GREMLIN Database
MNAA - UDP-N-acetylglucosamine 2-epimerase
UniProt: P39131 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (355)
Sequences: 4348 (2972)
Seq/√Len: 157.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_T141_T3.1711.00
170_F362_E2.9631.00
354_E357_R2.8771.00
92_I117_G2.8191.00
156_K160_L2.8091.00
29_Y364_L2.7811.00
354_E358_R2.7691.00
225_R323_E2.7641.00
25_E357_R2.7071.00
25_E28_K2.6081.00
86_K112_H2.5361.00
5_K33_D2.5281.00
142_G148_H2.5191.00
7_M37_T2.4661.00
82_D112_H2.4121.00
8_T34_S2.4091.00
157_D161_K2.3961.00
139_Q143_A2.3161.00
103_F140_M2.2661.00
156_K171_V2.2121.00
153_G157_D2.2101.00
234_Q260_H2.2011.00
94_L117_G2.1851.00
329_L332_Q2.1831.00
31_E364_L2.1781.00
204_L235_V2.1701.00
299_L319_A2.1221.00
35_Y88_I2.1151.00
221_K323_E2.1121.00
85_F114_I2.1021.00
202_I235_V2.0791.00
184_V275_A2.0761.00
78_L108_A2.0621.00
230_F335_T2.0531.00
230_F331_K1.9881.00
281_L301_L1.9831.00
310_G316_L1.9701.00
32_I364_L1.9531.00
200_K278_H1.9471.00
80_R83_E1.9391.00
165_K168_S1.8681.00
270_F287_V1.8571.00
279_F330_A1.8501.00
217_E251_K1.8381.00
93_V109_A1.8271.00
229_E331_K1.8271.00
352_D358_R1.8001.00
9_V105_G1.7951.00
117_G149_F1.7821.00
225_R327_Y1.7801.00
247_E251_K1.7521.00
24_L27_K1.7471.00
29_Y361_E1.7031.00
156_K166_A1.6941.00
26_L32_I1.6881.00
39_T101_T1.6871.00
322_D325_N1.6761.00
92_I363_L1.6591.00
47_D51_D1.6341.00
274_A280_I1.6181.00
319_A329_L1.5951.00
128_K146_D1.5891.00
75_S79_V1.5831.00
65_K76_N1.5801.00
236_V273_F1.5511.00
72_E83_E1.5491.00
128_K136_L1.5491.00
300_V316_L1.5411.00
83_E87_D1.5301.00
76_N79_V1.5231.00
154_Q312_E1.5221.00
227_V258_R1.5121.00
199_D234_Q1.4971.00
23_V36_V1.4891.00
50_L57_P1.4871.00
325_N329_L1.4751.00
191_P195_Q1.4741.00
149_F359_I1.4681.00
71_A112_H1.4671.00
59_F84_L1.4641.00
226_I330_A1.4571.00
85_F108_A1.4511.00
201_M276_K1.4391.00
147_L366_H1.4371.00
8_T23_V1.4271.00
150_A159_L1.4181.00
25_E29_Y1.4161.00
204_L223_I1.4131.00
59_F88_I1.4121.00
78_L107_L1.4121.00
40_A62_N1.4031.00
72_E79_V1.4011.00
22_L175_T1.3981.00
203_L274_A1.3961.00
277_S296_K1.3961.00
22_L356_S1.3961.00
76_N80_R1.3941.00
85_F93_V1.3941.00
92_I147_L1.3911.00
84_L88_I1.3871.00
143_A164_K1.3761.00
74_T104_A1.3611.00
71_A82_D1.3591.00
317_K329_L1.3521.00
9_V39_T1.3521.00
214_E217_E1.3451.00
8_T26_L1.3431.00
115_A146_D1.3421.00
26_L363_L1.3411.00
9_V81_L1.3321.00
69_T82_D1.3281.00
27_K34_S1.3061.00
95_V116_V1.3031.00
172_T355_A1.3011.00
190_H269_D1.2971.00
9_V93_V1.2861.00
26_L34_S1.2771.00
357_R361_E1.2711.00
200_K232_D1.2691.00
29_Y360_V1.2661.00
81_L105_G1.2611.00
106_S141_T1.2591.00
212_L244_V1.2471.00
220_F249_A1.2451.00
150_A156_K1.2441.00
149_F362_E1.2371.00
312_E318_L1.2331.00
224_R228_G1.2321.00
332_Q336_D1.2211.00
119_V359_I1.2211.00
7_M35_Y1.2211.00
229_E327_Y1.2131.00
