GREMLIN Database
IDH - Isocitrate dehydrogenase [NADP]
UniProt: P39126 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 423 (403)
Sequences: 749 (306)
Seq/√Len: 15.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_R243_E5.2791.00
83_I89_A4.7531.00
194_E198_S4.4721.00
192_V306_M4.4591.00
214_K301_D4.1041.00
213_R301_D4.0111.00
209_I279_I3.8261.00
400_A408_E3.7021.00
198_S242_K3.5340.99
197_T201_V3.3780.99
42_L366_G3.3480.99
137_D298_N3.2660.99
134_R137_D3.2050.99
206_D244_Y3.1900.99
166_L174_L3.1600.99
37_A415_G3.0820.98
6_K85_E3.0140.98
206_D210_E2.9480.98
168_S172_N2.9420.98
62_Y71_T2.8580.97
18_N53_E2.8320.97
410_K413_E2.8170.97
367_V371_E2.7950.97
385_S389_T2.7540.97
186_G231_A2.7310.96
77_A81_D2.6170.95
60_E66_K2.6020.95
205_I281_I2.5770.95
32_P36_N2.5550.95
40_K416_E2.5340.94
156_Y174_L2.5200.94
198_S238_E2.4120.93
165_K173_E2.3990.93
370_L378_A2.3830.92
385_S388_K2.3450.92
351_Y397_Y2.3330.91
56_I370_L2.2960.91
201_V239_L2.2890.91
371_E380_D2.2880.91
389_T421_N2.2750.90
351_Y357_V2.2690.90
215_S282_K2.2010.89
65_E69_N2.1820.88
167_I187_I2.1790.88
42_L370_L2.1550.88
355_D411_C2.1470.87
218_L236_G2.1350.87
198_S239_L2.1220.87
250_T253_Q2.0020.83
182_P195_E1.9990.83
288_I300_F1.9670.82
385_S418_L1.9600.82
73_E77_A1.9560.82
289_F313_I1.9300.81
203_A334_Y1.9120.80
388_K421_N1.9080.80
351_Y401_R1.8450.78
397_Y401_R1.8290.77
169_F174_L1.8210.77
184_T195_E1.8180.77
417_E420_K1.7660.75
35_W38_A1.7620.75
354_L408_E1.7590.74
42_L382_V1.7580.74
141_V213_R1.7370.73
38_A42_L1.7350.73
35_W42_L1.7300.73
26_E66_K1.7010.72
392_S421_N1.6960.72
326_I399_F1.6740.71
289_F293_I1.6620.70
350_K397_Y1.6560.70
416_E419_I1.6350.69
109_L340_I1.6310.68
394_V417_E1.6220.68
182_P185_S1.6200.68
356_K408_E1.6110.67
249_F257_I1.6100.67
140_M317_L1.6080.67
292_Q351_Y1.5850.66
249_F254_Y1.5740.66
334_Y337_G1.5470.64
371_E383_I1.5230.63
288_I292_Q1.5080.62
201_V218_L1.4770.61
68_Y71_T1.4770.61
156_Y166_L1.4660.60
125_F128_V1.4650.60
355_D410_K1.4580.59
150_I306_M1.4550.59
248_V251_W1.4520.59
249_F255_D1.4490.59
165_K169_F1.4420.59
139_D213_R1.4390.58
10_S13_V1.4320.58
157_A234_N1.4170.57
246_D252_A1.4120.57
296_R350_K1.4070.57
246_D250_T1.4020.56
132_V138_T1.4010.56
158_K194_E1.4000.56
241_E253_Q1.3810.55
59_K78_E1.3790.55
357_V397_Y1.3690.55
62_Y70_K1.3660.54
150_I192_V1.3530.54
200_L304_A1.3520.54
205_I216_V1.3510.54
59_K62_Y1.3300.52
381_L385_S1.3270.52
357_V401_R1.3230.52
296_R351_Y1.3210.52
234_N238_E1.3090.51
10_S15_N1.3030.51
394_V409_V1.2950.50
393_K405_G1.2920.50
259_E273_A1.2920.50
