MNAA - BACSU - GREMLIN Contacts

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MNAA - UDP-N-acetylglucosamine 2-epimerase

UniProt:	P39131	Sequences: MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQMLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTTFAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLLKENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMENMFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAKSHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLLTDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	380 (355)
Sequences:	4348 (2972)
Seq/√Len:	157.7

ECOLI - WECB
BACSU - MNAA
HALSA - Q9HM99

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
102_T	141_T	3.171	1.00
170_F	362_E	2.963	1.00
354_E	357_R	2.877	1.00
92_I	117_G	2.819	1.00
156_K	160_L	2.809	1.00
29_Y	364_L	2.781	1.00
354_E	358_R	2.769	1.00
225_R	323_E	2.764	1.00
25_E	357_R	2.707	1.00
25_E	28_K	2.608	1.00
86_K	112_H	2.536	1.00
5_K	33_D	2.528	1.00
142_G	148_H	2.519	1.00
7_M	37_T	2.466	1.00
82_D	112_H	2.412	1.00
8_T	34_S	2.409	1.00
157_D	161_K	2.396	1.00
139_Q	143_A	2.316	1.00
103_F	140_M	2.266	1.00
156_K	171_V	2.212	1.00
153_G	157_D	2.210	1.00
234_Q	260_H	2.201	1.00
94_L	117_G	2.185	1.00
329_L	332_Q	2.183	1.00
31_E	364_L	2.178	1.00
204_L	235_V	2.170	1.00
299_L	319_A	2.122	1.00
35_Y	88_I	2.115	1.00
221_K	323_E	2.112	1.00
85_F	114_I	2.102	1.00
202_I	235_V	2.079	1.00
184_V	275_A	2.076	1.00
78_L	108_A	2.062	1.00
230_F	335_T	2.053	1.00
230_F	331_K	1.988	1.00
281_L	301_L	1.983	1.00
310_G	316_L	1.970	1.00
32_I	364_L	1.953	1.00
200_K	278_H	1.947	1.00
80_R	83_E	1.939	1.00
165_K	168_S	1.868	1.00
270_F	287_V	1.857	1.00
279_F	330_A	1.850	1.00
217_E	251_K	1.838	1.00
93_V	109_A	1.827	1.00
229_E	331_K	1.827	1.00
352_D	358_R	1.800	1.00
9_V	105_G	1.795	1.00
117_G	149_F	1.782	1.00
225_R	327_Y	1.780	1.00
247_E	251_K	1.752	1.00
24_L	27_K	1.747	1.00
29_Y	361_E	1.703	1.00
156_K	166_A	1.694	1.00
26_L	32_I	1.688	1.00
39_T	101_T	1.687	1.00
322_D	325_N	1.676	1.00
92_I	363_L	1.659	1.00
47_D	51_D	1.634	1.00
274_A	280_I	1.618	1.00
319_A	329_L	1.595	1.00
128_K	146_D	1.589	1.00
75_S	79_V	1.583	1.00
65_K	76_N	1.580	1.00
236_V	273_F	1.551	1.00
72_E	83_E	1.549	1.00
128_K	136_L	1.549	1.00
300_V	316_L	1.541	1.00
83_E	87_D	1.530	1.00
76_N	79_V	1.523	1.00
154_Q	312_E	1.522	1.00
227_V	258_R	1.512	1.00
199_D	234_Q	1.497	1.00
23_V	36_V	1.489	1.00
50_L	57_P	1.487	1.00
325_N	329_L	1.475	1.00
191_P	195_Q	1.474	1.00
149_F	359_I	1.468	1.00
71_A	112_H	1.467	1.00
59_F	84_L	1.464	1.00
226_I	330_A	1.457	1.00
85_F	108_A	1.451	1.00
201_M	276_K	1.439	1.00
147_L	366_H	1.437	1.00
8_T	23_V	1.427	1.00
150_A	159_L	1.418	1.00
