GREMLIN Database
PHSG - Glycogen phosphorylase
UniProt: P39123 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 798 (784)
Sequences: 2239 (1261)
Seq/√Len: 45.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
289_R326_E5.4371.00
527_S568_T4.5461.00
471_E499_Q4.3061.00
488_E774_H4.2891.00
675_Y757_D4.1331.00
303_S416_Y4.1031.00
515_I523_V4.0411.00
497_I769_I3.9691.00
557_K601_A3.9171.00
702_D745_S3.9011.00
501_Q765_S3.8541.00
763_K767_H3.8351.00
417_S446_N3.7611.00
516_F522_V3.7531.00
546_V592_V3.7161.00
278_C282_K3.6631.00
374_E378_R3.6461.00
549_I569_F3.5821.00
558_E707_Q3.4321.00
505_S526_E3.4131.00
668_R777_Y3.3891.00
208_A279_A3.3631.00
483_S486_R3.3591.00
536_L573_A3.3491.00
485_I774_H3.1291.00
497_I762_R3.0891.00
335_H339_H3.0291.00
296_S332_E2.9991.00
699_Y710_D2.9681.00
551_Y744_F2.8931.00
448_K790_D2.8461.00
396_N436_D2.8071.00
492_T766_E2.8061.00
464_G510_E2.7431.00
500_F772_I2.7161.00
658_H680_K2.7021.00
666_L671_P2.6951.00
746_S749_D2.6291.00
427_D431_E2.6141.00
124_F783_T2.6071.00
706_R710_D2.5831.00
295_L328_M2.5061.00
435_R439_L2.4891.00
285_V321_I2.4681.00
480_Q483_S2.4531.00
554_N711_Q2.4221.00
628_V655_I2.4201.00
485_I488_E2.4031.00
464_G506_K2.3801.00
140_I253_S2.3691.00
448_K783_T2.3681.00
500_F768_S2.3631.00
628_V754_I2.3501.00
760_E763_K2.3461.00
99_N102_E2.3351.00
546_V549_I2.3321.00
476_E483_S2.3021.00
501_Q761_R2.3001.00
329_S332_E2.2811.00
297_G300_K2.2751.00
452_I649_M2.2751.00
470_T478_V2.2661.00
507_K510_E2.2621.00
348_T428_I2.2611.00
472_A490_Y2.2511.00
438_H443_N2.2441.00
556_L602_V2.2341.00
294_S297_G2.2061.00
466_S477_W2.1991.00
533_V622_I2.1951.00
155_H587_K2.1941.00
649_M775_S2.1851.00
472_A496_F2.1761.00
494_P762_R2.1741.00
696_R700_Q2.1671.00
505_S509_Q2.1621.00
284_I304_I2.1461.00
179_V210_P2.1341.00
500_F769_I2.1331.00
188_H201_E2.1041.00
361_F372_I2.0981.00
785_R789_K2.0921.00
281_L321_I2.0770.99
16_L27_S2.0660.99
464_G507_K2.0470.99
515_I570_I2.0210.99
694_R697_E2.0190.99
418_V444_R1.9960.99
288_Y297_G1.9850.99
757_D767_H1.9570.99
342_S416_Y1.9520.99
745_S749_D1.9460.99
393_R439_L1.9320.99
393_R397_M1.9200.99
665_I669_V1.9140.99
470_T477_W1.9090.99
330_W334_W1.9050.99
563_S759_R1.8990.99
653_L675_Y1.8910.99
786_E790_D1.8800.99
486_R489_P1.8770.99
186_E202_Q1.8770.99
627_D765_S1.8720.99
48_W225_T1.8540.99
376_N380_C1.8510.99
285_V298_L1.8470.99
699_Y706_R1.8230.99
267_I363_P1.8200.99
611_L618_M1.7980.98
531_V626_S1.7970.98
22_K31_D1.7910.98
658_H666_L1.7810.98
15_R19_T1.7760.98
567_Q751_Q1.7710.98
124_F784_I1.7640.98
666_L674_I1.7600.98
