GREMLIN Database
YHBF - Uncharacterized protein YhbF
UniProt: P39133 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (215)
Sequences: 276 (238)
Seq/√Len: 16.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_A213_G4.1491.00
45_Y62_L4.0121.00
133_V155_V3.5981.00
160_G163_I3.5341.00
28_K45_Y3.2970.99
165_V179_L3.2480.99
191_L199_V3.2060.99
159_G187_D2.8970.98
138_L159_G2.8380.98
79_Y96_K2.8010.97
182_D197_A2.6930.97
125_E140_N2.6110.96
62_L79_Y2.5530.95
142_G161_T2.4500.94
107_G124_T2.4300.94
45_Y79_Y2.4200.94
39_A42_C2.3070.92
56_T59_L2.2540.91
28_K79_Y2.2400.91
47_T81_T2.1450.89
19_G25_V2.1400.89
62_L96_K2.0440.87
25_V39_A1.9630.84
214_T233_T1.9000.82
200_R216_E1.8490.80
148_L209_G1.8480.80
20_G39_A1.8180.79
28_K62_L1.8110.79
202_K218_E1.7840.78
30_E64_E1.7810.78
203_E219_Y1.7790.78
64_E81_T1.7700.77
221_C232_K1.7120.75
20_G25_V1.7020.74
36_G56_T1.6980.74
204_V215_I1.6570.72
135_V139_L1.6560.72
19_G22_Y1.6490.72
36_G39_A1.6030.70
181_A184_I1.5900.69
140_N159_G1.5730.68
112_V116_L1.5700.68
184_I212_I1.5660.68
22_Y25_V1.5660.68
61_V78_I1.5610.67
127_F135_V1.5550.67
87_S103_G1.5550.67
45_Y96_K1.5540.67
206_I215_I1.5260.66
27_I31_G1.5110.65
26_S77_N1.4950.64
121_D137_G1.4850.63
38_S55_E1.4420.61
139_L216_E1.4330.61
19_G39_A1.4210.60
188_R203_E1.4200.60
42_C50_F1.4170.60
121_D138_L1.4080.59
190_Y227_S1.3910.58
127_F133_V1.3880.58
25_V42_C1.3860.58
171_F204_V1.3840.58
47_T64_E1.3800.58
53_K69_G1.3760.57
33_V36_G1.3730.57
122_C135_V1.3530.56
185_E200_R1.3290.55
122_C139_L1.3270.55
33_V39_A1.2930.53
84_V112_V1.2870.52
206_I212_I1.2830.52
165_V183_V1.2810.52
165_V204_V1.2650.51
193_N212_I1.2640.51
208_P224_D1.2430.50
20_G36_G1.2260.49
140_N187_D1.2190.48
156_Q182_D1.1910.47
44_I48_G1.1630.45
127_F144_I1.1600.45
159_G200_R1.1570.45
157_E187_D1.1530.44
186_G200_R1.1510.44
191_L210_C1.1470.44
129_V167_R1.1300.43
127_F146_L1.1270.43
19_G36_G1.1240.43
148_L179_L1.1240.43
25_V33_V1.1180.42
207_G210_C1.1000.41
212_I227_S1.0930.41
137_G200_R1.0860.41
69_G84_V1.0740.40
139_L200_R1.0690.40
70_D86_G1.0580.39
95_L112_V1.0430.38
96_K113_K1.0390.38
65_S130_T1.0340.38
215_I221_C1.0330.38
36_G42_C1.0210.37
195_E211_S1.0140.37
22_Y105_M1.0110.37
36_G53_K1.0090.36
129_V142_G1.0080.36
25_V73_A1.0030.36
144_I188_R0.9770.35
181_A213_G0.9740.35
48_G65_S0.9700.34
22_Y39_A0.9660.34
19_G33_V0.9580.34
187_D200_R0.9550.34
34_G51_L0.9490.33
39_A56_T0.9470.33
157_E185_E0.9470.33
159_G185_E0.9460.33
106_T144_I0.9460.33
221_C229_I0.9410.33
110_C124_T0.9410.33
33_V56_T0.9380.33
105_M110_C0.9320.32
48_G78_I0.9270.32
53_K70_D0.9150.31
144_I218_E0.9090.31
42_C59_L0.9050.31
28_K96_K0.8960.31
85_S171_F0.8940.30
133_V153_S0.8880.30
64_E118_V0.8870.30
28_K88_L0.8850.30
22_Y36_G0.8730.29
139_L160_G0.8680.29
224_D227_S0.8670.29
100_E155_V0.8640.29
30_E45_Y0.8620.29
140_N200_R0.8610.29
211_S230_K0.8560.29
44_I165_V0.8480.28
135_V160_G0.8400.28
205_I222_E0.8400.28
19_G42_C0.8370.28
61_V116_L0.8360.28
139_L159_G0.8350.28
30_E47_T0.8140.27
54_A118_V0.8140.27
70_D221_C0.8070.26
121_D155_V0.8050.26
108_E192_E0.8040.26
56_T73_A0.8040.26
23_H40_V0.8020.26
138_L187_D0.8020.26
21_A38_S0.8020.26
62_L113_K0.8000.26
198_V214_T0.7890.26
208_P226_H0.7870.25
193_N208_P0.7860.25
155_V181_A0.7850.25
122_C160_G0.7840.25
74_G104_N0.7730.25
201_G207_G0.7700.25
121_D142_G0.7620.24
118_V156_Q0.7600.24
196_A221_C0.7600.24
141_S144_I0.7580.24
127_F141_S0.7550.24
112_V146_L0.7520.24
19_G204_V0.7430.24
157_E182_D0.7410.23
155_V160_G0.7410.23
76_I234_K0.7410.23
