GREMLIN Database
GLGD - Glycogen biosynthesis protein GlgD
UniProt: P39124 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 343 (291)
Sequences: 8791 (5829)
Seq/√Len: 341.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_V273_C3.5911.00
272_N289_N3.1421.00
141_H149_T2.8251.00
273_C287_L2.7691.00
36_R45_S2.6431.00
287_L290_C2.6171.00
271_E288_K2.5661.00
256_K271_E2.5071.00
263_G278_A2.4791.00
304_L307_V2.4151.00
139_K143_E2.3761.00
288_K305_E2.3211.00
8_G52_I2.2961.00
299_G317_K2.2871.00
278_A295_K2.2591.00
262_N277_R2.2411.00
292_I298_I2.2001.00
54_S86_F2.1441.00
282_G300_E2.1071.00
8_G47_M2.0911.00
300_E317_K2.0811.00
261_A277_R2.0661.00
265_V280_H2.0481.00
120_Y142_Q2.0251.00
277_R294_Q2.0181.00
248_K265_V1.9821.00
242_K259_L1.9761.00
140_R144_V1.9381.00
245_P262_N1.9291.00
121_A165_T1.9251.00
146_C197_C1.9131.00
41_D69_H1.9061.00
137_V151_V1.8891.00
269_E286_K1.8841.00
275_L281_V1.8711.00
26_R32_P1.8691.00
56_A88_F1.8681.00
170_D174_G1.8661.00
275_L279_V1.8601.00
247_T264_C1.8231.00
255_V258_S1.8191.00
244_E262_N1.8111.00
283_K300_E1.8081.00
276_F294_Q1.7861.00
25_Q263_G1.7831.00
120_Y164_S1.7731.00
252_H268_G1.7661.00
289_N306_Q1.7521.00
268_G284_G1.7391.00
147_D164_S1.7311.00
44_L55_V1.6791.00
169_K172_I1.6541.00
208_I217_H1.6441.00
137_V162_I1.6141.00
257_N272_N1.6061.00
144_V197_C1.6041.00
240_K257_N1.5951.00
238_Y256_K1.5901.00
140_R199_Y1.5541.00
146_C149_T1.5461.00
47_M124_S1.5381.00
135_Q139_K1.5111.00
279_V296_T1.4971.00
284_G301_D1.4961.00
291_I308_I1.4891.00
100_F104_R1.4851.00
40_I70_L1.4751.00
267_E283_K1.4671.00
41_D45_S1.4601.00
63_Y67_M1.4351.00
168_L172_I1.4301.00
89_P97_Y1.4231.00
295_K312_D1.4201.00
280_H297_Q1.4191.00
259_L274_I1.3961.00
63_Y89_P1.3901.00
254_T269_E1.3861.00
174_G192_S1.3761.00
274_I291_I1.3741.00
7_L54_S1.3701.00
247_T277_R1.3611.00
292_I296_T1.3471.00
267_E282_G1.3451.00
260_V264_C1.3381.00
296_T313_V1.3311.00
294_Q311_K1.3141.00
264_C279_V1.3121.00
309_S313_V1.3091.00
282_G297_Q1.2901.00
293_M308_I1.2901.00
123_I163_M1.2801.00
297_Q314_K1.2801.00
110_L169_K1.2761.00
39_L208_I1.2721.00
264_C275_L1.2691.00
285_T302_C1.2681.00
138_L162_I1.2601.00
250_G267_E1.2601.00
59_P63_Y1.2601.00
250_G265_V1.2571.00
120_Y162_I1.2561.00
110_L173_Y1.2511.00
170_D192_S1.2251.00
165_T169_K1.2101.00
147_D194_L1.2051.00
104_R108_D1.1941.00
114_H169_K1.1911.00
167_L171_L1.1901.00
309_S315_I1.1871.00
71_G87_F1.1781.00
188_E191_S1.1761.00
282_G299_G1.1731.00
30_A69_H1.1691.00
206_A220_E1.1641.00
147_D195_T1.1551.00
244_E247_T1.1421.00
122_V162_I1.1411.00
34_A221_L1.1381.00
41_D73_G1.1371.00
204_Y220_E1.1331.00
60_K99_E1.1231.00
104_R107_S1.1171.00
148_V190_E1.1141.00
287_L292_I1.1141.00
296_T309_S1.1061.00
33_F218_S1.1031.00
225_R229_Q1.1001.00
288_K303_L1.0991.00
64_R68_D1.0981.00
125_N128_T1.0961.00
225_R228_Q1.0861.00
56_A112_Y1.0821.00
167_L194_L1.0821.00
286_K303_L1.0801.00
263_G277_R1.0781.00
290_C307_V1.0771.00
232_L235_Q1.0711.00
29_G126_S1.0651.00
157_S161_Y1.0621.00
230_V248_K1.0581.00
137_V149_T1.0581.00
136_Y139_K1.0551.00
106_F123_I1.0491.00
244_E277_R1.0441.00
107_S110_L1.0401.00
