GREMLIN Database
ROCE - Amino-acid permease RocE
UniProt: P39137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 467 (425)
Sequences: 24811 (16175)
Seq/√Len: 784.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_F345_M4.4431.00
327_A339_Y4.3621.00
387_M391_K3.5281.00
57_G250_L3.1551.00
379_I417_L3.1251.00
330_K339_Y3.1231.00
236_K240_R3.0501.00
16_K232_E2.9821.00
231_S237_T2.7581.00
81_Q321_E2.7371.00
233_D236_K2.6881.00
97_G318_M2.6661.00
172_G259_V2.6351.00
332_N338_M2.6321.00
319_A329_G2.6051.00
327_A330_K2.4781.00
21_F244_Q2.4741.00
133_L349_C2.4541.00
287_Y291_I2.4471.00
170_I174_A2.4291.00
438_Y442_P2.4201.00
17_S244_Q2.4001.00
229_G320_N2.3241.00
382_S416_G2.3111.00
69_E389_R2.3001.00
141_I145_I2.2351.00
17_S237_T2.2181.00
230_E313_R2.1811.00
342_I346_A2.1761.00
85_T93_G2.1731.00
442_P445_I2.1701.00
20_L231_S2.1521.00
316_Y320_N2.1161.00
17_S21_F2.1141.00
148_K152_E2.1131.00
448_Y452_H2.1101.00
278_A281_E2.1081.00
414_L418_T2.0811.00
140_F341_L2.0731.00
159_G163_L2.0381.00
137_A349_C2.0321.00
144_A338_M2.0191.00
240_R244_Q1.9981.00
88_I387_M1.9941.00
268_Q282_Q1.9861.00
328_L343_V1.9291.00
133_L352_L1.9251.00
85_T90_P1.9061.00
322_G326_K1.9021.00
66_C382_S1.9011.00
449_I453_V1.9001.00
16_K19_H1.8991.00
101_W344_T1.8971.00
11_L331_T1.8931.00
58_F62_L1.8751.00
40_T49_A1.8691.00
265_P268_Q1.8481.00
88_I383_L1.8261.00
132_C352_L1.8251.00
19_H155_F1.7581.00
243_K247_W1.7501.00
278_A282_Q1.7461.00
411_V415_I1.7401.00
233_D237_T1.7371.00
418_T422_V1.7301.00
137_A345_M1.7271.00
143_N305_N1.7251.00
383_L417_L1.7231.00
84_A96_F1.7101.00
96_F380_T1.7011.00
24_S245_T1.6731.00
189_P192_T1.6491.00
112_F304_A1.6301.00
21_F248_R1.6211.00
127_D130_I1.6171.00
332_N336_V1.6141.00
387_M390_R1.6141.00
89_S92_F1.6121.00
108_C348_A1.6081.00
163_L167_L1.6031.00
52_S210_T1.6021.00
144_A342_I1.5951.00
59_I419_L1.5901.00
434_R437_L1.5801.00
190_F193_H1.5611.00
136_A348_A1.5461.00
15_M19_H1.5401.00
189_P193_H1.5341.00
247_W251_V1.5271.00
56_G214_V1.5241.00
88_I92_F1.5181.00
227_A309_Y1.5161.00
233_D240_R1.4981.00
119_M131_W1.4601.00
281_E289_A1.4561.00
173_G259_V1.4531.00
315_L340_S1.4441.00
136_A345_M1.4361.00
64_M246_V1.4221.00
77_S229_G1.4221.00
316_Y331_T1.4211.00
11_L316_Y1.4181.00
133_L137_A1.4181.00
62_L415_I1.4171.00
164_I295_V1.4161.00
326_K329_G1.4121.00
112_F136_A1.4111.00
311_S344_T1.4091.00
339_Y343_V1.4001.00
58_F415_I1.3921.00
326_K330_K1.3731.00
84_A380_T1.3641.00
162_I166_L1.3631.00
126_I130_I1.3571.00
115_A297_L1.3561.00
19_H151_A1.3491.00
115_A135_F1.3471.00
444_M448_Y1.3451.00
383_L387_M1.3441.00
330_K338_M1.3381.00
12_Q335_G1.3341.00
272_V278_A1.3341.00
140_F342_I1.3321.00
312_T341_L1.3241.00
