GREMLIN Database
DEOR - Deoxyribonucleoside regulator
UniProt: P39140 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (302)
Sequences: 2218 (1712)
Seq/√Len: 98.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_D250_N7.0961.00
200_K267_D4.1111.00
113_G202_A3.4711.00
94_L279_G3.2311.00
287_I305_T2.9161.00
110_D203_N2.9141.00
247_A285_S2.9071.00
72_Y288_H2.8991.00
51_Q55_M2.8341.00
72_Y291_L2.8261.00
209_V276_L2.7241.00
245_F289_G2.7221.00
101_Y300_I2.6481.00
288_H292_T2.6411.00
276_L296_A2.5171.00
98_G277_V2.4621.00
21_Y29_Q2.4411.00
301_I305_T2.4331.00
183_K187_E2.4201.00
137_V164_F2.3781.00
193_E197_E2.2611.00
109_G134_G2.1661.00
80_V97_Y2.1631.00
278_A287_I2.1411.00
238_G289_G2.1361.00
208_T276_L2.1331.00
111_I198_M2.1291.00
308_A311_N2.1171.00
67_I70_E2.1101.00
203_N272_E2.1031.00
284_V309_L2.0161.00
284_V308_A2.0061.00
273_R298_V2.0011.00
180_A184_R1.9971.00
42_Q46_E1.9771.00
238_G245_F1.9751.00
43_Y47_K1.9411.00
139_Q154_A1.9351.00
78_H97_Y1.8971.00
98_G123_I1.8791.00
124_A156_T1.8631.00
284_V305_T1.8601.00
204_I275_I1.8131.00
264_E267_D1.8021.00
274_S297_N1.7931.00
177_F182_V1.7871.00
91_T118_T1.7821.00
123_I277_V1.7811.00
136_E169_R1.7531.00
66_S69_E1.7451.00
288_H309_L1.7311.00
111_I202_A1.7291.00
81_F303_Q1.7221.00
68_L77_A1.7071.00
199_G202_A1.7041.00
76_E298_V1.6941.00
140_L205_A1.6751.00
207_F274_S1.6481.00
12_A32_I1.6351.00
127_M160_F1.6291.00
111_I201_Q1.6151.00
69_E77_A1.6111.00
202_A271_K1.5991.00
180_A258_D1.5981.00
245_F286_S1.5961.00
207_F276_L1.5921.00
75_L273_R1.5881.00
178_D190_R1.5631.00
12_A26_I1.5581.00
229_K233_K1.5571.00
101_Y298_V1.5491.00
106_V112_V1.5221.00
247_A289_G1.5171.00
209_V286_S1.4891.00
280_G302_D1.4891.00
9_S40_L1.4711.00
248_K292_T1.4541.00
161_A168_P1.4381.00
17_Y52_I1.4331.00
92_H126_N1.4321.00
69_E76_E1.4311.00
115_S241_C1.4301.00
228_E259_R1.4261.00
225_N228_E1.4061.00
112_V204_I1.3950.99
254_S257_N1.3920.99
101_Y105_T1.3790.99
281_S308_A1.3510.99
35_P38_S1.3490.99
95_S122_Q1.3470.99
136_E198_M1.3360.99
9_S49_Y1.3070.99
125_Q159_L1.2990.99
113_G140_L1.2910.99
303_Q307_R1.2900.99
196_I199_G1.2870.99
287_I301_I1.2750.99
12_A30_L1.2660.99
99_A127_M1.2650.99
112_V137_V1.2560.99
124_A160_F1.2480.99
278_A301_I1.2360.99
178_D189_D1.2360.99
230_A234_K1.2320.99
246_D252_C1.2250.99
205_A271_K1.2140.99
14_R18_Q1.1940.98
159_L162_E1.1900.98
102_M204_I1.1870.98
20_D45_K1.1830.98
