GREMLIN Database
SFP - 4'-phosphopantetheinyl transferase sfp
UniProt: P39135 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (195)
Sequences: 1977 (1686)
Seq/√Len: 120.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_H103_P3.2131.00
37_H40_D3.0051.00
96_I202_M2.8941.00
124_S169_S2.8481.00
98_A104_I2.8251.00
28_K48_D2.7641.00
96_I106_I2.7271.00
156_Q189_C2.6551.00
75_K85_H2.5521.00
69_S77_C2.5461.00
149_M193_T2.4001.00
127_E150_K2.2471.00
149_M170_V2.2211.00
154_I165_L2.2141.00
55_I86_F2.1741.00
32_C45_L2.1281.00
35_F40_D2.1211.00
109_E148_S2.0771.00
149_M191_I2.0731.00
152_S205_C2.0461.00
91_S109_E2.0311.00
40_D43_R2.0141.00
148_S203_A1.9861.00
54_V97_C1.9511.00
54_V99_F1.9341.00
32_C44_T1.8541.00
154_I159_K1.8331.00
44_T48_D1.8301.00
21_M33_R1.8271.00
194_Y202_M1.8231.00
145_H193_T1.7371.00
126_T169_S1.7241.00
98_A106_I1.6901.00
75_K103_P1.6881.00
98_A204_V1.6641.00
69_S79_P1.6461.00
89_S96_I1.6331.00
131_L134_K1.5711.00
56_S66_I1.5711.00
119_A128_Y1.5551.00
50_L95_V1.5331.00
140_T144_Y1.5151.00
39_E43_R1.5081.00
119_A122_F1.4991.00
43_R93_R1.4981.00
136_K139_Q1.4851.00
130_D142_Y1.4791.00
130_D146_L1.4711.00
28_K44_T1.4501.00
31_K44_T1.4461.00
59_Y66_I1.4331.00
154_I163_L1.4321.00
92_G110_K1.4141.00
134_K142_Y1.4091.00
47_G95_V1.3711.00
159_K163_L1.3411.00
24_I28_K1.3351.00
48_D88_I1.3321.00
30_E34_R1.3281.00
154_I161_L1.3181.00
149_M203_A1.3151.00
47_G88_I1.3051.00
94_W108_I1.3041.00
46_L95_V1.3021.00
111_T144_Y1.2801.00
56_S63_K1.2771.00
36_Y40_D1.2590.99
170_V191_I1.2570.99
112_K144_Y1.2490.99
100_D104_I1.2270.99
71_Q77_C1.2190.99
138_E141_D1.2010.99
38_K41_A1.1900.99
88_I97_C1.1840.99
66_I78_I1.1640.99
193_T203_A1.1630.99
25_S52_R1.1570.99
28_K52_R1.1410.99
32_C35_F1.1370.99
31_K70_T1.1360.99
154_I168_F1.1360.99
161_L165_L1.1320.99
29_R33_R1.1300.99
24_I44_T1.1270.99
153_F157_E1.1230.99
120_K128_Y1.1140.99
51_V88_I1.1020.99
56_S59_Y1.1010.99
51_V97_C1.0760.98
52_R63_K1.0650.98
103_P207_A1.0610.98
26_P30_E1.0590.98
164_P167_S1.0350.98
59_Y78_I1.0300.98
197_D200_Y1.0290.98
61_L66_I1.0260.98
125_K129_S1.0100.98
153_F205_C1.0080.98
142_Y145_H1.0060.98
48_D52_R0.9990.97
67_R79_P0.9980.97
58_Q84_A0.9880.97
52_R56_S0.9870.97
142_Y146_L0.9810.97
26_P29_R0.9750.97
50_L97_C0.9610.97
21_M29_R0.9520.97
90_H108_I0.9520.97
40_D95_V0.9500.96
38_K42_H0.9400.96
85_H100_D0.9390.96
93_R200_Y0.9280.96
73_Y162_S0.9250.96
62_D65_D0.9210.96
52_R66_I0.9170.96
82_P106_I0.9010.95
91_S110_K0.8990.95
118_I154_I0.8900.95
145_H201_K0.8880.95
39_E92_G0.8850.95
13_S16_E0.8800.95
53_S57_R0.8750.94
86_F97_C0.8650.94
19_R22_S0.8580.94
144_Y201_K0.8540.94
75_K87_N0.8510.94
154_I160_G0.8510.94
116_L119_A0.8490.94
89_S108_I0.8440.93
134_K138_E0.8430.93
163_L167_S0.8410.93
75_K86_F0.8390.93
16_E19_R0.8360.93
91_S148_S0.8340.93
16_E20_F0.8270.93
86_F143_F0.8260.93
164_P168_F0.8250.93
111_T201_K0.8180.92
109_E119_A0.8100.92
118_I122_F0.8070.92
54_V58_Q0.8050.92
58_Q189_C0.8040.92
43_R92_G0.8010.91
148_S193_T0.8010.91
62_D114_I0.8000.91
28_K56_S0.8000.91
58_Q99_F0.7950.91
23_F53_S0.7930.91
48_D70_T0.7920.91
161_L164_P0.7910.91
75_K158_G0.7910.91
123_F168_F0.7880.91
43_R91_S0.7850.91
102_Q207_A0.7820.90
