GREMLIN Database
LPLB - Protein LplB
UniProt: P39128 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (257)
Sequences: 69374 (44300)
Seq/√Len: 2763.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_R226_H4.1681.00
91_R95_M3.1821.00
199_L203_A2.9771.00
214_I223_R2.9281.00
56_A77_F2.7701.00
117_E210_Y2.6421.00
89_L273_Y2.6271.00
88_R91_R2.5921.00
210_Y228_T2.5761.00
219_G222_R2.4811.00
213_A223_R2.4721.00
99_L183_V2.4651.00
103_F187_I2.4481.00
201_A235_T2.4011.00
75_D78_K2.3741.00
87_F91_R2.3711.00
268_D276_M2.3471.00
101_L240_L2.3441.00
78_K82_M2.3401.00
198_F236_I2.2831.00
75_D79_D2.2461.00
220_R223_R2.2451.00
221_F225_W2.2421.00
109_L224_M2.1141.00
218_A222_R2.0621.00
222_R225_W2.0261.00
283_A286_Y1.9991.00
202_L232_I1.9771.00
116_N203_A1.9731.00
194_G239_L1.9661.00
209_Q231_A1.8781.00
213_A218_A1.8711.00
54_L58_K1.8621.00
120_K123_Y1.8191.00
105_F240_L1.8051.00
95_M179_R1.8011.00
109_L232_I1.7791.00
128_Q199_L1.7541.00
108_P194_G1.7371.00
88_R92_N1.7231.00
214_I220_R1.7211.00
97_A244_I1.7031.00
303_F307_Y1.6941.00
210_Y223_R1.6611.00
111_L195_T1.6241.00
179_R267_A1.6171.00
115_L195_T1.6161.00
109_L198_F1.6071.00
79_D286_Y1.5981.00
95_M99_L1.5871.00
100_D247_F1.5821.00
53_V292_L1.5391.00
210_Y214_I1.4961.00
36_I40_L1.4791.00
120_K124_K1.4591.00
273_Y277_M1.4491.00
112_A198_F1.4421.00
207_Q210_Y1.4401.00
73_G76_Y1.4371.00
261_S266_V1.4271.00
123_Y126_C1.4151.00
119_R124_K1.3891.00
238_V242_L1.3851.00
194_G243_R1.3801.00
96_L269_I1.3751.00
202_L228_T1.3721.00
116_N199_L1.3711.00
229_L236_I1.3671.00
79_D82_M1.3641.00
74_F78_K1.3611.00
198_F239_L1.3271.00
252_F275_Y1.3261.00
259_T267_A1.3181.00
104_A243_R1.3011.00
213_A227_I1.2941.00
85_D88_R1.2871.00
117_E207_Q1.2831.00
252_F256_Y1.2811.00
106_P110_I1.2731.00
254_Q258_M1.2561.00
207_Q211_E1.2461.00
185_Q258_M1.2421.00
93_T270_F1.2381.00
109_L236_I1.2261.00
262_L266_V1.2261.00
51_W55_I1.2111.00
113_L202_L1.2041.00
150_F181_M1.2031.00
208_E211_E1.1911.00
30_W34_L1.1891.00
219_G223_R1.1691.00
29_K33_L1.1641.00
277_M281_Q1.1621.00
102_L106_P1.1601.00
205_V231_A1.1561.00
277_M283_A1.1461.00
99_L102_L1.1381.00
31_L35_L1.1361.00
126_C129_T1.1171.00
59_D62_P1.1161.00
198_F235_T1.1051.00
77_F292_L1.1041.00
28_D31_L1.1031.00
268_D273_Y1.1001.00
105_F236_I1.0811.00
92_N95_M1.0791.00
62_P71_W1.0781.00
307_Y310_K1.0771.00
40_L44_I1.0721.00
276_M280_T1.0681.00
278_G287_S1.0671.00
126_C130_F1.0651.00
52_G292_L1.0631.00
48_L51_W1.0571.00
113_L224_M1.0571.00
233_R237_I1.0521.00
197_L239_L1.0511.00
231_A234_S1.0451.00
81_F87_F1.0401.00
210_Y220_R1.0391.00
191_T195_T1.0381.00
100_D104_A1.0271.00
100_D186_S1.0241.00
255_V269_I1.0231.00
268_D272_T1.0171.00
90_L270_F1.0161.00
113_L220_R1.0161.00
56_A60_Y1.0101.00
103_F183_V1.0071.00
183_V187_I1.0071.00
