ARGI - BACSU - GREMLIN Contacts

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ARGI - Arginase

UniProt:	P39138	Sequences: MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAPKIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGVHLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	296 (260)
Sequences:	5205 (3371)
Seq/√Len:	209.1

ECOLI - SPEB
BACSU - ARGI SPEB HUTG
HALSA - HUTG Q9HP79
SULSO - Q97ZX8 Q97VA3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
28_I	93_L	3.893	1.00
222_L	248_S	3.570	1.00
81_N	109_K	3.388	1.00
77_A	105_A	3.106	1.00
104_L	144_S	3.052	1.00
227_L	282_T	2.938	1.00
26_S	49_D	2.721	1.00
232_A	279_T	2.645	1.00
224_L	235_V	2.564	1.00
77_A	109_K	2.561	1.00
264_A	290_L	2.311	1.00
181_K	185_E	2.141	1.00
46_D	49_D	2.121	1.00
9_G	29_R	2.101	1.00
224_L	269_V	2.010	1.00
245_Y	282_T	2.007	1.00
115_G	216_D	1.963	1.00
169_I	172_A	1.960	1.00
227_L	248_S	1.953	1.00
220_L	261_I	1.947	1.00
8_I	83_V	1.934	1.00
113_N	216_D	1.929	1.00
26_S	30_Y	1.928	1.00
189_K	207_E	1.889	1.00
201_M	205_I	1.886	1.00
6_S	88_K	1.843	1.00
142_A	146_G	1.814	1.00
74_E	78_Q	1.807	1.00
199_L	207_E	1.797	1.00
119_Y	226_G	1.781	1.00
77_A	106_G	1.780	1.00
80_V	103_T	1.767	1.00
10_M	92_V	1.754	1.00
28_I	283_A	1.734	1.00
189_K	211_Y	1.728	1.00
266_F	287_V	1.716	1.00
71_A	75_K	1.714	1.00
93_L	287_V	1.701	1.00
168_V	189_K	1.699	1.00
101_I	105_A	1.688	1.00
84_I	106_G	1.675	1.00
197_D	246_R	1.663	1.00
13_D	22_D	1.653	1.00
85_E	110_H	1.652	1.00
101_I	147_I	1.651	1.00
119_Y	251_A	1.623	1.00
226_G	243_I	1.610	1.00
92_V	103_T	1.579	1.00
81_N	85_E	1.573	1.00
80_V	92_V	1.565	1.00
91_L	264_A	1.521	1.00
269_V	283_A	1.520	1.00
112_D	217_G	1.512	1.00
84_I	110_H	1.506	1.00
231_D	245_Y	1.505	1.00
10_M	76_L	1.488	1.00
10_M	72_G	1.482	1.00
182_Y	186_S	1.457	1.00
206_E	210_D	1.456	1.00
9_G	48_G	1.455	1.00
29_R	49_D	1.447	1.00
244_S	247_E	1.439	1.00
172_A	190_V	1.433	1.00
107_T	114_L	1.430	1.00
113_N	166_N	1.414	1.00
224_L	266_F	1.404	1.00
4_T	43_T	1.397	1.00
6_S	47_L	1.397	1.00
68_S	71_A	1.395	1.00
219_H	263_S	1.387	1.00
166_N	216_D	1.379	1.00
83_V	90_P	1.376	1.00
199_L	203_K	1.366	1.00
203_K	207_E	1.364	1.00
6_S	83_V	1.356	1.00
203_K	206_E	1.355	1.00
224_L	232_A	1.348	1.00
99_I	267_V	1.334	1.00
117_I	255_L	1.331	1.00
198_R	250_L	1.326	1.00
5_I	291_L	1.317	1.00
226_G	248_S	1.315	1.00
77_A	81_N	1.314	1.00
28_I	269_V	1.305	1.00
253_E	289_S	1.295	1.00
27_A	280_G	1.294	1.00
200_G	204_V	1.283	1.00
