YXXB - BACSU - GREMLIN Contacts

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YXXB - Uncharacterized protein YxxB

UniProt:	P39139	Sequences: MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMTAAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRGLSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAGFIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIKTAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	275 (252)
Sequences:	760 (602)
Seq/√Len:	37.9

BACSU - YXXB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_G	220_A	4.550	1.00
175_A	199_R	4.267	1.00
158_G	217_I	4.185	1.00
38_G	256_I	3.594	1.00
229_R	233_G	3.572	1.00
170_M	174_R	3.560	1.00
79_I	120_A	3.412	1.00
141_S	154_T	3.352	1.00
75_G	124_L	3.282	1.00
46_A	249_S	3.242	1.00
160_G	163_V	3.174	1.00
160_G	164_F	3.102	1.00
172_G	203_I	3.094	1.00
82_V	117_T	3.082	1.00
163_V	167_V	2.783	1.00
30_F	258_Y	2.749	1.00
86_V	113_A	2.734	1.00
31_G	263_I	2.709	1.00
157_T	160_G	2.644	1.00
158_G	213_G	2.398	1.00
205_R	209_F	2.369	1.00
72_F	127_V	2.302	1.00
78_L	123_A	2.269	0.99
159_A	163_V	2.268	0.99
166_I	170_M	2.248	0.99
165_A	206_A	2.152	0.99
265_K	269_Q	2.022	0.99
42_F	252_A	1.988	0.99
214_Y	218_K	1.953	0.98
34_F	205_R	1.921	0.98
178_M	195_K	1.921	0.98
18_W	21_R	1.893	0.98
79_I	124_L	1.885	0.98
196_N	199_R	1.852	0.98
110_F	114_A	1.847	0.98
35_I	256_I	1.758	0.97
204_A	254_G	1.737	0.97
152_W	155_G	1.688	0.96
152_W	156_L	1.643	0.95
30_F	34_F	1.641	0.95
151_Q	155_G	1.605	0.95
42_F	249_S	1.601	0.95
145_L	225_P	1.573	0.94
222_T	227_D	1.565	0.94
258_Y	262_A	1.558	0.94
118_S	121_W	1.523	0.93
37_L	41_A	1.517	0.93
165_A	213_G	1.509	0.93
171_K	180_E	1.503	0.93
215_F	229_R	1.491	0.92
162_I	213_G	1.470	0.92
198_G	259_G	1.445	0.91
237_E	241_Q	1.443	0.91
200_A	257_L	1.438	0.91
35_I	259_G	1.435	0.91
61_L	71_L	1.416	0.90
41_A	235_L	1.411	0.90
75_G	78_L	1.406	0.90
177_F	195_K	1.396	0.90
37_L	156_L	1.393	0.89
162_I	165_A	1.392	0.89
145_L	151_Q	1.377	0.89
167_V	171_K	1.362	0.88
55_S	133_G	1.352	0.88
156_L	160_G	1.333	0.87
76_I	79_I	1.333	0.87
103_L	107_I	1.314	0.86
38_G	252_A	1.291	0.85
22_F	80_G	1.290	0.85
38_G	65_P	1.283	0.85
198_G	261_Y	1.282	0.85
144_V	147_Q	1.280	0.85
35_I	39_V	1.278	0.85
180_E	261_Y	1.271	0.85
58_L	228_T	1.270	0.85
218_K	222_T	1.267	0.84
197_T	260_M	1.267	0.84
29_A	77_G	1.262	0.84
151_Q	220_A	1.256	0.84
147_Q	153_L	1.251	0.84
86_V	110_F	1.236	0.83
30_F	269_Q	1.215	0.82