349_L637_K1.7540.98
513_D517_C1.7380.98
241_N244_S1.7170.98
546_V588_L1.7060.98
299_H339_H1.6950.98
491_A497_I1.6940.98
680_K683_E1.6940.98
648_M775_S1.6910.98
699_Y732_L1.6890.98
569_F606_I1.6840.98
749_D753_R1.6790.98
509_Q513_D1.6740.98
128_L135_G1.6720.98
472_A499_Q1.6630.97
750_A753_R1.6630.97
705_I744_F1.6610.97
468_I496_F1.6560.97
393_R396_N1.6540.97
423_K427_D1.6500.97
519_A612_E1.6390.97
470_T475_D1.6330.97
757_D763_K1.6260.97
377_E381_R1.6190.97
524_N604_Q1.6160.97
374_E377_E1.6150.97
555_R752_E1.6140.97
514_L518_T1.6000.97
473_I486_R1.5920.97
9_A95_E1.5850.97
29_K102_E1.5830.97
533_V647_F1.5810.97
288_Y299_H1.5810.97
653_L767_H1.5770.96
669_V674_I1.5740.96
59_S292_H1.5680.96
581_Y727_I1.5660.96
563_S605_L1.5630.96
523_V568_T1.5520.96
528_I628_V1.5520.96
713_I728_F1.5460.96
584_K726_S1.5460.96
559_D562_F1.5320.96
132_N220_T1.5290.96
556_L562_F1.5280.96
72_L122_A1.5170.96
63_T794_I1.5130.96
177_Q210_P1.5130.96
687_Y692_G1.5130.96
315_V341_I1.5110.96
323_L329_S1.5050.95
128_L133_L1.5050.95
510_E621_R1.5010.95
168_N213_I1.4990.95
298_L340_T1.4960.95
282_K321_I1.4880.95
464_G503_N1.4860.95
469_I473_I1.4850.95
313_L361_F1.4830.95
725_E729_D1.4780.95
314_A341_I1.4740.95
786_E789_K1.4730.95
312_A411_A1.4730.95
66_L280_S1.4700.95
133_L794_I1.4680.95
491_A770_V1.4610.95
362_K373_E1.4560.94
441_F444_R1.4520.94
780_S784_I1.4390.94
753_R756_A1.4290.94
141_R171_E1.4290.94
697_E700_Q1.4280.94
180_D205_I1.4260.94
312_A410_L1.4210.94
587_K591_S1.4060.93
298_L302_V1.4020.93
427_D430_K1.4000.93
319_M334_W1.4000.93
328_M336_I1.3980.93
469_I487_L1.3970.93
376_N398_A1.3930.93
369_Y405_V1.3930.93
524_N607_K1.3880.93
334_W375_I1.3870.93
469_I472_A1.3830.93
300_K339_H1.3830.93
704_R745_S1.3820.93
512_A525_P1.3820.93
355_K404_V1.3780.93
499_Q502_N1.3740.93
551_Y555_R1.3690.92
15_R42_E1.3690.92
699_Y741_L1.3670.92
438_H445_F1.3630.92
571_F608_V1.3620.92
571_F589_I1.3560.92
496_F769_I1.3540.92
390_D393_R1.3480.92
548_H552_L1.3430.92
554_N707_Q1.3430.92
90_E94_K1.3360.91
330_W374_E1.3340.91
392_K395_E1.3330.91
788_A794_I1.3300.91
491_A769_I1.3260.91
390_D396_N1.3220.91
313_L316_P1.3220.91
502_N506_K1.3140.91
782_R786_E1.3130.91
555_R704_R1.3130.91
288_Y293_K1.3110.91
75_L110_A1.3040.90
397_M436_D1.3020.90
361_F369_Y1.3020.90
744_F748_A1.3010.90
72_L75_L1.3010.90
468_I503_N1.2990.90
8_F12_F1.2990.90
594_E598_Y1.2950.90
289_R295_L1.2920.90
565_Y759_R1.2910.90
384_W391_W1.2860.90
132_N222_T1.2860.90
658_H676_T1.2820.90
127_S780_S1.2820.90
446_N790_D1.2820.90
417_S448_K1.2810.90
