CISY2 - BACSU - GREMLIN Contacts

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CISY2 - Citrate synthase 2

UniProt:	P39120	Sequences: MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEIIYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLGLLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTLNGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLHGGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKRLTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRMSGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	372 (360)
Sequences:	4167 (2024)
Seq/√Len:	106.7

ECOLI - CISY PRPC
BACSU - CISY2 CISY3 CISY
HALSA - Q9HNH4
SULSO - CISY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
195_C	208_A	7.349	1.00
34_D	364_K	4.059	1.00
192_A	209_A	3.958	1.00
52_R	58_E	3.456	1.00
56_K	60_E	3.330	1.00
154_E	170_V	3.125	1.00
39_A	365_F	3.095	1.00
31_D	34_D	3.035	1.00
166_S	280_L	3.035	1.00
292_R	295_D	3.035	1.00
37_E	272_E	2.855	1.00
195_C	212_A	2.761	1.00
245_K	250_E	2.683	1.00
295_D	299_S	2.682	1.00
151_G	154_E	2.644	1.00
55_N	58_E	2.636	1.00
275_K	291_I	2.610	1.00
200_S	214_K	2.553	1.00
237_N	240_P	2.486	1.00
187_A	198_T	2.416	1.00
239_E	299_S	2.391	1.00
43_E	59_L	2.368	1.00
230_T	316_H	2.356	1.00
233_G	237_N	2.345	1.00
169_E	318_L	2.340	1.00
239_E	292_R	2.251	1.00
194_V	351_I	2.240	1.00
52_R	363_Q	2.236	1.00
98_I	210_I	2.227	1.00
272_E	276_R	2.117	1.00
8_E	349_R	2.114	1.00
191_T	212_A	2.085	1.00
155_N	159_T	2.082	1.00
120_A	338_L	2.059	1.00
153_A	174_N	2.054	1.00
198_T	212_A	2.003	1.00
239_E	296_I	1.978	1.00
40_S	59_L	1.950	1.00
240_P	244_A	1.931	1.00
196_V	205_G	1.899	1.00
131_V	331_V	1.886	1.00
45_I	335_S	1.861	1.00
168_I	280_L	1.844	1.00
150_Y	154_E	1.831	1.00
78_E	81_K	1.827	1.00
292_R	296_I	1.793	1.00
290_S	313_S	1.792	1.00
46_Y	52_R	1.780	1.00
96_T	99_S	1.779	1.00
196_V	341_I	1.752	1.00
171_E	174_N	1.750	1.00
275_K	279_N	1.728	1.00
243_R	247_E	1.723	1.00
230_T	322_H	1.706	1.00
151_G	170_V	1.695	1.00
18_S	182_D	1.691	1.00
136_R	141_L	1.688	1.00
30_Y	363_Q	1.673	1.00
320_I	328_I	1.660	1.00
223_E	227_K	1.650	1.00
127_V	334_M	1.647	1.00
74_Q	78_E	1.645	1.00
39_A	178_I	1.615	1.00
176_A	315_Y	1.607	1.00
33_D	268_K	1.605	1.00
175_K	273_M	1.597	1.00
60_E	64_Q	1.592	1.00
244_A	248_K	1.591	1.00
95_R	99_S	1.588	1.00
97_A	130_L	1.581	1.00
57_K	61_E	1.568	1.00
176_A	270_L	1.552	1.00
284_S	316_H	1.543	1.00
95_R	211_G	1.538	1.00
160_L	320_I	1.527	1.00
64_Q	68_K	1.521	1.00
235_V	292_R	1.511	1.00
166_S	169_E	1.509	1.00