76_Y285_S1.0041.00
94_L98_S1.0021.00
179_R183_V0.9991.00
33_L37_P0.9991.00
32_Y36_I0.9991.00
99_L103_F0.9981.00
124_K203_A0.9971.00
182_I255_V0.9951.00
218_A223_R0.9921.00
86_F290_V0.9911.00
27_R31_L0.9901.00
180_P184_M0.9901.00
116_N202_L0.9891.00
304_G308_I0.9881.00
151_T154_T0.9831.00
269_I272_T0.9811.00
110_I114_L0.9791.00
256_Y272_T0.9781.00
223_R226_H0.9541.00
273_Y290_V0.9451.00
261_S267_A0.9371.00
30_W33_L0.9271.00
98_S102_L0.9131.00
95_M180_P0.9111.00
186_S247_F0.9081.00
112_A116_N0.9081.00
250_L255_V0.9061.00
43_L47_Y0.9061.00
35_L39_L0.9041.00
100_D183_V0.8991.00
233_R236_I0.8961.00
33_L36_I0.8961.00
156_V180_P0.8961.00
201_A232_I0.8941.00
92_N179_R0.8931.00
146_T258_M0.8891.00
102_L240_L0.8871.00
122_V125_R0.8831.00
55_I59_D0.8801.00
79_D83_N0.8771.00
224_M229_L0.8741.00
95_M98_S0.8741.00
115_L128_Q0.8691.00
28_D32_Y0.8691.00
194_G198_F0.8661.00
132_Y196_I0.8661.00
103_F106_P0.8641.00
277_M290_V0.8631.00
68_K71_W0.8591.00
80_F293_F0.8581.00
96_L179_R0.8561.00
225_W229_L0.8551.00
90_L94_L0.8551.00
185_Q254_Q0.8541.00
55_I58_K0.8451.00
243_R247_F0.8431.00
57_F72_V0.8411.00
232_I235_T0.8391.00
198_F232_I0.8341.00
108_P195_T0.8321.00
104_A108_P0.8281.00
58_K62_P0.8271.00
146_T185_Q0.8191.00
99_L187_I0.8171.00
284_Y287_S0.8161.00
304_G307_Y0.8161.00
55_I288_T0.8141.00
143_V257_L0.8141.00
112_A195_T0.8121.00
96_L186_S0.8101.00
112_A202_L0.8061.00
125_R128_Q0.8051.00
57_F73_G0.8031.00
114_L120_K0.8021.00
119_R123_Y0.7971.00
52_G288_T0.7941.00
286_Y290_V0.7911.00
209_Q227_I0.7901.00
180_P183_V0.7891.00
139_W189_K0.7861.00
91_R94_L0.7851.00
83_N87_F0.7811.00
147_F151_T0.7801.00
273_Y276_M0.7791.00
262_L268_D0.7781.00
277_M286_Y0.7741.00
223_R228_T0.7631.00
89_L92_N0.7551.00
104_A190_E0.7541.00
115_L127_I0.7531.00
89_L270_F0.7511.00
79_D283_A0.7461.00
52_G291_G0.7451.00
181_M185_Q0.7441.00
298_G302_I0.7431.00
78_K81_F0.7421.00
66_F69_S0.7411.00
220_R224_M0.7401.00
300_I304_G0.7341.00
105_F198_F0.7311.00
224_M228_T0.7311.00
93_T271_D0.7291.00
205_V232_I0.7261.00
66_F70_E0.7241.00
101_L244_I0.7241.00
158_N261_S0.7231.00
104_A194_G0.7221.00
37_P40_L0.7201.00
198_F202_L0.7181.00
132_Y135_H0.7141.00
156_V159_K0.7141.00
72_V75_D0.7121.00
111_L191_T0.7121.00
274_V290_V0.7111.00
270_F294_K0.7071.00
207_Q214_I0.7051.00
250_L269_I0.7001.00
142_V188_W0.6991.00
59_D70_E0.6981.00
101_L105_F0.6971.00
62_P70_E0.6971.00
108_P198_F0.6931.00
42_F46_K0.6921.00
155_G158_N0.6911.00
97_A101_L0.6901.00
139_W253_E0.6901.00
143_V253_E0.6901.00
115_L199_L0.6901.00
148_V153_D0.6841.00
29_K32_Y0.6811.00
288_T292_L0.6761.00
218_A226_H0.6751.00
253_E257_L0.6751.00
34_L37_P0.6741.00
87_F90_L0.6731.00
236_I239_L0.6731.00
305_A308_I0.6731.00
259_T268_D0.6711.00
107_A191_T0.6661.00
74_F77_F0.6651.00