303_S342_S1.2780.90
684_V739_F1.2760.89
547_L708_V1.2760.89
703_R706_R1.2750.89
614_Y623_F1.2720.89
550_M717_F1.2680.89
79_N216_I1.2550.89
237_Y245_Y1.2530.89
761_R765_S1.2520.89
567_Q755_Q1.2490.88
468_I472_A1.2470.88
358_I400_T1.2450.88
288_Y295_L1.2400.88
514_L621_R1.2360.88
138_M283_S1.2340.88
188_H199_R1.2250.87
506_K509_Q1.2230.87
698_Y705_I1.2200.87
140_I276_L1.2200.87
288_Y292_H1.2150.87
426_S446_N1.2100.87
675_Y754_I1.2070.87
552_L755_Q1.2030.87
358_I369_Y1.2020.86
658_H671_P1.2010.86
763_K766_E1.2000.86
448_K786_E1.2000.86
682_D686_S1.2000.86
751_Q754_I1.1990.86
484_L487_L1.1970.86
551_Y704_R1.1920.86
454_H481_P1.1900.86
288_Y294_S1.1890.86
498_E502_N1.1890.86
319_M330_W1.1860.86
498_E762_R1.1850.86
619_A623_F1.1850.86
552_L569_F1.1830.86
505_S525_P1.1820.86
488_E770_V1.1820.86
550_M588_L1.1790.85
334_W414_G1.1770.85
263_D359_H1.1710.85
521_V609_V1.1670.85
61_K303_S1.1670.85
179_V286_N1.1650.85
783_T790_D1.1590.84
13_L96_I1.1590.84
158_E583_K1.1570.84
726_S729_D1.1520.84
64_Y302_V1.1490.84
324_D367_R1.1390.83
338_V444_R1.1380.83
384_W394_I1.1380.83
338_V382_A1.1360.83
111_G146_L1.1350.83
497_I500_F1.1340.83
362_K369_Y1.1330.83
466_S470_T1.1310.83
183_F271_K1.1300.83
531_V622_I1.1280.83
12_F36_L1.1270.83
152_V157_V1.1270.83
412_I418_V1.1260.83
709_A728_F1.1250.83
187_V370_M1.1240.82
556_L605_L1.1240.82
8_F89_V1.1230.82
397_M440_L1.1230.82
673_C767_H1.1210.82
246_K250_E1.1200.82
482_E785_R1.1200.82
19_T38_N1.1150.82
219_E479_K1.1130.82
533_V623_F1.1110.82
90_E101_E1.1050.81
209_V232_E1.1050.81
299_H336_I1.1030.81
665_I674_I1.1020.81
350_S573_A1.1010.81
469_I496_F1.1000.81
331_E378_R1.0950.81
68_I273_Q1.0940.81
523_V529_F1.0940.81
494_P497_I1.0920.81
489_P497_I1.0910.81
473_I483_S1.0880.80
611_L622_I1.0880.80
182_P202_Q1.0870.80
666_L676_T1.0870.80
595_K717_F1.0840.80
532_Q545_N1.0830.80
180_D207_T1.0820.80
293_K297_G1.0820.80
186_E201_E1.0770.80
361_F405_V1.0740.80
312_A315_V1.0730.79
128_L794_I1.0670.79
667_E777_Y1.0630.79
381_R384_W1.0620.79
489_P492_T1.0610.79
459_L478_V1.0590.79
497_I765_S1.0580.78
321_I326_E1.0570.78
61_K416_Y1.0560.78
679_L742_K1.0540.78
133_L788_A1.0520.78
204_T271_K1.0480.78
380_C383_V1.0460.78
40_V76_L1.0440.78
299_H335_H1.0430.77
66_L314_A1.0400.77
399_I413_V1.0390.77
458_L649_M1.0390.77
713_I732_L1.0380.77
592_V596_V1.0370.77
515_I519_A1.0350.77
687_Y739_F1.0330.77
319_M337_T1.0310.77
602_V607_K1.0310.77
688_Q737_E1.0300.77
187_V198_F1.0270.76
551_Y748_A1.0270.76
487_L496_F1.0270.76
8_F92_G1.0270.76
61_K299_H1.0270.76
497_I766_E1.0270.76