25_E	29_Y	1.416	1.00
204_L	223_I	1.413	1.00
59_F	88_I	1.412	1.00
78_L	107_L	1.412	1.00
40_A	62_N	1.403	1.00
72_E	79_V	1.401	1.00
22_L	175_T	1.398	1.00
203_L	274_A	1.396	1.00
277_S	296_K	1.396	1.00
22_L	356_S	1.396	1.00
76_N	80_R	1.394	1.00
85_F	93_V	1.394	1.00
92_I	147_L	1.391	1.00
84_L	88_I	1.387	1.00
143_A	164_K	1.376	1.00
74_T	104_A	1.361	1.00
71_A	82_D	1.359	1.00
317_K	329_L	1.352	1.00
9_V	39_T	1.352	1.00
214_E	217_E	1.345	1.00
8_T	26_L	1.343	1.00
115_A	146_D	1.342	1.00
26_L	363_L	1.341	1.00
9_V	81_L	1.332	1.00
69_T	82_D	1.328	1.00
27_K	34_S	1.306	1.00
95_V	116_V	1.303	1.00
172_T	355_A	1.301	1.00
190_H	269_D	1.297	1.00
9_V	93_V	1.286	1.00
26_L	34_S	1.277	1.00
357_R	361_E	1.271	1.00
200_K	232_D	1.269	1.00
29_Y	360_V	1.266	1.00
81_L	105_G	1.261	1.00
106_S	141_T	1.259	1.00
212_L	244_V	1.247	1.00
220_F	249_A	1.245	1.00
150_A	156_K	1.244	1.00
149_F	362_E	1.237	1.00
312_E	318_L	1.233	1.00
224_R	228_G	1.232	1.00
332_Q	336_D	1.221	1.00
119_V	359_I	1.221	1.00
7_M	35_Y	1.221	1.00
229_E	327_Y	1.213	1.00
142_G	159_L	1.207	1.00
4_L	32_I	1.205	1.00
293_S	348_N	1.199	1.00
200_K	233_V	1.198	1.00
299_L	333_L	1.194	1.00
96_H	102_T	1.194	1.00
7_M	85_F	1.189	1.00
299_L	329_L	1.189	1.00
142_G	164_K	1.188	1.00
202_I	281_L	1.188	1.00
63_I	73_I	1.187	1.00
174_N	289_E	1.183	1.00
72_E	76_N	1.182	1.00
82_D	86_K	1.181	1.00
300_V	310_G	1.178	1.00
311_V	318_L	1.171	1.00
5_K	88_I	1.170	1.00
239_V	261_L	1.159	1.00
22_L	94_L	1.159	1.00
153_G	156_K	1.152	1.00
95_V	106_S	1.149	1.00
274_A	291_A	1.135	1.00
24_L	182_T	1.131	1.00
116_V	144_I	1.130	1.00
292_P	349_P	1.124	1.00
256_S	259_V	1.110	1.00
175_T	355_A	1.104	1.00
272_N	276_K	1.098	0.99
46_L	49_V	1.095	0.99
228_G	323_E	1.089	0.99
228_G	256_S	1.083	0.99
274_A	287_V	1.081	0.99
109_A	116_V	1.078	0.99
52_A	268_I	1.063	0.99
300_V	318_L	1.061	0.99
246_R	250_H	1.060	0.99
325_N	328_Q	1.057	0.99
160_L	166_A	1.057	0.99
43_R	60_D	1.055	0.99
127_N	304_T	1.053	0.99
244_V	248_A	1.052	0.99
280_I	291_A	1.051	0.99
180_L	294_L	1.050	0.99
323_E	327_Y	1.046	0.99
73_I	77_A	1.043	0.99
5_K	35_Y	1.039	0.99
266_E	269_D	1.033	0.99
188_Y	275_A	1.033	0.99
223_I	235_V	1.028	0.99
117_G	363_L	1.020	0.99
77_A	81_L	1.020	0.99
202_I	233_V	1.017	0.99
246_R	263_E	1.017	0.99
154_Q	157_D	1.016	0.99
361_E	365_F	1.008	0.99
54_H	186_D	1.004	0.99
327_Y	331_K	1.004	0.99
23_V	34_S	1.004	0.99
281_L	330_A	0.997	0.99
202_I	279_F	0.995	0.99
71_A	75_S	0.993	0.99
240_H	250_H	0.993	0.99
124_R	135_E	0.992	0.99
6_V	92_I	0.991	0.99
74_T	111_Y	0.990	0.99
57_P	87_D	0.990	0.99
38_V	57_P	0.990	0.99
224_R	323_E	0.990	0.99
145_A	148_H	0.987	0.99
324_E	328_Q	0.985	0.99
120_E	289_E	0.983	0.99
177_I	293_S	0.981	0.99