160_S163_V1.2840.50
49_A381_L1.2710.49
293_I313_I1.2600.48
273_A276_A1.2340.47
390_I395_V1.2250.46
38_A366_G1.2220.46
250_T276_A1.2190.46
251_W284_S1.2080.45
251_W254_Y1.1990.45
253_Q273_A1.1980.45
203_A337_G1.1970.45
129_P399_F1.1750.44
273_A277_G1.1620.43
236_G304_A1.1590.43
296_R299_E1.1560.43
253_Q278_K1.1550.42
89_A340_I1.1530.42
140_M293_I1.1510.42
337_G372_H1.1500.42
40_K415_G1.1470.42
169_F173_E1.1440.42
293_I303_V1.1430.42
59_K71_T1.1390.42
61_V83_I1.1310.41
42_L56_I1.1250.41
296_R401_R1.1170.40
118_C344_T1.1140.40
350_K401_R1.1130.40
8_T15_N1.1090.40
360_S386_M1.1050.40
33_D36_N1.1030.40
215_S281_I1.0990.39
350_K357_V1.0950.39
351_Y355_D1.0910.39
201_V236_G1.0880.39
63_A75_L1.0840.39
367_V383_I1.0810.38
102_I108_A1.0780.38
258_A273_A1.0750.38
258_A275_A1.0740.38
40_K419_I1.0740.38
203_A333_N1.0700.38
219_V305_T1.0620.37
333_N337_G1.0610.37
246_D277_G1.0590.37
167_I185_S1.0590.37
30_T362_V1.0560.37
254_Y258_A1.0530.37
164_Q167_I1.0490.37
246_D278_K1.0420.36
194_E242_K1.0330.36
251_W273_A1.0310.36
56_I378_A1.0300.36
32_P353_G1.0270.36
400_A409_V1.0260.36
246_D251_W1.0180.35
250_T278_K1.0160.35
164_Q183_E1.0110.35
248_V253_Q1.0110.35
218_L304_A1.0080.35
293_I316_A1.0080.35
139_D301_D1.0070.35
274_E280_I1.0050.34
56_I373_L0.9960.34
293_I300_F0.9950.34
169_F176_V0.9950.34
202_R244_Y0.9930.34
208_A216_V0.9900.34
355_D412_S0.9870.34
62_Y68_Y0.9870.34
61_V74_W0.9650.32
292_Q296_R0.9630.32
241_E249_F0.9590.32
201_V304_A0.9550.32
296_R397_Y0.9490.32
248_V255_D0.9440.31
258_A278_K0.9440.31
83_I340_I0.9410.31
356_K397_Y0.9390.31
293_I317_L0.9340.31
38_A362_V0.9330.31
249_F253_Q0.9280.31
210_E244_Y0.9270.31
254_Y275_A0.9260.31
32_P37_A0.9160.30
212_G274_E0.9160.30
388_K392_S0.9150.30
284_S289_F0.9100.30
124_Y320_Q0.9090.30
371_E379_A0.9050.30
351_Y412_S0.9050.30
184_T231_A0.9020.29
180_R195_E0.9010.29
249_F280_I0.8990.29
123_R383_I0.8970.29
249_F273_A0.8970.29
212_G277_G0.8960.29
386_M418_L0.8950.29
169_F175_N0.8950.29
34_I343_A0.8940.29
158_K184_T0.8920.29
241_E248_V0.8910.29
39_S43_E0.8900.29
9_V87_F0.8890.29
41_V363_I0.8880.29
30_T357_V0.8870.29
386_M389_T0.8780.28
74_W95_T0.8770.28
332_I337_G0.8760.28
389_T415_G0.8730.28
87_F203_A0.8720.28
32_P35_W0.8710.28
74_W102_I0.8700.28
253_Q259_E0.8650.28
251_W280_I0.8620.28
241_E255_D0.8580.27
13_V87_F0.8550.27
73_E78_E0.8530.27
284_S292_Q0.8480.27
138_T233_K0.8460.27
186_G201_V0.8460.27
259_E275_A0.8440.27
168_S177_N0.8400.27
350_K355_D0.8370.26
142_I403_M0.8360.26
19_N57_T0.8340.26
43_E55_K0.8340.26
251_W276_A0.8260.26
