GLGC - BACSU - GREMLIN Contacts

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GLGC - Glucose-1-phosphate adenylyltransferase

UniProt:	P39122	Sequences: MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLSNCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGTASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEASRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDFGKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYSVNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVTIGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	380 (323)
Sequences:	8881 (5839)
Seq/√Len:	324.9

ECOLI - GLGC GLMU RMLA1 RMLA2 GALF GALU
BACSU - GLGC GLMU GLGD GTAB RMLA YNGB RFBF YTDA
HALSA - Q9HSZ9 Q9HSZ8 Q9HS61 Q9HQQ4 Q9HSV0
SULSO - Q97ZD1 Q980H9 Q97XG0 Q7LXE7 Q7LXK9 Q980D4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
324_V	327_S	3.968	1.00
326_S	343_N	3.411	1.00
325_T	342_E	3.410	1.00
154_E	187_N	3.393	1.00
141_H	149_T	3.123	1.00
341_I	344_A	3.106	1.00
315_G	332_D	2.820	1.00
169_N	173_T	2.713	1.00
35_K	44_S	2.672	1.00
154_E	237_P	2.627	1.00
327_S	341_I	2.614	1.00
320_K	337_E	2.565	1.00
319_G	337_E	2.552	1.00
167_K	186_S	2.525	1.00
329_I	335_I	2.486	1.00
139_D	143_E	2.482	1.00
53_T	85_T	2.475	1.00
110_L	206_E	2.386	1.00
130_Y	133_D	2.347	1.00
7_A	51_I	2.291	1.00
146_A	234_S	2.249	1.00
207_M	229_E	2.219	1.00
332_D	349_G	2.162	1.00
120_Y	142_I	2.148	1.00
321_H	338_H	2.135	1.00
314_Q	331_P	2.133	1.00
313_F	331_P	2.091	1.00
140_Y	144_K	2.079	1.00
92_E	98_W	2.063	1.00
121_V	198_W	2.011	1.00
317_T	334_T	2.009	1.00
7_A	46_C	2.008	1.00
147_D	197_N	2.003	1.00
167_K	176_H	2.001	1.00
137_M	151_S	1.996	1.00
40_D	68_Y	1.976	1.00
174_I	235_A	1.968	1.00
25_M	31_S	1.950	1.00
152_V	235_A	1.940	1.00
333_V	350_M	1.910	1.00
336_G	354_D	1.906	1.00
337_E	354_D	1.814	1.00
346_V	350_M	1.762	1.00
120_Y	197_N	1.744	1.00
161_S	180_K	1.737	1.00
43_L	54_V	1.736	1.00
329_I	333_V	1.732	1.00
291_Q	311_V	1.678	1.00
173_T	232_K	1.673	1.00
24_N	315_G	1.671	1.00
312_L	318_V	1.662	1.00
245_V	254_A	1.656	1.00
137_M	195_I	1.627	1.00
311_V	328_V	1.595	1.00
331_P	348_N	1.594	1.00
144_K	234_S	1.579	1.00
169_N	175_T	1.566	1.00
203_Q	207_M	1.563	1.00
334_T	351_V	1.561	1.00
330_M	348_N	1.552	1.00
292_V	295_S	1.547	1.00
140_Y	236_Y	1.541	1.00
173_T	234_S	1.527	1.00
135_G	139_D	1.507	1.00
322_T	339_V	1.506	1.00
100_K	104_S	1.501	1.00
46_C	124_L	1.497	1.00
346_V	352_L	1.496	1.00
39_I	69_I	1.486	1.00
137_M	149_T	1.481	1.00
147_D	231_K	1.480	1.00