142_G159_L1.2071.00
4_L32_I1.2051.00
293_S348_N1.1991.00
200_K233_V1.1981.00
299_L333_L1.1941.00
96_H102_T1.1941.00
7_M85_F1.1891.00
299_L329_L1.1891.00
142_G164_K1.1881.00
202_I281_L1.1881.00
63_I73_I1.1871.00
174_N289_E1.1831.00
72_E76_N1.1821.00
82_D86_K1.1811.00
300_V310_G1.1781.00
311_V318_L1.1711.00
5_K88_I1.1701.00
239_V261_L1.1591.00
22_L94_L1.1591.00
153_G156_K1.1521.00
95_V106_S1.1491.00
274_A291_A1.1351.00
24_L182_T1.1311.00
116_V144_I1.1301.00
292_P349_P1.1241.00
256_S259_V1.1101.00
175_T355_A1.1041.00
272_N276_K1.0980.99
46_L49_V1.0950.99
228_G323_E1.0890.99
228_G256_S1.0830.99
274_A287_V1.0810.99
109_A116_V1.0780.99
52_A268_I1.0630.99
300_V318_L1.0610.99
246_R250_H1.0600.99
325_N328_Q1.0570.99
160_L166_A1.0570.99
43_R60_D1.0550.99
127_N304_T1.0530.99
244_V248_A1.0520.99
280_I291_A1.0510.99
180_L294_L1.0500.99
323_E327_Y1.0460.99
73_I77_A1.0430.99
5_K35_Y1.0390.99
266_E269_D1.0330.99
188_Y275_A1.0330.99
223_I235_V1.0280.99
117_G363_L1.0200.99
77_A81_L1.0200.99
202_I233_V1.0170.99
246_R263_E1.0170.99
154_Q157_D1.0160.99
361_E365_F1.0080.99
54_H186_D1.0040.99
327_Y331_K1.0040.99
23_V34_S1.0040.99
281_L330_A0.9970.99
202_I279_F0.9950.99
71_A75_S0.9930.99
240_H250_H0.9930.99
124_R135_E0.9920.99
6_V92_I0.9910.99
74_T111_Y0.9900.99
57_P87_D0.9900.99
38_V57_P0.9900.99
224_R323_E0.9900.99
145_A148_H0.9870.99
324_E328_Q0.9850.99
120_E289_E0.9830.99
177_I293_S0.9810.99
214_E218_N0.9800.99
45_M49_V0.9790.99
181_N184_V0.9780.99
45_M48_Q0.9750.99
81_L85_F0.9680.99
206_A301_L0.9590.99
71_A78_L0.9580.99
331_K335_T0.9570.99
333_L343_M0.9550.99
187_G272_N0.9460.98
178_D353_G0.9450.98
40_A47_D0.9440.98
85_F109_A0.9390.98
204_L226_I0.9350.98
147_L363_L0.9320.98
37_T81_L0.9300.98
201_M277_S0.9300.98
64_M68_Q0.9280.98
142_G145_A0.9220.98
224_R256_S0.9220.98
43_R64_M0.9210.98
126_G139_Q0.9180.98
5_K91_D0.9150.98
19_M96_H0.9140.98
20_A55_I0.9130.98
35_Y59_F0.9100.98
147_L362_E0.9080.98
206_A219_M0.9080.98
7_M88_I0.9030.98
265_L270_F0.9020.98
120_E174_N0.8990.98
71_A111_Y0.8940.98
6_V26_L0.8940.98
274_A294_L0.8930.98
195_Q269_D0.8890.98
206_A237_Y0.8840.98
233_V278_H0.8830.98
43_R62_N0.8820.98
25_E360_V0.8800.98
281_L326_I0.8780.98
45_M241_L0.8730.97
43_R47_D0.8710.97
232_D258_R0.8680.97
153_G171_V0.8660.97
74_T78_L0.8660.97
152_T309_E0.8610.97
362_E365_F0.8610.97
77_A105_G0.8600.97
280_I287_V0.8580.97
136_L144_I0.8530.97
328_Q332_Q0.8500.97
119_V149_F0.8470.97
16_A51_D0.8460.97
59_F87_D0.8450.97
102_T106_S0.8420.97
178_D355_A0.8400.97
24_L28_K0.8370.97
184_V188_Y0.8340.97
217_E221_K0.8310.97
63_I76_N0.8310.97
317_K332_Q0.8290.97
149_F170_F0.8280.96
216_M220_F0.8270.96
19_M94_L0.8270.96
166_A169_I0.8270.96
237_Y243_P0.8210.96
203_L270_F0.8180.96
95_V102_T0.8150.96
248_A252_H0.8150.96
239_V249_A0.8140.96
