GREMLIN Database
GLGA - Glycogen synthase
UniProt: P39125 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 484 (407)
Sequences: 12425 (8805)
Seq/√Len: 436.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
297_S369_S4.9651.00
210_H243_T4.1381.00
325_Q352_R3.4911.00
333_E337_E3.4001.00
293_I325_Q3.3311.00
130_H472_F3.2181.00
35_N469_Q3.1651.00
33_L466_K2.9251.00
313_R339_Y2.7431.00
440_F443_Q2.6941.00
372_F388_A2.6721.00
443_Q446_V2.6471.00
33_L469_Q2.6031.00
446_V450_I2.5701.00
317_E428_H2.5631.00
294_P438_L2.5101.00
338_D342_Y2.4801.00
463_K467_E2.4611.00
397_V421_T2.4151.00
321_E435_E2.3551.00
426_N429_D2.3461.00
452_K456_N2.3331.00
407_V419_G2.2551.00
444_Q448_K2.2251.00
334_R337_E2.2201.00
238_R241_D2.2121.00
219_R223_M2.2101.00
329_L365_I2.1971.00
399_E423_S2.1631.00
313_R427_A2.1541.00
295_L327_V2.1501.00
311_V373_L2.1221.00
336_F340_F2.1091.00
423_S429_D2.1041.00
433_T436_R2.0801.00
130_H161_T2.0431.00
317_E431_K2.0361.00
453_T457_A2.0341.00
448_K451_V2.0231.00
427_A431_K1.9981.00
29_A32_R1.9881.00
210_H474_Q1.9871.00
369_S393_A1.9851.00
441_Y444_Q1.9841.00
243_T474_Q1.9831.00
296_I371_M1.9481.00
420_F433_T1.9471.00
220_N224_T1.9361.00
394_I454_A1.9291.00
423_S426_N1.9271.00
284_R364_Q1.9211.00
38_A126_A1.9201.00
220_N223_M1.9201.00
410_Y417_G1.9071.00
340_F353_A1.8751.00
298_M308_L1.8621.00
334_R338_D1.8511.00
449_S453_T1.8441.00
454_A458_D1.8091.00
467_E470_R1.7771.00
296_I434_I1.7741.00
29_A462_G1.7631.00
319_L350_K1.7521.00
280_K284_R1.7091.00
315_M326_L1.6941.00
339_Y342_Y1.6921.00
448_K452_K1.6921.00
294_P371_M1.6831.00
339_Y343_A1.6831.00
216_P220_N1.6731.00
160_L208_A1.6701.00
436_R440_F1.6581.00
435_E439_S1.6501.00
447_W451_V1.6401.00
333_E336_F1.6371.00
245_I471_I1.6341.00
466_K470_R1.6341.00
279_T283_Q1.6161.00
428_H432_F1.6121.00
429_D432_F1.6091.00
160_L201_M1.6081.00
371_M396_I1.5991.00
469_Q473_E1.5991.00
29_A465_A1.5871.00
296_I373_L1.5771.00
316_H343_A1.5741.00
429_D433_T1.5641.00
318_L435_E1.5401.00
420_F436_R1.5301.00
302_L330_G1.5151.00
408_R417_G1.5121.00
436_R443_Q1.5121.00
341_R348_H1.5111.00
309_D377_K1.5021.00
327_V354_Y1.4961.00
311_V326_L1.4931.00
340_F347_F1.4911.00
418_N454_A1.4771.00
295_L368_G1.4641.00
157_K209_D1.4471.00
432_F436_R1.4401.00
38_A85_Y1.4391.00
372_F393_A1.4371.00
388_A393_A1.4351.00
298_M311_V1.4341.00
302_L328_V1.4311.00
223_M239_E1.4261.00
297_S365_I1.4171.00
399_E404_Y1.4171.00
280_K283_Q1.4121.00
318_L324_I1.3961.00
7_V23_A1.3921.00
396_I434_I1.3901.00
295_L325_Q1.3831.00
282_Q288_P1.3651.00
444_Q447_W1.3541.00
317_E321_E1.3511.00
