LPLC - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

LPLC - Protein LplC

UniProt:	P39129	Sequences: MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFATEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAYPLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLIIIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHALLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAVYPFLQKHFAKGMLIGSVKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	295 (252)
Sequences:	68087 (45418)
Seq/√Len:	2861.1

ECOLI - MALG YCJP UGPE POTH UGPA YCJO YDCU PSTC YDCV PSTA POTI POTB POTC CYST CYSW MALF THIP YNJC MODB SSUC TAUC PHNE YEHY YEHW
BACSU - LPLC YTCP YESQ ARAQ MDXG GANQ YURM GANP AMYC AMYD ARAP YESP YTEP MDXF LPLB YQGH YURN YQGI YVGM SSUC YTLD OPUAB METP TCYB YXEN
HALSA - Q9HHQ6 Q9HML6 Q9HP01 Q9HHQ7 Q9HP02 Q9HMT4 Q9HS11 Q9HPK3 Q9HR05 Q9HNI9
SULSO - Q97UF3 Q97YY3 Q97UY9 Q97ZC1 Q97YY2 Q97VC0 Q97UZ0 Q97UF4 Q97ZT6 Q97ZT7 Q97ZC2 Q97Z98

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
186_G	190_R	4.341	1.00
80_G	84_F	3.248	1.00
163_K	167_Q	3.066	1.00
178_K	187_V	2.996	1.00
42_S	66_Y	2.977	1.00
106_K	174_E	2.722	1.00
78_S	233_V	2.654	1.00
77_R	80_G	2.639	1.00
174_E	192_A	2.639	1.00
183_S	186_G	2.604	1.00
177_A	187_V	2.577	1.00
64_D	67_K	2.526	1.00
165_F	199_V	2.408	1.00
67_K	71_S	2.402	1.00
185_I	189_W	2.397	1.00
90_T	204_A	2.386	1.00
64_D	68_Y	2.379	1.00
76_L	80_G	2.378	1.00
162_I	200_I	2.313	1.00
92_V	153_A	2.298	1.00
184_E	187_V	2.269	1.00
228_W	236_Q	2.236	1.00
98_F	188_F	2.149	1.00
109_V	112_R	2.143	1.00
186_G	189_W	2.109	1.00
182_C	186_G	2.086	1.00
105_A	167_Q	2.052	1.00
88_V	149_I	2.048	1.00
158_N	203_F	2.041	1.00
258_E	261_I	2.032	1.00
166_F	196_S	1.995	1.00
173_L	195_L	1.950	1.00
177_A	182_C	1.863	1.00
94_L	204_A	1.859	1.00
36_L	40_A	1.850	1.00
98_F	196_S	1.817	1.00
86_T	208_A	1.792	1.00
97_T	158_N	1.779	1.00
77_R	81_V	1.776	1.00
178_K	184_E	1.757	1.00
84_F	145_Y	1.754	1.00
116_L	163_K	1.739	1.00
174_E	187_V	1.732	1.00
40_A	44_A	1.718	1.00
104_L	159_L	1.681	1.00
84_F	88_V	1.654	1.00
100_M	159_L	1.641	1.00
98_F	162_I	1.636	1.00
89_G	211_I	1.594	1.00
68_Y	261_I	1.566	1.00
174_E	178_K	1.551	1.00
108_H	112_R	1.507	1.00
39_I	267_V	1.506	1.00
21_I	25_G	1.467	1.00
33_L	37_Y	1.465	1.00
105_A	163_K	1.442	1.00
193_L	200_I	1.442	1.00
233_V	237_V	1.427	1.00
171_R	174_E	1.426	1.00
101_A	162_I	1.421	1.00
202_T	206_F	1.420	1.00
62_T	65_A	1.418	1.00
63_L	67_K	1.409	1.00
111_G	114_L	1.404	1.00
158_N	207_Y	1.399	1.00
215_F	219_L	1.398	1.00
