GREMLIN Database
YXXB - Uncharacterized protein YxxB
UniProt: P39139 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (252)
Sequences: 760 (602)
Seq/√Len: 37.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_G220_A4.5501.00
175_A199_R4.2671.00
158_G217_I4.1851.00
38_G256_I3.5941.00
229_R233_G3.5721.00
170_M174_R3.5601.00
79_I120_A3.4121.00
141_S154_T3.3521.00
75_G124_L3.2821.00
46_A249_S3.2421.00
160_G163_V3.1741.00
160_G164_F3.1021.00
172_G203_I3.0941.00
82_V117_T3.0821.00
163_V167_V2.7831.00
30_F258_Y2.7491.00
86_V113_A2.7341.00
31_G263_I2.7091.00
157_T160_G2.6441.00
158_G213_G2.3981.00
205_R209_F2.3691.00
72_F127_V2.3021.00
78_L123_A2.2690.99
159_A163_V2.2680.99
166_I170_M2.2480.99
165_A206_A2.1520.99
265_K269_Q2.0220.99
42_F252_A1.9880.99
214_Y218_K1.9530.98
34_F205_R1.9210.98
178_M195_K1.9210.98
18_W21_R1.8930.98
79_I124_L1.8850.98
196_N199_R1.8520.98
110_F114_A1.8470.98
35_I256_I1.7580.97
204_A254_G1.7370.97
152_W155_G1.6880.96
152_W156_L1.6430.95
30_F34_F1.6410.95
151_Q155_G1.6050.95
42_F249_S1.6010.95
145_L225_P1.5730.94
222_T227_D1.5650.94
258_Y262_A1.5580.94
118_S121_W1.5230.93
37_L41_A1.5170.93
165_A213_G1.5090.93
171_K180_E1.5030.93
215_F229_R1.4910.92
162_I213_G1.4700.92
198_G259_G1.4450.91
237_E241_Q1.4430.91
200_A257_L1.4380.91
35_I259_G1.4350.91
61_L71_L1.4160.90
41_A235_L1.4110.90
75_G78_L1.4060.90
177_F195_K1.3960.90
37_L156_L1.3930.89
162_I165_A1.3920.89
145_L151_Q1.3770.89
167_V171_K1.3620.88
55_S133_G1.3520.88
156_L160_G1.3330.87
76_I79_I1.3330.87
103_L107_I1.3140.86
38_G252_A1.2910.85
22_F80_G1.2900.85
38_G65_P1.2830.85
198_G261_Y1.2820.85
144_V147_Q1.2800.85
35_I39_V1.2780.85
180_E261_Y1.2710.85
58_L228_T1.2700.85
218_K222_T1.2670.84
197_T260_M1.2670.84
29_A77_G1.2620.84
151_Q220_A1.2560.84
147_Q153_L1.2510.84
86_V110_F1.2360.83
30_F269_Q1.2150.82
253_L257_L1.2120.82
25_L80_G1.2080.81
211_A238_L1.2050.81
36_L259_G1.2020.81
56_G62_S1.1790.80
75_G127_V1.1740.79
30_F262_A1.1720.79
41_A141_S1.1600.79
92_D109_N1.1420.78
58_L123_A1.1400.77
133_G137_E1.1280.77
249_S252_A1.1270.77
74_I78_L1.1120.76
141_S219_T1.1060.75
258_Y271_M1.1060.75
246_L249_S1.0970.75
45_A248_L1.0920.74
172_G202_N1.0880.74
66_Y69_L1.0880.74
148_P153_L1.0850.74
151_Q223_A1.0850.74
81_Y265_K1.0840.74
169_F247_I1.0810.74
149_F153_L1.0650.72
73_F76_I1.0640.72
28_F266_G1.0510.71
212_I234_A1.0470.71
27_Y54_S1.0320.70
54_S234_A1.0290.70
150_G213_G1.0260.70
89_A110_F1.0190.69
112_S205_R1.0140.69
61_L239_A1.0140.69
161_F216_L1.0120.68
40_L61_L1.0080.68
169_F210_S0.9950.67
167_V170_M0.9880.67
208_I255_L0.9800.66
173_V203_I0.9790.66
29_A74_I0.9760.66
215_F234_A0.9720.65
157_T216_L0.9690.65
219_T228_T0.9690.65
107_I110_F0.9670.65
20_K64_M0.9660.65