358_D361_L1.3471.00
450_I453_T1.3461.00
392_G452_K1.3431.00
113_R117_E1.3431.00
316_H320_E1.3401.00
315_M318_L1.3371.00
338_D341_R1.3371.00
219_R244_G1.3361.00
210_H471_I1.3331.00
214_V247_N1.3321.00
212_T468_Y1.3241.00
361_L364_Q1.3231.00
337_E341_R1.3221.00
296_I326_L1.3181.00
315_M324_I1.3171.00
76_H83_N1.3121.00
297_S366_Y1.3021.00
408_R418_N1.2901.00
463_K466_K1.2871.00
301_R306_K1.2801.00
371_M437_A1.2751.00
314_I430_L1.2701.00
306_K379_E1.2681.00
128_I209_D1.2611.00
104_D107_R1.2551.00
336_F339_Y1.2511.00
216_P219_R1.2511.00
205_I211_V1.2471.00
397_V407_V1.2401.00
282_Q325_Q1.2401.00
362_A366_Y1.2391.00
374_M384_G1.2301.00
306_K376_S1.2281.00
248_G461_W1.2161.00
317_E427_A1.2131.00
144_K209_D1.2081.00
318_L434_I1.2041.00
447_W450_I1.2021.00
166_Q169_G1.1931.00
293_I323_D1.1861.00
132_H163_H1.1811.00
254_Y363_H1.1731.00
128_I159_V1.1681.00
329_L354_Y1.1641.00
96_D99_Y1.1631.00
446_V449_S1.1631.00
420_F440_F1.1591.00
443_Q447_W1.1551.00
422_F433_T1.1551.00
190_E193_E1.1471.00
212_T471_I1.1451.00
159_V212_T1.1421.00
324_I438_L1.1331.00
131_T158_S1.1141.00
420_F447_W1.1101.00
441_Y445_D1.1091.00
104_D108_F1.1031.00
316_H346_A1.1021.00
294_P370_D1.0961.00
445_D449_S1.0911.00
317_E320_E1.0891.00
326_L351_C1.0771.00
14_V41_L1.0721.00
32_R462_G1.0711.00
250_D254_Y1.0701.00
379_E382_G1.0661.00
246_L459_Y1.0621.00
216_P405_D1.0611.00
440_F444_Q1.0601.00
366_Y384_G1.0601.00
24_G28_K1.0571.00
354_Y365_I1.0561.00
366_Y388_A1.0521.00
374_M385_Q1.0441.00
389_L418_N1.0431.00
431_K435_E1.0411.00
335_E339_Y1.0411.00
202_K206_I1.0371.00
470_R473_E1.0351.00
245_I468_Y1.0311.00
101_H104_D1.0291.00
322_Q435_E1.0231.00
219_R242_V1.0211.00
158_S208_A1.0211.00
38_A83_N1.0201.00
17_G301_R1.0151.00
444_Q451_V1.0121.00
385_Q403_L1.0111.00
281_L285_M1.0101.00
333_E340_F1.0091.00
409_A458_D1.0071.00
441_Y447_W1.0051.00
128_I472_F0.9981.00
437_A447_W0.9961.00
253_F363_H0.9901.00
440_F446_V0.9891.00
27_P39_V0.9881.00
299_V362_A0.9731.00
26_L468_Y0.9731.00
305_Q378_F0.9721.00
243_T471_I0.9711.00
208_A211_V0.9671.00
299_V366_Y0.9651.00
31_A37_V0.9621.00
163_H383_L0.9611.00
212_T245_I0.9611.00
398_R422_F0.9581.00
470_R474_Q0.9551.00
399_E421_T0.9521.00
29_A461_W0.9521.00
189_Y193_E0.9511.00
62_T69_Q0.9501.00
435_E438_L0.9471.00
445_D448_K0.9461.00
131_T160_L0.9401.00
420_F437_A0.9401.00
284_R361_L0.9381.00
314_I317_E0.9381.00
359_E363_H0.9351.00
294_P324_I0.9261.00
327_V352_R0.9261.00
33_L465_A0.9251.00
131_T140_N0.9221.00
216_P244_G0.9221.00
249_I390_Q0.9211.00
6_A115_V0.9161.00
161_T212_T0.9141.00
460_S463_K0.9131.00
103_D107_R0.9131.00