145_Y	227_K	1.376	1.00
37_Y	41_G	1.363	1.00
93_Q	207_Y	1.338	1.00
166_F	192_A	1.334	1.00
162_I	203_F	1.329	1.00
68_Y	71_S	1.326	1.00
217_H	221_Y	1.302	1.00
95_F	99_T	1.300	1.00
177_A	191_I	1.283	1.00
74_T	77_R	1.282	1.00
106_K	171_R	1.272	1.00
131_P	137_K	1.245	1.00
171_R	175_E	1.242	1.00
98_F	200_I	1.225	1.00
85_I	229_P	1.211	1.00
151_P	221_Y	1.200	1.00
169_L	195_L	1.197	1.00
102_Y	166_F	1.190	1.00
282_K	285_A	1.189	1.00
66_Y	267_V	1.176	1.00
183_S	187_V	1.167	1.00
215_F	235_R	1.154	1.00
38_I	267_V	1.153	1.00
16_F	20_N	1.152	1.00
172_E	175_E	1.151	1.00
88_V	91_A	1.150	1.00
91_A	95_F	1.139	1.00
145_Y	149_I	1.132	1.00
15_V	19_C	1.131	1.00
94_L	200_I	1.124	1.00
13_G	16_F	1.122	1.00
25_G	29_A	1.104	1.00
14_R	18_V	1.104	1.00
222_I	227_K	1.096	1.00
197_K	201_A	1.088	1.00
149_I	153_A	1.087	1.00
161_I	203_F	1.080	1.00
273_I	277_Y	1.078	1.00
140_G	143_D	1.072	1.00
114_L	117_N	1.069	1.00
70_F	76_L	1.069	1.00
162_I	199_V	1.066	1.00
195_L	198_P	1.062	1.00
18_V	22_L	1.062	1.00
102_Y	188_F	1.059	1.00
48_E	60_T	1.057	1.00
226_A	230_L	1.056	1.00
114_L	118_L	1.055	1.00
278_P	282_K	1.054	1.00
133_Y	137_K	1.038	1.00
88_V	92_V	1.037	1.00
45_T	48_E	1.033	1.00
81_V	84_F	1.026	1.00
228_W	233_V	1.025	1.00
146_W	149_I	1.022	1.00
214_D	218_A	1.015	1.00
68_Y	72_T	1.010	1.00
174_E	184_E	1.008	1.00
105_A	166_F	1.008	1.00
83_I	87_V	1.007	1.00
99_T	103_P	1.001	1.00
146_W	150_L	0.994	1.00
229_P	232_M	0.988	1.00
214_D	217_H	0.984	1.00
89_G	93_Q	0.980	1.00
136_V	147_A	0.978	1.00
102_Y	184_E	0.971	1.00
65_A	260_G	0.970	1.00
112_R	167_Q	0.966	1.00
139_L	142_L	0.966	1.00
20_N	24_L	0.965	1.00
279_F	283_H	0.965	1.00
89_G	152_M	0.960	1.00
182_C	187_V	0.954	1.00
18_V	21_I	0.939	1.00
235_R	239_I	0.937	1.00
233_V	236_Q	0.932	1.00
43_F	61_F	0.929	1.00
165_F	196_S	0.925	1.00
187_V	190_R	0.923	1.00
15_V	18_V	0.922	1.00
228_W	232_M	0.922	1.00
152_M	211_I	0.922	1.00
110_K	113_N	0.912	1.00
17_D	21_I	0.910	1.00
131_P	134_L	0.904	1.00
75_F	265_V	0.900	1.00
37_Y	40_A	0.898	1.00
148_L	218_A	0.896	1.00
226_A	229_P	0.895	1.00
41_G	263_L	0.891	1.00
197_K	200_I	0.891	1.00
87_V	91_A	0.889	1.00
141_L	146_W	0.885	1.00
28_G	32_I	0.878	1.00
79_M	230_L	0.878	1.00
188_F	193_L	0.876	1.00
196_S	199_V	0.875	1.00
120_I	160_I	0.872	1.00
13_G	17_D	0.871	1.00
92_V	149_I	0.866	1.00
151_P	217_H	0.864	1.00
79_M	83_I	0.858	1.00
84_F	87_V	0.856	1.00
93_Q	97_T	0.853	1.00
92_V	95_F	0.852	1.00
144_T	227_K	0.850	1.00
162_I	196_S	0.849	1.00
101_A	105_A	0.848	1.00
43_F	62_T	0.845	1.00
97_T	159_L	0.845	1.00
