GREMLIN Database
YHBE - Uncharacterized protein YhbE
UniProt: P39132 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (230)
Sequences: 293 (249)
Seq/√Len: 16.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_N60_S4.8231.00
199_K215_E4.2721.00
131_C153_A4.1231.00
158_C161_L4.0151.00
193_L201_V3.8691.00
163_V181_L3.8191.00
26_N43_N3.2100.99
136_L157_G3.0570.99
45_N62_S2.8380.98
26_N77_N2.7220.97
43_N77_N2.6810.97
157_G189_D2.6620.97
184_E199_K2.5940.96
140_D159_R2.5570.96
10_N26_N2.5170.95
28_S62_S2.4370.94
54_A57_V2.3810.94
123_E138_N2.3570.93
6_K21_Q2.3540.93
77_N94_A2.2910.92
133_I137_L2.2260.91
60_S77_N2.1640.90
105_A122_T2.1540.90
45_N79_T2.1030.88
216_T235_T2.0790.88
12_S28_S2.0650.87
205_K221_G2.0480.87
26_N60_S2.0230.86
37_C40_F2.0110.86
208_I214_I1.8900.82
204_N220_S1.8870.82
208_I217_V1.8780.82
223_Y234_S1.8680.81
193_L212_C1.8640.81
32_A49_D1.8310.80
146_L211_D1.8200.80
202_R218_E1.8020.79
72_E102_T1.6640.73
62_S79_T1.6620.73
60_S94_A1.6430.72
135_G202_R1.6040.70
183_A186_I1.5760.69
13_G149_G1.5670.68
186_I214_I1.5510.68
138_N157_G1.5140.66
163_V206_V1.5040.65
9_I34_D1.4910.64
7_L146_L1.4610.63
137_L158_C1.4580.63
119_D135_G1.4230.61
110_I114_A1.3920.59
15_S20_F1.3910.59
8_V216_T1.3790.58
85_E101_G1.3710.58
59_I76_M1.3580.57
157_G202_R1.3450.56
187_E202_R1.3300.55
82_I110_I1.3260.55
120_C133_I1.3190.55
133_I158_C1.3170.55
51_S67_G1.3060.54
16_K20_F1.2940.53
197_K213_Q1.2850.53
125_F144_I1.2830.53
36_E53_K1.2820.53
137_L218_E1.2640.51
42_F46_G1.2560.51
163_V185_L1.2410.50
13_G29_G1.2270.49
12_S31_V1.2190.49
41_S75_R1.2140.49
155_E189_D1.2070.48
210_P226_D1.2040.48
108_I122_T1.1970.48
50_G101_G1.1960.47
76_M176_M1.1690.46
125_F131_C1.1530.45
27_G78_G1.1410.44
190_V205_K1.1280.44
183_A215_E1.1250.43
125_F142_V1.1250.43
206_V217_V1.1180.43
120_C137_L1.1050.42
119_D153_A1.1040.42
19_T36_E1.0970.42
214_I229_A1.0930.42
154_R184_E1.0920.41
9_I29_G1.0880.41
73_S206_V1.0850.41
138_N189_D1.0730.40
125_F139_A1.0690.40
188_G202_R1.0630.40
34_D51_S1.0590.40
158_C188_G1.0560.39
146_L181_L1.0560.39
10_N30_T1.0520.39
210_P228_S1.0460.39
223_Y226_D1.0450.39
223_Y231_V1.0350.38
192_E229_A1.0280.38
78_G112_G1.0270.38
208_I213_Q1.0220.38
195_N214_I1.0200.37
128_E206_V1.0170.37
217_V223_Y1.0120.37
50_G144_I1.0060.37
10_N43_N1.0050.37
59_I97_S1.0040.37
43_N94_A1.0030.36
154_R231_V0.9930.36
40_F48_A0.9870.36
17_G23_V0.9860.36
161_L188_G0.9840.35
155_E187_E0.9820.35
57_V235_T0.9770.35
193_L198_A0.9690.35