316_H319_L0.9121.00
417_G450_I0.9101.00
461_W464_S0.9091.00
295_L370_D0.9081.00
420_F443_Q0.9061.00
213_T219_R0.9051.00
27_P37_V0.8991.00
23_A132_H0.8931.00
290_K293_I0.8921.00
167_F303_T0.8911.00
294_P323_D0.8871.00
159_V472_F0.8871.00
357_F365_I0.8871.00
335_E338_D0.8871.00
307_G310_L0.8841.00
436_R439_S0.8841.00
137_A140_N0.8821.00
376_S379_E0.8811.00
109_A113_R0.8811.00
193_E196_G0.8811.00
451_V455_M0.8811.00
396_I433_T0.8791.00
434_I438_L0.8771.00
8_S135_H0.8761.00
357_F361_L0.8721.00
314_I431_K0.8691.00
29_A33_L0.8681.00
134_W137_A0.8661.00
110_F114_A0.8651.00
189_Y192_L0.8631.00
430_L434_I0.8611.00
410_Y418_N0.8581.00
397_V403_L0.8521.00
302_L332_G0.8431.00
58_Q61_C0.8421.00
132_H161_T0.8411.00
314_I318_L0.8401.00
317_E435_E0.8381.00
382_G385_Q0.8371.00
372_F384_G0.8341.00
213_T242_V0.8311.00
373_L434_I0.8281.00
86_F90_E0.8271.00
222_I242_V0.8261.00
64_A69_Q0.8251.00
28_K80_N0.8191.00
26_L465_A0.8191.00
321_E432_F0.8171.00
250_D253_F0.8161.00
299_V329_L0.8141.00
130_H159_V0.8111.00
384_G388_A0.8111.00
313_R343_A0.8101.00
312_R340_F0.8081.00
140_N158_S0.8051.00
211_V241_D0.8021.00
134_W141_Y0.8021.00
104_D110_F0.8011.00
310_L427_A0.7991.00
82_V85_Y0.7971.00
210_H241_D0.7951.00
251_D460_S0.7901.00
428_H431_K0.7891.00
451_V454_A0.7841.00
13_F86_F0.7821.00
136_T140_N0.7811.00
453_T456_N0.7791.00
251_D390_Q0.7781.00
213_T222_I0.7781.00
58_Q62_T0.7751.00
111_F114_A0.7741.00
91_Y94_N0.7731.00
78_A83_N0.7721.00
30_L37_V0.7711.00
217_T220_N0.7671.00
26_L464_S0.7671.00
10_C24_G0.7671.00
10_C39_V0.7671.00
396_I422_F0.7651.00
294_P441_Y0.7651.00
366_Y372_F0.7651.00
385_Q406_T0.7641.00
70_Q74_I0.7631.00
388_A395_P0.7591.00
309_D339_Y0.7571.00
313_R316_H0.7561.00
390_Q456_N0.7561.00
137_A160_L0.7561.00
296_I324_I0.7551.00
312_R339_Y0.7541.00
58_Q64_A0.7531.00
371_M434_I0.7501.00
377_K425_F0.7501.00
431_K434_I0.7481.00
118_A122_V0.7451.00
396_I430_L0.7421.00
437_A444_Q0.7401.00
449_S452_K0.7401.00
466_K469_Q0.7381.00
329_L357_F0.7341.00
9_E20_A0.7341.00
314_I321_E0.7331.00
307_G375_P0.7331.00
120_K146_E0.7321.00
306_K384_G0.7301.00
221_E224_T0.7271.00
214_V218_Y0.7251.00
10_C41_L0.7231.00
18_G22_V0.7231.00
38_A124_V0.7221.00
31_A83_N0.7211.00
22_V163_H0.7191.00
364_Q367_A0.7191.00
104_D111_F0.7161.00
214_V380_P0.7141.00
19_L22_V0.7131.00
126_A156_M0.7131.00
452_K455_M0.7101.00
409_A417_G0.7101.00
296_I315_M0.7091.00
424_A429_D0.7081.00
366_Y391_Y0.7061.00
381_C386_L0.7061.00
394_I448_K0.7061.00
343_A347_F0.7031.00
393_A448_K0.7031.00
371_M447_W0.7021.00
279_T291_N0.7021.00
447_W454_A0.6991.00
246_L381_C0.6961.00