40_D	44_S	1.458	1.00
310_S	324_V	1.451	1.00
328_V	345_I	1.448	1.00
312_L	316_V	1.444	1.00
285_F	302_V	1.442	1.00
323_T	340_V	1.442	1.00
62_P	66_N	1.442	1.00
309_H	326_S	1.419	1.00
247_T	274_I	1.418	1.00
200_L	231_K	1.413	1.00
203_Q	229_E	1.381	1.00
338_H	355_G	1.354	1.00
58_T	62_P	1.339	1.00
287_S	290_A	1.338	1.00
316_V	333_V	1.327	1.00
204_Y	225_L	1.322	1.00
152_V	166_M	1.310	1.00
290_A	303_V	1.305	1.00
6_V	53_T	1.302	1.00
138_L	195_I	1.287	1.00
148_V	226_L	1.281	1.00
319_G	336_G	1.277	1.00
162_R	180_K	1.270	1.00
104_S	108_E	1.261	1.00
38_I	245_V	1.255	1.00
147_D	232_K	1.249	1.00
131_K	241_Y	1.248	1.00
324_V	329_I	1.246	1.00
204_Y	229_E	1.241	1.00
225_L	229_E	1.238	1.00
129_I	133_D	1.234	1.00
168_A	188_L	1.227	1.00
336_G	351_V	1.221	1.00
123_I	196_F	1.220	1.00
340_V	357_V	1.219	1.00
104_S	107_Y	1.218	1.00
168_A	235_A	1.206	1.00
29_A	68_Y	1.200	1.00
136_K	139_D	1.199	1.00
88_P	92_E	1.199	1.00
207_M	225_L	1.199	1.00
289_D	293_Q	1.198	1.00
55_G	112_Y	1.196	1.00
293_Q	314_Q	1.195	1.00
287_S	304_Y	1.194	1.00
120_Y	195_I	1.193	1.00
333_V	346_V	1.181	1.00
305_G	309_H	1.175	1.00
199_P	203_Q	1.165	1.00
243_K	257_D	1.163	1.00
40_D	72_G	1.156	1.00
167_K	178_D	1.156	1.00
330_M	345_I	1.155	1.00
303_V	310_S	1.151	1.00
226_L	231_K	1.144	1.00
281_Q	284_Q	1.142	1.00
224_P	228_E	1.130	1.00
118_P	199_P	1.130	1.00
295_S	316_V	1.129	1.00
289_D	305_G	1.124	1.00
339_V	354_D	1.119	1.00
59_Q	99_Y	1.115	1.00
300_G	321_H	1.106	1.00
319_G	334_T	1.101	1.00
159_E	162_R	1.099	1.00
264_E	274_I	1.099	1.00
159_E	180_K	1.098	1.00
32_F	255_N	1.096	1.00
33_G	258_L	1.095	1.00
122_L	195_I	1.089	1.00
63_L	67_S	1.086	1.00
190_S	194_Y	1.084	1.00
276_S	279_P	1.083	1.00
301_C	320_K	1.083	1.00
125_S	128_H	1.082	1.00
124_L	134_Y	1.078	1.00
140_Y	234_S	1.077	1.00
152_V	188_L	1.074	1.00
241_Y	257_D	1.074	1.00
28_P	126_G	1.071	1.00
55_G	87_L	1.070	1.00
25_M	64_E	1.063	1.00
281_Q	299_E	1.061	1.00
277_V	282_P	1.061	1.00
107_Y	110_L	1.058	1.00
278_N	282_P	1.057	1.00
26_A	64_E	1.056	1.00
103_A	208_D	1.051	1.00
200_L	203_Q	1.049	1.00
41_F	258_L	1.048	1.00
342_E	359_R	1.045	1.00
289_D	309_H	1.035	1.00
278_N	281_Q	1.035	1.00
284_Q	301_C	1.033	1.00
339_V	352_L	1.030	1.00
256_M	283_P	1.027	1.00
64_E	67_S	1.026	1.00
31_S	37_R	1.023	1.00
243_K	253_E	1.020	1.00
106_I	123_I	1.017	1.00
333_V	347_P	1.017	1.00
249_Q	253_E	1.017	1.00
277_V	281_Q	1.004	1.00
37_R	40_D	1.000	1.00
62_P	88_P	1.000	1.00
316_V	331_P	0.993	1.00
215_S	221_D	0.983	1.00
99_Y	104_S	0.981	1.00
