GREMLIN Database
ARGI - Arginase
UniProt: P39138 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (260)
Sequences: 5205 (3371)
Seq/√Len: 209.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_I93_L3.8931.00
222_L248_S3.5701.00
81_N109_K3.3881.00
77_A105_A3.1061.00
104_L144_S3.0521.00
227_L282_T2.9381.00
26_S49_D2.7211.00
232_A279_T2.6451.00
224_L235_V2.5641.00
77_A109_K2.5611.00
264_A290_L2.3111.00
181_K185_E2.1411.00
46_D49_D2.1211.00
9_G29_R2.1011.00
224_L269_V2.0101.00
245_Y282_T2.0071.00
115_G216_D1.9631.00
169_I172_A1.9601.00
227_L248_S1.9531.00
220_L261_I1.9471.00
8_I83_V1.9341.00
113_N216_D1.9291.00
26_S30_Y1.9281.00
189_K207_E1.8891.00
201_M205_I1.8861.00
6_S88_K1.8431.00
142_A146_G1.8141.00
74_E78_Q1.8071.00
199_L207_E1.7971.00
119_Y226_G1.7811.00
77_A106_G1.7801.00
80_V103_T1.7671.00
10_M92_V1.7541.00
28_I283_A1.7341.00
189_K211_Y1.7281.00
266_F287_V1.7161.00
71_A75_K1.7141.00
93_L287_V1.7011.00
168_V189_K1.6991.00
101_I105_A1.6881.00
84_I106_G1.6751.00
197_D246_R1.6631.00
13_D22_D1.6531.00
85_E110_H1.6521.00
101_I147_I1.6511.00
119_Y251_A1.6231.00
226_G243_I1.6101.00
92_V103_T1.5791.00
81_N85_E1.5731.00
80_V92_V1.5651.00
91_L264_A1.5211.00
269_V283_A1.5201.00
112_D217_G1.5121.00
84_I110_H1.5061.00
231_D245_Y1.5051.00
10_M76_L1.4881.00
10_M72_G1.4821.00
182_Y186_S1.4571.00
206_E210_D1.4561.00
9_G48_G1.4551.00
29_R49_D1.4471.00
244_S247_E1.4391.00
172_A190_V1.4331.00
107_T114_L1.4301.00
113_N166_N1.4141.00
224_L266_F1.4041.00
4_T43_T1.3971.00
6_S47_L1.3971.00
68_S71_A1.3951.00
219_H263_S1.3871.00
166_N216_D1.3791.00
83_V90_P1.3761.00
199_L203_K1.3661.00
203_K207_E1.3641.00
6_S83_V1.3561.00
203_K206_E1.3551.00
224_L232_A1.3481.00
99_I267_V1.3341.00
117_I255_L1.3311.00
198_R250_L1.3261.00
5_I291_L1.3171.00
226_G248_S1.3151.00
77_A81_N1.3141.00
28_I269_V1.3051.00
253_E289_S1.2951.00
27_A280_G1.2941.00
200_G204_V1.2831.00
168_V211_Y1.2791.00
118_W169_I1.2651.00
192_T195_E1.2641.00
18_R273_L1.2631.00
106_G110_H1.2611.00
27_A30_Y1.2581.00
206_E254_M1.2521.00
8_I92_V1.2441.00
234_G279_T1.2441.00
91_L287_V1.2411.00
137_H236_G1.2381.00
84_I107_T1.2351.00
143_V146_G1.2261.00
209_L254_M1.2241.00
9_G46_D1.2241.00
29_R46_D1.2211.00
269_V279_T1.2101.00
249_H289_S1.2101.00
142_A182_Y1.1941.00
72_G76_L1.1801.00
16_Q21_V1.1791.00
220_L264_A1.1771.00
73_N98_S1.1751.00
97_H221_S1.1731.00
197_D247_E1.1681.00
234_G274_D1.1621.00
23_M272_I1.1581.00
202_T206_E1.1481.00
111_Y262_T1.1441.00
200_G203_K1.1371.00
137_H237_T1.1261.00
9_G49_D1.1201.00
79_K82_K1.1181.00
254_M257_D1.1071.00
141_L169_I1.1011.00
116_V141_L1.1011.00
123_G175_L1.1001.00
162_I167_V1.0991.00
136_I139_M1.0941.00
19_R23_M1.0881.00
127_T143_V1.0821.00
80_V90_P1.0671.00
125_L183_I1.0541.00
224_L283_A1.0501.00
8_I80_V1.0481.00
232_A282_T1.0431.00
