GREMLIN Database
LPLC - Protein LplC
UniProt: P39129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 295 (252)
Sequences: 68087 (45418)
Seq/√Len: 2861.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_G190_R4.3411.00
80_G84_F3.2481.00
163_K167_Q3.0661.00
178_K187_V2.9961.00
42_S66_Y2.9771.00
106_K174_E2.7221.00
78_S233_V2.6541.00
77_R80_G2.6391.00
174_E192_A2.6391.00
183_S186_G2.6041.00
177_A187_V2.5771.00
64_D67_K2.5261.00
165_F199_V2.4081.00
67_K71_S2.4021.00
185_I189_W2.3971.00
90_T204_A2.3861.00
64_D68_Y2.3791.00
76_L80_G2.3781.00
162_I200_I2.3131.00
92_V153_A2.2981.00
184_E187_V2.2691.00
228_W236_Q2.2361.00
98_F188_F2.1491.00
109_V112_R2.1431.00
186_G189_W2.1091.00
182_C186_G2.0861.00
105_A167_Q2.0521.00
88_V149_I2.0481.00
158_N203_F2.0411.00
258_E261_I2.0321.00
166_F196_S1.9951.00
173_L195_L1.9501.00
177_A182_C1.8631.00
94_L204_A1.8591.00
36_L40_A1.8501.00
98_F196_S1.8171.00
86_T208_A1.7921.00
97_T158_N1.7791.00
77_R81_V1.7761.00
178_K184_E1.7571.00
84_F145_Y1.7541.00
116_L163_K1.7391.00
174_E187_V1.7321.00
40_A44_A1.7181.00
104_L159_L1.6811.00
84_F88_V1.6541.00
100_M159_L1.6411.00
98_F162_I1.6361.00
89_G211_I1.5941.00
68_Y261_I1.5661.00
174_E178_K1.5511.00
108_H112_R1.5071.00
39_I267_V1.5061.00
21_I25_G1.4671.00
33_L37_Y1.4651.00
105_A163_K1.4421.00
193_L200_I1.4421.00
233_V237_V1.4271.00
171_R174_E1.4261.00
101_A162_I1.4211.00
202_T206_F1.4201.00
62_T65_A1.4181.00
63_L67_K1.4091.00
111_G114_L1.4041.00
158_N207_Y1.3991.00
215_F219_L1.3981.00
145_Y227_K1.3761.00
37_Y41_G1.3631.00
93_Q207_Y1.3381.00
166_F192_A1.3341.00
162_I203_F1.3291.00
68_Y71_S1.3261.00
217_H221_Y1.3021.00
95_F99_T1.3001.00
177_A191_I1.2831.00
74_T77_R1.2821.00
106_K171_R1.2721.00
131_P137_K1.2451.00
171_R175_E1.2421.00
98_F200_I1.2251.00
85_I229_P1.2111.00
151_P221_Y1.2001.00
169_L195_L1.1971.00
102_Y166_F1.1901.00
282_K285_A1.1891.00
66_Y267_V1.1761.00
183_S187_V1.1671.00
215_F235_R1.1541.00
38_I267_V1.1531.00
16_F20_N1.1521.00
172_E175_E1.1511.00
88_V91_A1.1501.00
91_A95_F1.1391.00
145_Y149_I1.1321.00
15_V19_C1.1311.00
94_L200_I1.1241.00
13_G16_F1.1221.00
25_G29_A1.1041.00
14_R18_V1.1041.00
222_I227_K1.0961.00
197_K201_A1.0881.00
149_I153_A1.0871.00
161_I203_F1.0801.00
273_I277_Y1.0781.00
140_G143_D1.0721.00
114_L117_N1.0691.00
70_F76_L1.0691.00
162_I199_V1.0661.00
195_L198_P1.0621.00
18_V22_L1.0621.00
102_Y188_F1.0591.00
48_E60_T1.0571.00
226_A230_L1.0561.00
114_L118_L1.0551.00
278_P282_K1.0541.00
133_Y137_K1.0381.00
88_V92_V1.0371.00
45_T48_E1.0331.00
81_V84_F1.0261.00
228_W233_V1.0251.00
146_W149_I1.0221.00
214_D218_A1.0151.00
68_Y72_T1.0101.00
174_E184_E1.0081.00
105_A166_F1.0081.00
83_I87_V1.0071.00
99_T103_P1.0011.00
146_W150_L0.9941.00