294_D	309_H	0.977	1.00
341_I	346_V	0.977	1.00
85_T	88_P	0.975	1.00
181_P	213_Y	0.975	1.00
133_D	136_K	0.969	1.00
298_N	301_C	0.965	1.00
329_I	346_V	0.956	1.00
165_I	189_A	0.953	1.00
63_L	66_N	0.951	1.00
247_T	250_S	0.950	1.00
158_E	187_N	0.944	1.00
172_G	237_P	0.940	1.00
319_G	322_T	0.939	1.00
174_I	233_L	0.935	1.00
276_S	283_P	0.935	1.00
15_G	27_K	0.930	1.00
316_V	330_M	0.930	1.00
276_S	281_Q	0.929	1.00
39_I	65_L	0.928	1.00
107_Y	206_E	0.928	1.00
266_K	292_V	0.927	1.00
140_Y	143_E	0.927	1.00
339_V	356_A	0.925	1.00
208_D	214_S	0.925	1.00
276_S	282_P	0.918	1.00
278_N	294_D	0.918	1.00
287_S	305_G	0.917	1.00
70_G	86_V	0.913	1.00
196_F	222_I	0.909	1.00
313_F	316_V	0.909	1.00
119_E	198_W	0.908	1.00
49_S	134_Y	0.905	1.00
136_K	140_Y	0.892	1.00
119_E	197_N	0.888	1.00
340_V	355_G	0.885	1.00
37_R	68_Y	0.877	1.00
84_V	88_P	0.876	1.00
155_V	189_A	0.876	1.00
197_N	200_L	0.876	1.00
333_V	348_N	0.875	1.00
110_L	114_N	0.870	1.00
249_Q	274_I	0.868	1.00
262_D	266_K	0.867	1.00
316_V	329_I	0.866	1.00
204_Y	226_L	0.863	1.00
39_I	56_I	0.859	1.00
290_A	293_Q	0.857	1.00
8_M	55_G	0.856	1.00
150_I	174_I	0.855	1.00
148_V	196_F	0.853	1.00
166_M	174_I	0.846	1.00
147_D	200_L	0.843	1.00
122_L	138_L	0.839	1.00
208_D	222_I	0.839	1.00
287_S	302_V	0.838	1.00
9_L	46_C	0.837	1.00
178_D	185_K	0.834	1.00
6_V	113_L	0.828	1.00
225_L	228_E	0.823	1.00
203_Q	206_E	0.819	1.00
59_Q	104_S	0.817	1.00
138_L	142_I	0.816	1.00
188_L	237_P	0.815	1.00
56_I	69_I	0.813	1.00
153_I	189_A	0.812	1.00
8_M	121_V	0.812	1.00
298_N	317_T	0.812	1.00
304_Y	325_T	0.810	1.00
47_S	72_G	0.810	1.00
282_P	299_E	0.808	1.00
29_A	64_E	0.807	1.00
315_G	331_P	0.806	1.00
256_M	259_L	0.806	1.00
342_E	357_V	0.803	1.00
153_I	242_W	0.797	1.00
178_D	184_P	0.794	1.00
335_I	341_I	0.793	1.00
289_D	292_V	0.792	1.00
266_K	275_Y	0.792	1.00
322_T	337_E	0.791	1.00
304_Y	320_K	0.790	1.00
260_K	264_E	0.790	1.00
122_L	134_Y	0.789	1.00
136_K	239_K	0.788	1.00
322_T	354_D	0.787	1.00
249_Q	264_E	0.786	1.00
17_R	27_K	0.786	1.00
257_D	260_K	0.785	1.00
150_I	166_M	0.785	1.00
58_T	66_N	0.783	1.00
61_Q	64_E	0.781	1.00
8_M	106_I	0.776	1.00
286_I	290_A	0.774	1.00
40_D	69_I	0.772	1.00
9_L	43_L	0.768	1.00
42_T	124_L	0.768	1.00
100_K	217_D	0.766	1.00
321_H	337_E	0.766	1.00
200_L	226_L	0.765	1.00
47_S	73_S	0.765	1.00
303_V	312_L	0.764	1.00
210_Q	217_D	0.762	1.00
178_D	183_F	0.762	1.00
148_V	223_I	0.761	0.99
333_V	352_L	0.756	0.99
227_L	233_L	0.756	0.99
167_K	175_T	0.755	0.99
335_I	339_V	0.752	0.99
6_V	117_D	0.749	0.99