119_D136_L0.9660.35
191_I206_V0.9640.34
215_E236_K0.9630.34
90_Q206_V0.9600.34
187_E191_I0.9490.34
33_G215_E0.9490.34
142_V190_V0.9440.33
156_I181_L0.9400.33
28_S45_N0.9360.33
17_G20_F0.9340.33
71_A82_I0.9230.32
54_A206_V0.9200.32
11_G18_G0.9150.32
21_Q38_D0.9110.32
157_G187_E0.9080.31
121_E157_G0.9080.31
217_V229_A0.9080.31
209_G212_C0.9060.31
131_C151_S0.9050.31
127_S165_C0.8980.31
139_A142_V0.8870.30
47_K179_P0.8830.30
93_I110_I0.8710.30
189_D202_R0.8670.29
74_I232_E0.8640.29
133_I161_L0.8600.29
10_N13_G0.8570.29
226_D229_A0.8570.29
77_N151_S0.8520.29
137_L157_G0.8500.29
153_A183_A0.8490.29
119_D140_D0.8490.29
40_F57_V0.8480.29
6_K151_S0.8460.28
207_I224_T0.8360.28
221_G236_K0.8340.28
186_I212_C0.8220.27
137_L161_L0.8190.27
136_L189_D0.8150.27
32_A35_V0.8120.27
27_G33_G0.8100.27
142_V220_S0.8060.27
50_G202_R0.7990.26
137_L202_R0.7980.26
138_N187_E0.7980.26
127_S140_D0.7910.26
102_T118_A0.7890.26
22_S25_I0.7890.26
55_K222_D0.7860.26
200_T216_T0.7760.25
116_M191_I0.7750.25
12_S45_N0.7740.25
138_N200_T0.7740.25
30_T166_R0.7740.25
12_S16_K0.7730.25
103_V108_I0.7710.25
55_K72_E0.7710.25
99_F207_I0.7680.25
196_T201_V0.7670.25
77_N111_S0.7660.25
35_V65_I0.7650.25
173_L236_K0.7650.25
7_L15_S0.7640.25
195_N210_P0.7640.25
10_N77_N0.7610.25
193_L196_T0.7600.25
139_A196_T0.7600.25
112_G129_G0.7580.24
51_S68_D0.7560.24
146_L151_S0.7540.24
213_Q232_E0.7490.24
69_V86_V0.7460.24
34_D146_L0.7410.24
62_S116_M0.7400.24
28_S43_N0.7320.23
124_T182_T0.7320.23
211_D228_S0.7300.23
75_R88_A0.7290.23
116_M154_R0.7290.23
152_Y229_A0.7260.23
69_V82_I0.7230.23
72_E134_S0.7200.23
28_S79_T0.7140.23
57_V132_K0.7110.22
138_N202_R0.7100.22
9_I13_G0.7020.22
40_F46_G0.6990.22
207_I226_D0.6950.22
114_A182_T0.6950.22
91_L97_S0.6940.22
57_V71_A0.6920.22
17_G37_C0.6910.22
125_F133_I0.6870.21
108_I171_T0.6870.21
21_Q41_S0.6850.21
76_M114_A0.6840.21
36_E65_I0.6810.21
76_M93_I0.6800.21
52_V72_E0.6710.21
198_A209_G0.6690.21
61_G95_G0.6690.21
141_Q173_L0.6650.21
50_G194_T0.6640.21
84_G95_G0.6620.20
50_G188_G0.6610.20
97_S120_C0.6600.20
18_G201_V0.6560.20
82_I114_A0.6540.20
51_S174_R0.6530.20
59_I80_G0.6530.20
24_E163_V0.6520.20
122_T185_L0.6520.20
73_S229_A0.6510.20
131_C183_A0.6500.20
120_C127_S0.6490.20
69_V169_M0.6480.20
120_C183_A0.6450.20
215_E232_E0.6450.20
12_S26_N0.6440.20
225_C234_S0.6440.20
31_V35_V0.6430.20
35_V232_E0.6330.19
124_T221_G0.6330.19
223_Y230_S0.6330.19
26_N94_A0.6310.19
9_I14_S0.6290.19
121_E202_R0.6260.19