440_G444_M1.3191.00
74_F86_K1.3101.00
87_F384_S1.2991.00
169_I255_L1.2951.00
35_L114_S1.2941.00
63_T382_S1.2901.00
290_D294_F1.2851.00
15_M151_A1.2821.00
234_P239_P1.2801.00
237_T240_R1.2721.00
251_V255_L1.2711.00
28_V249_T1.2681.00
379_I421_T1.2681.00
76_V82_T1.2671.00
190_F194_F1.2661.00
386_I414_L1.2581.00
17_S240_R1.2581.00
438_Y445_I1.2561.00
446_I450_I1.2511.00
176_M262_G1.2461.00
15_M20_L1.2391.00
64_M242_I1.2381.00
315_L324_A1.2331.00
82_T86_K1.2271.00
41_I49_A1.2231.00
168_F172_G1.2091.00
66_C413_P1.2041.00
111_E303_V1.2021.00
422_V426_S1.2021.00
91_A451_Y1.1991.00
408_L412_L1.1971.00
76_V86_K1.1951.00
65_L243_K1.1941.00
48_G207_M1.1921.00
18_R22_M1.1871.00
173_G177_F1.1831.00
410_P414_L1.1781.00
393_I402_L1.1741.00
408_L411_V1.1741.00
139_M304_A1.1681.00
274_S278_A1.1641.00
50_V258_I1.1611.00
172_G263_M1.1581.00
20_L241_S1.1571.00
281_E286_P1.1551.00
445_I449_I1.1531.00
232_E237_T1.1451.00
442_P446_I1.1441.00
435_I442_P1.1361.00
101_W315_L1.1351.00
153_S157_F1.1321.00
14_T232_E1.1301.00
448_Y451_Y1.1261.00
191_L194_F1.1211.00
94_F98_W1.1201.00
67_L80_F1.1171.00
436_A440_G1.1101.00
435_I438_Y1.1091.00
129_W133_L1.1091.00
390_R410_P1.1011.00
385_Q413_P1.0981.00
142_L153_S1.0981.00
421_T425_I1.0981.00
411_V414_L1.0951.00
187_Q190_F1.0911.00
154_E305_N1.0851.00
400_E403_K1.0841.00
167_L171_L1.0831.00
188_A191_L1.0821.00
193_H197_D1.0811.00
45_G48_G1.0741.00
24_S224_I1.0741.00
434_R438_Y1.0731.00
71_A83_Y1.0731.00
339_Y342_I1.0701.00
25_L248_R1.0651.00
390_R393_I1.0641.00
130_I134_V1.0631.00
331_T335_G1.0631.00
433_Q436_A1.0591.00
450_I453_V1.0571.00
443_F447_C1.0551.00
320_N329_G1.0551.00
81_Q317_A1.0511.00
152_E156_W1.0481.00
73_A402_L1.0461.00
447_C451_Y1.0461.00
409_Y413_P1.0411.00
144_A336_V1.0371.00
23_I227_A1.0361.00
447_C450_I1.0361.00
84_A92_F1.0351.00
86_K392_Y1.0311.00
166_L170_I1.0281.00
399_I402_L1.0261.00
187_Q191_L1.0251.00
69_E72_V1.0231.00
116_G131_W1.0231.00
157_F302_S1.0221.00
25_L249_T1.0181.00
275_P280_F1.0141.00
147_T309_Y1.0081.00
134_V138_L1.0071.00
54_L254_V1.0021.00
389_R393_I0.9931.00
174_A178_G0.9881.00
140_F144_A0.9861.00
432_E435_I0.9861.00
393_I399_I0.9851.00
228_A238_I0.9851.00
382_S417_L0.9831.00
137_A141_I0.9821.00
189_P194_F0.9781.00
441_V445_I0.9781.00
379_I420_N0.9761.00
265_P282_Q0.9741.00
203_G206_A0.9721.00
346_A350_L0.9651.00
438_Y443_F0.9651.00
73_A400_E0.9641.00
425_I429_F0.9621.00
119_M123_F0.9551.00
100_Y104_W0.9551.00
119_M297_L0.9481.00
192_T195_Y0.9451.00
431_P435_I0.9401.00
208_L422_V0.9361.00
144_A332_N0.9341.00
437_L440_G0.9331.00
417_L421_T0.9321.00
439_C443_F0.9281.00
62_L412_L0.9271.00
330_K333_Q0.9271.00
162_I252_F0.9251.00
392_Y399_I0.9211.00