277_V	283_P	0.749	0.99
288_S	305_G	0.747	0.99
83_G	87_L	0.745	0.99
146_A	232_K	0.744	0.99
27_K	127_D	0.743	0.99
26_A	61_Q	0.743	0.99
148_V	233_L	0.738	0.99
43_L	69_I	0.737	0.99
46_C	51_I	0.736	0.99
353_P	356_A	0.731	0.99
47_S	54_V	0.731	0.99
145_K	197_N	0.727	0.99
279_P	284_Q	0.720	0.99
295_S	331_P	0.720	0.99
298_N	304_Y	0.719	0.99
301_C	316_V	0.716	0.99
265_L	275_Y	0.716	0.99
37_R	41_F	0.716	0.99
114_N	206_E	0.715	0.99
164_G	179_E	0.714	0.99
278_N	283_P	0.713	0.99
262_D	265_L	0.707	0.99
174_I	177_F	0.705	0.99
170_P	175_T	0.704	0.99
51_I	138_L	0.702	0.99
155_V	187_N	0.700	0.99
297_V	301_C	0.695	0.99
208_D	225_L	0.695	0.99
13_G	27_K	0.693	0.99
290_A	310_S	0.691	0.99
84_V	87_L	0.689	0.99
204_Y	222_I	0.689	0.99
216_H	221_D	0.688	0.99
111_N	114_N	0.685	0.99
41_F	44_S	0.683	0.99
304_Y	319_G	0.682	0.99
253_E	256_M	0.682	0.99
125_S	192_G	0.680	0.99
107_Y	209_D	0.680	0.99
208_D	220_K	0.679	0.99
326_S	342_E	0.676	0.99
83_G	86_V	0.671	0.99
129_I	132_M	0.668	0.99
45_N	132_M	0.666	0.99
98_W	104_S	0.665	0.99
33_G	41_F	0.664	0.99
107_Y	217_D	0.662	0.99
33_G	255_N	0.662	0.99
298_N	320_K	0.659	0.99
279_P	282_P	0.658	0.99
336_G	353_P	0.655	0.99
176_H	224_P	0.653	0.98
211_N	214_S	0.653	0.98
57_L	105_S	0.648	0.98
44_S	48_N	0.647	0.98
45_N	49_S	0.646	0.98
288_S	293_Q	0.643	0.98
304_Y	323_T	0.641	0.98
151_S	193_I	0.639	0.98
107_Y	205_L	0.638	0.98
55_G	109_N	0.634	0.98
330_M	347_P	0.634	0.98
188_L	235_A	0.633	0.98
150_I	233_L	0.632	0.98
152_V	174_I	0.630	0.98
288_S	292_V	0.629	0.98
58_T	65_L	0.628	0.98
155_V	160_A	0.628	0.98
325_T	340_V	0.627	0.98
178_D	181_P	0.626	0.98
13_G	17_R	0.625	0.98
19_S	23_K	0.624	0.98
38_I	42_T	0.623	0.98
35_K	41_F	0.622	0.98
113_L	201_L	0.620	0.98
338_H	354_D	0.619	0.98
32_F	38_I	0.619	0.98
6_V	121_V	0.618	0.98
92_E	99_Y	0.614	0.98
66_N	88_P	0.613	0.98
109_N	113_L	0.611	0.98
10_L	125_S	0.608	0.98
114_N	118_P	0.606	0.98
296_L	317_T	0.604	0.97
257_D	261_E	0.603	0.97
292_V	297_V	0.603	0.97
339_V	353_P	0.602	0.97
200_L	204_Y	0.601	0.97
297_V	303_V	0.598	0.97
293_Q	331_P	0.598	0.97
133_D	241_Y	0.597	0.97
136_K	236_Y	0.595	0.97
289_D	294_D	0.595	0.97
66_N	70_G	0.594	0.97
243_K	254_A	0.594	0.97
155_V	159_E	0.594	0.97
238_F	242_W	0.593	0.97
160_A	184_P	0.593	0.97
284_Q	287_S	0.592	0.97
219_G	222_I	0.591	0.97
117_D	199_P	0.590	0.97
191_M	242_W	0.590	0.97
166_M	188_L	0.590	0.97
332_D	348_N	0.588	0.97
141_H	197_N	0.587	0.97
10_L	57_L	0.587	0.97
175_T	227_L	0.587	0.97
324_V	341_I	0.585	0.97
292_V	312_L	0.585	0.97