42_S	46_E	0.843	1.00
91_A	204_A	0.841	1.00
158_N	162_I	0.839	1.00
41_G	44_A	0.838	1.00
113_N	116_L	0.835	1.00
189_W	193_L	0.834	1.00
69_V	268_I	0.830	1.00
218_A	229_P	0.828	1.00
81_V	145_Y	0.825	1.00
173_L	191_I	0.814	1.00
47_A	50_A	0.814	1.00
261_I	265_V	0.811	1.00
104_L	116_L	0.806	1.00
134_L	137_K	0.803	1.00
224_D	227_K	0.802	1.00
103_P	109_V	0.802	1.00
132_T	135_V	0.801	1.00
44_A	48_E	0.795	1.00
236_Q	239_I	0.794	1.00
80_G	83_I	0.793	1.00
68_Y	258_E	0.793	1.00
145_Y	148_L	0.792	1.00
259_Q	263_L	0.786	1.00
230_L	234_L	0.785	1.00
230_L	239_I	0.779	1.00
101_A	166_F	0.779	1.00
33_L	36_L	0.774	1.00
162_I	166_F	0.772	1.00
187_V	192_A	0.770	1.00
207_Y	211_I	0.767	1.00
101_A	159_L	0.767	1.00
269_A	273_I	0.766	1.00
263_L	267_V	0.764	1.00
88_V	153_A	0.763	1.00
197_K	283_H	0.762	1.00
147_A	151_P	0.761	1.00
38_I	263_L	0.757	1.00
84_F	146_W	0.755	1.00
148_L	152_M	0.755	1.00
94_L	162_I	0.752	1.00
143_D	224_D	0.751	1.00
275_A	279_F	0.750	1.00
46_E	50_A	0.748	1.00
230_L	233_V	0.748	1.00
169_L	196_S	0.744	1.00
85_I	145_Y	0.742	1.00
104_L	115_L	0.738	1.00
280_L	283_H	0.737	1.00
62_T	66_Y	0.736	1.00
184_E	188_F	0.736	1.00
86_T	90_T	0.727	1.00
89_G	149_I	0.727	1.00
231_Q	234_L	0.726	1.00
144_T	147_A	0.724	1.00
230_L	237_V	0.724	1.00
93_Q	158_N	0.723	1.00
233_V	238_T	0.723	1.00
82_S	231_Q	0.722	1.00
188_F	192_A	0.719	1.00
120_I	123_M	0.715	1.00
225_S	228_W	0.713	1.00
85_I	152_M	0.705	1.00
232_M	236_Q	0.705	1.00
171_R	178_K	0.701	1.00
152_M	155_N	0.700	1.00
22_L	25_G	0.700	1.00
78_S	81_V	0.698	1.00
127_G	216_F	0.696	1.00
222_I	228_W	0.695	1.00
237_V	258_E	0.694	1.00
226_A	239_I	0.692	1.00
138_S	142_L	0.685	1.00
200_I	203_F	0.681	1.00
90_T	208_A	0.675	1.00
45_T	59_K	0.671	1.00
260_G	263_L	0.671	1.00
232_M	235_R	0.670	1.00
263_L	266_I	0.669	1.00
67_K	70_F	0.668	1.00
104_L	163_K	0.666	1.00
69_V	261_I	0.666	1.00
19_C	23_F	0.665	1.00
72_T	76_L	0.664	1.00
90_T	94_L	0.663	1.00
146_W	153_A	0.661	1.00
38_I	266_I	0.660	1.00
132_T	221_Y	0.659	1.00
41_G	45_T	0.653	1.00
219_L	232_M	0.653	1.00
61_F	64_D	0.650	1.00
138_S	141_L	0.650	1.00
76_L	79_M	0.650	1.00
132_T	137_K	0.648	1.00
69_V	265_V	0.643	1.00
182_C	190_R	0.640	1.00
192_A	195_L	0.639	1.00
57_F	60_T	0.639	1.00
44_A	58_P	0.638	1.00
134_L	138_S	0.637	1.00
234_L	237_V	0.636	1.00
200_I	204_A	0.636	1.00
48_E	59_K	0.635	1.00
145_Y	151_P	0.635	1.00
82_S	230_L	0.634	1.00
176_S	180_D	0.634	1.00
45_T	60_T	0.634	1.00
97_T	162_I	0.633	1.00
27_V	31_T	0.632	1.00
63_L	66_Y	0.630	1.00
19_C	22_L	0.627	1.00
222_I	225_S	0.626	1.00