299_L330_A0.8140.96
201_M296_K0.8140.96
148_H164_K0.8120.96
128_K139_Q0.8110.96
233_V334_L0.8090.96
69_T72_E0.8090.96
218_N222_A0.8050.96
212_L242_N0.8020.96
225_R229_E0.8010.96
29_Y32_I0.8010.96
83_E86_K0.8000.96
12_T15_E0.7950.96
77_A104_A0.7940.96
106_S116_V0.7910.95
106_S144_I0.7910.95
360_V364_L0.7800.95
65_K73_I0.7800.95
7_M90_P0.7780.95
200_K234_Q0.7770.95
123_L151_P0.7760.95
160_L169_I0.7750.95
26_L360_V0.7750.95
92_I115_A0.7750.95
220_F224_R0.7750.95
201_M233_V0.7690.95
22_L360_V0.7690.95
201_M236_V0.7680.95
227_V256_S0.7650.95
327_Y330_A0.7630.94
235_V258_R0.7620.94
198_E276_K0.7620.94
136_L140_M0.7610.94
68_Q72_E0.7590.94
209_R212_L0.7570.94
65_K72_E0.7570.94
292_P348_N0.7540.94
19_M119_V0.7540.94
60_D63_I0.7540.94
223_I247_E0.7530.94
241_L246_R0.7520.94
10_F36_V0.7500.94
302_R306_E0.7490.94
150_A171_V0.7490.94
180_L271_H0.7440.94
24_L54_H0.7430.94
265_L273_F0.7420.94
172_T359_I0.7410.94
253_F261_L0.7400.94
178_D351_G0.7400.94
25_E356_S0.7390.93
320_G325_N0.7390.93
73_I100_T0.7370.93
147_L170_F0.7360.93
52_A266_E0.7330.93
74_T100_T0.7330.93
289_E307_R0.7310.93
267_V271_H0.7240.93
178_D356_S0.7230.93
313_A349_P0.7220.93
157_D160_L0.7170.92
103_F107_L0.7150.92
28_K357_R0.7150.92
11_G105_G0.7140.92
4_L8_T0.7130.92
190_H193_L0.7130.92
72_E82_D0.7120.92
279_F334_L0.7110.92
298_V315_T0.7080.92
21_P182_T0.7080.92
100_T111_Y0.7060.92
146_D168_S0.7040.92
200_K334_L0.7000.92
225_R228_G0.7000.92
206_A216_M0.6970.91
50_L58_D0.6960.91
303_D306_E0.6950.91
221_K225_R0.6940.91
36_V55_I0.6930.91
70_L111_Y0.6890.91
203_L277_S0.6870.91
46_L50_L0.6870.91
139_Q164_K0.6800.90
222_A226_I0.6700.90
156_K169_I0.6690.90
227_V235_V0.6690.90
16_A38_V0.6680.90
222_A225_R0.6680.90
40_A43_R0.6660.89
38_V50_L0.6650.89
186_D189_S0.6650.89
63_I80_R0.6650.89
218_N323_E0.6640.89
7_M84_L0.6620.89
128_K143_A0.6600.89
228_G258_R0.6590.89
110_F128_K0.6540.89
64_M73_I0.6520.88
6_V117_G0.6510.88
50_L55_I0.6510.88
81_L108_A0.6470.88
126_G161_K0.6460.88
317_K325_N0.6450.88
295_G346_A0.6430.88
110_F146_D0.6430.88
236_V262_I0.6410.88
343_M346_A0.6410.88
172_T362_E0.6400.87
333_L336_D0.6390.87
279_F333_L0.6390.87
47_D62_N0.6380.87
27_K58_D0.6360.87
229_E335_T0.6360.87
221_K252_H0.6340.87
204_L301_L0.6330.87
11_G41_Q0.6310.87
4_L363_L0.6300.87
5_K90_P0.6270.86
216_M219_M0.6260.86
299_L317_K0.6240.86
10_F38_V0.6220.86
79_V82_D0.6220.86
32_I360_V0.6210.86
250_H254_G0.6200.86
11_G15_E0.6200.86
275_A296_K0.6160.85
270_F304_T0.6160.85
120_E123_L0.6140.85
274_A277_S0.6120.85
262_I265_L0.6110.85
311_V316_L0.6110.85
229_E330_A0.6090.85
8_T94_L0.6090.85
96_H316_L0.6090.85
295_G343_M0.6090.85
336_D343_M0.6010.84
239_V263_E0.6010.84
239_V246_R0.6010.84
174_N307_R0.6000.84
361_E364_L0.5990.84
191_P194_D0.5980.84
216_M248_A0.5980.84
79_V83_E0.5980.84