286_P290_D0.9201.00
219_Q374_A0.9161.00
431_P434_R0.9121.00
116_G132_C0.9111.00
169_I173_G0.9051.00
169_I259_V0.9041.00
78_G82_T0.9031.00
250_L254_V0.9031.00
284_G288_A0.8981.00
200_F207_M0.8971.00
138_L301_L0.8961.00
11_L230_E0.8941.00
222_E226_V0.8931.00
433_Q437_L0.8931.00
430_D433_Q0.8911.00
14_T148_K0.8901.00
11_L313_R0.8881.00
446_I452_H0.8871.00
416_G420_N0.8871.00
161_K299_A0.8861.00
139_M305_N0.8851.00
442_P447_C0.8831.00
379_I383_L0.8811.00
22_M155_F0.8801.00
436_A442_P0.8781.00
51_L207_M0.8771.00
125_H128_V0.8771.00
50_V261_A0.8751.00
110_I216_F0.8731.00
328_L339_Y0.8731.00
57_G218_F0.8731.00
168_F280_F0.8731.00
85_T321_E0.8711.00
338_M342_I0.8661.00
402_L405_K0.8621.00
439_C442_P0.8611.00
131_W134_V0.8591.00
89_S452_H0.8571.00
110_I367_L0.8571.00
258_I262_G0.8541.00
78_G81_Q0.8511.00
152_E155_F0.8481.00
444_M447_C0.8481.00
209_I213_T0.8461.00
188_A192_T0.8451.00
409_Y412_L0.8431.00
285_I288_A0.8401.00
430_D434_R0.8391.00
308_L345_M0.8381.00
17_S241_S0.8361.00
72_V403_K0.8331.00
437_L444_M0.8321.00
29_I32_G0.8321.00
19_H152_E0.8241.00
401_D405_K0.8221.00
244_Q248_R0.8201.00
98_W324_A0.8181.00
204_I207_M0.8151.00
18_R155_F0.8151.00
174_A177_F0.8131.00
432_E436_A0.8121.00
141_I144_A0.8111.00
186_E189_P0.8071.00
432_E437_L0.8071.00
400_E405_K0.8051.00
324_A328_L0.8041.00
84_A384_S0.8031.00
115_A301_L0.8021.00
61_F65_L0.7991.00
73_A403_K0.7981.00
91_A95_A0.7951.00
120_Q128_V0.7911.00
433_Q438_Y0.7911.00
129_W352_L0.7891.00
345_M349_C0.7891.00
223_L310_A0.7881.00
333_Q338_M0.7881.00
61_F243_K0.7831.00
195_Y199_L0.7811.00
115_A300_L0.7811.00
422_V425_I0.7791.00
191_L195_Y0.7781.00
29_I34_F0.7771.00
63_T420_N0.7731.00
440_G443_F0.7711.00
70_L385_Q0.7711.00
280_F283_I0.7691.00
192_T196_E0.7691.00
435_I448_Y0.7681.00
29_I161_K0.7681.00
70_L83_Y0.7651.00
196_E200_F0.7631.00
432_E445_I0.7611.00
92_F380_T0.7591.00
105_A347_V0.7571.00
139_M308_L0.7531.00
176_M259_V0.7491.00
386_I390_R0.7491.00
272_V275_P0.7481.00
442_P449_I0.7471.00
54_L58_F0.7461.00
407_P411_V0.7421.00
193_H196_E0.7411.00
145_I149_A0.7391.00
436_A443_F0.7331.00
392_Y400_E0.7321.00
239_P242_I0.7311.00
315_L343_V0.7311.00
190_F196_E0.7311.00
386_I410_P0.7311.00
432_E443_F0.7291.00
33_F256_S0.7281.00
113_L366_L0.7271.00
193_H198_G0.7271.00
369_L373_S0.7271.00
233_D239_P0.7261.00
46_P261_A0.7211.00
107_T370_A0.7211.00
62_L66_C0.7201.00
190_F195_Y0.7171.00
424_L427_L0.7171.00
386_I413_P0.7141.00
263_M279_V0.7141.00
87_F387_M0.7141.00
133_L353_L0.7141.00
21_F241_S0.7131.00
28_V245_T0.7111.00
385_Q389_R0.7101.00
219_Q378_W0.7101.00
126_I129_W0.7071.00
204_I208_L0.7071.00
275_P279_V0.7041.00
14_T147_T0.7031.00
136_A352_L0.7021.00