266_I	269_A	0.623	1.00
24_L	28_G	0.623	1.00
137_K	142_L	0.622	1.00
123_M	156_P	0.621	1.00
259_Q	262_K	0.619	1.00
93_Q	211_I	0.615	1.00
116_L	160_I	0.612	1.00
86_T	211_I	0.611	1.00
147_A	221_Y	0.609	1.00
161_I	199_V	0.606	1.00
66_Y	264_A	0.606	1.00
117_N	121_F	0.605	1.00
28_G	31_T	0.603	1.00
228_W	231_Q	0.599	1.00
155_N	207_Y	0.599	1.00
108_H	113_N	0.599	1.00
23_F	27_V	0.598	1.00
149_I	152_M	0.594	1.00
138_S	143_D	0.594	1.00
279_F	282_K	0.594	1.00
199_V	203_F	0.593	1.00
103_P	107_R	0.590	1.00
274_L	278_P	0.589	1.00
100_M	119_V	0.587	1.00
176_S	179_I	0.585	1.00
93_Q	155_N	0.583	1.00
17_D	20_N	0.580	1.00
65_A	68_Y	0.576	1.00
238_T	262_K	0.569	1.00
209_V	213_N	0.566	1.00
44_A	60_T	0.563	1.00
109_V	115_L	0.561	1.00
58_P	61_F	0.558	1.00
101_A	163_K	0.555	1.00
111_G	115_L	0.553	1.00
119_V	156_P	0.552	1.00
231_Q	239_I	0.547	1.00
227_K	231_Q	0.546	1.00
73_P	77_R	0.546	1.00
115_L	119_V	0.546	1.00
183_S	189_W	0.544	1.00
216_F	220_L	0.543	1.00
257_P	261_I	0.541	1.00
136_V	142_L	0.540	1.00
151_P	154_I	0.539	1.00
169_L	174_E	0.538	1.00
227_K	230_L	0.535	1.00
14_R	17_D	0.534	1.00
237_V	265_V	0.534	1.00
130_I	133_Y	0.533	1.00
261_I	264_A	0.533	1.00
42_S	264_A	0.533	1.00
44_A	59_K	0.532	1.00
90_T	211_I	0.531	1.00
42_S	267_V	0.531	1.00
73_P	76_L	0.528	1.00
123_M	157_F	0.528	1.00
21_I	24_L	0.527	1.00
86_T	212_W	0.527	1.00
152_M	218_A	0.524	1.00
255_V	258_E	0.523	1.00
210_G	213_N	0.522	1.00
187_V	191_I	0.521	1.00
82_S	212_W	0.521	1.00
235_R	238_T	0.520	1.00
258_E	262_K	0.519	1.00
108_H	171_R	0.518	1.00
113_N	117_N	0.518	1.00
277_Y	281_Q	0.518	1.00
118_L	122_S	0.516	1.00
226_A	238_T	0.515	1.00
155_N	210_G	0.514	1.00
139_L	143_D	0.513	1.00
144_T	153_A	0.511	1.00
85_I	89_G	0.510	1.00
226_A	237_V	0.510	1.00
144_T	230_L	0.509	1.00
85_I	148_L	0.506	1.00
230_L	269_A	0.506	1.00
104_L	109_V	0.506	1.00
94_L	98_F	0.505	1.00
70_F	73_P	0.504	1.00
130_I	134_L	0.504	1.00
60_T	64_D	0.503	1.00
189_W	192_A	0.503	1.00
201_A	204_A	0.503	1.00
231_Q	235_R	0.502	1.00
148_L	153_A	0.502	1.00
39_I	43_F	0.501	1.00
122_S	156_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4tquN	1	0.9559	100	0.294	Contact Map
3rlfG	1	0.8949	100	0.343	Contact Map
2onkC	2	0.8068	100	0.387	Contact Map
3d31C	2	0.7898	100	0.41	Contact Map
4tquM	1	0.8644	100	0.411	Contact Map
3rlfF	1	0.8847	100	0.45	Contact Map
4ymuD	2	0.7119	99.9	0.554	Contact Map
3tuiA	2	0.6915	99.9	0.582	Contact Map
2m8rA	1	0.1288	16.7	0.947	Contact Map
3hd7A	1	0.1254	16.6	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.