276_S	294_D	0.582	0.97
139_D	142_I	0.582	0.97
357_V	360_S	0.581	0.97
12_G	57_L	0.579	0.97
162_R	250_S	0.574	0.97
9_L	42_T	0.574	0.97
58_T	86_V	0.574	0.97
284_Q	303_V	0.574	0.97
173_T	227_L	0.572	0.97
341_I	358_I	0.572	0.97
6_V	55_G	0.571	0.96
322_T	338_H	0.570	0.96
305_G	310_S	0.567	0.96
45_N	134_Y	0.567	0.96
311_V	314_Q	0.566	0.96
295_S	314_Q	0.566	0.96
10_L	105_S	0.565	0.96
204_Y	231_K	0.564	0.96
18_L	30_V	0.563	0.96
127_D	244_D	0.562	0.96
67_S	70_G	0.561	0.96
322_T	336_G	0.560	0.96
283_P	300_G	0.560	0.96
253_E	257_D	0.559	0.96
347_P	350_M	0.556	0.96
280_N	284_Q	0.556	0.96
153_I	191_M	0.555	0.96
285_F	288_S	0.554	0.96
17_R	28_P	0.553	0.96
324_V	335_I	0.550	0.96
344_A	361_E	0.548	0.96
33_G	262_D	0.548	0.96
28_P	65_L	0.547	0.96
343_N	360_S	0.546	0.95
49_S	135_G	0.545	0.95
164_G	180_K	0.543	0.95
57_L	91_A	0.542	0.95
45_N	48_N	0.542	0.95
288_S	291_Q	0.541	0.95
144_K	232_K	0.540	0.95
322_T	335_I	0.539	0.95
255_N	259_L	0.539	0.95
277_V	280_N	0.539	0.95
14_K	99_Y	0.539	0.95
316_V	348_N	0.538	0.95
85_T	112_Y	0.538	0.95
258_L	262_D	0.538	0.95
119_E	199_P	0.536	0.95
124_L	193_I	0.535	0.95
140_Y	149_T	0.534	0.95
110_L	113_L	0.532	0.95
318_V	322_T	0.532	0.95
196_F	201_L	0.531	0.95
179_E	190_S	0.529	0.95
15_G	28_P	0.529	0.95
342_E	360_S	0.527	0.95
323_T	336_G	0.525	0.94
251_L	330_M	0.525	0.94
161_S	182_K	0.524	0.94
250_S	253_E	0.523	0.94
263_S	279_P	0.522	0.94
69_I	72_G	0.522	0.94
150_I	194_Y	0.522	0.94
217_D	220_K	0.521	0.94
5_C	138_L	0.521	0.94
149_T	236_Y	0.519	0.94
11_A	56_I	0.517	0.94
125_S	194_Y	0.517	0.94
327_S	344_A	0.516	0.94
313_F	348_N	0.514	0.94
333_V	349_G	0.514	0.94
323_T	337_E	0.511	0.94
31_S	296_L	0.511	0.94
24_N	314_Q	0.510	0.94
55_G	113_L	0.509	0.93
196_F	200_L	0.509	0.93
25_M	347_P	0.509	0.93
34_G	296_L	0.508	0.93
123_I	219_G	0.507	0.93
337_E	355_G	0.507	0.93
130_Y	193_I	0.505	0.93
102_T	127_D	0.505	0.93
224_P	227_L	0.504	0.93
91_A	104_S	0.504	0.93
285_F	299_E	0.503	0.93
168_A	172_G	0.502	0.93
121_V	201_L	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3brkX	2	0.9421	100	0.35	Contact Map
1yp2A	4	0.9737	100	0.37	Contact Map
2ggoA	3	0.8895	100	0.419	Contact Map
4g3qA	3	0.9447	100	0.429	Contact Map
1hm9A	3	0.9263	100	0.438	Contact Map
2v0hA	3	0.9158	100	0.454	Contact Map
4fceA	3	0.9026	100	0.467	Contact Map
2icyA	1	0.8526	100	0.513	Contact Map
2i5kA	5	0.8553	100	0.541	Contact Map
3jukA	3	0.6342	100	0.556	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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