550_M712_L1.0230.76
359_H362_K1.0220.76
770_V774_H1.0210.76
168_N171_E1.0190.76
753_R757_D1.0170.76
509_Q525_P1.0160.76
242_I245_Y1.0160.76
380_C398_A1.0160.76
321_I325_E1.0150.76
44_I216_I1.0120.75
298_L322_L1.0100.75
395_E402_H1.0090.75
752_E756_A1.0040.75
183_F206_V1.0030.75
358_I373_E1.0030.75
51_T55_S1.0000.74
295_L298_L0.9990.74
27_S31_D0.9970.74
711_Q716_F0.9950.74
547_L712_L0.9900.74
144_H161_E0.9890.74
709_A741_L0.9870.73
81_M459_L0.9870.73
284_I302_V0.9850.73
679_L687_Y0.9840.73
36_L89_V0.9820.73
597_N607_K0.9820.73
430_K438_H0.9810.73
86_R90_E0.9810.73
426_S448_K0.9790.73
426_S429_L0.9790.73
459_L466_S0.9780.73
319_M371_I0.9770.73
466_S469_I0.9760.73
77_E104_L0.9700.72
429_L433_E0.9700.72
518_T615_R0.9690.72
697_E701_H0.9690.72
29_K106_I0.9670.72
587_K724_F0.9670.72
392_K396_N0.9620.72
783_T786_E0.9610.71
74_Q109_D0.9590.71
150_K159_L0.9590.71
679_L684_V0.9570.71
12_F93_L0.9570.71
749_D752_E0.9560.71
416_Y793_G0.9550.71
718_E724_F0.9550.71
400_T405_V0.9540.71
492_T760_E0.9540.71
155_H723_E0.9530.71
679_L739_F0.9520.71
261_T578_S0.9510.71
591_S724_F0.9490.70
543_L727_I0.9490.70
722_D725_E0.9490.70
655_I750_A0.9480.70
550_M595_K0.9430.70
63_T135_G0.9420.70
8_F88_V0.9400.70
373_E376_N0.9350.69
75_L213_I0.9340.69
383_V394_I0.9330.69
611_L621_R0.9310.69
138_M280_S0.9310.69
683_E686_S0.9310.69
511_L515_I0.9300.69
603_K607_K0.9290.69
200_H203_A0.9290.69
591_S594_E0.9240.68
23_S26_D0.9230.68
297_G328_M0.9230.68
182_P205_I0.9220.68
704_R744_F0.9220.68
32_Q98_I0.9220.68
495_A498_E0.9200.68
555_R559_D0.9200.68
234_Y237_Y0.9180.68
765_S769_I0.9180.68
426_S681_A0.9180.68
80_L100_L0.9170.68
452_I458_L0.9170.68
687_Y691_G0.9130.67
519_A523_V0.9130.67
746_S750_A0.9120.67
485_I668_R0.9110.67
423_K667_E0.9110.67
77_E460_K0.9110.67
544_L744_F0.9100.67
59_S301_K0.9080.67
369_Y373_E0.9060.67
277_V313_L0.9060.67
148_E613_N0.9050.67
278_C321_I0.9040.67
198_F370_M0.9000.66
528_I565_Y0.9000.66
626_S647_F0.8990.66
653_L768_S0.8990.66
602_V605_L0.8990.66
338_V416_Y0.8970.66
383_V440_L0.8950.66
492_T497_I0.8940.66
12_F39_M0.8940.66
27_S32_Q0.8920.66
527_S607_K0.8920.66
273_Q313_L0.8900.65
276_L313_L0.8880.65
698_Y742_K0.8870.65
732_L741_L0.8860.65
588_L712_L0.8860.65
675_Y750_A0.8850.65
488_E491_A0.8820.65
766_E770_V0.8790.64
342_S417_S0.8750.64
589_I608_V0.8750.64
601_A604_Q0.8740.64
122_A226_L0.8730.64
543_L740_V0.8720.64
383_V388_P0.8710.64
141_R211_Y0.8710.64
283_S286_N0.8690.64
28_A503_N0.8650.63
173_R232_E0.8630.63
671_P674_I0.8620.63
81_M86_R0.8600.63
298_L318_L0.8600.63
37_G169_V0.8570.63
