GREMLIN Database
LPLD - Alpha-galacturonidase
UniProt: P39130 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (410)
Sequences: 1740 (1005)
Seq/√Len: 49.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_K139_D5.6121.00
200_D220_R4.2791.00
77_L141_A4.0021.00
82_I340_L3.9501.00
73_L136_A3.8241.00
104_R438_D3.4021.00
137_I146_V3.3301.00
54_E69_A3.2721.00
373_T378_Q3.1701.00
412_T437_N3.1191.00
72_T75_K3.0921.00
216_K223_D3.0811.00
416_F436_F3.0491.00
137_I167_I2.9931.00
74_K136_A2.9871.00
338_A345_L2.9801.00
107_I435_L2.8561.00
349_V372_I2.8071.00
39_T68_E2.7351.00
39_T66_R2.7311.00
222_I227_I2.5481.00
358_L384_A2.5401.00
415_A436_F2.5351.00
54_E58_N2.5181.00
11_K41_A2.4521.00
356_Q366_V2.4001.00
385_L393_A2.3921.00
138_R165_P2.3661.00
170_I377_V2.3571.00
41_A68_E2.3391.00
409_T414_L2.3021.00
135_R138_R2.3011.00
194_E200_D2.2971.00
120_I403_V2.2551.00
349_V370_A2.2281.00
89_P129_I2.2151.00
51_Q55_V2.2081.00
137_I141_A2.1231.00
285_Y293_K2.0991.00
134_A160_L2.0981.00
132_E135_R2.0911.00
219_Y224_L2.0631.00
360_L393_A2.0561.00
107_I117_P2.0341.00
162_K405_D2.0321.00
138_R166_G2.0061.00
127_V159_V1.9670.99
354_Q362_I1.9660.99
194_E199_E1.9620.99
105_C434_Q1.9610.99
105_C438_D1.9430.99
359_N390_E1.9110.99
51_Q54_E1.8900.99
224_L227_I1.8820.99
355_G362_I1.8450.99
74_K140_Y1.8230.99
161_Y352_P1.8070.99
34_E337_A1.8050.99
27_M40_V1.7910.99
131_A159_V1.7860.99
41_A70_V1.7750.99
127_V155_V1.7640.99
145_W168_K1.7470.99
405_D409_T1.7370.99
75_K78_S1.7270.99
339_L342_L1.7260.99
405_D414_L1.7150.99
11_K39_T1.6970.98
97_V442_C1.6790.98
411_D414_L1.6780.98
295_H298_P1.6730.98
82_I339_L1.6650.98
297_T317_I1.6430.98
126_A129_I1.6320.98
371_F380_I1.6260.98
337_A341_G1.6150.98
344_E373_T1.6070.98
55_V58_N1.5920.98
227_I231_F1.5750.97
204_N216_K1.5740.97
108_Y277_L1.5470.97
68_E75_K1.5430.97
414_L417_Q1.5270.97
244_G247_W1.5210.97
96_E288_Q1.5120.97
81_D143_E1.5040.97
191_L228_F1.4990.96
130_F160_L1.4950.96
120_I399_N1.4940.96
47_F51_Q1.4760.96
160_L169_A1.4750.96
358_L383_G1.4720.96
256_H260_F1.4660.96
93_D292_W1.4530.96
230_E234_H1.4520.96
143_E168_K1.4460.96
115_V396_H1.4460.96
346_V371_F1.4370.96
213_W267_G1.4280.95
13_A80_A1.4250.95
18_G44_D1.4210.95
359_N383_G1.4170.95
105_C435_L1.4120.95
373_T376_R1.4050.95
134_A137_I1.3960.95
35_R336_I1.3940.95
298_P302_R1.3930.95
406_A415_A1.3920.95
127_V407_G1.3740.94
407_G410_K1.3720.94
300_S303_K1.3690.94
390_E394_A1.3660.94
70_V76_A1.3430.94
101_L442_C1.3380.93
96_E289_P1.3330.93
131_A408_L1.3310.93
93_D96_E1.3260.93
117_P425_V1.3220.93
293_K297_T1.3210.93
358_L362_I1.3150.93