253_L	257_L	1.212	0.82
25_L	80_G	1.208	0.81
211_A	238_L	1.205	0.81
36_L	259_G	1.202	0.81
56_G	62_S	1.179	0.80
75_G	127_V	1.174	0.79
30_F	262_A	1.172	0.79
41_A	141_S	1.160	0.79
92_D	109_N	1.142	0.78
58_L	123_A	1.140	0.77
133_G	137_E	1.128	0.77
249_S	252_A	1.127	0.77
74_I	78_L	1.112	0.76
141_S	219_T	1.106	0.75
258_Y	271_M	1.106	0.75
246_L	249_S	1.097	0.75
45_A	248_L	1.092	0.74
172_G	202_N	1.088	0.74
66_Y	69_L	1.088	0.74
148_P	153_L	1.085	0.74
151_Q	223_A	1.085	0.74
81_Y	265_K	1.084	0.74
169_F	247_I	1.081	0.74
149_F	153_L	1.065	0.72
73_F	76_I	1.064	0.72
28_F	266_G	1.051	0.71
212_I	234_A	1.047	0.71
27_Y	54_S	1.032	0.70
54_S	234_A	1.029	0.70
150_G	213_G	1.026	0.70
89_A	110_F	1.019	0.69
112_S	205_R	1.014	0.69
61_L	239_A	1.014	0.69
161_F	216_L	1.012	0.68
40_L	61_L	1.008	0.68
169_F	210_S	0.995	0.67
167_V	170_M	0.988	0.67
208_I	255_L	0.980	0.66
173_V	203_I	0.979	0.66
29_A	74_I	0.976	0.66
215_F	234_A	0.972	0.65
157_T	216_L	0.969	0.65
219_T	228_T	0.969	0.65
107_I	110_F	0.967	0.65
20_K	64_M	0.966	0.65
144_V	154_T	0.964	0.65
77_G	119_I	0.962	0.64
82_V	86_V	0.941	0.63
34_F	81_Y	0.939	0.63
59_Q	137_E	0.932	0.62
146_A	157_T	0.929	0.62
81_Y	108_G	0.928	0.62
173_V	199_R	0.919	0.61
34_F	85_M	0.917	0.61
245_K	249_S	0.917	0.61
91_K	220_A	0.914	0.60
92_D	102_G	0.900	0.59
59_Q	224_D	0.895	0.59
105_R	198_G	0.885	0.58
85_M	88_S	0.885	0.58
143_Y	146_A	0.874	0.57
169_F	203_I	0.869	0.57
124_L	128_F	0.863	0.56
53_D	232_D	0.862	0.56
154_T	216_L	0.859	0.56
144_V	155_G	0.858	0.56
20_K	37_L	0.849	0.55
235_L	248_L	0.845	0.54
39_V	256_I	0.845	0.54
209_F	212_I	0.845	0.54
69_L	76_I	0.841	0.54
52_K	56_G	0.839	0.54
169_F	208_I	0.837	0.54
139_T	222_T	0.835	0.54
117_T	121_W	0.835	0.54
85_M	265_K	0.831	0.53
40_L	50_R	0.822	0.52
30_F	109_N	0.813	0.52
62_S	232_D	0.813	0.52
23_G	88_S	0.811	0.51
164_F	167_V	0.808	0.51
232_D	239_A	0.805	0.51
93_T	109_N	0.804	0.51
27_Y	231_F	0.798	0.50
168_Q	258_Y	0.787	0.49
54_S	202_N	0.785	0.49
142_A	181_F	0.780	0.49
68_S	214_Y	0.779	0.49
144_V	157_T	0.776	0.48
180_E	269_Q	0.772	0.48
224_D	228_T	0.770	0.48
167_V	180_E	0.770	0.48
30_F	85_M	0.767	0.48
127_V	157_T	0.762	0.47
123_A	262_A	0.761	0.47
85_M	266_G	0.761	0.47
195_K	199_R	0.759	0.47
246_L	250_I	0.758	0.47
156_L	221_M	0.752	0.46
79_I	240_Q	0.747	0.46
28_F	113_A	0.746	0.46
182_D	185_K	0.746	0.46
34_F	172_G	0.746	0.46
34_F	38_G	0.745	0.46
41_A	255_L	0.739	0.45
139_T	245_K	0.739	0.45