296_S328_M0.8570.63
304_I340_T0.8570.63
237_Y240_G0.8550.62
655_I665_I0.8550.62
80_L86_R0.8540.62
581_Y726_S0.8540.62
189_M198_F0.8530.62
504_K758_Y0.8510.62
87_D90_E0.8510.62
91_A95_E0.8490.62
380_C402_H0.8480.62
597_N603_K0.8470.62
476_E480_Q0.8460.61
565_Y755_Q0.8450.61
446_N783_T0.8430.61
755_Q759_R0.8430.61
204_T248_E0.8430.61
241_N245_Y0.8380.61
398_A401_A0.8380.61
528_I754_I0.8370.61
282_K325_E0.8330.60
292_H297_G0.8330.60
288_Y298_L0.8320.60
524_N566_P0.8310.60
728_F732_L0.8310.60
467_A471_E0.8310.60
240_G245_Y0.8300.60
178_A209_V0.8290.60
412_I433_E0.8280.60
90_E99_N0.8260.60
629_S654_T0.8250.60
288_Y328_M0.8240.59
10_D14_K0.8220.59
64_Y287_N0.8210.59
387_Y393_R0.8200.59
206_V475_D0.8190.59
636_S685_L0.8190.59
312_A414_G0.8170.59
316_P323_L0.8160.59
675_Y767_H0.8140.59
124_F448_K0.8140.59
584_K723_E0.8130.58
705_I741_L0.8120.58
141_R164_L0.8120.58
581_Y730_S0.8110.58
277_V312_A0.8110.58
525_P529_F0.8110.58
663_I681_A0.8100.58
17_E46_A0.8080.58
581_Y585_I0.8080.58
529_F570_I0.8080.58
522_V604_Q0.8020.57
686_S689_E0.8020.57
133_L785_R0.7990.57
131_L785_R0.7990.57
143_K254_E0.7990.57
332_E336_I0.7980.57
696_R732_L0.7960.57
523_V611_L0.7950.57
515_I611_L0.7920.56
547_L731_L0.7920.56
476_E479_K0.7910.56
235_A239_G0.7900.56
550_M554_N0.7890.56
55_S222_T0.7880.56
614_Y619_A0.7880.56
357_P360_L0.7880.56
424_I549_I0.7850.56
200_H368_M0.7850.56
637_K737_E0.7850.56
64_Y284_I0.7850.56
631_Q652_A0.7850.56
543_L585_I0.7840.56
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361_F487_L0.5050.30
273_Q338_V0.5050.30
141_R279_A0.5040.30
655_I751_Q0.5040.30
345_N352_A0.5040.30
96_I99_N0.5040.30
319_M324_D0.5040.30
236_H244_S0.5040.30
23_S56_R0.5030.30
50_E54_K0.5030.30
464_G467_A0.5030.30
619_A622_I0.5020.30
70_F545_N0.5020.30
55_S132_N0.5020.30
155_H584_K0.5020.30
91_A94_K0.5020.30
663_I685_L0.5010.29
276_L388_P0.5010.29
85_V89_V0.5010.29
684_V687_Y0.5010.29
252_V271_K0.5010.29
122_A127_S0.5010.29
332_E335_H0.5010.29
653_L703_R0.5000.29
426_S790_D0.5000.29
551_Y606_I0.5000.29
458_L465_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ygpA 2 0.9862 100 0.283 Contact Map
4bqeA 2 0.99 100 0.302 Contact Map
2gj4A 2 0.9825 100 0.335 Contact Map
1l5wA 2 0.9799 100 0.339 Contact Map
2c4mA 4 0.9662 100 0.37 Contact Map
4l22A 1 0.9373 100 0.428 Contact Map
3vueA 1 0.6003 99 0.968 Contact Map
4qlbA 3 0.6679 98.4 0.973 Contact Map
3nb0A 4 0.6667 98.4 0.974 Contact Map
1rzuA 1 0.5038 92.9 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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