GREMLIN Database
GLGC - Glucose-1-phosphate adenylyltransferase
UniProt: P39122 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (323)
Sequences: 8881 (5839)
Seq/√Len: 324.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
324_V327_S3.9681.00
326_S343_N3.4111.00
325_T342_E3.4101.00
154_E187_N3.3931.00
141_H149_T3.1231.00
341_I344_A3.1061.00
315_G332_D2.8201.00
169_N173_T2.7131.00
35_K44_S2.6721.00
154_E237_P2.6271.00
327_S341_I2.6141.00
320_K337_E2.5651.00
319_G337_E2.5521.00
167_K186_S2.5251.00
329_I335_I2.4861.00
139_D143_E2.4821.00
53_T85_T2.4751.00
110_L206_E2.3861.00
130_Y133_D2.3471.00
7_A51_I2.2911.00
146_A234_S2.2491.00
207_M229_E2.2191.00
332_D349_G2.1621.00
120_Y142_I2.1481.00
321_H338_H2.1351.00
314_Q331_P2.1331.00
313_F331_P2.0911.00
140_Y144_K2.0791.00
92_E98_W2.0631.00
121_V198_W2.0111.00
317_T334_T2.0091.00
7_A46_C2.0081.00
147_D197_N2.0031.00
167_K176_H2.0011.00
137_M151_S1.9961.00
40_D68_Y1.9761.00
174_I235_A1.9681.00
25_M31_S1.9501.00
152_V235_A1.9401.00
333_V350_M1.9101.00
336_G354_D1.9061.00
337_E354_D1.8141.00
346_V350_M1.7621.00
120_Y197_N1.7441.00
161_S180_K1.7371.00
43_L54_V1.7361.00
329_I333_V1.7321.00
291_Q311_V1.6781.00
173_T232_K1.6731.00
24_N315_G1.6711.00
312_L318_V1.6621.00
245_V254_A1.6561.00
137_M195_I1.6271.00
311_V328_V1.5951.00
331_P348_N1.5941.00
144_K234_S1.5791.00
169_N175_T1.5661.00
203_Q207_M1.5631.00
334_T351_V1.5611.00
330_M348_N1.5521.00
292_V295_S1.5471.00
140_Y236_Y1.5411.00
173_T234_S1.5271.00
135_G139_D1.5071.00
322_T339_V1.5061.00
100_K104_S1.5011.00
46_C124_L1.4971.00
346_V352_L1.4961.00
39_I69_I1.4861.00
137_M149_T1.4811.00
147_D231_K1.4801.00
40_D44_S1.4581.00
310_S324_V1.4511.00
328_V345_I1.4481.00
312_L316_V1.4441.00
285_F302_V1.4421.00
323_T340_V1.4421.00
62_P66_N1.4421.00
309_H326_S1.4191.00
247_T274_I1.4181.00
200_L231_K1.4131.00
203_Q229_E1.3811.00
338_H355_G1.3541.00
58_T62_P1.3391.00
287_S290_A1.3381.00
316_V333_V1.3271.00
204_Y225_L1.3221.00
152_V166_M1.3101.00
290_A303_V1.3051.00
6_V53_T1.3021.00
138_L195_I1.2871.00
148_V226_L1.2811.00
319_G336_G1.2771.00
162_R180_K1.2701.00
104_S108_E1.2611.00
38_I245_V1.2551.00
147_D232_K1.2491.00
131_K241_Y1.2481.00
324_V329_I1.2461.00
204_Y229_E1.2411.00
225_L229_E1.2381.00
129_I133_D1.2341.00
168_A188_L1.2271.00
336_G351_V1.2211.00
123_I196_F1.2201.00
340_V357_V1.2191.00
104_S107_Y1.2181.00
168_A235_A1.2061.00
29_A68_Y1.2001.00
136_K139_D1.1991.00
88_P92_E1.1991.00
207_M225_L1.1991.00
289_D293_Q1.1981.00
55_G112_Y1.1961.00
293_Q314_Q1.1951.00
287_S304_Y1.1941.00
120_Y195_I1.1931.00
333_V346_V1.1811.00