229_P232_M0.9881.00
214_D217_H0.9841.00
89_G93_Q0.9801.00
136_V147_A0.9781.00
102_Y184_E0.9711.00
65_A260_G0.9701.00
112_R167_Q0.9661.00
139_L142_L0.9661.00
20_N24_L0.9651.00
279_F283_H0.9651.00
89_G152_M0.9601.00
182_C187_V0.9541.00
18_V21_I0.9391.00
235_R239_I0.9371.00
233_V236_Q0.9321.00
43_F61_F0.9291.00
165_F196_S0.9251.00
187_V190_R0.9231.00
15_V18_V0.9221.00
228_W232_M0.9221.00
152_M211_I0.9221.00
110_K113_N0.9121.00
17_D21_I0.9101.00
131_P134_L0.9041.00
75_F265_V0.9001.00
37_Y40_A0.8981.00
148_L218_A0.8961.00
226_A229_P0.8951.00
41_G263_L0.8911.00
197_K200_I0.8911.00
87_V91_A0.8891.00
141_L146_W0.8851.00
28_G32_I0.8781.00
79_M230_L0.8781.00
188_F193_L0.8761.00
196_S199_V0.8751.00
120_I160_I0.8721.00
13_G17_D0.8711.00
92_V149_I0.8661.00
151_P217_H0.8641.00
79_M83_I0.8581.00
84_F87_V0.8561.00
93_Q97_T0.8531.00
92_V95_F0.8521.00
144_T227_K0.8501.00
162_I196_S0.8491.00
101_A105_A0.8481.00
43_F62_T0.8451.00
97_T159_L0.8451.00
42_S46_E0.8431.00
91_A204_A0.8411.00
158_N162_I0.8391.00
41_G44_A0.8381.00
113_N116_L0.8351.00
189_W193_L0.8341.00
69_V268_I0.8301.00
218_A229_P0.8281.00
81_V145_Y0.8251.00
173_L191_I0.8141.00
47_A50_A0.8141.00
261_I265_V0.8111.00
104_L116_L0.8061.00
134_L137_K0.8031.00
224_D227_K0.8021.00
103_P109_V0.8021.00
132_T135_V0.8011.00
44_A48_E0.7951.00
236_Q239_I0.7941.00
80_G83_I0.7931.00
68_Y258_E0.7931.00
145_Y148_L0.7921.00
259_Q263_L0.7861.00
230_L234_L0.7851.00
230_L239_I0.7791.00
101_A166_F0.7791.00
33_L36_L0.7741.00
162_I166_F0.7721.00
187_V192_A0.7701.00
207_Y211_I0.7671.00
101_A159_L0.7671.00
269_A273_I0.7661.00
263_L267_V0.7641.00
88_V153_A0.7631.00
197_K283_H0.7621.00
147_A151_P0.7611.00
38_I263_L0.7571.00
84_F146_W0.7551.00
148_L152_M0.7551.00
94_L162_I0.7521.00
143_D224_D0.7511.00
275_A279_F0.7501.00
46_E50_A0.7481.00
230_L233_V0.7481.00
169_L196_S0.7441.00
85_I145_Y0.7421.00
104_L115_L0.7381.00
280_L283_H0.7371.00
62_T66_Y0.7361.00
184_E188_F0.7361.00
86_T90_T0.7271.00
89_G149_I0.7271.00
231_Q234_L0.7261.00
144_T147_A0.7241.00
230_L237_V0.7241.00
93_Q158_N0.7231.00
233_V238_T0.7231.00
82_S231_Q0.7221.00
188_F192_A0.7191.00
120_I123_M0.7151.00
225_S228_W0.7131.00
85_I152_M0.7051.00
232_M236_Q0.7051.00
171_R178_K0.7011.00
152_M155_N0.7001.00
22_L25_G0.7001.00
78_S81_V0.6981.00
127_G216_F0.6961.00
222_I228_W0.6951.00
237_V258_E0.6941.00
226_A239_I0.6921.00
138_S142_L0.6851.00
200_I203_F0.6811.00
90_T208_A0.6751.00
45_T59_K0.6711.00
260_G263_L0.6711.00
232_M235_R0.6701.00
263_L266_I0.6691.00
67_K70_F0.6681.00
104_L163_K0.6661.00
69_V261_I0.6661.00
19_C23_F0.6651.00
72_T76_L0.6641.00
90_T94_L0.6631.00
146_W153_A0.6611.00
38_I266_I0.6601.00
132_T221_Y0.6591.00
41_G45_T0.6531.00
219_L232_M0.6531.00