81_D85_E0.8260.26
239_L242_K0.8250.26
33_D397_Y0.8230.26
166_L187_I0.8210.26
324_I399_F0.8180.26
284_S290_L0.8160.26
116_F334_Y0.8150.25
389_T417_E0.8120.25
87_F333_N0.8110.25
160_S186_G0.8100.25
249_F275_A0.8090.25
393_K399_F0.8030.25
126_T387_E0.7940.25
206_D209_I0.7920.25
366_G370_L0.7920.25
33_D412_S0.7900.24
238_E242_K0.7900.24
296_R355_D0.7900.24
113_L302_V0.7890.24
108_A112_E0.7870.24
332_I338_H0.7860.24
184_T333_N0.7860.24
254_Y273_A0.7820.24
88_I340_I0.7820.24
344_T361_S0.7800.24
203_A332_I0.7790.24
254_Y257_I0.7790.24
132_V201_V0.7790.24
251_W255_D0.7780.24
36_N71_T0.7780.24
24_F43_E0.7780.24
133_K391_A0.7740.24
202_R239_L0.7730.24
249_F256_R0.7730.24
246_D255_D0.7690.24
23_P86_Y0.7680.24
246_D276_A0.7680.24
294_L320_Q0.7670.23
296_R402_L0.7670.23
249_F278_K0.7660.23
44_A419_I0.7660.23
157_A160_S0.7660.23
179_I290_L0.7640.23
369_L373_L0.7600.23
83_I87_F0.7600.23
39_S416_E0.7590.23
35_W362_V0.7580.23
212_G258_A0.7560.23
288_I360_S0.7540.23
35_W366_G0.7540.23
292_Q401_R0.7530.23
78_E82_V0.7530.23
239_L243_E0.7520.23
341_F361_S0.7520.23
211_H376_N0.7510.23
174_L227_F0.7490.23
164_Q168_S0.7490.23
108_A373_L0.7440.23
124_Y136_E0.7430.23
202_R206_D0.7410.22
367_V379_A0.7400.22
252_A275_A0.7330.22
38_A370_L0.7250.22
192_V305_T0.7250.22
37_A410_K0.7220.22
118_C343_A0.7220.22
297_P344_T0.7210.22
239_L418_L0.7200.22
288_I353_G0.7160.21
293_I320_Q0.7160.21
370_L379_A0.7160.21
241_E273_A0.7140.21
250_T273_A0.7130.21
212_G276_A0.7110.21
32_P38_A0.7100.21
168_S173_E0.7100.21
234_N354_L0.7050.21
68_Y340_I0.7040.21
36_N353_G0.7030.21
73_E81_D0.7000.21
168_S384_K0.7000.21
26_E165_K0.6980.21
289_F300_F0.6970.21
173_E176_V0.6970.21
159_G243_E0.6970.21
394_V421_N0.6970.21
394_V407_T0.6960.21
257_I273_A0.6950.21
371_E376_N0.6940.21
219_V306_M0.6940.21
397_Y412_S0.6910.21
253_Q257_I0.6910.21
246_D253_Q0.6900.20
78_E369_L0.6900.20
252_A278_K0.6890.20
337_G340_I0.6880.20
62_Y78_E0.6860.20
296_R357_V0.6860.20
252_A276_A0.6850.20
77_A84_R0.6850.20
19_N245_G0.6840.20
24_F39_S0.6830.20
299_E397_Y0.6820.20
373_L416_E0.6820.20
274_E277_G0.6800.20
37_A40_K0.6780.20
80_L112_E0.6770.20
253_Q276_A0.6770.20
212_G273_A0.6760.20
68_Y75_L0.6760.20
250_T254_Y0.6760.20
87_F334_Y0.6750.20
418_L422_M0.6750.20
117_V333_N0.6730.20
299_E401_R0.6730.20
61_V89_A0.6720.20
249_F259_E0.6720.20
251_W277_G0.6700.20
197_T306_M0.6690.20
8_T238_E0.6680.20
251_W278_K0.6670.20
11_N242_K0.6670.20
248_V252_A0.6660.20
179_I324_I0.6650.20
24_F35_W0.6650.20
367_V380_D0.6640.20
35_W39_S0.6620.19
166_L169_F0.6610.19