305_G309_H1.1751.00
199_P203_Q1.1651.00
243_K257_D1.1631.00
40_D72_G1.1561.00
167_K178_D1.1561.00
330_M345_I1.1551.00
303_V310_S1.1511.00
226_L231_K1.1441.00
281_Q284_Q1.1421.00
224_P228_E1.1301.00
118_P199_P1.1301.00
295_S316_V1.1291.00
289_D305_G1.1241.00
339_V354_D1.1191.00
59_Q99_Y1.1151.00
300_G321_H1.1061.00
319_G334_T1.1011.00
159_E162_R1.0991.00
264_E274_I1.0991.00
159_E180_K1.0981.00
32_F255_N1.0961.00
33_G258_L1.0951.00
122_L195_I1.0891.00
63_L67_S1.0861.00
190_S194_Y1.0841.00
276_S279_P1.0831.00
301_C320_K1.0831.00
125_S128_H1.0821.00
124_L134_Y1.0781.00
140_Y234_S1.0771.00
152_V188_L1.0741.00
241_Y257_D1.0741.00
28_P126_G1.0711.00
55_G87_L1.0701.00
25_M64_E1.0631.00
281_Q299_E1.0611.00
277_V282_P1.0611.00
107_Y110_L1.0581.00
278_N282_P1.0571.00
26_A64_E1.0561.00
103_A208_D1.0511.00
200_L203_Q1.0491.00
41_F258_L1.0481.00
342_E359_R1.0451.00
289_D309_H1.0351.00
278_N281_Q1.0351.00
284_Q301_C1.0331.00
339_V352_L1.0301.00
256_M283_P1.0271.00
64_E67_S1.0261.00
31_S37_R1.0231.00
243_K253_E1.0201.00
106_I123_I1.0171.00
333_V347_P1.0171.00
249_Q253_E1.0171.00
277_V281_Q1.0041.00
37_R40_D1.0001.00
62_P88_P1.0001.00
316_V331_P0.9931.00
215_S221_D0.9831.00
99_Y104_S0.9811.00
294_D309_H0.9771.00
341_I346_V0.9771.00
85_T88_P0.9751.00
181_P213_Y0.9751.00
133_D136_K0.9691.00
298_N301_C0.9651.00
329_I346_V0.9561.00
165_I189_A0.9531.00
63_L66_N0.9511.00
247_T250_S0.9501.00
158_E187_N0.9441.00
172_G237_P0.9401.00
319_G322_T0.9391.00
174_I233_L0.9351.00
276_S283_P0.9351.00
15_G27_K0.9301.00
316_V330_M0.9301.00
276_S281_Q0.9291.00
39_I65_L0.9281.00
107_Y206_E0.9281.00
266_K292_V0.9271.00
140_Y143_E0.9271.00
339_V356_A0.9251.00
208_D214_S0.9251.00
276_S282_P0.9181.00
278_N294_D0.9181.00
287_S305_G0.9171.00
70_G86_V0.9131.00
196_F222_I0.9091.00
313_F316_V0.9091.00
119_E198_W0.9081.00
49_S134_Y0.9051.00
136_K140_Y0.8921.00
119_E197_N0.8881.00
340_V355_G0.8851.00
37_R68_Y0.8771.00
84_V88_P0.8761.00
155_V189_A0.8761.00
197_N200_L0.8761.00
333_V348_N0.8751.00
110_L114_N0.8701.00
249_Q274_I0.8681.00
262_D266_K0.8671.00
316_V329_I0.8661.00
204_Y226_L0.8631.00
39_I56_I0.8591.00
290_A293_Q0.8571.00
8_M55_G0.8561.00
150_I174_I0.8551.00
148_V196_F0.8531.00
166_M174_I0.8461.00
147_D200_L0.8431.00
122_L138_L0.8391.00
208_D222_I0.8391.00
287_S302_V0.8381.00
9_L46_C0.8371.00
178_D185_K0.8341.00
6_V113_L0.8281.00
225_L228_E0.8231.00
203_Q206_E0.8191.00
59_Q104_S0.8171.00
138_L142_I0.8161.00
188_L237_P0.8151.00
56_I69_I0.8131.00
153_I189_A0.8121.00
8_M121_V0.8121.00
298_N317_T0.8121.00
304_Y325_T0.8101.00
47_S72_G0.8101.00