13_A41_A1.3060.93
20_Q299_I1.2930.92
316_L319_Q1.2850.92
347_T372_I1.2830.92
373_T377_V1.2770.92
34_E343_G1.2690.91
46_D91_S1.2630.91
301_F317_I1.2610.91
107_I431_D1.2560.91
265_T433_E1.2360.90
193_I219_Y1.2300.90
247_W250_S1.2290.90
85_I130_F1.2240.90
435_L439_M1.2230.90
296_L300_S1.2230.90
13_A77_L1.2210.90
419_F439_M1.2210.90
200_D219_Y1.2200.90
79_A143_E1.2050.89
38_G66_R1.1980.89
78_S140_Y1.1960.89
219_Y222_I1.1930.89
12_I35_R1.1930.89
202_R218_S1.1870.88
96_E100_H1.1820.88
441_Q444_M1.1750.88
83_V137_I1.1680.88
128_P407_G1.1660.88
301_F304_Q1.1650.87
359_N394_A1.1640.87
229_R263_F1.1620.87
419_F432_A1.1610.87
375_N378_Q1.1540.87
206_L215_T1.1540.87
51_Q69_A1.1460.87
206_L385_L1.1460.87
346_V380_I1.1440.87
289_P292_W1.1430.86
294_F298_P1.1420.86
211_F396_H1.1380.86
83_V144_S1.1300.86
412_T436_F1.1290.86
98_D125_R1.1240.86
77_L140_Y1.1210.85
302_R305_D1.1120.85
358_L381_L1.1110.85
130_F156_C1.1090.85
10_I340_L1.1070.85
256_H259_A1.1070.85
97_V443_I1.1030.84
387_K398_S1.0960.84
399_N419_F1.0930.84
88_L95_M1.0930.84
256_H261_D1.0860.84
276_H280_F1.0790.83
102_P105_C1.0720.83
356_Q368_T1.0720.83
43_Y76_A1.0680.82
15_I146_V1.0590.82
420_L429_R1.0580.82
388_G417_Q1.0450.81
223_D226_P1.0440.81
416_F432_A1.0400.81
351_M370_A1.0400.81
135_R139_D1.0380.81
278_A282_P1.0300.80
87_I133_I1.0290.80
416_F433_E1.0250.80
107_I426_Q1.0230.80
57_G67_Y1.0220.80
342_L374_R1.0200.79
301_F305_D1.0180.79
227_I230_E1.0130.79
102_P439_M1.0090.79
158_R401_E1.0080.79
357_V366_V1.0070.79
121_I440_L1.0040.78
154_S400_Q1.0040.78
211_F392_L1.0030.78
415_A440_L0.9900.77
120_I419_F0.9900.77
138_R167_I0.9890.77
95_M99_V0.9880.77
277_L280_F0.9850.77
216_K225_L0.9820.77
123_G365_I0.9750.76
47_F71_S0.9730.76
205_V214_I0.9680.76
136_A140_Y0.9660.76
371_F378_Q0.9660.76
278_A281_L0.9580.75
50_A69_A0.9560.75
180_Q203_V0.9530.75
156_C159_V0.9520.75
134_A166_G0.9400.74
275_R279_E0.9390.74
243_E246_C0.9380.73
364_A397_I0.9360.73
426_Q431_D0.9360.73
202_R346_V0.9350.73
346_V369_N0.9340.73
173_C210_H0.9340.73
178_G182_L0.9330.73
251_V254_S0.9320.73
87_I153_M0.9320.73
262_L266_Y0.9280.73
164_F167_I0.9280.73
135_R164_F0.9260.72
15_I133_I0.9190.72
13_A43_Y0.9180.72
82_I336_I0.9110.71
412_T433_E0.9110.71
96_E292_W0.9100.71
359_N366_V0.9080.71
295_H302_R0.9030.71
119_G125_R0.9010.70
93_D97_V0.9000.70
109_Q118_G0.8970.70
420_L432_A0.8970.70
205_V212_T0.8960.70
419_F435_L0.8940.70
298_P301_F0.8930.70
425_V432_A0.8930.70
105_C280_F0.8930.70
412_T416_F0.8920.70
158_R162_K0.8920.70
23_A86_S0.8910.70
299_I303_K0.8900.69
412_T440_L0.8890.69
231_F235_Y0.8870.69
