GREMLIN Database
DEOC - Deoxyribose-phosphate aldolase
UniProt: P39121 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 223 (209)
Sequences: 3229 (2108)
Seq/√Len: 145.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_T191_D3.6141.00
106_E145_S2.9351.00
98_K135_E2.8681.00
79_D83_K2.8371.00
101_E104_V2.7961.00
113_V122_V2.7251.00
102_D138_R2.7111.00
144_V178_I2.5641.00
179_G201_S2.5171.00
6_I196_V2.3821.00
136_K166_D2.3441.00
106_E110_R2.2701.00
97_L102_D2.2121.00
130_L158_S2.1931.00
22_L45_L2.1531.00
96_A104_V2.1301.00
96_A101_E2.1191.00
35_S58_C2.0241.00
168_A172_K1.9861.00
70_T74_A1.8971.00
90_M109_I1.8651.00
11_A16_T1.8601.00
22_L49_E1.8351.00
138_R141_R1.8291.00
56_D86_T1.7931.00
164_K194_T1.7851.00
92_I97_L1.7761.00
11_A21_I1.7141.00
137_E173_T1.7071.00
133_D165_E1.6981.00
26_E30_T1.6941.00
69_T79_D1.6671.00
189_K193_D1.6531.00
78_K82_S1.6081.00
77_T116_V1.5871.00
192_V203_I1.5831.00
110_R114_E1.5761.00
144_V175_G1.5751.00
193_D197_E1.5511.00
108_D112_V1.5391.00
34_A56_D1.4871.00
26_E49_E1.4831.00
44_E83_K1.4641.00
129_C158_S1.4601.00
39_N65_L1.4551.00
124_V148_A1.4341.00
72_T75_F1.4321.00
77_T88_V1.4211.00
71_E79_D1.4181.00
22_L26_E1.4131.00
86_T120_A1.4111.00
132_T135_E1.4101.00
69_T83_K1.3871.00
79_D82_S1.3851.00
97_L139_A1.3821.00
18_K99_D1.3711.00
171_R176_P1.3711.00
133_D136_K1.3681.00
47_A86_T1.3641.00
97_L142_L1.3491.00
7_I208_G1.3491.00
43_V57_V1.3361.00
39_N67_A1.3221.00
81_I115_A1.3201.00
167_I180_V1.3121.00
126_I136_K1.3091.00
187_R191_D1.2941.00
191_D194_T1.2891.00
92_I139_A1.2711.00
41_T93_N1.2641.00
68_N72_T1.2591.00
164_K198_A1.2531.00
140_C170_M1.2511.00
128_T183_S1.2501.00
106_E142_L1.2481.00
191_D195_M1.2481.00
32_K54_G1.2361.00
129_C159_T1.2261.00
18_K45_L1.2091.00
45_L49_E1.2061.00
116_V122_V1.1981.00
19_A22_L1.1801.00
17_Q20_D1.1791.00
18_K42_W1.1681.00
40_P68_N1.1591.00
140_C174_V1.1561.00
137_E172_K1.1561.00
33_F208_G1.1450.99
187_R207_A1.1380.99
190_E194_T1.1310.99
174_V180_V1.1200.99
144_V177_D1.1180.99
40_P59_T1.1130.99
209_V212_V1.1090.99
11_A20_D1.1080.99
160_G163_T1.1040.99
46_A57_V1.1010.99
68_N76_E1.0970.99
20_D23_K1.0940.99
43_V59_T1.0930.99
126_I151_V1.0910.99
29_K53_T1.0860.99
35_S56_D1.0850.99
171_R179_G1.0770.99
70_T108_D1.0730.99
107_A111_G1.0730.99
9_H208_G1.0660.99
61_I88_V1.0470.99
81_I120_A1.0460.99
4_A32_K1.0300.99
113_V116_V1.0160.99
5_N32_K1.0110.99
128_T166_D1.0070.99
25_I36_V0.9990.99
137_E141_R0.9980.99
121_L149_D0.9930.99
18_K22_L0.9820.98
190_E193_D0.9640.98
113_V149_D0.9520.98
111_G114_E0.9480.98
107_A110_R0.9470.98
18_K101_E0.9430.98
93_N108_D0.9390.98
171_R201_S0.9370.98
31_Y209_V0.9370.98
140_C151_V0.9340.98
164_K195_M0.9340.98
25_I49_E0.9310.98
165_E168_A0.9290.98
47_A57_V0.9280.98
74_A115_A0.9170.98
143_A148_A0.9140.98
50_L55_V0.9120.97
15_H130_L0.9100.97
5_N54_G0.9070.97
105_V108_D0.9060.97
73_K108_D0.9060.97
44_E48_K0.9060.97
37_C58_C0.9050.97
136_K169_L0.9050.97
126_I139_A0.9020.97
14_P65_L0.9010.97
40_P69_T0.8990.97
102_D142_L0.8910.97
3_L192_V0.8860.97
62_G68_N0.8720.97
137_E169_L0.8710.97
143_A146_A0.8650.97
37_C60_V0.8640.97
106_E146_A0.8610.96
103_D106_E0.8560.96
26_E29_K0.8550.96
48_K51_K0.8510.96
170_M180_V0.8490.96
103_D107_A0.8430.96
164_K168_A0.8430.96
33_F212_V0.8410.96
151_V170_M0.8360.96
75_F78_K0.8330.96
43_V83_K0.8310.96
3_L6_I0.8280.96
21_I42_W0.8210.95
160_G166_D0.8200.95
194_T198_A0.8120.95