282_P299_E0.8081.00
29_A64_E0.8071.00
315_G331_P0.8061.00
256_M259_L0.8061.00
342_E357_V0.8031.00
153_I242_W0.7971.00
178_D184_P0.7941.00
335_I341_I0.7931.00
289_D292_V0.7921.00
266_K275_Y0.7921.00
322_T337_E0.7911.00
304_Y320_K0.7901.00
260_K264_E0.7901.00
122_L134_Y0.7891.00
136_K239_K0.7881.00
322_T354_D0.7871.00
249_Q264_E0.7861.00
17_R27_K0.7861.00
257_D260_K0.7851.00
150_I166_M0.7851.00
58_T66_N0.7831.00
61_Q64_E0.7811.00
8_M106_I0.7761.00
286_I290_A0.7741.00
40_D69_I0.7721.00
9_L43_L0.7681.00
42_T124_L0.7681.00
100_K217_D0.7661.00
321_H337_E0.7661.00
200_L226_L0.7651.00
47_S73_S0.7651.00
303_V312_L0.7641.00
210_Q217_D0.7621.00
178_D183_F0.7621.00
148_V223_I0.7610.99
333_V352_L0.7560.99
227_L233_L0.7560.99
167_K175_T0.7550.99
335_I339_V0.7520.99
6_V117_D0.7490.99
277_V283_P0.7490.99
288_S305_G0.7470.99
83_G87_L0.7450.99
146_A232_K0.7440.99
27_K127_D0.7430.99
26_A61_Q0.7430.99
148_V233_L0.7380.99
43_L69_I0.7370.99
46_C51_I0.7360.99
353_P356_A0.7310.99
47_S54_V0.7310.99
145_K197_N0.7270.99
279_P284_Q0.7200.99
295_S331_P0.7200.99
298_N304_Y0.7190.99
301_C316_V0.7160.99
265_L275_Y0.7160.99
37_R41_F0.7160.99
114_N206_E0.7150.99
164_G179_E0.7140.99
278_N283_P0.7130.99
262_D265_L0.7070.99
174_I177_F0.7050.99
170_P175_T0.7040.99
51_I138_L0.7020.99
155_V187_N0.7000.99
297_V301_C0.6950.99
208_D225_L0.6950.99
13_G27_K0.6930.99
290_A310_S0.6910.99
84_V87_L0.6890.99
204_Y222_I0.6890.99
216_H221_D0.6880.99
111_N114_N0.6850.99
41_F44_S0.6830.99
304_Y319_G0.6820.99
253_E256_M0.6820.99
125_S192_G0.6800.99
107_Y209_D0.6800.99
208_D220_K0.6790.99
326_S342_E0.6760.99
83_G86_V0.6710.99
129_I132_M0.6680.99
45_N132_M0.6660.99
98_W104_S0.6650.99
33_G41_F0.6640.99
107_Y217_D0.6620.99
33_G255_N0.6620.99
298_N320_K0.6590.99
279_P282_P0.6580.99
336_G353_P0.6550.99
176_H224_P0.6530.98
211_N214_S0.6530.98
57_L105_S0.6480.98
44_S48_N0.6470.98
45_N49_S0.6460.98
288_S293_Q0.6430.98
304_Y323_T0.6410.98
151_S193_I0.6390.98
107_Y205_L0.6380.98
55_G109_N0.6340.98
330_M347_P0.6340.98
188_L235_A0.6330.98
150_I233_L0.6320.98
152_V174_I0.6300.98
288_S292_V0.6290.98
58_T65_L0.6280.98
155_V160_A0.6280.98
325_T340_V0.6270.98
178_D181_P0.6260.98
13_G17_R0.6250.98
19_S23_K0.6240.98
38_I42_T0.6230.98
35_K41_F0.6220.98
113_L201_L0.6200.98
338_H354_D0.6190.98
32_F38_I0.6190.98
6_V121_V0.6180.98
92_E99_Y0.6140.98
66_N88_P0.6130.98
109_N113_L0.6110.98
10_L125_S0.6080.98
114_N118_P0.6060.98
296_L317_T0.6040.97
257_D261_E0.6030.97
292_V297_V0.6030.97
339_V353_P0.6020.97
200_L204_Y0.6010.97
297_V303_V0.5980.97
293_Q331_P0.5980.97
133_D241_Y0.5970.97