177_F186_V1.1790.98
169_R198_M1.1770.98
197_E201_Q1.1720.98
111_I203_N1.1630.98
71_K309_L1.1600.98
122_Q125_Q1.1570.98
12_A40_L1.1500.98
113_G116_W1.1480.98
21_Y25_Q1.1470.98
63_A67_I1.1310.98
27_A37_V1.1310.98
66_S70_E1.1250.98
230_A233_K1.1110.97
8_L40_L1.1050.97
192_I196_I1.1030.97
123_I206_L1.1000.97
9_S43_Y1.0960.97
68_L79_V1.0930.97
102_M206_L1.0900.97
143_G239_D1.0900.97
229_K232_L1.0870.97
67_I71_K1.0830.97
105_T273_R1.0700.97
15_L29_Q1.0590.97
71_K310_V1.0590.97
110_D204_I1.0580.97
186_V261_I1.0580.97
108_D133_K1.0530.96
37_V41_L1.0520.96
243_R262_G1.0400.96
10_I49_Y1.0370.96
76_E104_E1.0330.96
68_L310_V1.0300.96
16_Y34_R1.0200.96
208_T278_A1.0170.96
68_L309_L1.0030.95
291_L296_A0.9950.95
124_A159_L0.9940.95
139_Q152_Y0.9940.95
245_F290_A0.9900.95
184_R188_K0.9850.95
22_S34_R0.9850.95
307_R311_N0.9760.95
194_R197_E0.9700.94
247_A292_T0.9660.94
182_V189_D0.9590.94
265_L295_Y0.9580.94
136_E167_M0.9540.94
243_R257_N0.9510.94
247_A288_H0.9500.94
75_L297_N0.9460.94
143_G152_Y0.9440.94
209_V287_I0.9430.94
78_H101_Y0.9420.93
115_S243_R0.9400.93
239_D242_S0.9400.93
197_E200_K0.9330.93
205_A268_L0.9330.93
72_Y77_A0.9260.93
207_F296_A0.9210.93
22_S25_Q0.9180.93
9_S12_A0.9160.93
116_W243_R0.9130.92
302_D305_T0.9070.92
116_W239_D0.9060.92
206_L275_I0.9050.92
157_I168_P0.9030.92
115_S139_Q0.8900.91
107_K110_D0.8870.91
253_S258_D0.8830.91
155_E158_Q0.8820.91
61_L65_G0.8810.91
111_I138_V0.8780.91
253_S257_N0.8770.91
197_E230_A0.8750.91
175_V242_S0.8660.90
290_A293_G0.8590.90
112_V160_F0.8560.90
15_L26_I0.8540.90
94_L98_G0.8510.89
67_I307_R0.8470.89
173_L261_I0.8460.89
12_A15_L0.8410.89
263_V271_K0.8390.89
188_K193_E0.8300.88
294_K297_N0.8260.88
74_L299_L0.8250.88
208_T296_A0.8250.88
82_S304_H0.8190.88
236_A252_C0.8190.88
154_A172_P0.8190.88
95_S279_G0.8130.87
208_T287_I0.8110.87
96_R126_N0.8110.87
8_L32_I0.8100.87
41_L45_K0.8060.87
284_V288_H0.8040.87
64_L79_V0.7980.86
101_Y275_I0.7970.86
145_S152_Y0.7950.86
137_V166_T0.7930.86
13_A41_L0.7910.86
114_V160_F0.7890.86
102_M123_I0.7860.85
15_L23_Q0.7850.85
12_A37_V0.7850.85
177_F261_I0.7810.85
218_L221_L0.7790.85
176_V260_T0.7760.85
8_L11_E0.7750.85
72_Y309_L0.7750.85
108_D134_G0.7720.84
231_L236_A0.7660.84
86_D89_G0.7640.84
23_Q35_P0.7640.84
280_G283_K0.7610.83
276_L287_I0.7610.83
23_Q38_S0.7600.83
224_F228_E0.7570.83
14_R38_S0.7540.83
24_Q28_E0.7500.83
289_G292_T0.7500.83
175_V212_V0.7500.83