44_V48_G1.0321.00
76_L92_V1.0221.00
103_T265_E1.0141.00
78_Q82_K1.0091.00
197_D250_L1.0071.00
103_T219_H1.0041.00
10_M99_I1.0031.00
248_S286_L0.9981.00
7_V93_L0.9951.00
205_I254_M0.9941.00
193_M197_D0.9921.00
111_Y217_G0.9911.00
71_A74_E0.9891.00
105_A147_I0.9861.00
123_G172_A0.9811.00
217_G262_T0.9731.00
270_N273_L0.9721.00
222_L286_L0.9711.00
27_A31_A0.9681.00
100_A104_L0.9591.00
275_H278_K0.9551.00
210_D213_S0.9500.99
19_R22_D0.9470.99
39_D44_V0.9420.99
122_H225_D0.9420.99
243_I251_A0.9390.99
48_G54_R0.9360.99
73_N102_G0.9330.99
89_F264_A0.9330.99
183_I188_M0.9230.99
81_N106_G0.9220.99
81_N110_H0.9140.99
8_I79_K0.9110.99
141_L167_V0.9070.99
199_L204_V0.9060.99
137_H268_E0.9050.99
123_G190_V0.9050.99
5_I89_F0.9040.99
118_W221_S0.9020.99
123_G169_I0.9020.99
208_T211_Y0.9000.99
174_S239_V0.8960.99
170_I208_T0.8920.99
137_H235_V0.8900.99
104_L116_V0.8850.99
21_V270_N0.8830.99
127_T142_A0.8800.99
195_E199_L0.8760.99
82_K85_E0.8670.99
138_G237_T0.8670.99
120_D124_D0.8660.99
220_L252_M0.8650.99
113_N163_K0.8620.99
97_H268_E0.8600.99
107_T263_S0.8560.99
227_L245_Y0.8540.99
191_Y196_I0.8530.99
202_T254_M0.8480.99
194_H253_E0.8440.99
114_L262_T0.8430.99
52_I72_G0.8420.99
204_V208_T0.8290.99
182_Y185_E0.8270.99
173_R229_P0.8250.99
46_D54_R0.8240.99
208_T212_L0.8220.99
119_Y243_I0.8200.98
100_A265_E0.8090.98
115_G166_N0.8050.98
163_K166_N0.7980.98
100_A140_P0.7950.98
279_T283_A0.7930.98
97_H137_H0.7910.98
13_D21_V0.7870.98
78_Q81_N0.7830.98
277_N280_G0.7820.98
251_A254_M0.7820.98
125_L145_L0.7800.98
8_I90_P0.7780.98
13_D20_G0.7730.98
5_I42_Y0.7720.98
209_L258_A0.7670.98
184_K190_V0.7660.98
115_G212_L0.7630.98
51_P54_R0.7630.98
13_D18_R0.7590.98
194_H250_L0.7520.97
271_P274_D0.7490.97
97_H265_E0.7490.97
220_L290_L0.7480.97
12_M69_V0.7470.97
173_R228_D0.7470.97
90_P107_T0.7440.97
243_I248_S0.7390.97
235_V238_P0.7390.97
231_D244_S0.7320.97
107_T262_T0.7300.97
82_K86_E0.7290.97
168_V208_T0.7280.97
191_Y211_Y0.7270.97
256_Y261_I0.7260.97
227_L231_D0.7260.97
83_V88_K0.7260.97
287_V290_L0.7250.97
245_Y249_H0.7250.97
207_E211_Y0.7250.97
48_G51_P0.7240.97
115_G168_V0.7230.97
24_G270_N0.7230.97
29_R48_G0.7210.97
13_D19_R0.7210.97
249_H286_L0.7200.97
127_T134_G0.7190.97
47_L83_V0.7180.97
116_V144_S0.7180.97
117_I170_I0.7130.96
167_V188_M0.7130.96
91_L291_L0.7100.96
170_I243_I0.7010.96
104_L114_L0.7010.96
145_L167_V0.7000.96
117_I212_L0.6990.96
103_T263_S0.6950.96
207_E210_D0.6930.96
80_V106_G0.6870.96
39_D54_R0.6860.96
7_V91_L0.6850.95
128_L143_V0.6840.95
195_E198_R0.6770.95
209_L212_L0.6740.95
137_H140_P0.6730.95
4_T88_K0.6720.95
121_A173_R0.6690.95
117_I218_V0.6670.95
116_V162_I0.6670.95
24_G27_A0.6650.95
269_V280_G0.6610.95
46_D50_I0.6570.94
230_N245_Y0.6560.94
221_S267_V0.6540.94
100_A141_L0.6540.94