61_F64_D0.6501.00
138_S141_L0.6501.00
76_L79_M0.6501.00
132_T137_K0.6481.00
69_V265_V0.6431.00
182_C190_R0.6401.00
192_A195_L0.6391.00
57_F60_T0.6391.00
44_A58_P0.6381.00
134_L138_S0.6371.00
234_L237_V0.6361.00
200_I204_A0.6361.00
48_E59_K0.6351.00
145_Y151_P0.6351.00
82_S230_L0.6341.00
176_S180_D0.6341.00
45_T60_T0.6341.00
97_T162_I0.6331.00
27_V31_T0.6321.00
63_L66_Y0.6301.00
19_C22_L0.6271.00
222_I225_S0.6261.00
266_I269_A0.6231.00
24_L28_G0.6231.00
137_K142_L0.6221.00
123_M156_P0.6211.00
259_Q262_K0.6191.00
93_Q211_I0.6151.00
116_L160_I0.6121.00
86_T211_I0.6111.00
147_A221_Y0.6091.00
161_I199_V0.6061.00
66_Y264_A0.6061.00
117_N121_F0.6051.00
28_G31_T0.6031.00
228_W231_Q0.5991.00
155_N207_Y0.5991.00
108_H113_N0.5991.00
23_F27_V0.5981.00
149_I152_M0.5941.00
138_S143_D0.5941.00
279_F282_K0.5941.00
199_V203_F0.5931.00
103_P107_R0.5901.00
274_L278_P0.5891.00
100_M119_V0.5871.00
176_S179_I0.5851.00
93_Q155_N0.5831.00
17_D20_N0.5801.00
65_A68_Y0.5761.00
238_T262_K0.5691.00
209_V213_N0.5661.00
44_A60_T0.5631.00
109_V115_L0.5611.00
58_P61_F0.5581.00
101_A163_K0.5551.00
111_G115_L0.5531.00
119_V156_P0.5521.00
231_Q239_I0.5471.00
227_K231_Q0.5461.00
73_P77_R0.5461.00
115_L119_V0.5461.00
183_S189_W0.5441.00
216_F220_L0.5431.00
257_P261_I0.5411.00
136_V142_L0.5401.00
151_P154_I0.5391.00
169_L174_E0.5381.00
227_K230_L0.5351.00
14_R17_D0.5341.00
237_V265_V0.5341.00
130_I133_Y0.5331.00
261_I264_A0.5331.00
42_S264_A0.5331.00
44_A59_K0.5321.00
90_T211_I0.5311.00
42_S267_V0.5311.00
73_P76_L0.5281.00
123_M157_F0.5281.00
21_I24_L0.5271.00
86_T212_W0.5271.00
152_M218_A0.5241.00
255_V258_E0.5231.00
210_G213_N0.5221.00
187_V191_I0.5211.00
82_S212_W0.5211.00
235_R238_T0.5201.00
258_E262_K0.5191.00
108_H171_R0.5181.00
113_N117_N0.5181.00
277_Y281_Q0.5181.00
118_L122_S0.5161.00
226_A238_T0.5151.00
155_N210_G0.5141.00
139_L143_D0.5131.00
144_T153_A0.5111.00
85_I89_G0.5101.00
226_A237_V0.5101.00
144_T230_L0.5091.00
85_I148_L0.5061.00
230_L269_A0.5061.00
104_L109_V0.5061.00
94_L98_F0.5051.00
70_F73_P0.5041.00
130_I134_L0.5041.00
60_T64_D0.5031.00
189_W192_A0.5031.00
201_A204_A0.5031.00
231_Q235_R0.5021.00
148_L153_A0.5021.00
39_I43_F0.5011.00
122_S156_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquN 1 0.9559 100 0.294 Contact Map
3rlfG 1 0.8949 100 0.343 Contact Map
2onkC 2 0.8068 100 0.387 Contact Map
3d31C 2 0.7898 100 0.41 Contact Map
4tquM 1 0.8644 100 0.411 Contact Map
3rlfF 1 0.8847 100 0.45 Contact Map
4ymuD 2 0.7119 99.9 0.554 Contact Map
3tuiA 2 0.6915 99.9 0.582 Contact Map
2m8rA 1 0.1288 16.7 0.947 Contact Map
3hd7A 1 0.1254 16.6 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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