176_V259_R0.7490.83
122_Q208_T0.7490.83
26_I54_V0.7470.82
116_W139_Q0.7460.82
26_I39_R0.7430.82
157_I161_A0.7410.82
187_E196_I0.7410.82
101_Y104_E0.7380.82
266_Q269_R0.7380.82
114_V156_T0.7370.82
11_E14_R0.7360.81
185_M189_D0.7360.81
138_V195_I0.7340.81
61_L79_V0.7310.81
160_F286_S0.7310.81
94_L277_V0.7170.80
289_G293_G0.7120.79
106_V164_F0.7120.79
17_Y41_L0.7100.79
103_H130_K0.7090.79
230_A255_A0.7070.79
105_T204_I0.7050.79
128_Q163_A0.7040.78
64_L307_R0.7010.78
279_G305_T0.7000.78
210_G239_D0.6980.78
94_L301_I0.6950.78
159_L163_A0.6920.77
181_D184_R0.6890.77
278_A283_K0.6880.77
140_L241_C0.6870.77
32_I37_V0.6840.76
107_K203_N0.6830.76
208_T260_T0.6810.76
105_T297_N0.6810.76
243_R260_T0.6770.76
117_G303_Q0.6750.76
279_G287_I0.6720.75
13_A44_A0.6700.75
171_L261_I0.6690.75
152_Y242_S0.6690.75
106_V135_V0.6690.75
74_L297_N0.6680.75
263_V267_D0.6670.75
98_G208_T0.6660.75
139_Q189_D0.6660.75
77_A291_L0.6650.74
268_L271_K0.6640.74
275_I297_N0.6630.74
139_Q172_P0.6620.74
103_H164_F0.6600.74
197_E311_N0.6600.74
179_N182_V0.6580.74
11_E69_E0.6580.74
176_V180_A0.6570.74
80_V90_I0.6560.73
255_A284_V0.6560.73
177_F192_I0.6550.73
243_R264_E0.6540.73
61_L81_F0.6540.73
35_P141_K0.6520.73
38_S239_D0.6500.73
240_I290_A0.6500.73
227_E230_A0.6500.73
257_N260_T0.6480.73
98_G300_I0.6480.73
194_R198_M0.6480.73
63_A272_E0.6450.72
68_L72_Y0.6450.72
37_V268_L0.6450.72
216_A219_F0.6400.72
80_V94_L0.6380.71
158_Q172_P0.6350.71
174_P177_F0.6330.71
65_G77_A0.6320.71
50_V54_V0.6290.70
189_D242_S0.6280.70
34_R45_K0.6250.70
231_L244_F0.6240.70
24_Q34_R0.6240.70
131_Q165_Q0.6240.70
141_K217_L0.6240.70
256_I277_V0.6230.70
287_I299_L0.6220.69
26_I98_G0.6220.69
71_K292_T0.6210.69
35_P175_V0.6200.69
39_R259_R0.6200.69
40_L168_P0.6180.69
15_L21_Y0.6170.69
197_E285_S0.6140.68
98_G206_L0.6130.68
115_S169_R0.6110.68
12_A36_T0.6110.68
141_K175_V0.6090.68
92_H125_Q0.6090.68
112_V248_K0.6070.68
279_G302_D0.6050.67
105_T298_V0.6040.67
39_R172_P0.6040.67
85_P304_H0.6020.67
113_G120_M0.6010.67
41_L239_D0.5990.67
16_Y23_Q0.5980.66
251_I265_L0.5970.66
30_L97_Y0.5960.66
40_L44_A0.5960.66
8_L65_G0.5960.66
237_V252_C0.5950.66
153_S217_L0.5950.66
82_S303_Q0.5950.66
77_A80_V0.5940.66
154_A208_T0.5920.66
237_V289_G0.5910.66
114_V153_S0.5890.65
92_H122_Q0.5880.65
16_Y38_S0.5870.65
34_R175_V0.5870.65
9_S44_A0.5860.65
137_V157_I0.5850.65
218_L289_G0.5810.64
100_E103_H0.5810.64