27_S65_S1.0401.00
133_Q204_Y1.0371.00
231_F235_Q1.0371.00
42_F221_L1.0311.00
140_R197_C1.0261.00
167_L172_I1.0251.00
110_L172_I1.0241.00
243_D247_T1.0201.00
32_P38_R1.0151.00
124_S134_F1.0131.00
65_S68_D1.0121.00
67_M89_P0.9991.00
210_S213_K0.9961.00
26_R65_S0.9931.00
270_V275_L0.9831.00
206_A216_T0.9831.00
190_E194_L0.9811.00
179_G185_E0.9811.00
7_L113_F0.9791.00
70_L85_L0.9781.00
46_N131_N0.9701.00
38_R41_D0.9681.00
299_G314_K0.9661.00
40_I57_I0.9641.00
302_C317_K0.9591.00
122_V138_L0.9571.00
241_V255_V0.9551.00
167_L170_D0.9551.00
141_H164_S0.9541.00
229_Q243_D0.9461.00
212_E216_T0.9441.00
99_E104_R0.9441.00
247_T261_A0.9351.00
212_E227_W0.9331.00
285_T299_G0.9321.00
48_V84_G0.9301.00
249_Y255_V0.9301.00
250_G253_S0.9291.00
244_E261_A0.9241.00
279_V293_M0.9221.00
146_C150_E0.9221.00
147_D150_E0.9161.00
117_T169_K0.9131.00
118_Q166_T0.9091.00
40_I66_L0.9051.00
256_K269_E0.9051.00
189_K192_S0.9051.00
38_R69_H0.9051.00
279_V311_K0.9021.00
119_Q165_T0.9001.00
49_N131_N0.9001.00
174_G189_K0.8961.00
16_K28_L0.8941.00
281_V285_T0.8881.00
119_Q164_S0.8841.00
258_S270_V0.8821.00
136_Y140_R0.8811.00
175_H178_K0.8681.00
171_L174_G0.8671.00
163_M186_A0.8671.00
237_I241_V0.8641.00
267_E280_H0.8631.00
64_R67_M0.8621.00
223_Q227_W0.8601.00
140_R143_E0.8541.00
18_S28_L0.8481.00
279_V298_I0.8471.00
264_C276_F0.8431.00
236_P254_T0.8401.00
48_V73_G0.8381.00
30_A65_S0.8331.00
100_F181_K0.8311.00
261_A264_C0.8291.00
133_Q136_Y0.8271.00
62_R65_S0.8221.00
14_T18_S0.8201.00
86_F112_Y0.8201.00
67_M87_F0.8131.00
252_H267_E0.8131.00
219_M222_I0.8111.00
276_F291_I0.8091.00
298_I304_L0.8071.00
276_F279_V0.8051.00
166_T170_D0.8031.00
281_V287_L0.8021.00
110_L114_H0.8011.00
249_Y253_S0.7961.00
220_E223_Q0.7931.00
120_Y141_H0.7931.00
10_I47_M0.7921.00
59_P87_F0.7911.00
286_K301_D0.7901.00
155_G200_E0.7901.00
279_V294_Q0.7891.00
246_P262_N0.7851.00
168_L174_G0.7841.00
238_Y241_V0.7841.00
44_L85_L0.7721.00
57_I85_L0.7681.00
171_L192_S0.7681.00
146_C195_T0.7671.00
287_L304_L0.7661.00
28_L127_H0.7641.00
10_I44_L0.7631.00
122_V134_F0.7611.00
246_P263_G0.7601.00
7_L117_T0.7591.00
148_V163_M0.7561.00
219_M233_P0.7541.00
301_D317_K0.7521.00
247_T260_V0.7511.00
43_M124_S0.7501.00
60_K104_R0.7461.00
216_T219_M0.7421.00
139_K142_Q0.7421.00
169_K173_Y0.7370.99
59_P67_M0.7360.99
50_A134_F0.7330.99
27_S62_R0.7320.99
293_M311_K0.7310.99
285_T298_I0.7270.99
141_H162_I0.7260.99
7_L56_A0.7250.99
98_D104_R0.7250.99
299_G316_G0.7220.99
48_V55_V0.7220.99
275_L287_L0.7190.99
57_I70_L0.7180.99
279_V292_I0.7140.99
253_S256_K0.7110.99
260_V266_L0.7110.99
155_G198_P0.7110.99
44_L70_L0.7110.99
138_L142_Q0.7100.99
47_M52_I0.7100.99
14_T28_L0.7080.99
302_C315_I0.7030.99
235_Q255_V0.7010.99
289_N305_E0.6990.99
244_E259_L0.6980.99
41_D70_L0.6980.99
59_P66_L0.6980.99
285_T301_D0.6930.99
34_A218_S0.6930.99
54_S84_G0.6910.99
243_D260_V0.6900.99
9_V56_A0.6880.99
125_N159_Q0.6870.99
70_L87_F0.6850.99
9_V121_A0.6830.99
6_M138_L0.6810.99
38_R42_F0.6780.99
9_V106_F0.6760.99
136_Y202_S0.6700.99
183_I186_A0.6690.99
171_L190_E0.6680.99
243_D249_Y0.6670.99
264_C277_R0.6640.99
215_Y232_L0.6640.99