20_G33_V0.7340.23
27_I167_R0.7300.23
123_E159_G0.7260.23
140_N185_E0.7250.23
163_I186_G0.7230.23
130_T171_F0.7200.23
30_E79_Y0.7160.22
32_I168_R0.7150.22
34_G37_L0.7130.22
130_T204_V0.7110.22
167_R189_V0.7110.22
121_D200_R0.7100.22
30_E81_T0.7100.22
45_Y64_E0.7080.22
25_V194_T0.7080.22
199_V212_I0.7060.22
208_P212_I0.7030.22
72_T228_Q0.7020.22
87_S120_G0.6970.22
133_V179_L0.6970.22
125_E216_E0.6960.22
213_G234_K0.6940.22
205_I224_D0.6940.22
140_N163_I0.6930.21
108_E222_E0.6910.21
31_G42_C0.6910.21
154_H180_I0.6890.21
191_L196_A0.6890.21
157_E216_E0.6850.21
65_S99_T0.6820.21
59_L70_D0.6800.21
116_L180_I0.6750.21
120_G165_V0.6720.21
69_G163_I0.6690.21
219_Y234_K0.6660.20
63_G97_G0.6660.20
122_C196_A0.6620.20
165_V191_L0.6620.20
35_E51_L0.6570.20
31_G163_I0.6540.20
186_G201_G0.6510.20
187_D198_V0.6480.20
187_D216_E0.6470.20
67_C85_S0.6460.20
25_V52_G0.6440.20
22_Y35_E0.6400.19
215_I227_S0.6370.19
137_G187_D0.6370.19
30_E62_L0.6360.19
154_H230_K0.6350.19
73_A116_L0.6250.19
84_V226_H0.6250.19
53_K93_F0.6240.19
156_Q229_I0.6210.19
99_T177_G0.6210.19
23_H165_V0.6200.19
201_G206_I0.6200.19
46_G97_G0.6200.19
122_C173_S0.6170.19
76_I90_F0.6160.19
107_G158_I0.6110.18
22_Y33_V0.6110.18
71_L88_L0.6090.18
125_E200_R0.6050.18
92_R109_S0.6010.18
223_C232_K0.5990.18
22_Y42_C0.5980.18
221_C224_D0.5970.18
52_G103_G0.5960.18
82_M88_L0.5950.18
78_I161_T0.5930.18
142_G187_D0.5880.18
55_E72_T0.5870.18
101_I146_L0.5870.18
20_G199_V0.5860.18
162_T188_R0.5810.17
47_T98_Q0.5810.17
92_R204_V0.5810.17
167_R193_N0.5780.17
189_V204_V0.5770.17
67_C177_G0.5740.17
53_K67_C0.5730.17
66_E81_T0.5720.17
199_V206_I0.5710.17
185_E216_E0.5680.17
90_F94_N0.5670.17
27_I35_E0.5660.17
220_K225_P0.5660.17
79_Y153_S0.5650.17
200_R214_T0.5630.17
59_L108_E0.5620.17
126_M143_E0.5620.17
47_T84_V0.5620.17
93_F219_Y0.5600.17
93_F172_F0.5600.17
87_S136_S0.5600.17
68_K180_I0.5590.17
40_V221_C0.5590.17
103_G123_E0.5580.17
134_D147_G0.5550.17
110_C119_I0.5500.16
207_G212_I0.5500.16
160_G186_G0.5500.16
38_S76_I0.5500.16
89_Q145_K0.5490.16
76_I230_K0.5490.16
27_I99_T0.5480.16
81_T113_K0.5470.16
123_E140_N0.5450.16
221_C228_Q0.5440.16
97_G131_G0.5440.16
58_R68_K0.5420.16
79_Y113_K0.5410.16
104_N120_G0.5410.16
49_L161_T0.5400.16
93_F99_T0.5400.16
80_G114_G0.5370.16
25_V36_G0.5370.16
71_L226_H0.5360.16
85_S116_L0.5350.16
87_S118_V0.5350.16
101_I205_I0.5350.16
122_C129_V0.5310.16
153_S219_Y0.5310.16
142_G176_K0.5300.16
114_G131_G0.5300.16
33_V37_L0.5300.16
37_L171_F0.5300.16
47_T62_L0.5280.16
196_A227_S0.5270.16
141_S194_T0.5260.16
144_I158_I0.5260.16
94_N155_V0.5180.15
90_F93_F0.5160.15
57_E86_G0.5160.15
140_N198_V0.5140.15
193_N209_G0.5100.15
135_V161_T0.5100.15
67_C209_G0.5090.15
59_L134_D0.5080.15
148_L153_S0.5070.15
124_T183_V0.5070.15
78_I99_T0.5070.15
129_V153_S0.5060.15
179_L194_T0.5060.15
33_V44_I0.5060.15
194_T217_Y0.5050.15
35_E213_G0.5040.15
66_E75_K0.5030.15
155_V158_I0.5030.15
127_F153_S0.5030.15
139_L186_G0.5030.15
77_N181_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lycA 2 0.6638 94.8 0.908 Contact Map
3jx8A 4 0.6383 93.8 0.912 Contact Map
3petA 2 0.5915 93.6 0.913 Contact Map
4opwA 1 0.6383 91.8 0.918 Contact Map
4yguA 3 0.4553 88.7 0.923 Contact Map
5afuV 1 0.4043 37.1 0.948 Contact Map
1xatA 3 0.3787 36 0.949 Contact Map
4eqyA 3 0.2979 22.9 0.953 Contact Map
2pigA 1 0.6638 22.6 0.953 Contact Map
2wlgA 3 0.3404 20.5 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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