136_K236_Y0.5950.97
289_D294_D0.5950.97
66_N70_G0.5940.97
243_K254_A0.5940.97
155_V159_E0.5940.97
238_F242_W0.5930.97
160_A184_P0.5930.97
284_Q287_S0.5920.97
219_G222_I0.5910.97
117_D199_P0.5900.97
191_M242_W0.5900.97
166_M188_L0.5900.97
332_D348_N0.5880.97
141_H197_N0.5870.97
10_L57_L0.5870.97
175_T227_L0.5870.97
324_V341_I0.5850.97
292_V312_L0.5850.97
276_S294_D0.5820.97
139_D142_I0.5820.97
357_V360_S0.5810.97
12_G57_L0.5790.97
162_R250_S0.5740.97
9_L42_T0.5740.97
58_T86_V0.5740.97
284_Q303_V0.5740.97
173_T227_L0.5720.97
341_I358_I0.5720.97
6_V55_G0.5710.96
322_T338_H0.5700.96
305_G310_S0.5670.96
45_N134_Y0.5670.96
311_V314_Q0.5660.96
295_S314_Q0.5660.96
10_L105_S0.5650.96
204_Y231_K0.5640.96
18_L30_V0.5630.96
127_D244_D0.5620.96
67_S70_G0.5610.96
322_T336_G0.5600.96
283_P300_G0.5600.96
253_E257_D0.5590.96
347_P350_M0.5560.96
280_N284_Q0.5560.96
153_I191_M0.5550.96
285_F288_S0.5540.96
17_R28_P0.5530.96
324_V335_I0.5500.96
344_A361_E0.5480.96
33_G262_D0.5480.96
28_P65_L0.5470.96
343_N360_S0.5460.95
49_S135_G0.5450.95
164_G180_K0.5430.95
57_L91_A0.5420.95
45_N48_N0.5420.95
288_S291_Q0.5410.95
144_K232_K0.5400.95
322_T335_I0.5390.95
255_N259_L0.5390.95
277_V280_N0.5390.95
14_K99_Y0.5390.95
316_V348_N0.5380.95
85_T112_Y0.5380.95
258_L262_D0.5380.95
119_E199_P0.5360.95
124_L193_I0.5350.95
140_Y149_T0.5340.95
110_L113_L0.5320.95
318_V322_T0.5320.95
196_F201_L0.5310.95
179_E190_S0.5290.95
15_G28_P0.5290.95
342_E360_S0.5270.95
323_T336_G0.5250.94
251_L330_M0.5250.94
161_S182_K0.5240.94
250_S253_E0.5230.94
263_S279_P0.5220.94
69_I72_G0.5220.94
150_I194_Y0.5220.94
217_D220_K0.5210.94
5_C138_L0.5210.94
149_T236_Y0.5190.94
11_A56_I0.5170.94
125_S194_Y0.5170.94
327_S344_A0.5160.94
313_F348_N0.5140.94
333_V349_G0.5140.94
323_T337_E0.5110.94
31_S296_L0.5110.94
24_N314_Q0.5100.94
55_G113_L0.5090.93
196_F200_L0.5090.93
25_M347_P0.5090.93
34_G296_L0.5080.93
123_I219_G0.5070.93
337_E355_G0.5070.93
130_Y193_I0.5050.93
102_T127_D0.5050.93
224_P227_L0.5040.93
91_A104_S0.5040.93
285_F299_E0.5030.93
168_A172_G0.5020.93
121_V201_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3brkX 2 0.9421 100 0.35 Contact Map
1yp2A 4 0.9737 100 0.37 Contact Map
2ggoA 3 0.8895 100 0.419 Contact Map
4g3qA 3 0.9447 100 0.429 Contact Map
1hm9A 3 0.9263 100 0.438 Contact Map
2v0hA 3 0.9158 100 0.454 Contact Map
4fceA 3 0.9026 100 0.467 Contact Map
2icyA 1 0.8526 100 0.513 Contact Map
2i5kA 5 0.8553 100 0.541 Contact Map
3jukA 3 0.6342 100 0.556 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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