144_V154_T0.9640.65
77_G119_I0.9620.64
82_V86_V0.9410.63
34_F81_Y0.9390.63
59_Q137_E0.9320.62
146_A157_T0.9290.62
81_Y108_G0.9280.62
173_V199_R0.9190.61
34_F85_M0.9170.61
245_K249_S0.9170.61
91_K220_A0.9140.60
92_D102_G0.9000.59
59_Q224_D0.8950.59
105_R198_G0.8850.58
85_M88_S0.8850.58
143_Y146_A0.8740.57
169_F203_I0.8690.57
124_L128_F0.8630.56
53_D232_D0.8620.56
154_T216_L0.8590.56
144_V155_G0.8580.56
20_K37_L0.8490.55
235_L248_L0.8450.54
39_V256_I0.8450.54
209_F212_I0.8450.54
69_L76_I0.8410.54
52_K56_G0.8390.54
169_F208_I0.8370.54
139_T222_T0.8350.54
117_T121_W0.8350.54
85_M265_K0.8310.53
40_L50_R0.8220.52
30_F109_N0.8130.52
62_S232_D0.8130.52
23_G88_S0.8110.51
164_F167_V0.8080.51
232_D239_A0.8050.51
93_T109_N0.8040.51
27_Y231_F0.7980.50
168_Q258_Y0.7870.49
54_S202_N0.7850.49
142_A181_F0.7800.49
68_S214_Y0.7790.49
144_V157_T0.7760.48
180_E269_Q0.7720.48
224_D228_T0.7700.48
167_V180_E0.7700.48
30_F85_M0.7670.48
127_V157_T0.7620.47
123_A262_A0.7610.47
85_M266_G0.7610.47
195_K199_R0.7590.47
246_L250_I0.7580.47
156_L221_M0.7520.46
79_I240_Q0.7470.46
28_F113_A0.7460.46
182_D185_K0.7460.46
34_F172_G0.7460.46
34_F38_G0.7450.46
41_A255_L0.7390.45
139_T245_K0.7390.45
29_A33_V0.7350.45
181_F247_I0.7320.44
74_I107_I0.7320.44
161_F212_I0.7320.44
210_S214_Y0.7310.44
75_G123_A0.7290.44
138_Q148_P0.7290.44
68_S240_Q0.7280.44
34_F74_I0.7270.44
91_K255_L0.7250.44
142_A225_P0.7240.44
170_M176_A0.7230.44
162_I210_S0.7210.43
25_L247_I0.7210.43
202_N261_Y0.7200.43
204_A212_I0.7200.43
222_T238_L0.7180.43
15_T44_T0.7170.43
222_T243_H0.7160.43
152_W220_A0.7140.43
19_I22_F0.7130.43
47_G57_A0.7100.42
110_F113_A0.7100.42
66_Y211_A0.7080.42
108_G167_V0.7060.42
42_F46_A0.7060.42
166_I192_C0.7050.42
85_M112_S0.7020.42
92_D103_L0.7020.42
161_F259_G0.7010.42
27_Y105_R0.7000.42
38_G41_A0.6980.41
74_I77_G0.6980.41
50_R113_A0.6970.41
182_D190_M0.6960.41
210_S217_I0.6940.41
210_S242_P0.6930.41
245_K271_M0.6920.41
138_Q153_L0.6920.41
114_A253_L0.6890.41
41_A65_P0.6880.41
23_G86_V0.6840.40
256_I259_G0.6830.40
125_R131_G0.6820.40
105_R109_N0.6820.40
80_G215_F0.6800.40
141_S155_G0.6750.39
158_G215_F0.6720.39
139_T145_L0.6700.39
44_T52_K0.6700.39
30_F265_K0.6680.39
39_V43_M0.6660.39
92_D112_S0.6640.39
192_C196_N0.6630.38
140_W181_F0.6620.38
209_F233_G0.6610.38
239_A261_Y0.6600.38
73_F203_I0.6590.38
176_A252_A0.6580.38
94_E102_G0.6580.38
120_A238_L0.6500.37
40_L74_I0.6480.37
33_V243_H0.6470.37
157_T161_F0.6460.37
144_V207_I0.6460.37
25_L77_G0.6450.37
138_Q238_L0.6430.37
135_T240_Q0.6420.37
126_F193_I0.6400.37
125_R159_A0.6380.36
81_Y191_I0.6380.36
39_V246_L0.6370.36
90_I250_I0.6350.36
33_V123_A0.6350.36
177_F198_G0.6350.36
211_A233_G0.6340.36
86_V195_K0.6330.36
34_F265_K0.6300.36
