0.5660.36
275_I283_Y0.5650.36
347_S351_I0.5650.36
60_A259_V0.5650.36
207_I353_A0.5650.36
43_G378_A0.5650.36
101_S151_I0.5650.36
139_V296_W0.5650.36
157_L269_F0.5650.36
131_G218_K0.5640.36
147_S254_M0.5620.36
160_L389_V0.5610.36
237_L389_V0.5610.36
6_G391_L0.5600.36
99_F134_E0.5600.36
175_T331_R0.5590.36
194_V335_I0.5590.36
248_A251_V0.5590.36
141_S149_V0.5560.35
190_P321_L0.5560.35
206_I371_G0.5550.35
43_G382_S0.5550.35
295_P301_N0.5550.35
35_M39_Q0.5550.35
117_I392_I0.5540.35
250_V354_G0.5530.35
14_L359_L0.5530.35
4_L122_L0.5520.35
26_R338_V0.5520.35
387_A390_G0.5520.35
321_L326_F0.5510.35
294_I332_T0.5490.35
41_I129_G0.5480.35
64_G189_K0.5470.35
212_N370_F0.5470.35
96_P201_L0.5460.35
308_T313_N0.5460.35
38_L225_V0.5430.34
105_G235_E0.5420.34
8_I12_V0.5420.34
281_L311_V0.5420.34
146_Q238_G0.5410.34
348_S351_I0.5410.34
74_I195_T0.5400.34
74_I387_A0.5400.34
100_I151_I0.5370.34
239_E364_G0.5360.34
71_A165_L0.5360.34
81_L91_M0.5350.34
188_L341_V0.5340.33
100_I389_V0.5340.33
141_S172_A0.5340.33
62_G264_L0.5330.33
319_T323_Q0.5320.33
360_N366_V0.5320.33
234_F346_F0.5320.33
4_L237_L0.5310.33
188_L294_I0.5310.33
142_A201_L0.5300.33
128_N171_S0.5300.33
192_Y334_A0.5290.33
70_A92_N0.5280.33
318_M340_L0.5280.33
280_I303_G0.5270.33
70_A207_I0.5250.33
280_I284_V0.5250.33
9_G389_V0.5220.32
70_A227_E0.5210.32
388_I391_L0.5210.32
254_M379_T0.5200.32
182_G186_T0.5200.32
379_T383_F0.5200.32
144_L355_A0.5200.32
209_S214_Y0.5190.32
180_I351_I0.5190.32
83_N87_T0.5170.32
202_F338_V0.5160.32
152_S204_G0.5160.32
17_A379_T0.5160.32
117_I248_A0.5150.32
351_I355_A0.5150.32
164_R277_F0.5130.32
298_E332_T0.5130.32
5_I9_G0.5130.32
65_Y112_V0.5130.32
123_A297_N0.5120.32
268_I301_N0.5120.32
38_L128_N0.5110.31
117_I188_L0.5110.31
146_Q303_G0.5100.31
35_M56_V0.5080.31
121_G127_V0.5080.31
180_I348_S0.5050.31
295_P299_A0.5050.31
139_V171_S0.5020.31
109_K297_N0.5020.31
82_V87_T0.5020.31
199_L386_A0.5020.31
251_V260_A0.5020.31
349_I373_K0.5020.31
184_Y378_A0.5010.31
155_K361_E0.5010.31
49_T211_I0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.9695 100 0.117 Contact Map
2cfqA 1 0.8753 25.3 0.979 Contact Map
2mofA 1 0.0814 23.2 0.979 Contact Map
4oh3A 2 0.4224 10.2 0.982 Contact Map
4ikvA 1 0.4224 8 0.983 Contact Map
4f35D 2 0.888 6.1 0.984 Contact Map
1q90G 1 0.0585 3.2 0.986 Contact Map
4o6yA 2 0.4682 3.1 0.986 Contact Map
4j05A 3 0.3664 3 0.986 Contact Map
4r1iA 2 0.9389 2.9 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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