304_L309_S0.6630.99
255_V260_V0.6630.99
278_A294_Q0.6630.99
164_S167_L0.6620.99
276_F293_M0.6600.99
145_G149_T0.6570.99
296_T310_D0.6570.99
45_S49_N0.6550.99
253_S266_L0.6540.99
58_F105_Q0.6520.99
33_F39_L0.6490.99
10_I43_M0.6490.99
224_P228_Q0.6470.99
244_E264_C0.6460.99
231_F234_Q0.6460.99
231_F249_Y0.6440.99
158_L205_A0.6430.99
191_S194_L0.6410.99
314_K317_K0.6410.99
247_T262_N0.6400.99
290_C304_L0.6370.98
151_V160_I0.6320.98
168_L171_L0.6310.98
68_D71_G0.6280.98
56_A109_H0.6250.98
52_I138_L0.6250.98
145_G164_S0.6240.98
269_E288_K0.6210.98
107_S181_K0.6180.98
130_C133_Q0.6170.98
11_D125_N0.6170.98
241_V258_S0.6160.98
284_G300_E0.6150.98
250_G256_K0.6110.98
167_L190_E0.6090.98
147_D167_L0.6090.98
114_H173_Y0.6040.98
211_V215_Y0.6040.98
296_T311_K0.6040.98
56_A113_F0.6040.98
218_S222_I0.6040.98
169_K174_G0.6020.98
171_L189_K0.6020.98
111_D114_H0.6010.98
39_L43_M0.6010.98
180_Y185_E0.6000.98
136_Y199_Y0.5990.98
275_L292_I0.5980.98
124_S160_I0.5970.98
301_D305_E0.5950.98
88_F109_H0.5930.98
42_F45_S0.5930.98
56_A86_F0.5910.98
251_K254_T0.5900.98
264_C278_A0.5890.97
271_E286_K0.5860.97
13_T58_F0.5850.97
11_D105_Q0.5840.97
148_V196_I0.5840.97
206_A217_H0.5840.97
252_H256_K0.5830.97
201_Y205_A0.5830.97
7_L121_A0.5820.97
104_R181_K0.5820.97
36_R42_F0.5820.97
96_E104_R0.5810.97
11_D58_F0.5790.97
216_T220_E0.5790.97
239_T257_N0.5780.97
130_C160_I0.5780.97
285_T317_K0.5770.97
46_N50_A0.5770.97
183_I188_E0.5770.97
173_Y189_K0.5740.97
292_I309_S0.5730.97
310_D313_V0.5690.97
106_F182_T0.5680.97
181_K184_Q0.5680.97
293_M296_T0.5670.97
127_H207_V0.5660.97
270_V281_V0.5660.97
147_D151_V0.5640.97
34_A42_F0.5600.97
20_Q24_A0.5580.97
300_E314_K0.5560.96
13_T16_K0.5550.96
33_F217_H0.5540.96
238_Y254_T0.5530.96
213_K216_T0.5530.96
253_S268_G0.5500.96
295_K311_K0.5500.96
46_N134_F0.5480.96
46_N49_N0.5470.96
223_Q226_F0.5460.96
170_D173_Y0.5460.96
184_Q188_E0.5440.96
251_K255_V0.5410.96
171_L186_A0.5410.96
226_F229_Q0.5410.96
269_E283_K0.5410.96
182_T185_E0.5390.96
282_G285_T0.5380.96
113_F168_L0.5370.96
119_Q166_T0.5340.96
25_Q245_P0.5330.96
237_I243_D0.5300.95
18_S29_G0.5280.95
166_T169_K0.5280.95
303_L306_Q0.5260.95
31_I211_V0.5260.95
16_K207_V0.5250.95
231_F236_P0.5250.95
117_T165_T0.5240.95
109_H112_Y0.5200.95
50_A135_Q0.5180.95
297_Q300_E0.5180.95
29_G66_L0.5130.94
16_K29_G0.5110.94
158_L161_Y0.5110.94
238_Y258_S0.5110.94
26_R310_D0.5100.94
251_K256_K0.5090.94
300_E305_E0.5090.94
300_E303_L0.5080.94
240_K243_D0.5080.94
19_L31_I0.5070.94
102_S127_H0.5040.94
201_Y204_Y0.5040.94
214_Y293_M0.5010.94
30_A63_Y0.5010.94
44_L57_I0.5010.94
67_M71_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3brkX 2 0.9388 100 0.395 Contact Map
1yp2A 4 0.9796 100 0.408 Contact Map
2ggoA 3 0.9155 100 0.449 Contact Map
4g3qA 3 0.9446 100 0.467 Contact Map
1hm9A 3 0.9242 100 0.474 Contact Map
2v0hA 3 0.9271 100 0.484 Contact Map
4fceA 3 0.9096 100 0.491 Contact Map
2icyA 1 0.8542 100 0.545 Contact Map
2i5kA 5 0.863 100 0.574 Contact Map
4r7pA 4 0.8688 100 0.585 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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