168_V	211_Y	1.279	1.00
118_W	169_I	1.265	1.00
192_T	195_E	1.264	1.00
18_R	273_L	1.263	1.00
106_G	110_H	1.261	1.00
27_A	30_Y	1.258	1.00
206_E	254_M	1.252	1.00
8_I	92_V	1.244	1.00
234_G	279_T	1.244	1.00
91_L	287_V	1.241	1.00
137_H	236_G	1.238	1.00
84_I	107_T	1.235	1.00
143_V	146_G	1.226	1.00
209_L	254_M	1.224	1.00
9_G	46_D	1.224	1.00
29_R	46_D	1.221	1.00
269_V	279_T	1.210	1.00
249_H	289_S	1.210	1.00
142_A	182_Y	1.194	1.00
72_G	76_L	1.180	1.00
16_Q	21_V	1.179	1.00
220_L	264_A	1.177	1.00
73_N	98_S	1.175	1.00
97_H	221_S	1.173	1.00
197_D	247_E	1.168	1.00
234_G	274_D	1.162	1.00
23_M	272_I	1.158	1.00
202_T	206_E	1.148	1.00
111_Y	262_T	1.144	1.00
200_G	203_K	1.137	1.00
137_H	237_T	1.126	1.00
9_G	49_D	1.120	1.00
79_K	82_K	1.118	1.00
254_M	257_D	1.107	1.00
141_L	169_I	1.101	1.00
116_V	141_L	1.101	1.00
123_G	175_L	1.100	1.00
162_I	167_V	1.099	1.00
136_I	139_M	1.094	1.00
19_R	23_M	1.088	1.00
127_T	143_V	1.082	1.00
80_V	90_P	1.067	1.00
125_L	183_I	1.054	1.00
224_L	283_A	1.050	1.00
8_I	80_V	1.048	1.00
232_A	282_T	1.043	1.00
44_V	48_G	1.032	1.00
76_L	92_V	1.022	1.00
103_T	265_E	1.014	1.00
78_Q	82_K	1.009	1.00
197_D	250_L	1.007	1.00
103_T	219_H	1.004	1.00
10_M	99_I	1.003	1.00
248_S	286_L	0.998	1.00
7_V	93_L	0.995	1.00
205_I	254_M	0.994	1.00
193_M	197_D	0.992	1.00
111_Y	217_G	0.991	1.00
71_A	74_E	0.989	1.00
105_A	147_I	0.986	1.00
123_G	172_A	0.981	1.00
217_G	262_T	0.973	1.00
270_N	273_L	0.972	1.00
222_L	286_L	0.971	1.00
27_A	31_A	0.968	1.00
100_A	104_L	0.959	1.00
275_H	278_K	0.955	1.00
210_D	213_S	0.950	0.99
19_R	22_D	0.947	0.99
39_D	44_V	0.942	0.99
122_H	225_D	0.942	0.99
243_I	251_A	0.939	0.99
48_G	54_R	0.936	0.99
73_N	102_G	0.933	0.99
89_F	264_A	0.933	0.99
183_I	188_M	0.923	0.99
81_N	106_G	0.922	0.99
81_N	110_H	0.914	0.99
8_I	79_K	0.911	0.99
141_L	167_V	0.907	0.99
199_L	204_V	0.906	0.99
137_H	268_E	0.905	0.99
123_G	190_V	0.905	0.99
5_I	89_F	0.904	0.99
118_W	221_S	0.902	0.99
123_G	169_I	0.902	0.99
208_T	211_Y	0.900	0.99
174_S	239_V	0.896	0.99
170_I	208_T	0.892	0.99
137_H	235_V	0.890	0.99
104_L	116_V	0.885	0.99
21_V	270_N	0.883	0.99
127_T	142_A	0.880	0.99
195_E	199_L	0.876	0.99
82_K	85_E	0.867	0.99
138_G	237_T	0.867	0.99
120_D	124_D	0.866	0.99
220_L	252_M	0.865	0.99
113_N	163_K	0.862	0.99
97_H	268_E	0.860	0.99
107_T	263_S	0.856	0.99
227_L	245_Y	0.854	0.99
191_Y	196_I	0.853	0.99
202_T	254_M	0.848	0.99
194_H	253_E	0.844	0.99
114_L	262_T	0.843	0.99
52_I	72_G	0.842	0.99
204_V	208_T	0.829	0.99
182_Y	185_E	0.827	0.99