334_N345_L0.8850.69
80_A141_A0.8850.69
242_L248_R0.8840.69
351_M372_I0.8830.69
249_D253_C0.8830.69
114_T119_G0.8800.69
294_F301_F0.8800.69
77_L83_V0.8790.68
247_W251_V0.8780.68
315_R321_R0.8720.68
194_E219_Y0.8710.68
117_P419_F0.8700.68
396_H422_D0.8620.67
162_K401_E0.8570.66
288_Q291_V0.8560.66
294_F297_T0.8560.66
260_F263_F0.8530.66
115_V422_D0.8520.66
58_N75_K0.8470.66
439_M442_C0.8440.65
146_V160_L0.8430.65
100_H289_P0.8370.65
248_R251_V0.8350.64
364_A401_E0.8350.64
391_M398_S0.8340.64
372_I377_V0.8320.64
149_Y332_G0.8310.64
434_Q437_N0.8290.64
26_L86_S0.8260.64
337_A343_G0.8260.64
88_L99_V0.8240.63
58_N66_R0.8210.63
10_I38_G0.8180.63
89_P126_A0.8160.63
297_T301_F0.8160.63
14_Y84_I0.8150.63
293_K296_L0.8140.62
177_F335_I0.8110.62
204_N382_S0.8100.62
175_E260_F0.8090.62
123_G127_V0.8090.62
295_H301_F0.8080.62
29_D174_H0.8080.62
370_A379_P0.8060.62
244_G250_S0.8020.61
132_E136_A0.7940.61
164_F408_L0.7920.60
170_I339_L0.7890.60
294_F302_R0.7870.60
402_A417_Q0.7870.60
102_P435_L0.7860.60
193_I200_D0.7810.59
145_W339_L0.7800.59
226_P230_E0.7730.58
101_L438_D0.7680.58
11_K80_A0.7680.58
357_V383_G0.7660.58
153_M176_V0.7650.58
17_G432_A0.7650.58
158_R397_I0.7640.58
114_T155_V0.7600.57
398_S401_E0.7510.56
147_I336_I0.7490.56
129_I132_E0.7490.56
41_A193_I0.7490.56
135_R165_P0.7480.56
117_P435_L0.7440.56
98_D119_G0.7420.55
243_E248_R0.7410.55
121_I141_A0.7400.55
315_R318_V0.7380.55
180_Q214_I0.7370.55
40_V437_N0.7370.55
48_E355_G0.7330.54
120_I415_A0.7320.54
280_F283_G0.7310.54
179_T212_T0.7310.54
115_V211_F0.7300.54
121_I439_M0.7290.54
73_L77_L0.7290.54
47_F230_E0.7280.54
157_T171_G0.7270.54
51_Q378_Q0.7230.53
277_L281_L0.7220.53
348_N369_N0.7220.53
149_Y154_S0.7210.53
48_E51_Q0.7210.53
206_L382_S0.7200.53
134_A165_P0.7200.53
40_V65_W0.7200.53
186_M228_F0.7190.53
276_H279_E0.7180.53
102_P118_G0.7160.53
17_G54_E0.7160.53
68_E139_D0.7150.53
338_A347_T0.7140.53
395_R421_N0.7130.52
121_I443_I0.7110.52
154_S211_F0.7100.52
24_R113_D0.7100.52
359_N384_A0.7090.52
244_G248_R0.7080.52
109_Q400_Q0.7070.52
19_S22_W0.7060.52
211_F422_D0.7050.52
73_L132_E0.7050.52
48_E362_I0.7030.51
97_V101_L0.7030.51
106_G282_P0.7010.51
131_A164_F0.6990.51
95_M443_I0.6960.51
199_E222_I0.6950.51
83_V141_A0.6930.50
30_L380_I0.6900.50
246_C251_V0.6880.50
173_C209_N0.6870.50
134_A167_I0.6870.50
53_N69_A0.6850.50
113_D122_R0.6820.49
218_S223_D0.6820.49
146_V169_A0.6810.49
58_N143_E0.6790.49
416_F419_F0.6770.49
42_L57_G0.6760.49
154_S396_H0.6750.49
29_D330_E0.6750.49
261_D422_D0.6750.49
388_G393_A0.6730.48
434_Q438_D0.6730.48
397_I400_Q0.6720.48