214_E	218_N	0.980	0.99
45_M	49_V	0.979	0.99
181_N	184_V	0.978	0.99
45_M	48_Q	0.975	0.99
81_L	85_F	0.968	0.99
206_A	301_L	0.959	0.99
71_A	78_L	0.958	0.99
331_K	335_T	0.957	0.99
333_L	343_M	0.955	0.99
187_G	272_N	0.946	0.98
178_D	353_G	0.945	0.98
40_A	47_D	0.944	0.98
85_F	109_A	0.939	0.98
204_L	226_I	0.935	0.98
147_L	363_L	0.932	0.98
37_T	81_L	0.930	0.98
201_M	277_S	0.930	0.98
64_M	68_Q	0.928	0.98
142_G	145_A	0.922	0.98
224_R	256_S	0.922	0.98
43_R	64_M	0.921	0.98
126_G	139_Q	0.918	0.98
5_K	91_D	0.915	0.98
19_M	96_H	0.914	0.98
20_A	55_I	0.913	0.98
35_Y	59_F	0.910	0.98
147_L	362_E	0.908	0.98
206_A	219_M	0.908	0.98
7_M	88_I	0.903	0.98
265_L	270_F	0.902	0.98
120_E	174_N	0.899	0.98
71_A	111_Y	0.894	0.98
6_V	26_L	0.894	0.98
274_A	294_L	0.893	0.98
195_Q	269_D	0.889	0.98
206_A	237_Y	0.884	0.98
233_V	278_H	0.883	0.98
43_R	62_N	0.882	0.98
25_E	360_V	0.880	0.98
281_L	326_I	0.878	0.98
45_M	241_L	0.873	0.97
43_R	47_D	0.871	0.97
232_D	258_R	0.868	0.97
153_G	171_V	0.866	0.97
74_T	78_L	0.866	0.97
152_T	309_E	0.861	0.97
362_E	365_F	0.861	0.97
77_A	105_G	0.860	0.97
280_I	287_V	0.858	0.97
136_L	144_I	0.853	0.97
328_Q	332_Q	0.850	0.97
119_V	149_F	0.847	0.97
16_A	51_D	0.846	0.97
59_F	87_D	0.845	0.97
102_T	106_S	0.842	0.97
178_D	355_A	0.840	0.97
24_L	28_K	0.837	0.97
184_V	188_Y	0.834	0.97
217_E	221_K	0.831	0.97
63_I	76_N	0.831	0.97
317_K	332_Q	0.829	0.97
149_F	170_F	0.828	0.96
216_M	220_F	0.827	0.96
19_M	94_L	0.827	0.96
166_A	169_I	0.827	0.96
237_Y	243_P	0.821	0.96
203_L	270_F	0.818	0.96
95_V	102_T	0.815	0.96
248_A	252_H	0.815	0.96
239_V	249_A	0.814	0.96
299_L	330_A	0.814	0.96
201_M	296_K	0.814	0.96
148_H	164_K	0.812	0.96
128_K	139_Q	0.811	0.96
233_V	334_L	0.809	0.96
69_T	72_E	0.809	0.96
218_N	222_A	0.805	0.96
212_L	242_N	0.802	0.96
225_R	229_E	0.801	0.96
29_Y	32_I	0.801	0.96
83_E	86_K	0.800	0.96
12_T	15_E	0.795	0.96
77_A	104_A	0.794	0.96
106_S	116_V	0.791	0.95
106_S	144_I	0.791	0.95
360_V	364_L	0.780	0.95
65_K	73_I	0.780	0.95
7_M	90_P	0.778	0.95
200_K	234_Q	0.777	0.95
123_L	151_P	0.776	0.95
160_L	169_I	0.775	0.95
26_L	360_V	0.775	0.95
92_I	115_A	0.775	0.95
220_F	224_R	0.775	0.95
201_M	233_V	0.769	0.95
22_L	360_V	0.769	0.95
201_M	236_V	0.768	0.95
227_V	256_S	0.765	0.95
327_Y	330_A	0.763	0.94
235_V	258_R	0.762	0.94
198_E	276_K	0.762	0.94
136_L	140_M	0.761	0.94
68_Q	72_E	0.759	0.94
209_R	212_L	0.757	0.94
65_K	72_E	0.757	0.94
292_P	348_N	0.754	0.94
19_M	119_V	0.754	0.94
60_D	63_I	0.754	0.94
223_I	247_E	0.753	0.94
241_L	246_R	0.752	0.94
10_F	36_V	0.750	0.94
302_R	306_E	0.749	0.94
150_A	171_V	0.749	0.94
180_L	271_H	0.744	0.94
24_L	54_H	0.743	0.94
265_L	273_F	0.742	0.94
172_T	359_I	0.741	0.94