173_R	229_P	0.825	0.99
46_D	54_R	0.824	0.99
208_T	212_L	0.822	0.99
119_Y	243_I	0.820	0.98
100_A	265_E	0.809	0.98
115_G	166_N	0.805	0.98
163_K	166_N	0.798	0.98
100_A	140_P	0.795	0.98
279_T	283_A	0.793	0.98
97_H	137_H	0.791	0.98
13_D	21_V	0.787	0.98
78_Q	81_N	0.783	0.98
277_N	280_G	0.782	0.98
251_A	254_M	0.782	0.98
125_L	145_L	0.780	0.98
8_I	90_P	0.778	0.98
13_D	20_G	0.773	0.98
5_I	42_Y	0.772	0.98
209_L	258_A	0.767	0.98
184_K	190_V	0.766	0.98
115_G	212_L	0.763	0.98
51_P	54_R	0.763	0.98
13_D	18_R	0.759	0.98
194_H	250_L	0.752	0.97
271_P	274_D	0.749	0.97
97_H	265_E	0.749	0.97
220_L	290_L	0.748	0.97
12_M	69_V	0.747	0.97
173_R	228_D	0.747	0.97
90_P	107_T	0.744	0.97
243_I	248_S	0.739	0.97
235_V	238_P	0.739	0.97
231_D	244_S	0.732	0.97
107_T	262_T	0.730	0.97
82_K	86_E	0.729	0.97
168_V	208_T	0.728	0.97
191_Y	211_Y	0.727	0.97
256_Y	261_I	0.726	0.97
227_L	231_D	0.726	0.97
83_V	88_K	0.726	0.97
287_V	290_L	0.725	0.97
245_Y	249_H	0.725	0.97
207_E	211_Y	0.725	0.97
48_G	51_P	0.724	0.97
115_G	168_V	0.723	0.97
24_G	270_N	0.723	0.97
29_R	48_G	0.721	0.97
13_D	19_R	0.721	0.97
249_H	286_L	0.720	0.97
127_T	134_G	0.719	0.97
47_L	83_V	0.718	0.97
116_V	144_S	0.718	0.97
117_I	170_I	0.713	0.96
167_V	188_M	0.713	0.96
91_L	291_L	0.710	0.96
170_I	243_I	0.701	0.96
104_L	114_L	0.701	0.96
145_L	167_V	0.700	0.96
117_I	212_L	0.699	0.96
103_T	263_S	0.695	0.96
207_E	210_D	0.693	0.96
80_V	106_G	0.687	0.96
39_D	54_R	0.686	0.96
7_V	91_L	0.685	0.95
128_L	143_V	0.684	0.95
195_E	198_R	0.677	0.95
209_L	212_L	0.674	0.95
137_H	140_P	0.673	0.95
4_T	88_K	0.672	0.95
121_A	173_R	0.669	0.95
117_I	218_V	0.667	0.95
116_V	162_I	0.667	0.95
24_G	27_A	0.665	0.95
269_V	280_G	0.661	0.95
46_D	50_I	0.657	0.94
230_N	245_Y	0.656	0.94
221_S	267_V	0.654	0.94
100_A	141_L	0.654	0.94
92_V	99_I	0.650	0.94
205_I	208_T	0.650	0.94
27_A	271_P	0.647	0.94
209_L	213_S	0.646	0.94
103_T	107_T	0.646	0.94
54_R	67_N	0.644	0.94
191_Y	207_E	0.644	0.94
254_M	258_A	0.643	0.94
191_Y	195_E	0.642	0.94
75_K	79_K	0.642	0.94
278_K	282_T	0.641	0.94
30_Y	277_N	0.639	0.93
145_L	188_M	0.638	0.93
117_I	168_V	0.638	0.93
173_R	239_V	0.638	0.93
145_L	164_P	0.636	0.93
119_Y	220_L	0.636	0.93
31_A	284_V	0.633	0.93
15_G	96_D	0.633	0.93
119_Y	170_I	0.631	0.93
125_L	186_S	0.630	0.93
24_G	236_G	0.625	0.93
171_G	226_G	0.625	0.93
74_E	77_A	0.624	0.93
112_D	216_D	0.623	0.93
75_K	78_Q	0.622	0.93
196_I	251_A	0.617	0.92
231_D	282_T	0.616	0.92
14_L	72_G	0.614	0.92
98_S	135_N	0.614	0.92