92_V99_I0.6500.94
205_I208_T0.6500.94
27_A271_P0.6470.94
209_L213_S0.6460.94
103_T107_T0.6460.94
54_R67_N0.6440.94
191_Y207_E0.6440.94
254_M258_A0.6430.94
191_Y195_E0.6420.94
75_K79_K0.6420.94
278_K282_T0.6410.94
30_Y277_N0.6390.93
145_L188_M0.6380.93
117_I168_V0.6380.93
173_R239_V0.6380.93
145_L164_P0.6360.93
119_Y220_L0.6360.93
31_A284_V0.6330.93
15_G96_D0.6330.93
119_Y170_I0.6310.93
125_L186_S0.6300.93
24_G236_G0.6250.93
171_G226_G0.6250.93
74_E77_A0.6240.93
112_D216_D0.6230.93
75_K78_Q0.6220.93
196_I251_A0.6170.92
231_D282_T0.6160.92
14_L72_G0.6140.92
98_S135_N0.6140.92
48_G53_N0.6130.92
232_A269_V0.6130.92
124_D268_E0.6120.92
76_L99_I0.6120.92
94_G99_I0.6080.92
102_G106_G0.6080.92
18_R238_P0.6080.92
114_L217_G0.6040.91
202_T250_L0.6030.91
234_G269_V0.6010.91
125_L182_Y0.5970.91
31_A280_G0.5890.90
123_G126_N0.5880.90
10_M103_T0.5860.90
118_W237_T0.5860.90
108_A162_I0.5850.90
118_W141_L0.5850.90
108_A147_I0.5850.90
168_V191_Y0.5810.90
145_L165_E0.5810.90
235_V270_N0.5800.90
201_M250_L0.5780.90
123_G183_I0.5750.89
250_L254_M0.5750.89
246_R250_L0.5710.89
28_I284_V0.5700.89
219_H265_E0.5700.89
97_H267_V0.5670.89
69_V73_N0.5630.88
39_D48_G0.5610.88
193_M243_I0.5570.88
11_P49_D0.5560.88
15_G69_V0.5530.87
116_V167_V0.5530.87
196_I247_E0.5520.87
73_N76_L0.5520.87
31_A277_N0.5510.87
266_F286_L0.5500.87
229_P232_A0.5490.87
221_S265_E0.5470.87
40_M47_L0.5460.87
16_Q19_R0.5450.87
100_A267_V0.5430.86
126_N176_D0.5430.86
218_V261_I0.5380.86
144_S148_G0.5360.86
198_R202_T0.5360.86
104_L162_I0.5360.86
219_H262_T0.5350.86
5_I290_L0.5340.86
233_P279_T0.5330.85
181_K184_K0.5330.85
7_V34_I0.5330.85
79_K83_V0.5330.85
27_A277_N0.5320.85
97_H122_H0.5310.85
205_I251_A0.5300.85
177_E181_K0.5300.85
87_K110_H0.5290.85
40_M45_E0.5290.85
35_E38_S0.5290.85
97_H219_H0.5280.85
68_S133_S0.5220.84
87_K90_P0.5210.84
97_H236_G0.5170.84
201_M251_A0.5170.84
255_L259_G0.5150.83
68_S76_L0.5140.83
198_R253_E0.5130.83
213_S216_D0.5130.83
24_G271_P0.5120.83
70_L74_E0.5120.83
118_W140_P0.5090.83
101_I143_V0.5090.83
133_S139_M0.5070.83
113_N217_G0.5060.82
200_G247_E0.5060.82
99_I221_S0.5050.82
124_D225_D0.5050.82
51_P75_K0.5050.82
105_A144_S0.5040.82
200_G205_I0.5040.82
139_M143_V0.5030.82
39_D43_T0.5010.82
107_T111_Y0.5010.82
39_D46_D0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cevA 5 0.9932 100 0.097 Contact Map
2ef5A 4 0.9223 100 0.118 Contact Map
4q40A 5 1 100 0.121 Contact Map
3sl1A 5 0.9764 100 0.128 Contact Map
4iu0A 3 0.9932 100 0.131 Contact Map
2aebA 3 0.9966 100 0.133 Contact Map
4hzeA 3 0.9932 100 0.138 Contact Map
4g3hA 1 0.973 100 0.14 Contact Map
1gq6A 5 0.9088 100 0.152 Contact Map
3m1rA 5 0.9122 100 0.156 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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