18_R152_E0.7011.00
60_M221_T0.7011.00
436_A445_I0.6991.00
434_R445_I0.6951.00
425_I428_A0.6931.00
143_N341_L0.6931.00
353_L356_F0.6931.00
26_G158_S0.6901.00
194_F197_D0.6901.00
308_L312_T0.6891.00
188_A193_H0.6891.00
276_F280_F0.6871.00
189_P195_Y0.6861.00
173_G255_L0.6851.00
441_V444_M0.6841.00
346_A349_C0.6781.00
384_S388_F0.6771.00
248_R252_F0.6741.00
287_Y290_D0.6741.00
188_A194_F0.6731.00
437_L441_V0.6721.00
14_T18_R0.6711.00
431_P438_Y0.6711.00
169_I256_S0.6701.00
65_L412_L0.6701.00
151_A155_F0.6701.00
392_Y402_L0.6701.00
44_A48_G0.6681.00
410_P413_P0.6671.00
332_N335_G0.6661.00
106_V369_L0.6661.00
313_R316_Y0.6651.00
171_L175_A0.6641.00
49_A257_I0.6641.00
51_L54_L0.6621.00
312_T340_S0.6611.00
327_A343_V0.6581.00
434_R443_F0.6561.00
423_V427_L0.6551.00
328_L340_S0.6551.00
88_I384_S0.6531.00
271_V274_S0.6521.00
67_L381_I0.6521.00
119_M135_F0.6521.00
139_M301_L0.6511.00
337_P340_S0.6501.00
238_I242_I0.6491.00
438_Y441_V0.6471.00
437_L442_P0.6461.00
269_A272_V0.6461.00
143_N309_Y0.6451.00
449_I452_H0.6451.00
50_V54_L0.6441.00
73_A393_I0.6441.00
129_W132_C0.6431.00
21_F24_S0.6431.00
55_V211_M0.6431.00
334_R338_M0.6411.00
64_M221_T0.6411.00
103_G374_A0.6401.00
81_Q85_T0.6401.00
319_A328_L0.6391.00
44_A47_L0.6391.00
437_L447_C0.6381.00
200_F203_G0.6371.00
274_S277_V0.6371.00
373_S377_G0.6361.00
271_V275_P0.6341.00
116_G128_V0.6341.00
116_G119_M0.6321.00
81_Q97_G0.6311.00
146_T149_A0.6311.00
107_T110_I0.6291.00
436_A441_V0.6261.00
71_A225_G0.6251.00
244_Q247_W0.6231.00
122_W294_F0.6221.00
229_G316_Y0.6211.00
31_T216_F0.6201.00
46_P49_A0.6181.00
225_G242_I0.6181.00
158_S161_K0.6171.00
51_L55_V0.6171.00
37_T257_I0.6171.00
118_L296_I0.6171.00
144_A341_L0.6161.00
112_F116_G0.6141.00
77_S316_Y0.6121.00
160_I164_I0.6111.00
121_R293_N0.6111.00
25_L158_S0.6111.00
420_N423_V0.6101.00
11_L14_T0.6101.00
109_A351_S0.6091.00
80_F222_E0.6091.00
27_G306_S0.6091.00
81_Q93_G0.6081.00
99_L377_G0.6081.00
206_A209_I0.6061.00
24_S28_V0.6061.00
275_P283_I0.6051.00
87_F388_F0.6041.00
18_R21_F0.6041.00
418_T421_T0.6041.00
27_G307_G0.6041.00
109_A366_L0.6011.00
219_Q222_E0.6001.00
435_I439_C0.6001.00
68_G72_V0.5981.00
39_F364_M0.5971.00
311_S315_L0.5961.00
234_P237_T0.5951.00
186_E190_F0.5941.00
111_E304_A0.5941.00
111_E300_L0.5921.00
264_I268_Q0.5921.00
440_G445_I0.5911.00
433_Q444_M0.5911.00
147_T227_A0.5901.00
88_I91_A0.5901.00
256_S260_I0.5891.00
406_T409_Y0.5881.00
71_A238_I0.5871.00
269_A275_P0.5851.00
50_V53_Y0.5851.00
62_L416_G0.5841.00
433_Q440_G0.5841.00
53_Y217_A0.5831.00
270_G274_S0.5801.00
160_I295_V0.5801.00
36_G367_L0.5801.00
186_E194_F0.5801.00
194_F198_G0.5791.00
66_C416_G0.5791.00
50_V254_V0.5791.00
226_V310_A0.5781.00