29_A	33_V	0.735	0.45
181_F	247_I	0.732	0.44
74_I	107_I	0.732	0.44
161_F	212_I	0.732	0.44
210_S	214_Y	0.731	0.44
75_G	123_A	0.729	0.44
138_Q	148_P	0.729	0.44
68_S	240_Q	0.728	0.44
34_F	74_I	0.727	0.44
91_K	255_L	0.725	0.44
142_A	225_P	0.724	0.44
170_M	176_A	0.723	0.44
162_I	210_S	0.721	0.43
25_L	247_I	0.721	0.43
202_N	261_Y	0.720	0.43
204_A	212_I	0.720	0.43
222_T	238_L	0.718	0.43
15_T	44_T	0.717	0.43
222_T	243_H	0.716	0.43
152_W	220_A	0.714	0.43
19_I	22_F	0.713	0.43
47_G	57_A	0.710	0.42
110_F	113_A	0.710	0.42
66_Y	211_A	0.708	0.42
108_G	167_V	0.706	0.42
42_F	46_A	0.706	0.42
166_I	192_C	0.705	0.42
85_M	112_S	0.702	0.42
92_D	103_L	0.702	0.42
161_F	259_G	0.701	0.42
27_Y	105_R	0.700	0.42
38_G	41_A	0.698	0.41
74_I	77_G	0.698	0.41
50_R	113_A	0.697	0.41
182_D	190_M	0.696	0.41
210_S	217_I	0.694	0.41
210_S	242_P	0.693	0.41
245_K	271_M	0.692	0.41
138_Q	153_L	0.692	0.41
114_A	253_L	0.689	0.41
41_A	65_P	0.688	0.41
23_G	86_V	0.684	0.40
256_I	259_G	0.683	0.40
125_R	131_G	0.682	0.40
105_R	109_N	0.682	0.40
80_G	215_F	0.680	0.40
141_S	155_G	0.675	0.39
158_G	215_F	0.672	0.39
139_T	145_L	0.670	0.39
44_T	52_K	0.670	0.39
30_F	265_K	0.668	0.39
39_V	43_M	0.666	0.39
92_D	112_S	0.664	0.39
192_C	196_N	0.663	0.38
140_W	181_F	0.662	0.38
209_F	233_G	0.661	0.38
239_A	261_Y	0.660	0.38
73_F	203_I	0.659	0.38
176_A	252_A	0.658	0.38
94_E	102_G	0.658	0.38
120_A	238_L	0.650	0.37
40_L	74_I	0.648	0.37
33_V	243_H	0.647	0.37
157_T	161_F	0.646	0.37
144_V	207_I	0.646	0.37
25_L	77_G	0.645	0.37
138_Q	238_L	0.643	0.37
135_T	240_Q	0.642	0.37
126_F	193_I	0.640	0.37
125_R	159_A	0.638	0.36
81_Y	191_I	0.638	0.36
39_V	246_L	0.637	0.36
90_I	250_I	0.635	0.36
33_V	123_A	0.635	0.36
177_F	198_G	0.635	0.36
211_A	233_G	0.634	0.36
86_V	195_K	0.633	0.36
34_F	265_K	0.630	0.36
56_G	177_F	0.629	0.36
139_T	251_L	0.624	0.35
37_L	165_A	0.622	0.35
23_G	116_Y	0.622	0.35
36_L	207_I	0.620	0.35
55_S	227_D	0.619	0.35
37_L	57_A	0.619	0.35
158_G	214_Y	0.618	0.35
204_A	251_L	0.617	0.35
88_S	109_N	0.615	0.34
126_F	233_G	0.615	0.34
60_T	141_S	0.615	0.34
161_F	239_A	0.613	0.34
22_F	83_I	0.612	0.34
47_G	270_H	0.608	0.34
182_D	194_T	0.606	0.34
79_I	179_K	0.604	0.34
30_F	168_Q	0.604	0.34
50_R	249_S	0.604	0.34
251_L	264_M	0.602	0.33
109_N	198_G	0.602	0.33
124_L	197_T	0.602	0.33
169_F	206_A	0.598	0.33
218_K	238_L	0.597	0.33
18_W	22_F	0.596	0.33
34_F	208_I	0.595	0.33
195_K	237_E	0.594	0.33
173_V	259_G	0.594	0.33