230_A254_S0.5810.64
82_S161_A0.5800.64
14_R56_D0.5800.64
80_V111_I0.5790.64
120_M156_T0.5780.64
77_A92_H0.5780.64
35_P56_D0.5770.64
121_Y208_T0.5760.64
66_S304_H0.5740.63
48_G294_K0.5740.63
200_K270_L0.5720.63
219_F222_G0.5700.63
143_G173_L0.5700.63
66_S281_S0.5700.63
73_G294_K0.5690.63
18_Q115_S0.5680.62
74_L298_V0.5660.62
196_I261_I0.5640.62
116_W140_L0.5640.62
137_V160_F0.5630.62
106_V132_V0.5630.62
257_N264_E0.5620.62
286_S289_G0.5610.62
243_R265_L0.5610.62
14_R139_Q0.5600.61
76_E101_Y0.5580.61
103_H128_Q0.5570.61
281_S304_H0.5550.61
182_V186_V0.5550.61
61_L303_Q0.5540.61
121_Y159_L0.5530.60
140_L199_G0.5530.60
197_E227_E0.5520.60
209_V296_A0.5520.60
82_S302_D0.5500.60
22_S35_P0.5500.60
270_L311_N0.5500.60
226_E229_K0.5480.60
153_S262_G0.5470.60
296_A299_L0.5460.59
212_V286_S0.5460.59
192_I195_I0.5460.59
256_I260_T0.5450.59
114_V220_R0.5440.59
290_A294_K0.5430.59
101_Y272_E0.5420.59
154_A217_L0.5420.59
247_A250_N0.5410.59
177_F268_L0.5400.59
11_E303_Q0.5400.59
124_A163_A0.5390.58
281_S305_T0.5370.58
95_S126_N0.5370.58
182_V185_M0.5370.58
199_G263_V0.5360.58
78_H298_V0.5360.58
137_V243_R0.5350.58
112_V149_V0.5320.58
71_K250_N0.5320.58
27_A32_I0.5320.58
38_S56_D0.5310.57
147_S150_N0.5310.57
129_P165_Q0.5280.57
236_A244_F0.5270.57
117_G260_T0.5260.57
203_N271_K0.5260.57
27_A129_P0.5260.57
283_K302_D0.5250.57
175_V239_D0.5250.57
242_S262_G0.5250.57
86_D233_K0.5230.56
131_Q181_D0.5220.56
106_V186_V0.5220.56
33_S174_P0.5210.56
70_E250_N0.5210.56
25_Q28_E0.5210.56
41_L50_V0.5210.56
120_M168_P0.5200.56
67_I73_G0.5200.56
138_V299_L0.5150.55
137_V161_A0.5130.55
34_R52_I0.5130.55
140_L263_V0.5120.55
119_T280_G0.5110.55
80_V256_I0.5110.55
139_Q213_R0.5090.54
17_Y134_G0.5080.54
161_A166_T0.5080.54
14_R81_F0.5070.54
174_P242_S0.5070.54
102_M112_V0.5070.54
54_V215_E0.5050.54
179_N262_G0.5050.54
34_R116_W0.5050.54
90_I302_D0.5030.53
298_V301_I0.5020.53
199_G242_S0.5010.53
143_G154_A0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w48A 3 0.9872 100 0.37 Contact Map
4l5jA 4 0.9649 100 0.381 Contact Map
4l4yA 2 0.7572 100 0.449 Contact Map
3efbA 2 0.7923 100 0.453 Contact Map
2o0mA 1 0.7732 100 0.465 Contact Map
4oqpA 2 0.8115 100 0.467 Contact Map
2r5fA 1 0.6837 100 0.469 Contact Map
4r9nA 1 0.7859 100 0.472 Contact Map
3kv1A 2 0.7923 100 0.473 Contact Map
2gnpA 1 0.8243 100 0.473 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.