80_A83_V0.6720.48
315_R323_V0.6710.48
436_F440_L0.6700.48
294_F305_D0.6690.48
151_N209_N0.6670.48
361_P364_A0.6670.48
109_Q112_G0.6660.48
302_R306_R0.6660.48
275_R278_A0.6660.48
53_N57_G0.6640.47
403_V419_F0.6640.47
88_L400_Q0.6640.47
303_K306_R0.6620.47
32_I64_R0.6620.47
70_V75_K0.6590.47
60_S312_E0.6580.47
201_I219_Y0.6570.47
194_E220_R0.6570.47
77_L136_A0.6570.47
205_V348_N0.6560.47
199_E220_R0.6560.47
161_Y169_A0.6550.47
246_C250_S0.6540.46
440_L444_M0.6520.46
126_A407_G0.6520.46
66_R220_R0.6500.46
314_E318_V0.6490.46
295_H299_I0.6480.46
102_P121_I0.6470.46
435_L438_D0.6460.46
243_E247_W0.6430.45
87_I323_V0.6430.45
75_K441_Q0.6420.45
261_D276_H0.6410.45
84_I168_K0.6410.45
313_T316_L0.6400.45
88_L122_R0.6400.45
362_I384_A0.6390.45
38_G64_R0.6380.45
149_Y331_E0.6370.45
183_L217_A0.6370.45
15_I77_L0.6370.45
242_L246_C0.6370.45
99_V113_D0.6370.45
94_D443_I0.6370.45
402_A418_A0.6360.45
147_I170_I0.6340.44
12_I336_I0.6330.44
134_A164_F0.6320.44
257_R260_F0.6300.44
394_A398_S0.6300.44
359_N385_L0.6300.44
32_I338_A0.6300.44
295_H304_Q0.6290.44
117_P161_Y0.6280.44
55_V69_A0.6280.44
387_K394_A0.6240.43
22_W339_L0.6240.43
99_V109_Q0.6230.43
203_V214_I0.6220.43
399_N403_V0.6220.43
213_W417_Q0.6200.43
259_A262_L0.6190.43
19_S25_S0.6170.43
430_S434_Q0.6140.42
159_V407_G0.6140.42
225_L229_R0.6140.42
215_T384_A0.6120.42
180_Q198_R0.6120.42
169_A365_I0.6120.42
51_Q252_F0.6110.42
339_L343_G0.6110.42
123_G159_V0.6090.42
50_A71_S0.6080.42
25_S329_G0.6070.42
13_A78_S0.6060.42
126_A156_C0.6040.41
262_L318_V0.6040.41
104_R280_F0.6030.41
115_V399_N0.6010.41
78_S135_R0.6000.41
16_G19_S0.6000.41
369_N386_P0.6000.41
302_R307_A0.5970.41
194_E198_R0.5960.41
181_K185_E0.5950.40
15_I45_L0.5930.40
12_I30_L0.5920.40
47_F139_D0.5910.40
114_T125_R0.5910.40
419_F425_V0.5910.40
356_Q363_Q0.5900.40
184_A193_I0.5900.40
193_I220_R0.5890.40
368_T382_S0.5880.40
164_F169_A0.5880.40
58_N93_D0.5860.40
151_N210_H0.5860.40
259_A263_F0.5860.40
392_L402_A0.5850.40
175_E261_D0.5850.40
43_Y70_V0.5830.39
15_I73_L0.5830.39
109_Q113_D0.5820.39
270_P274_D0.5810.39
88_L109_Q0.5810.39
410_K438_D0.5800.39
131_A135_R0.5790.39
133_I146_V0.5790.39
396_H400_Q0.5780.39
40_V222_I0.5780.39
393_A417_Q0.5770.39
23_A26_L0.5770.39
344_E371_F0.5750.39
312_E316_L0.5740.38
61_G335_I0.5740.38
202_R216_K0.5740.38
363_Q407_G0.5740.38
43_Y77_L0.5730.38
78_S354_Q0.5720.38
344_E374_R0.5710.38
31_S36_M0.5710.38
175_E179_T0.5700.38
61_G67_Y0.5690.38
371_F381_L0.5680.38
175_E212_T0.5680.38
230_E339_L0.5670.38
140_Y200_D0.5670.38
109_Q153_M0.5650.38
175_E331_E0.5650.38