56_G177_F0.6290.36
139_T251_L0.6240.35
37_L165_A0.6220.35
23_G116_Y0.6220.35
36_L207_I0.6200.35
55_S227_D0.6190.35
37_L57_A0.6190.35
158_G214_Y0.6180.35
204_A251_L0.6170.35
88_S109_N0.6150.34
126_F233_G0.6150.34
60_T141_S0.6150.34
161_F239_A0.6130.34
22_F83_I0.6120.34
47_G270_H0.6080.34
182_D194_T0.6060.34
79_I179_K0.6040.34
30_F168_Q0.6040.34
50_R249_S0.6040.34
251_L264_M0.6020.33
109_N198_G0.6020.33
124_L197_T0.6020.33
169_F206_A0.5980.33
218_K238_L0.5970.33
18_W22_F0.5960.33
34_F208_I0.5950.33
195_K237_E0.5940.33
173_V259_G0.5940.33
74_I123_A0.5910.33
96_H102_G0.5910.33
81_Y85_M0.5900.32
40_L219_T0.5870.32
260_M264_M0.5860.32
172_G256_I0.5820.32
76_I251_L0.5810.32
33_V75_G0.5810.32
183_T191_I0.5790.32
100_R104_S0.5770.31
17_P21_R0.5770.31
241_Q247_I0.5750.31
168_Q266_G0.5750.31
120_A128_F0.5730.31
213_G217_I0.5730.31
146_A210_S0.5720.31
35_I208_I0.5710.31
87_L178_M0.5700.31
76_I155_G0.5680.31
103_L156_L0.5680.31
258_Y269_Q0.5650.31
159_A250_I0.5640.30
154_T238_L0.5640.30
151_Q210_S0.5640.30
197_T257_L0.5640.30
117_T211_A0.5630.30
125_R130_Q0.5630.30
40_L236_A0.5620.30
125_R243_H0.5610.30
76_I173_V0.5600.30
33_V159_A0.5600.30
175_A181_F0.5550.30
55_S171_K0.5540.30
20_K82_V0.5540.30
193_I271_M0.5490.29
56_G232_D0.5480.29
154_T220_A0.5470.29
35_I263_I0.5470.29
224_D227_D0.5470.29
145_L157_T0.5450.29
209_F269_Q0.5450.29
119_I178_M0.5450.29
56_G72_F0.5450.29
51_A253_L0.5440.29
32_G253_L0.5440.29
156_L250_I0.5420.29
34_F215_F0.5410.29
165_A216_L0.5410.29
139_T237_E0.5390.29
44_T236_A0.5380.29
61_L211_A0.5370.28
93_T258_Y0.5360.28
86_V90_I0.5360.28
89_A120_A0.5330.28
189_Q193_I0.5310.28
193_I196_N0.5290.28
101_R157_T0.5270.28
64_M224_D0.5260.28
215_F251_L0.5260.28
28_F31_G0.5250.28
211_A247_I0.5250.28
32_G189_Q0.5250.28
107_I114_A0.5230.27
39_V70_L0.5200.27
41_A45_A0.5200.27
122_N158_G0.5170.27
158_G218_K0.5160.27
168_Q171_K0.5120.27
85_M209_F0.5110.27
61_L103_L0.5100.27
64_M139_T0.5090.26
156_L227_D0.5070.26
159_A203_I0.5070.26
229_R234_A0.5070.26
140_W163_V0.5070.26
107_I111_F0.5040.26
28_F190_M0.5020.26
176_A179_K0.5020.26
165_A210_S0.5010.26
200_A227_D0.5010.26
123_A152_W0.5000.26
76_I240_Q0.5000.26
20_K130_Q0.5000.26
148_P169_F0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wswA 3 0.3091 18.1 0.966 Contact Map
4wgvA 2 0.6545 7.2 0.971 Contact Map
2wdqD 2 0.3818 6.8 0.972 Contact Map
4a01A 2 0.4618 6.1 0.972 Contact Map
4c7rA 3 0.2655 5.3 0.973 Contact Map
2mpnA 2 0.2327 5 0.973 Contact Map
2k9jB 1 0.1564 4.4 0.974 Contact Map
2kncB 1 0.1673 4 0.974 Contact Map
3j1zP 8 0.3382 3.8 0.975 Contact Map
2lomA 1 0.2182 3.7 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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