422_F429_D0.6941.00
337_E340_F0.6941.00
164_N301_R0.6921.00
309_D336_F0.6891.00
363_H367_A0.6881.00
432_F435_E0.6881.00
191_R195_N0.6871.00
336_F343_A0.6871.00
22_V247_N0.6851.00
58_Q63_V0.6851.00
329_L332_G0.6841.00
373_L430_L0.6831.00
280_K364_Q0.6811.00
118_A121_V0.6791.00
62_T66_G0.6781.00
322_Q438_L0.6771.00
440_F450_I0.6761.00
65_V68_R0.6721.00
112_S115_V0.6711.00
213_T218_Y0.6681.00
22_V383_L0.6591.00
135_H138_M0.6591.00
145_E207_A0.6591.00
134_W140_N0.6591.00
290_K323_D0.6571.00
7_V10_C0.6561.00
33_L462_G0.6551.00
86_F89_N0.6551.00
243_T467_E0.6530.99
138_M141_Y0.6530.99
119_A122_V0.6500.99
300_T308_L0.6500.99
389_L395_P0.6500.99
323_D350_K0.6490.99
310_L425_F0.6490.99
245_I464_S0.6480.99
170_I197_F0.6480.99
83_N87_I0.6440.99
130_H468_Y0.6430.99
318_L321_E0.6410.99
65_V69_Q0.6410.99
163_H214_V0.6400.99
254_Y391_Y0.6390.99
410_Y419_G0.6350.99
471_I474_Q0.6340.99
327_V369_S0.6340.99
169_G173_P0.6330.99
18_G301_R0.6330.99
331_T356_G0.6320.99
168_Q171_F0.6300.99
107_R110_F0.6300.99
296_I438_L0.6300.99
340_F343_A0.6290.99
255_Q258_S0.6290.99
125_Q156_M0.6290.99
110_F113_R0.6280.99
134_W139_V0.6260.99
385_Q395_P0.6250.99
308_L328_V0.6250.99
311_V375_P0.6240.99
422_F430_L0.6230.99
72_C75_E0.6220.99
134_W138_M0.6210.99
336_F341_R0.6200.99
310_L398_R0.6180.99
46_Q49_E0.6180.99
246_L464_S0.6170.99
60_E64_A0.6160.99
160_L204_G0.6150.99
171_F176_T0.6150.99
437_A441_Y0.6100.99
62_T65_V0.6080.99
318_L431_K0.6070.99
462_G466_K0.6070.99
161_T472_F0.6060.99
129_V156_M0.6060.99
280_K285_M0.6060.99
398_R424_A0.6030.99
78_A81_D0.6020.99
375_P430_L0.6010.99
301_R305_Q0.6010.99
165_L222_I0.6000.99
134_W144_K0.6000.99
461_W465_A0.5990.99
63_V69_Q0.5980.99
168_Q173_P0.5970.99
402_G405_D0.5970.99
107_R114_A0.5940.99
312_R347_F0.5930.99
407_V421_T0.5920.99
301_R384_G0.5910.99
171_F174_D0.5910.99
315_M319_L0.5880.99
90_E94_N0.5880.99
464_S467_E0.5880.99
310_L430_L0.5860.99
281_L368_G0.5860.99
108_F112_S0.5850.99
327_V365_I0.5850.99
374_M403_L0.5850.99
297_S327_V0.5850.99
63_V66_G0.5830.99
128_I157_K0.5830.99
191_R194_C0.5820.99
63_V67_W0.5820.99
166_Q170_I0.5820.99
294_P297_S0.5820.99
363_H391_Y0.5810.99
199_N202_K0.5800.99
292_D323_D0.5790.99
245_I467_E0.5770.99
59_A63_V0.5770.99
142_L145_E0.5760.99
64_A68_R0.5760.99
298_M328_V0.5750.99
297_S372_F0.5750.99
427_A430_L0.5740.99
162_I205_I0.5720.99
298_M375_P0.5720.99
61_C64_A0.5720.99
165_L221_E0.5700.99
114_A117_E0.5700.99
253_F359_E0.5680.99
279_T282_Q0.5650.99
324_I434_I0.5650.99
392_G449_S0.5650.99
396_I437_A0.5640.99
25_A29_A0.5640.99
9_E19_L0.5640.99
217_T404_Y0.5630.98