141_D201_K0.7800.90
129_S133_A0.7750.90
118_I143_F0.7730.90
194_Y197_D0.7590.89
157_E163_L0.7550.89
163_L168_F0.7460.88
123_F128_Y0.7450.88
25_S28_K0.7390.88
24_I48_D0.7340.87
94_W197_D0.7340.87
123_F165_L0.7330.87
52_R68_F0.7320.87
167_S182_L0.7270.87
113_P140_T0.7270.87
51_V78_I0.7250.87
79_P82_P0.7230.87
149_M153_F0.7230.87
25_S48_D0.7220.87
131_L146_L0.7210.86
51_V95_V0.7160.86
116_L139_Q0.7150.86
91_S200_Y0.7120.86
47_G51_V0.7100.86
110_K199_G0.7090.86
35_F44_T0.7080.85
51_V109_E0.7070.85
135_D138_E0.7040.85
48_D152_S0.7010.85
120_K132_L0.7010.85
26_P133_A0.6980.85
196_V202_M0.6960.84
171_R174_Q0.6940.84
22_S64_S0.6920.84
191_I205_C0.6890.84
50_L96_I0.6880.84
48_D51_V0.6840.83
153_F156_Q0.6830.83
149_M202_M0.6830.83
122_F165_L0.6820.83
92_G200_Y0.6820.83
146_L170_V0.6800.83
114_I140_T0.6800.83
131_L142_Y0.6760.83
30_E33_R0.6730.82
117_E121_R0.6720.82
51_V86_F0.6660.82
109_E112_K0.6620.81
71_Q87_N0.6610.81
128_Y132_L0.6590.81
87_N154_I0.6540.81
194_Y204_V0.6460.80
107_D151_E0.6420.79
141_D195_E0.6400.79
108_I200_Y0.6360.79
48_D156_Q0.6360.79
29_R37_H0.6350.79
17_N22_S0.6310.78
28_K31_K0.6290.78
189_C205_C0.6290.78
55_I63_K0.6280.78
51_V55_I0.6280.78
21_M32_C0.6270.78
24_I41_A0.6250.78
189_C207_A0.6230.77
20_F23_F0.6210.77
61_L65_D0.6210.77
190_Y194_Y0.6200.77
124_S150_K0.6190.77
50_L53_S0.6150.76
28_K152_S0.6150.76
149_M171_R0.6140.76
153_F189_C0.6110.76
17_N24_I0.6070.76
104_I111_T0.6050.75
51_V99_F0.6000.75
183_P186_H0.6000.75
118_I121_R0.5990.75
17_N41_A0.5990.75
18_E21_M0.5960.74
119_A131_L0.5950.74
122_F128_Y0.5930.74
51_V68_F0.5910.74
87_N97_C0.5910.74
44_T47_G0.5880.73
32_C52_R0.5880.73
15_E19_R0.5870.73
40_D44_T0.5850.73
116_L131_L0.5850.73
122_F168_F0.5810.72
44_T88_I0.5760.72
100_D206_A0.5730.71
40_D92_G0.5720.71
177_Q181_E0.5700.71
112_K133_A0.5640.70
52_R55_I0.5640.70
190_Y206_A0.5580.69
13_S129_S0.5540.69
146_L149_M0.5520.68
32_C184_D0.5520.68
40_D114_I0.5500.68
154_I162_S0.5490.68
31_K45_L0.5470.68
188_P204_V0.5440.67
153_F191_I0.5440.67
105_G155_K0.5430.67
91_S144_Y0.5430.67
128_Y131_L0.5430.67
33_R41_A0.5410.67
51_V91_S0.5400.67
123_F143_F0.5400.67
188_P207_A0.5400.67
24_I63_K0.5390.67
105_G151_E0.5380.67
77_C99_F0.5380.67
145_H149_M0.5360.66
172_L178_V0.5360.66
116_L152_S0.5350.66
23_F28_K0.5340.66
118_I123_F0.5330.66
28_K156_Q0.5320.66
25_S68_F0.5300.65
51_V70_T0.5290.65
31_K41_A0.5290.65
54_V88_I0.5280.65
125_K166_D0.5260.65
153_F160_G0.5200.64
183_P187_S0.5170.63
22_S29_R0.5160.63
50_L89_S0.5160.63
84_A153_F0.5140.63
156_Q205_C0.5130.63
87_N158_G0.5090.62
124_S131_L0.5070.62
34_R70_T0.5040.62
87_N144_Y0.5030.61
14_Q20_F0.5020.61
53_S60_Q0.5010.61
122_F166_D0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qr0A 2 1 100 0.175 Contact Map
2c43A 1 0.9866 100 0.254 Contact Map
4qjkA 1 0.8929 100 0.457 Contact Map
4qvhA 2 0.875 100 0.457 Contact Map
4jm7A 3 0.5491 99.9 0.588 Contact Map
3hykA 3 0.5 99.7 0.676 Contact Map
2wasA 3 0.4732 99.7 0.685 Contact Map
1fthA 3 0.4911 99.7 0.687 Contact Map
1f7lA 3 0.4866 99.6 0.694 Contact Map
2wdsA 3 0.4821 99.6 0.694 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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