255_L259_V0.5761.00
208_L426_S0.5751.00
70_L87_F0.5741.00
299_A302_S0.5731.00
104_W307_G0.5711.00
438_Y444_M0.5711.00
136_A349_C0.5701.00
435_I444_M0.5701.00
230_E337_P0.5691.00
434_R441_V0.5691.00
149_A152_E0.5671.00
137_A140_F0.5641.00
84_A93_G0.5641.00
151_A305_N0.5631.00
416_G419_L0.5621.00
372_M424_L0.5601.00
107_T111_E0.5591.00
259_V262_G0.5581.00
413_P417_L0.5571.00
231_S238_I0.5571.00
145_I334_R0.5561.00
135_F304_A0.5561.00
388_F392_Y0.5561.00
122_W293_N0.5551.00
379_I424_L0.5551.00
11_L77_S0.5551.00
27_G223_L0.5541.00
248_R251_V0.5541.00
172_G176_M0.5531.00
89_S93_G0.5521.00
433_Q446_I0.5521.00
29_I252_F0.5501.00
40_T44_A0.5501.00
236_K239_P0.5491.00
187_Q193_H0.5481.00
155_F159_G0.5471.00
80_F226_V0.5471.00
364_M367_L0.5471.00
432_E438_Y0.5461.00
435_I443_F0.5451.00
105_A351_S0.5451.00
190_F262_G0.5441.00
434_R444_M0.5431.00
406_T412_L0.5421.00
176_M263_M0.5421.00
140_F308_L0.5411.00
414_L417_L0.5411.00
277_V281_E0.5411.00
65_L407_P0.5411.00
160_I298_I0.5411.00
294_F298_I0.5401.00
149_A153_S0.5381.00
40_T210_T0.5361.00
438_Y447_C0.5361.00
431_P445_I0.5351.00
96_F377_G0.5341.00
434_R440_G0.5331.00
20_L227_A0.5331.00
64_M68_G0.5321.00
30_G34_F0.5321.00
219_Q370_A0.5301.00
413_P427_L0.5281.00
231_S241_S0.5281.00
150_F309_Y0.5261.00
40_T214_V0.5261.00
350_L353_L0.5251.00
39_F42_N0.5241.00
134_V137_A0.5231.00
235_E240_R0.5221.00
260_I276_F0.5221.00
435_I445_I0.5211.00
171_L285_I0.5201.00
256_S276_F0.5201.00
393_I400_E0.5191.00
448_Y453_V0.5191.00
315_L319_A0.5181.00
313_R331_T0.5181.00
276_F279_V0.5171.00
138_L142_L0.5161.00
100_Y377_G0.5161.00
312_T344_T0.5161.00
417_L420_N0.5161.00
415_I418_T0.5151.00
436_A444_M0.5151.00
112_F139_M0.5151.00
79_S225_G0.5141.00
147_T151_A0.5131.00
399_I403_K0.5131.00
37_T260_I0.5131.00
235_E403_K0.5131.00
195_Y198_G0.5111.00
389_R409_Y0.5111.00
111_E114_S0.5111.00
226_V314_I0.5101.00
356_F363_Y0.5091.00
327_A331_T0.5081.00
273_E277_V0.5071.00
343_V347_V0.5061.00
437_L443_F0.5061.00
66_C406_T0.5061.00
34_F161_K0.5041.00
304_A307_G0.5031.00
154_E302_S0.5031.00
388_F393_I0.5021.00
420_N424_L0.5021.00
93_G97_G0.5011.00
196_E199_L0.5011.00
166_L169_I0.5001.00
253_F257_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8951 100 0.295 Contact Map
3giaA 1 0.9101 100 0.359 Contact Map
4djkA 2 0.8779 100 0.36 Contact Map
3dh4A 3 0.9143 99.1 0.843 Contact Map
2xq2A 2 0.9165 99.1 0.847 Contact Map
2jlnA 1 0.9101 98.8 0.861 Contact Map
4xp4A 1 0.9229 98.3 0.881 Contact Map
2a65A 2 0.9208 98.2 0.885 Contact Map
4wgvA 2 0.788 97.7 0.899 Contact Map
4us3A 1 0.8415 97.7 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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