87_F338_H0.6600.19
117_V150_I0.6600.19
332_I372_H0.6580.19
163_V187_I0.6580.19
22_I86_Y0.6570.19
32_P351_Y0.6550.19
156_Y160_S0.6530.19
341_F344_T0.6520.19
394_V408_E0.6520.19
102_I227_F0.6490.19
255_D259_E0.6490.19
36_N40_K0.6470.19
333_N338_H0.6450.19
363_I418_L0.6450.19
171_Q183_E0.6440.19
5_E19_N0.6440.19
248_V278_K0.6440.19
73_E117_V0.6410.19
399_F406_A0.6410.19
38_A368_L0.6400.19
384_K388_K0.6370.19
355_D397_Y0.6370.19
316_A320_Q0.6370.19
37_A354_L0.6370.19
33_D389_T0.6350.19
134_R298_N0.6330.18
9_V13_V0.6330.18
50_Y377_E0.6320.18
181_F195_E0.6320.18
385_S421_N0.6320.18
9_V203_A0.6310.18
210_E422_M0.6300.18
299_E350_K0.6290.18
367_V376_N0.6270.18
159_G164_Q0.6260.18
181_F324_I0.6260.18
21_I82_V0.6240.18
132_V294_L0.6240.18
290_L324_I0.6240.18
289_F303_V0.6230.18
118_C318_A0.6220.18
30_T386_M0.6220.18
68_Y73_E0.6220.18
343_A361_S0.6220.18
18_N77_A0.6220.18
9_V337_G0.6220.18
68_Y74_W0.6210.18
252_A273_A0.6200.18
392_S417_E0.6190.18
399_F408_E0.6170.18
30_T83_I0.6160.18
54_K377_E0.6150.18
124_Y132_V0.6150.18
357_V411_C0.6150.18
191_P224_I0.6140.18
292_Q397_Y0.6140.18
284_S324_I0.6140.18
188_G286_A0.6110.18
254_Y259_E0.6100.18
219_V326_I0.6100.18
404_D418_L0.6100.18
250_T259_E0.6100.18
397_Y411_C0.6100.18
273_A278_K0.6090.18
26_E201_V0.6070.18
211_H371_E0.6070.18
370_L382_V0.6070.18
318_A321_V0.6070.18
389_T392_S0.6050.18
175_N178_K0.6050.18
38_A386_M0.6050.18
42_L378_A0.6050.18
157_A186_G0.6030.17
25_I411_C0.6000.17
138_T369_L0.6000.17
350_K390_I0.6000.17
62_Y67_A0.6000.17
255_D277_G0.5990.17
165_K174_L0.5980.17
141_V207_Y0.5970.17
257_I275_A0.5970.17
389_T394_V0.5970.17
13_V206_D0.5970.17
254_Y278_K0.5960.17
33_D351_Y0.5960.17
252_A255_D0.5950.17
181_F257_I0.5950.17
393_K406_A0.5940.17
206_D279_I0.5940.17
339_A368_L0.5940.17
33_D350_K0.5940.17
249_F258_A0.5930.17
128_V326_I0.5930.17
299_E357_V0.5930.17
388_K418_L0.5910.17
30_T35_W0.5910.17
26_E169_F0.5900.17
123_R387_E0.5890.17
39_S362_V0.5890.17
324_I334_Y0.5890.17
300_F353_G0.5880.17
248_V277_G0.5870.17
288_I403_M0.5860.17
291_Q324_I0.5840.17
73_E206_D0.5830.17
211_H367_V0.5810.17
108_A160_S0.5790.17
245_G279_I0.5790.17
323_G328_P0.5790.17
39_S42_L0.5790.17
159_G198_S0.5790.17
256_R277_G0.5770.17
354_L410_K0.5770.17
157_A394_V0.5760.17
250_T258_A0.5760.17
183_E420_K0.5750.17
281_I393_K0.5740.17
167_I171_Q0.5730.17
205_I240_A0.5730.17
247_K388_K0.5720.16
255_D273_A0.5710.16
35_W68_Y0.5710.16
251_W334_Y0.5710.16
184_T238_E0.5700.16
139_D298_N0.5700.16
306_M326_I0.5680.16
289_F353_G0.5680.16
84_R238_E0.5680.16