201_M234_Q0.5970.84
330_A334_L0.5960.83
4_L92_I0.5950.83
243_P247_E0.5940.83
244_V247_E0.5940.83
320_G326_I0.5930.83
219_M222_A0.5910.83
15_E99_T0.5910.83
228_G327_Y0.5910.83
105_G109_A0.5890.83
49_V52_A0.5890.83
224_R252_H0.5890.83
140_M143_A0.5880.83
123_L155_A0.5880.83
278_H334_L0.5880.83
188_Y191_P0.5860.82
85_F105_G0.5850.82
12_T18_K0.5850.82
35_Y87_D0.5830.82
152_T311_V0.5810.82
205_T238_P0.5800.82
77_A80_R0.5800.82
177_I353_G0.5800.82
151_P175_T0.5780.82
181_N293_S0.5780.82
315_T346_A0.5760.81
18_K120_E0.5750.81
206_A212_L0.5750.81
295_G315_T0.5720.81
107_L111_Y0.5720.81
296_K310_G0.5720.81
356_S360_V0.5710.81
94_L363_L0.5700.81
219_M326_I0.5700.81
125_T304_T0.5700.81
42_H45_M0.5680.80
206_A218_N0.5670.80
272_N275_A0.5670.80
203_L265_L0.5660.80
204_L237_Y0.5640.80
251_K254_G0.5620.80
192_V196_V0.5620.80
277_S280_I0.5620.80
220_F248_A0.5600.80
294_L315_T0.5580.79
303_D321_T0.5580.79
19_M23_V0.5580.79
158_N161_K0.5580.79
150_A155_A0.5560.79
92_I170_F0.5550.79
62_N80_R0.5550.79
14_P18_K0.5550.79
225_R324_E0.5540.79
21_P24_L0.5530.79
167_D170_F0.5520.79
42_H207_H0.5520.79
16_A49_V0.5520.79
221_K224_R0.5510.78
194_D345_Q0.5500.78
248_A251_K0.5500.78
7_M81_L0.5470.78
21_P356_S0.5470.78
319_A326_I0.5420.77
218_N221_K0.5410.77
205_T266_E0.5410.77
292_P315_T0.5410.77
303_D325_N0.5400.77
279_F299_L0.5360.77
21_P183_T0.5360.77
218_N322_D0.5350.76
181_N354_E0.5350.76
94_L119_V0.5350.76
238_P270_F0.5340.76
281_L327_Y0.5340.76
230_F235_V0.5340.76
12_T17_I0.5330.76
238_P241_L0.5330.76
18_K96_H0.5330.76
332_Q337_P0.5320.76
35_Y58_D0.5320.76
126_G154_Q0.5300.76
115_A147_L0.5300.76
37_T84_L0.5280.76
206_A321_T0.5270.75
96_H176_A0.5270.75
70_L74_T0.5260.75
4_L91_D0.5250.75
74_T103_F0.5240.75
336_D344_S0.5240.75
192_V195_Q0.5210.75
199_D232_D0.5210.75
110_F144_I0.5190.74
187_G268_I0.5170.74
291_A298_V0.5170.74
152_T155_A0.5170.74
305_T318_L0.5130.73
185_R188_Y0.5130.73
324_E327_Y0.5120.73
47_D50_L0.5120.73
305_T311_V0.5120.73
216_M237_Y0.5110.73
92_I146_D0.5100.73
163_N167_D0.5080.73
21_P25_E0.5070.73
202_I226_I0.5060.72
15_E96_H0.5060.72
15_E19_M0.5050.72
246_R249_A0.5050.72
201_M265_L0.5050.72
140_M144_I0.5040.72
206_A326_I0.5040.72
41_Q120_E0.5030.72
227_V259_V0.5030.72
187_G190_H0.5020.72
78_L104_A0.5000.72
120_E151_P0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v4vA 2 0.9816 100 0.523 Contact Map
1vgvA 2 0.9658 100 0.542 Contact Map
3dzcA 2 0.9579 100 0.555 Contact Map
4fkzA 2 0.9974 100 0.643 Contact Map
4nesA 2 0.9211 100 0.661 Contact Map
3ot5A 2 0.9895 100 0.675 Contact Map
4hwgA 5 0.9447 100 0.693 Contact Map
3l7iA 4 0.8947 99.9 0.786 Contact Map
3otgA 2 0.8895 99.9 0.813 Contact Map
3wadA 2 0.9053 99.8 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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