33_F209_V0.8120.95
141_R173_T0.8120.95
8_D35_S0.8070.95
65_L157_F0.8070.95
192_V212_V0.8060.95
69_T72_T0.8030.95
194_T197_E0.8020.95
122_V149_D0.8020.95
208_G212_V0.7970.95
151_V174_V0.7930.94
23_K27_E0.7850.94
109_I148_A0.7830.94
10_T24_L0.7790.94
130_L159_T0.7790.94
154_S161_G0.7730.94
9_H27_E0.7700.94
42_W99_D0.7700.94
150_F179_G0.7690.93
38_V46_A0.7610.93
143_A170_M0.7600.93
74_A112_V0.7590.93
126_I143_A0.7530.93
29_K52_G0.7520.93
11_A24_L0.7510.93
74_A111_G0.7490.93
129_C154_S0.7440.92
109_I143_A0.7370.92
29_K54_G0.7360.92
128_T160_G0.7360.92
207_A210_S0.7360.92
96_A99_D0.7280.91
38_V43_V0.7220.91
90_M112_V0.7130.91
205_A208_G0.7120.91
113_V118_G0.7120.91
41_T104_V0.7050.90
59_T80_A0.7010.90
93_N96_A0.7010.90
41_T96_A0.7000.90
154_S162_A0.7000.90
62_G76_E0.6970.90
5_N34_A0.6940.89
144_V174_V0.6930.89
74_A78_K0.6930.89
88_V116_V0.6910.89
3_L189_K0.6870.89
192_V196_V0.6860.89
144_V151_V0.6830.89
80_A85_A0.6800.88
168_A197_E0.6790.88
136_K140_C0.6750.88
186_V207_A0.6720.88
31_Y212_V0.6670.87
90_M108_D0.6660.87
141_R145_S0.6650.87
126_I170_M0.6630.87
71_E75_F0.6600.87
80_A83_K0.6570.87
136_K163_T0.6570.87
142_L146_A0.6520.86
21_I24_L0.6510.86
136_K170_M0.6490.86
6_I201_S0.6480.86
23_K26_E0.6470.86
144_V173_T0.6390.85
81_I118_G0.6370.85
89_D152_K0.6360.85
75_F79_D0.6350.85
61_I80_A0.6340.85
81_I88_V0.6310.84
14_P159_T0.6310.84
138_R142_L0.6300.84
22_L25_I0.6290.84
8_D58_C0.6280.84
38_V59_T0.6280.84
189_K211_I0.6270.84
128_T136_K0.6260.84
43_V46_A0.6250.84
90_M148_A0.6230.84
112_V122_V0.6180.83
205_A211_I0.6140.83
29_K49_E0.6100.82
47_A51_K0.6070.82
19_A23_K0.6050.82
77_T112_V0.6030.82
136_K160_G0.6030.82
65_L68_N0.6020.82
92_I105_V0.6000.81
100_K105_V0.5930.81
171_R180_V0.5920.81
70_T107_A0.5910.80
95_A99_D0.5850.80
78_K114_E0.5850.80
182_A186_V0.5820.79
6_I150_F0.5820.79
15_H20_D0.5780.79
77_T81_I0.5760.79
70_T104_V0.5750.79
3_L212_V0.5750.79
22_L48_K0.5730.78
74_A108_D0.5690.78
62_G73_K0.5630.77
71_E83_K0.5600.77
113_V119_K0.5600.77
104_V107_A0.5590.77
109_I124_V0.5590.77
122_V148_A0.5580.77
129_C160_G0.5570.76
90_M124_V0.5560.76
167_I200_A0.5550.76
40_P72_T0.5510.76
126_I140_C0.5510.76
17_Q99_D0.5500.75
28_A55_V0.5490.75
94_I97_L0.5480.75
25_I46_A0.5470.75
7_I33_F0.5390.74
81_I116_V0.5390.74
57_V86_T0.5380.74
166_D169_L0.5380.74
171_R175_G0.5370.74
12_L157_F0.5360.74
56_D121_L0.5310.73
100_K135_E0.5300.73
133_D166_D0.5280.73
67_A93_N0.5280.73
186_V195_M0.5270.72
71_E111_G0.5270.72
142_L145_S0.5250.72
141_R144_V0.5240.72
25_I50_L0.5230.72
161_G183_S0.5220.72
112_V115_A0.5200.71
192_V211_I0.5160.71
42_W45_L0.5160.71
80_A88_V0.5160.71
94_I130_L0.5150.71
29_K55_V0.5150.71
90_M122_V0.5140.71
140_C173_T0.5130.70
113_V120_A0.5130.70
134_E137_E0.5130.70
144_V176_P0.5120.70
16_T20_D0.5110.70
133_D172_K0.5080.70
167_I195_M0.5070.70
92_I124_V0.5060.69
139_A146_A0.5050.69
12_L37_C0.5030.69
42_W95_A0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a4aA 2 0.9596 100 0.172 Contact Map
4eivA 2 0.9776 100 0.174 Contact Map
1p1xA 1 0.9731 100 0.192 Contact Map
3r12A 2 0.9821 100 0.202 Contact Map
3oa3A 2 0.9686 100 0.204 Contact Map
1vcvA 2 0.9238 100 0.214 Contact Map
3ngjA 4 0.9641 100 0.229 Contact Map
3ndoA 2 0.9686 100 0.264 Contact Map
1ub3A 3 0.9507 100 0.299 Contact Map
1n7kA 3 0.9552 100 0.351 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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