136_T139_V0.5620.98
394_I450_I0.5610.98
111_F115_V0.5610.98
288_P349_E0.5610.98
312_R336_F0.5600.98
307_G377_K0.5590.98
159_V209_D0.5590.98
319_L349_E0.5580.98
142_L146_E0.5560.98
381_C459_Y0.5560.98
315_M350_K0.5550.98
417_G446_V0.5540.98
42_P45_S0.5540.98
409_A433_T0.5520.98
141_Y145_E0.5510.98
347_F351_C0.5500.98
22_V132_H0.5500.98
144_K207_A0.5490.98
297_S329_L0.5490.98
17_G247_N0.5490.98
442_C445_D0.5480.98
103_D106_E0.5480.98
11_T24_G0.5470.98
81_D85_Y0.5460.98
318_L322_Q0.5460.98
374_M382_G0.5450.98
302_L333_E0.5440.98
458_D467_E0.5440.98
164_N380_P0.5440.98
30_L35_N0.5440.98
282_Q285_M0.5430.98
6_A40_M0.5420.98
254_Y390_Q0.5410.98
404_Y421_T0.5400.98
316_H347_F0.5390.98
330_G355_I0.5380.98
315_M321_E0.5370.98
60_E63_V0.5360.98
360_P364_Q0.5360.98
468_Y472_F0.5350.98
312_R318_L0.5340.98
108_F111_F0.5340.98
313_R317_E0.5330.98
321_E439_S0.5320.98
58_Q68_R0.5320.98
215_S218_Y0.5310.98
329_L362_A0.5310.98
192_L196_G0.5310.98
251_D456_N0.5310.98
106_E109_A0.5290.98
430_L433_T0.5280.98
458_D463_K0.5270.98
103_D108_F0.5260.98
18_G306_K0.5250.98
366_Y387_I0.5250.98
106_E110_F0.5240.98
48_P52_K0.5240.98
450_I454_A0.5240.98
6_A129_V0.5240.98
63_V68_R0.5230.98
167_F170_I0.5230.98
434_I437_A0.5230.98
427_A433_T0.5230.98
137_A141_Y0.5200.97
357_F362_A0.5190.97
441_Y451_V0.5190.97
285_M352_R0.5180.97
81_D84_Y0.5180.97
437_A440_F0.5170.97
17_G20_A0.5170.97
107_R111_F0.5160.97
408_R454_A0.5160.97
252_T255_Q0.5160.97
401_G404_Y0.5160.97
138_M142_L0.5150.97
382_G406_T0.5150.97
164_N383_L0.5140.97
61_C65_V0.5140.97
407_V418_N0.5130.97
192_L195_N0.5130.97
394_I437_A0.5130.97
108_F114_A0.5120.97
247_N468_Y0.5120.97
255_Q390_Q0.5120.97
216_P246_L0.5110.97
70_Q91_Y0.5110.97
72_C78_A0.5100.97
359_E362_A0.5100.97
237_Y240_D0.5090.97
58_Q65_V0.5090.97
162_I165_L0.5080.97
312_R351_C0.5080.97
30_L469_Q0.5080.97
319_L347_F0.5070.97
454_A459_Y0.5060.97
19_L133_D0.5050.97
382_G403_L0.5040.97
297_S393_A0.5040.97
64_A67_W0.5030.97
88_D94_N0.5020.97
318_L438_L0.5010.97
10_C84_Y0.5010.97
431_K438_L0.5000.97
75_E78_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rzuA 1 0.9545 100 0.307 Contact Map
2qzsA 1 0.9504 100 0.308 Contact Map
3vueA 1 0.938 100 0.309 Contact Map
4qlbA 3 0.9298 100 0.342 Contact Map
3froA 3 0.8822 100 0.352 Contact Map
4hlnA 1 0.9442 100 0.354 Contact Map
2r60A 1 0.8574 100 0.359 Contact Map
3c48A 2 0.8099 100 0.363 Contact Map
3nb0A 4 0.9277 100 0.377 Contact Map
4n9wA 1 0.7335 100 0.389 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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