119_D172_L0.6240.19
110_I144_I0.6230.19
110_I127_S0.6200.19
23_V196_T0.6180.19
106_D224_T0.6180.19
152_Y232_E0.6150.19
15_S32_A0.6150.19
160_H190_V0.6150.19
29_G40_F0.6150.19
67_G82_I0.6100.19
18_G37_C0.6100.19
65_I186_I0.6090.19
40_F236_K0.6050.18
33_G129_G0.6030.18
70_E162_Q0.6010.18
12_S62_S0.5990.18
6_K71_A0.5960.18
170_L176_M0.5960.18
155_E218_E0.5960.18
137_L164_T0.5950.18
165_C191_I0.5930.18
98_T153_A0.5920.18
198_A223_Y0.5880.18
65_I74_I0.5850.18
95_G212_C0.5840.18
25_I156_I0.5820.18
121_E139_A0.5810.18
203_G209_G0.5810.18
79_T236_K0.5810.18
194_T218_E0.5800.18
173_L182_T0.5780.17
128_E184_E0.5780.17
21_Q97_S0.5780.17
222_D229_A0.5750.17
18_G23_V0.5730.17
20_F33_G0.5720.17
10_N60_S0.5720.17
76_M97_S0.5690.17
23_V37_C0.5690.17
79_T140_D0.5680.17
15_S213_Q0.5680.17
26_N45_N0.5660.17
192_E210_P0.5630.17
35_V221_G0.5620.17
132_K145_K0.5620.17
120_C198_A0.5610.17
78_G129_G0.5600.17
123_E191_I0.5590.17
177_P180_V0.5590.17
50_G187_E0.5560.17
91_L175_L0.5540.17
137_L188_G0.5530.17
28_S60_S0.5530.17
30_T98_T0.5500.17
26_N31_V0.5480.16
94_A111_S0.5480.16
55_K165_C0.5470.16
165_C195_N0.5450.16
213_Q224_T0.5450.16
35_V57_V0.5440.16
163_V193_L0.5400.16
155_E184_E0.5340.16
17_G67_G0.5340.16
110_I125_F0.5330.16
124_T141_Q0.5330.16
22_S28_S0.5300.16
52_V185_L0.5290.16
73_S205_K0.5280.16
183_A198_A0.5270.16
203_G208_I0.5270.16
138_N161_L0.5270.16
197_K208_I0.5250.16
31_V220_S0.5230.16
53_K70_E0.5230.16
191_I203_G0.5230.16
45_N111_S0.5220.16
114_A173_L0.5200.16
6_K121_E0.5200.16
65_I72_E0.5200.16
68_D84_G0.5190.16
130_K217_V0.5180.16
135_G204_N0.5180.16
105_A156_I0.5160.15
88_A92_K0.5140.15
183_A193_L0.5140.15
85_E116_M0.5130.15
108_I117_E0.5120.15
10_N14_S0.5120.15
216_T233_T0.5120.15
24_E114_A0.5110.15
195_N211_D0.5100.15
16_K74_I0.5100.15
123_E202_R0.5090.15
34_D37_C0.5090.15
181_L196_T0.5050.15
123_E218_E0.5040.15
43_N205_K0.5030.15
85_E118_A0.5010.15
153_A222_D0.5010.15
138_N218_E0.5010.15
181_L209_G0.5000.15
120_C161_L0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lycA 2 0.6835 94.4 0.908 Contact Map
3jx8A 4 0.6498 94.1 0.909 Contact Map
4opwA 1 0.6667 92.7 0.914 Contact Map
3petA 2 0.5654 90.8 0.918 Contact Map
4yguA 3 0.443 87.3 0.923 Contact Map
2pigA 1 0.8945 54.7 0.941 Contact Map
1xatA 3 0.2996 41.4 0.946 Contact Map
4eqyA 3 0.2954 37.5 0.947 Contact Map
4mfgA 3 0.4135 26.5 0.951 Contact Map
3tv0A 3 0.4008 25 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0079 seconds.