233_R308_I0.6641.00
271_D294_K0.6611.00
58_K69_S0.6581.00
288_T291_G0.6571.00
255_V272_T0.6551.00
43_L46_K0.6551.00
212_A216_D0.6551.00
181_M258_M0.6521.00
104_A247_F0.6511.00
38_G42_F0.6491.00
96_L183_V0.6491.00
284_Y288_T0.6491.00
190_E243_R0.6481.00
182_I259_T0.6481.00
228_T231_A0.6471.00
153_D156_V0.6421.00
34_L38_G0.6411.00
96_L182_I0.6391.00
212_A215_M0.6371.00
135_H192_G0.6371.00
190_E246_S0.6341.00
55_I60_Y0.6331.00
80_F286_Y0.6321.00
59_D71_W0.6321.00
73_G77_F0.6301.00
236_I240_L0.6281.00
262_L267_A0.6271.00
51_W54_L0.6251.00
275_Y279_I0.6241.00
76_Y79_D0.6241.00
93_T248_L0.6231.00
235_T239_L0.6231.00
39_L43_L0.6221.00
299_I303_F0.6201.00
84_P88_R0.6201.00
197_L235_T0.6141.00
107_A187_I0.6131.00
80_F290_V0.6131.00
151_T157_I0.6121.00
140_T257_L0.6101.00
272_T276_M0.6091.00
32_Y35_L0.6091.00
118_V124_K0.6091.00
250_L254_Q0.6081.00
27_R30_W0.6041.00
131_I192_G0.6031.00
123_Y127_I0.6011.00
84_P87_F0.5981.00
114_L118_V0.5951.00
77_F289_A0.5951.00
146_T149_F0.5941.00
285_S288_T0.5941.00
150_F157_I0.5921.00
97_A247_F0.5861.00
245_G249_N0.5851.00
54_L57_F0.5761.00
56_A289_A0.5741.00
148_V151_T0.5741.00
111_L131_I0.5741.00
104_A187_I0.5741.00
71_W74_F0.5731.00
119_R122_V0.5731.00
128_Q196_I0.5721.00
135_H193_W0.5701.00
246_S249_N0.5691.00
219_G225_W0.5661.00
52_G56_A0.5621.00
105_F109_L0.5601.00
52_G55_I0.5591.00
182_I186_S0.5581.00
58_K71_W0.5581.00
92_N267_A0.5571.00
85_D273_Y0.5511.00
134_P192_G0.5501.00
112_A199_L0.5471.00
96_L100_D0.5471.00
127_I131_I0.5471.00
137_V141_I0.5431.00
113_L228_T0.5431.00
205_V210_Y0.5421.00
125_R129_T0.5411.00
97_A248_L0.5401.00
189_K192_G0.5381.00
100_D187_I0.5381.00
71_W75_D0.5381.00
129_T133_V0.5371.00
149_F157_I0.5361.00
101_L247_F0.5341.00
237_I240_L0.5331.00
86_F273_Y0.5331.00
294_K298_G0.5321.00
60_Y69_S0.5291.00
139_W143_V0.5271.00
56_A59_D0.5271.00
223_R227_I0.5261.00
53_V56_A0.5231.00
111_L114_L0.5231.00
58_K70_E0.5211.00
240_L243_R0.5201.00
128_Q203_A0.5151.00
189_K254_Q0.5151.00
120_K127_I0.5141.00
44_I48_L0.5111.00
142_V189_K0.5101.00
67_W70_E0.5091.00
92_N269_I0.5071.00
274_V291_G0.5071.00
36_I39_L0.5071.00
272_T275_Y0.5041.00
130_F134_P0.5041.00
104_A191_T0.5031.00
59_D73_G0.5021.00
31_L34_L0.5021.00
69_S72_V0.5011.00
225_W228_T0.5011.00
83_N286_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.8899 100 0.306 Contact Map
2onkC 2 0.7893 100 0.367 Contact Map
3d31C 2 0.7799 100 0.374 Contact Map
3rlfF 1 0.9308 100 0.378 Contact Map
3rlfG 1 0.8459 100 0.42 Contact Map
4tquN 1 0.8302 100 0.435 Contact Map
4ymuD 2 0.673 99.9 0.542 Contact Map
3tuiA 2 0.6572 99.9 0.549 Contact Map
2m8rA 1 0.173 24.9 0.945 Contact Map
2kogA 1 0.1761 22.1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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