253_F	261_L	0.740	0.94
178_D	351_G	0.740	0.94
25_E	356_S	0.739	0.93
320_G	325_N	0.739	0.93
73_I	100_T	0.737	0.93
147_L	170_F	0.736	0.93
52_A	266_E	0.733	0.93
74_T	100_T	0.733	0.93
289_E	307_R	0.731	0.93
267_V	271_H	0.724	0.93
178_D	356_S	0.723	0.93
313_A	349_P	0.722	0.93
157_D	160_L	0.717	0.92
103_F	107_L	0.715	0.92
28_K	357_R	0.715	0.92
11_G	105_G	0.714	0.92
4_L	8_T	0.713	0.92
190_H	193_L	0.713	0.92
72_E	82_D	0.712	0.92
279_F	334_L	0.711	0.92
298_V	315_T	0.708	0.92
21_P	182_T	0.708	0.92
100_T	111_Y	0.706	0.92
146_D	168_S	0.704	0.92
200_K	334_L	0.700	0.92
225_R	228_G	0.700	0.92
206_A	216_M	0.697	0.91
50_L	58_D	0.696	0.91
303_D	306_E	0.695	0.91
221_K	225_R	0.694	0.91
36_V	55_I	0.693	0.91
70_L	111_Y	0.689	0.91
203_L	277_S	0.687	0.91
46_L	50_L	0.687	0.91
139_Q	164_K	0.680	0.90
222_A	226_I	0.670	0.90
156_K	169_I	0.669	0.90
227_V	235_V	0.669	0.90
16_A	38_V	0.668	0.90
222_A	225_R	0.668	0.90
40_A	43_R	0.666	0.89
38_V	50_L	0.665	0.89
186_D	189_S	0.665	0.89
63_I	80_R	0.665	0.89
218_N	323_E	0.664	0.89
7_M	84_L	0.662	0.89
128_K	143_A	0.660	0.89
228_G	258_R	0.659	0.89
110_F	128_K	0.654	0.89
64_M	73_I	0.652	0.88
6_V	117_G	0.651	0.88
50_L	55_I	0.651	0.88
81_L	108_A	0.647	0.88
126_G	161_K	0.646	0.88
317_K	325_N	0.645	0.88
295_G	346_A	0.643	0.88
110_F	146_D	0.643	0.88
236_V	262_I	0.641	0.88
343_M	346_A	0.641	0.88
172_T	362_E	0.640	0.87
333_L	336_D	0.639	0.87
279_F	333_L	0.639	0.87
47_D	62_N	0.638	0.87
27_K	58_D	0.636	0.87
229_E	335_T	0.636	0.87
221_K	252_H	0.634	0.87
204_L	301_L	0.633	0.87
11_G	41_Q	0.631	0.87
4_L	363_L	0.630	0.87
5_K	90_P	0.627	0.86
216_M	219_M	0.626	0.86
299_L	317_K	0.624	0.86
10_F	38_V	0.622	0.86
79_V	82_D	0.622	0.86
32_I	360_V	0.621	0.86
250_H	254_G	0.620	0.86
11_G	15_E	0.620	0.86
275_A	296_K	0.616	0.85
270_F	304_T	0.616	0.85
120_E	123_L	0.614	0.85
274_A	277_S	0.612	0.85
262_I	265_L	0.611	0.85
311_V	316_L	0.611	0.85
229_E	330_A	0.609	0.85
8_T	94_L	0.609	0.85
96_H	316_L	0.609	0.85
295_G	343_M	0.609	0.85
336_D	343_M	0.601	0.84
239_V	263_E	0.601	0.84
239_V	246_R	0.601	0.84
174_N	307_R	0.600	0.84
361_E	364_L	0.599	0.84
191_P	194_D	0.598	0.84
216_M	248_A	0.598	0.84
79_V	83_E	0.598	0.84
201_M	234_Q	0.597	0.84
330_A	334_L	0.596	0.83
4_L	92_I	0.595	0.83
243_P	247_E	0.594	0.83
244_V	247_E	0.594	0.83
320_G	326_I	0.593	0.83
219_M	222_A	0.591	0.83
15_E	99_T	0.591	0.83
228_G	327_Y	0.591	0.83
105_G	109_A	0.589	0.83
49_V	52_A	0.589	0.83
224_R	252_H	0.589	0.83
140_M	143_A	0.588	0.83
123_L	155_A	0.588	0.83
278_H	334_L	0.588	0.83
188_Y	191_P	0.586	0.82
85_F	105_G	0.585	0.82
12_T	18_K	0.585	0.82
35_Y	87_D	0.583	0.82
152_T	311_V	0.581	0.82
205_T	238_P	0.580	0.82
77_A	80_R	0.580	0.82