204_N215_T0.5630.37
95_M114_T0.5630.37
85_I169_A0.5630.37
151_N173_C0.5630.37
263_F270_P0.5620.37
99_V400_Q0.5620.37
22_W92_L0.5600.37
134_A350_N0.5590.37
219_Y227_I0.5590.37
301_F306_R0.5580.37
336_I383_G0.5580.37
99_V112_G0.5580.37
85_I150_T0.5580.37
121_I394_A0.5570.37
319_Q441_Q0.5560.37
85_I146_V0.5560.37
122_R126_A0.5550.37
242_L245_E0.5550.37
337_A370_A0.5550.37
161_Y350_N0.5550.37
12_I106_G0.5530.36
88_L103_E0.5530.36
184_A363_Q0.5530.36
54_E67_Y0.5510.36
115_V155_V0.5510.36
52_K410_K0.5490.36
202_R384_A0.5490.36
402_A421_N0.5480.36
354_Q381_L0.5460.36
386_P389_V0.5460.36
276_H330_E0.5450.36
101_L435_L0.5420.35
143_E194_E0.5410.35
127_V403_V0.5400.35
98_D116_G0.5390.35
132_E139_D0.5390.35
14_Y91_S0.5370.35
155_V404_A0.5370.35
361_P401_E0.5370.35
11_K79_A0.5350.35
101_L105_C0.5350.35
145_W170_I0.5340.35
184_A213_W0.5330.35
161_Y363_Q0.5320.34
135_R166_G0.5320.34
390_E401_E0.5300.34
413_G417_Q0.5300.34
20_Q92_L0.5280.34
171_G423_P0.5280.34
97_V104_R0.5280.34
51_Q132_E0.5280.34
11_K38_G0.5270.34
265_T323_V0.5270.34
57_G86_S0.5270.34
176_V348_N0.5270.34
368_T379_P0.5250.34
362_I441_Q0.5250.34
392_L396_H0.5250.34
56_I415_A0.5250.34
363_Q381_L0.5240.34
170_I372_I0.5240.34
130_F134_A0.5240.34
231_F234_H0.5220.34
213_W393_A0.5210.33
363_Q437_N0.5210.33
297_T302_R0.5210.33
141_A167_I0.5200.33
30_L40_V0.5180.33
22_W331_E0.5170.33
289_P293_K0.5170.33
124_L407_G0.5160.33
88_L443_I0.5160.33
332_G336_I0.5160.33
77_L133_I0.5150.33
115_V365_I0.5140.33
226_P256_H0.5120.33
215_T386_P0.5120.33
85_I137_I0.5110.33
363_Q401_E0.5110.33
77_L115_V0.5110.33
15_I43_Y0.5110.33
206_L386_P0.5100.32
307_A320_Q0.5090.32
414_L420_L0.5080.32
191_L227_I0.5080.32
156_C407_G0.5080.32
22_W86_S0.5080.32
321_R329_G0.5080.32
289_P405_D0.5070.32
56_I204_N0.5070.32
399_N422_D0.5070.32
112_G400_Q0.5070.32
58_N68_E0.5060.32
235_Y242_L0.5060.32
120_I123_G0.5060.32
350_N365_I0.5050.32
89_P133_I0.5030.32
81_D145_W0.5030.32
242_L247_W0.5020.32
24_R56_I0.5020.32
44_D112_G0.5020.32
50_A53_N0.5010.32
298_P305_D0.5010.32
13_A68_E0.5010.32
116_G125_R0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1obbA 2 0.9305 100 0.372 Contact Map
3fefA 3 0.9619 100 0.393 Contact Map
1s6yA 1 0.8901 100 0.406 Contact Map
1up7A 3 0.9148 100 0.407 Contact Map
1u8xX 1 0.9193 100 0.407 Contact Map
3u95A 2 0.9372 100 0.429 Contact Map
1pzgA 4 0.7108 100 0.711 Contact Map
4rorA 4 0.6996 100 0.72 Contact Map
3p7mA 4 0.6996 100 0.723 Contact Map
4plzA 4 0.6525 100 0.724 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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