48_G	53_N	0.613	0.92
232_A	269_V	0.613	0.92
124_D	268_E	0.612	0.92
76_L	99_I	0.612	0.92
94_G	99_I	0.608	0.92
102_G	106_G	0.608	0.92
18_R	238_P	0.608	0.92
114_L	217_G	0.604	0.91
202_T	250_L	0.603	0.91
234_G	269_V	0.601	0.91
125_L	182_Y	0.597	0.91
31_A	280_G	0.589	0.90
123_G	126_N	0.588	0.90
10_M	103_T	0.586	0.90
118_W	237_T	0.586	0.90
108_A	162_I	0.585	0.90
118_W	141_L	0.585	0.90
108_A	147_I	0.585	0.90
168_V	191_Y	0.581	0.90
145_L	165_E	0.581	0.90
235_V	270_N	0.580	0.90
201_M	250_L	0.578	0.90
123_G	183_I	0.575	0.89
250_L	254_M	0.575	0.89
246_R	250_L	0.571	0.89
28_I	284_V	0.570	0.89
219_H	265_E	0.570	0.89
97_H	267_V	0.567	0.89
69_V	73_N	0.563	0.88
39_D	48_G	0.561	0.88
193_M	243_I	0.557	0.88
11_P	49_D	0.556	0.88
15_G	69_V	0.553	0.87
116_V	167_V	0.553	0.87
196_I	247_E	0.552	0.87
73_N	76_L	0.552	0.87
31_A	277_N	0.551	0.87
266_F	286_L	0.550	0.87
229_P	232_A	0.549	0.87
221_S	265_E	0.547	0.87
40_M	47_L	0.546	0.87
16_Q	19_R	0.545	0.87
100_A	267_V	0.543	0.86
126_N	176_D	0.543	0.86
218_V	261_I	0.538	0.86
144_S	148_G	0.536	0.86
198_R	202_T	0.536	0.86
104_L	162_I	0.536	0.86
219_H	262_T	0.535	0.86
5_I	290_L	0.534	0.86
233_P	279_T	0.533	0.85
181_K	184_K	0.533	0.85
7_V	34_I	0.533	0.85
79_K	83_V	0.533	0.85
27_A	277_N	0.532	0.85
97_H	122_H	0.531	0.85
205_I	251_A	0.530	0.85
177_E	181_K	0.530	0.85
87_K	110_H	0.529	0.85
40_M	45_E	0.529	0.85
35_E	38_S	0.529	0.85
97_H	219_H	0.528	0.85
68_S	133_S	0.522	0.84
87_K	90_P	0.521	0.84
97_H	236_G	0.517	0.84
201_M	251_A	0.517	0.84
255_L	259_G	0.515	0.83
68_S	76_L	0.514	0.83
198_R	253_E	0.513	0.83
213_S	216_D	0.513	0.83
24_G	271_P	0.512	0.83
70_L	74_E	0.512	0.83
118_W	140_P	0.509	0.83
101_I	143_V	0.509	0.83
133_S	139_M	0.507	0.83
113_N	217_G	0.506	0.82
200_G	247_E	0.506	0.82
99_I	221_S	0.505	0.82
124_D	225_D	0.505	0.82
51_P	75_K	0.505	0.82
105_A	144_S	0.504	0.82
200_G	205_I	0.504	0.82
139_M	143_V	0.503	0.82
39_D	43_T	0.501	0.82
107_T	111_Y	0.501	0.82
39_D	46_D	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cevA	5	0.9932	100	0.097	Contact Map
2ef5A	4	0.9223	100	0.118	Contact Map
4q40A	5	1	100	0.121	Contact Map
3sl1A	5	0.9764	100	0.128	Contact Map
4iu0A	3	0.9932	100	0.131	Contact Map
2aebA	3	0.9966	100	0.133	Contact Map
4hzeA	3	0.9932	100	0.138	Contact Map
4g3hA	1	0.973	100	0.14	Contact Map
1gq6A	5	0.9088	100	0.152	Contact Map
3m1rA	5	0.9122	100	0.156	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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