177_I	353_G	0.580	0.82
151_P	175_T	0.578	0.82
181_N	293_S	0.578	0.82
315_T	346_A	0.576	0.81
18_K	120_E	0.575	0.81
206_A	212_L	0.575	0.81
295_G	315_T	0.572	0.81
107_L	111_Y	0.572	0.81
296_K	310_G	0.572	0.81
356_S	360_V	0.571	0.81
94_L	363_L	0.570	0.81
219_M	326_I	0.570	0.81
125_T	304_T	0.570	0.81
42_H	45_M	0.568	0.80
206_A	218_N	0.567	0.80
272_N	275_A	0.567	0.80
203_L	265_L	0.566	0.80
204_L	237_Y	0.564	0.80
251_K	254_G	0.562	0.80
192_V	196_V	0.562	0.80
277_S	280_I	0.562	0.80
220_F	248_A	0.560	0.80
294_L	315_T	0.558	0.79
303_D	321_T	0.558	0.79
19_M	23_V	0.558	0.79
158_N	161_K	0.558	0.79
150_A	155_A	0.556	0.79
92_I	170_F	0.555	0.79
62_N	80_R	0.555	0.79
14_P	18_K	0.555	0.79
225_R	324_E	0.554	0.79
21_P	24_L	0.553	0.79
167_D	170_F	0.552	0.79
42_H	207_H	0.552	0.79
16_A	49_V	0.552	0.79
221_K	224_R	0.551	0.78
194_D	345_Q	0.550	0.78
248_A	251_K	0.550	0.78
7_M	81_L	0.547	0.78
21_P	356_S	0.547	0.78
319_A	326_I	0.542	0.77
218_N	221_K	0.541	0.77
205_T	266_E	0.541	0.77
292_P	315_T	0.541	0.77
303_D	325_N	0.540	0.77
279_F	299_L	0.536	0.77
21_P	183_T	0.536	0.77
218_N	322_D	0.535	0.76
181_N	354_E	0.535	0.76
94_L	119_V	0.535	0.76
238_P	270_F	0.534	0.76
281_L	327_Y	0.534	0.76
230_F	235_V	0.534	0.76
12_T	17_I	0.533	0.76
238_P	241_L	0.533	0.76
18_K	96_H	0.533	0.76
332_Q	337_P	0.532	0.76
35_Y	58_D	0.532	0.76
126_G	154_Q	0.530	0.76
115_A	147_L	0.530	0.76
37_T	84_L	0.528	0.76
206_A	321_T	0.527	0.75
96_H	176_A	0.527	0.75
70_L	74_T	0.526	0.75
4_L	91_D	0.525	0.75
74_T	103_F	0.524	0.75
336_D	344_S	0.524	0.75
192_V	195_Q	0.521	0.75
199_D	232_D	0.521	0.75
110_F	144_I	0.519	0.74
187_G	268_I	0.517	0.74
291_A	298_V	0.517	0.74
152_T	155_A	0.517	0.74
305_T	318_L	0.513	0.73
185_R	188_Y	0.513	0.73
324_E	327_Y	0.512	0.73
47_D	50_L	0.512	0.73
305_T	311_V	0.512	0.73
216_M	237_Y	0.511	0.73
92_I	146_D	0.510	0.73
163_N	167_D	0.508	0.73
21_P	25_E	0.507	0.73
202_I	226_I	0.506	0.72
15_E	96_H	0.506	0.72
15_E	19_M	0.505	0.72
246_R	249_A	0.505	0.72
201_M	265_L	0.505	0.72
140_M	144_I	0.504	0.72
206_A	326_I	0.504	0.72
41_Q	120_E	0.503	0.72
227_V	259_V	0.503	0.72
187_G	190_H	0.502	0.72
78_L	104_A	0.500	0.72
120_E	151_P	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1v4vA	2	0.9816	100	0.523	Contact Map
1vgvA	2	0.9658	100	0.542	Contact Map
3dzcA	2	0.9579	100	0.555	Contact Map
4fkzA	2	0.9974	100	0.643	Contact Map
4nesA	2	0.9211	100	0.661	Contact Map
3ot5A	2	0.9895	100	0.675	Contact Map
4hwgA	5	0.9447	100	0.693	Contact Map
3l7iA	4	0.8947	99.9	0.786	Contact Map
3otgA	2	0.8895	99.9	0.813	Contact Map
3wadA	2	0.9053	99.8	0.822	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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