254_Y284_S0.5670.16
84_R252_A0.5670.16
40_K353_G0.5660.16
249_F252_A0.5660.16
388_K394_V0.5650.16
18_N73_E0.5640.16
250_T277_G0.5640.16
300_F320_Q0.5620.16
32_P71_T0.5610.16
372_H419_I0.5600.16
47_E168_S0.5590.16
117_V300_F0.5580.16
23_P61_V0.5580.16
109_L387_E0.5580.16
12_G87_F0.5580.16
181_F290_L0.5580.16
98_V288_I0.5580.16
67_A76_P0.5570.16
6_K10_S0.5570.16
111_Q328_P0.5540.16
329_G343_A0.5540.16
117_V147_T0.5530.16
250_T255_D0.5530.16
150_I289_F0.5500.16
241_E275_A0.5500.16
33_D355_D0.5490.16
102_I113_L0.5490.16
156_Y418_L0.5480.16
251_W257_I0.5470.16
11_N15_N0.5470.16
321_V344_T0.5440.16
51_K422_M0.5440.16
251_W258_A0.5440.16
219_V303_V0.5430.16
170_L193_S0.5430.16
288_I357_V0.5430.16
399_F403_M0.5420.16
87_F340_I0.5420.16
395_V399_F0.5410.16
334_Y338_H0.5400.16
65_E74_W0.5400.16
363_I369_L0.5390.15
128_V387_E0.5380.15
47_E186_G0.5370.15
171_Q179_I0.5360.15
125_F387_E0.5350.15
318_A343_A0.5340.15
198_S241_E0.5340.15
161_E164_Q0.5330.15
200_L236_G0.5330.15
22_I418_L0.5330.15
85_E382_V0.5320.15
71_T82_V0.5320.15
351_Y356_K0.5300.15
224_I323_G0.5290.15
288_I299_E0.5280.15
197_T368_L0.5280.15
162_E172_N0.5270.15
218_L281_I0.5270.15
246_D254_Y0.5270.15
182_P193_S0.5270.15
333_N372_H0.5270.15
63_A79_T0.5270.15
388_K391_A0.5260.15
237_Y283_D0.5260.15
47_E407_T0.5250.15
140_M303_V0.5250.15
259_E276_A0.5250.15
186_G197_T0.5250.15
401_R412_S0.5250.15
166_L313_I0.5240.15
241_E251_W0.5230.15
117_V284_S0.5230.15
9_V12_G0.5210.15
385_S411_C0.5210.15
233_K409_V0.5200.15
52_G377_E0.5200.15
188_G227_F0.5200.15
171_Q174_L0.5180.15
80_L133_K0.5180.15
248_V282_K0.5180.15
11_N87_F0.5180.15
161_E281_I0.5160.15
34_I50_Y0.5160.15
87_F337_G0.5130.15
38_A378_A0.5120.15
37_A356_K0.5110.15
88_I164_Q0.5110.15
44_A48_K0.5090.15
316_A395_V0.5070.15
382_V422_M0.5070.15
133_K214_K0.5060.15
288_I293_I0.5050.14
294_L302_V0.5050.14
105_L200_L0.5030.14
102_I118_C0.5020.14
163_V167_I0.5020.14
257_I281_I0.5010.14
332_I340_I0.5010.14
134_R138_T0.5010.14
245_G253_Q0.5010.14
35_W334_Y0.5000.14
157_A404_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hqsA 2 1 100 0.295 Contact Map
2d4vA 2 0.9929 100 0.306 Contact Map
1tyoA 2 0.9574 100 0.317 Contact Map
3dmsA 2 0.9551 100 0.32 Contact Map
2iv0A 2 0.9504 100 0.326 Contact Map
2e0cA 2 0.9314 100 0.329 Contact Map
2d1cA 2 0.8251 100 0.431 Contact Map
2uxqA 4 0.8747 100 0.433 Contact Map
3flkA 3 0.8132 100 0.438 Contact Map
4xxvA 2 0.8132 100 0.44 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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