74_I	123_A	0.591	0.33
96_H	102_G	0.591	0.33
81_Y	85_M	0.590	0.32
40_L	219_T	0.587	0.32
260_M	264_M	0.586	0.32
172_G	256_I	0.582	0.32
76_I	251_L	0.581	0.32
33_V	75_G	0.581	0.32
183_T	191_I	0.579	0.32
100_R	104_S	0.577	0.31
17_P	21_R	0.577	0.31
241_Q	247_I	0.575	0.31
168_Q	266_G	0.575	0.31
120_A	128_F	0.573	0.31
213_G	217_I	0.573	0.31
146_A	210_S	0.572	0.31
35_I	208_I	0.571	0.31
87_L	178_M	0.570	0.31
76_I	155_G	0.568	0.31
103_L	156_L	0.568	0.31
258_Y	269_Q	0.565	0.31
159_A	250_I	0.564	0.30
154_T	238_L	0.564	0.30
151_Q	210_S	0.564	0.30
197_T	257_L	0.564	0.30
117_T	211_A	0.563	0.30
125_R	130_Q	0.563	0.30
40_L	236_A	0.562	0.30
125_R	243_H	0.561	0.30
76_I	173_V	0.560	0.30
33_V	159_A	0.560	0.30
175_A	181_F	0.555	0.30
55_S	171_K	0.554	0.30
20_K	82_V	0.554	0.30
193_I	271_M	0.549	0.29
56_G	232_D	0.548	0.29
154_T	220_A	0.547	0.29
35_I	263_I	0.547	0.29
224_D	227_D	0.547	0.29
145_L	157_T	0.545	0.29
209_F	269_Q	0.545	0.29
119_I	178_M	0.545	0.29
56_G	72_F	0.545	0.29
51_A	253_L	0.544	0.29
32_G	253_L	0.544	0.29
156_L	250_I	0.542	0.29
34_F	215_F	0.541	0.29
165_A	216_L	0.541	0.29
139_T	237_E	0.539	0.29
44_T	236_A	0.538	0.29
61_L	211_A	0.537	0.28
93_T	258_Y	0.536	0.28
86_V	90_I	0.536	0.28
89_A	120_A	0.533	0.28
189_Q	193_I	0.531	0.28
193_I	196_N	0.529	0.28
101_R	157_T	0.527	0.28
64_M	224_D	0.526	0.28
215_F	251_L	0.526	0.28
28_F	31_G	0.525	0.28
211_A	247_I	0.525	0.28
32_G	189_Q	0.525	0.28
107_I	114_A	0.523	0.27
39_V	70_L	0.520	0.27
41_A	45_A	0.520	0.27
122_N	158_G	0.517	0.27
158_G	218_K	0.516	0.27
168_Q	171_K	0.512	0.27
85_M	209_F	0.511	0.27
61_L	103_L	0.510	0.27
64_M	139_T	0.509	0.26
156_L	227_D	0.507	0.26
159_A	203_I	0.507	0.26
229_R	234_A	0.507	0.26
140_W	163_V	0.507	0.26
107_I	111_F	0.504	0.26
28_F	190_M	0.502	0.26
176_A	179_K	0.502	0.26
165_A	210_S	0.501	0.26
200_A	227_D	0.501	0.26
123_A	152_W	0.500	0.26
76_I	240_Q	0.500	0.26
20_K	130_Q	0.500	0.26
148_P	169_F	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wswA	3	0.3091	18.1	0.966	Contact Map
4wgvA	2	0.6545	7.2	0.971	Contact Map
2wdqD	2	0.3818	6.8	0.972	Contact Map
4a01A	2	0.4618	6.1	0.972	Contact Map
4c7rA	3	0.2655	5.3	0.973	Contact Map
2mpnA	2	0.2327	5	0.973	Contact Map
2k9jB	1	0.1564	4.4	0.974	Contact Map
2kncB	1	0.1673	4	0.974	Contact Map
3j1zP	8	0.3382	3.8	0.975	Contact Map
2lomA	1	0.2182	3.7	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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