49_W	124_Q	1.492	1.00
208_A	212_A	1.475	1.00
132_A	156_F	1.473	1.00
42_E	66_L	1.466	1.00
65_Q	121_I	1.465	1.00
93_A	134_F	1.462	1.00
244_A	249_K	1.435	1.00
24_T	31_D	1.433	1.00
167_P	171_E	1.431	1.00
191_T	208_A	1.429	1.00
144_V	159_T	1.426	1.00
112_N	115_A	1.420	1.00
46_Y	58_E	1.405	1.00
69_E	122_R	1.391	1.00
252_I	297_V	1.383	1.00
44_I	178_I	1.381	1.00
242_I	297_V	1.381	1.00
272_E	275_K	1.377	1.00
146_P	155_N	1.374	1.00
34_D	38_N	1.374	1.00
147_R	158_Y	1.373	1.00
171_E	175_K	1.372	1.00
187_A	212_A	1.371	1.00
147_R	164_E	1.361	1.00
98_I	127_V	1.345	1.00
78_E	82_S	1.343	0.99
244_A	250_E	1.341	0.99
213_L	330_A	1.328	0.99
14_T	356_D	1.311	0.99
263_G	268_K	1.307	0.99
77_I	133_A	1.300	0.99
232_I	245_K	1.288	0.99
147_R	150_Y	1.286	0.99
8_E	258_R	1.283	0.99
271_K	294_E	1.278	0.99
279_N	284_S	1.264	0.99
255_F	297_V	1.258	0.99
30_Y	53_L	1.242	0.99
184_E	354_R	1.235	0.99
65_Q	118_R	1.235	0.99
113_P	346_D	1.231	0.99
200_S	204_S	1.230	0.99
218_H	221_A	1.227	0.99
243_R	300_E	1.214	0.99
181_A	335_S	1.211	0.99
79_H	100_L	1.205	0.99
43_E	365_F	1.204	0.99
33_D	269_H	1.200	0.99
204_S	214_K	1.198	0.99
191_T	195_C	1.197	0.99
70_A	152_I	1.189	0.99
191_T	194_V	1.189	0.99
28_V	51_L	1.187	0.99
192_A	341_I	1.172	0.99
274_S	313_S	1.169	0.99
48_L	335_S	1.163	0.99
202_I	338_L	1.163	0.99
27_Y	181_A	1.162	0.99
316_H	322_H	1.161	0.99
138_R	323_D	1.157	0.98
47_L	53_L	1.147	0.98
91_M	222_N	1.145	0.98
81_K	142_E	1.141	0.98
146_P	159_T	1.141	0.98
46_Y	50_H	1.137	0.98
70_A	148_E	1.135	0.98
69_E	121_I	1.129	0.98
227_K	322_H	1.120	0.98
119_K	202_I	1.119	0.98
115_A	119_K	1.110	0.98
273_M	276_R	1.108	0.98
296_I	299_S	1.107	0.98
49_W	338_L	1.096	0.98
270_L	314_V	1.094	0.98
32_I	269_H	1.085	0.98
161_N	169_E	1.082	0.98
61_E	65_Q	1.080	0.98
234_E	237_N	1.079	0.98
63_K	67_A	1.072	0.98
271_K	275_K	1.069	0.97
217_L	251_K	1.066	0.97
30_Y	47_L	1.051	0.97
39_A	43_E	1.050	0.97
202_I	341_I	1.049	0.97
14_T	358_T	1.042	0.97
40_S	174_N	1.041	0.97
154_E	167_P	1.032	0.97
94_L	131_V	1.031	0.97
34_D	37_E	1.029	0.97
174_N	178_I	1.025	0.97
288_E	291_I	1.014	0.97
60_E	63_K	1.012	0.96
65_Q	69_E	1.011	0.96
123_L	206_I	1.008	0.96
168_I	276_R	1.007	0.96
228_M	245_K	0.998	0.96
206_I	338_L	0.995	0.96
290_S	312_A	0.994	0.96
144_V	162_G	0.993	0.96
144_V	158_Y	0.993	0.96
142_E	145_E	0.992	0.96
71_A	145_E	0.991	0.96
241_Y	245_K	0.990	0.96
229_L	293_I	0.986	0.96
41_F	335_S	0.985	0.96
129_G	146_P	0.982	0.96
271_K	291_I	0.982	0.96
193_R	344_Q	0.981	0.96
200_S	205_G	0.972	0.96
27_Y	44_I	0.971	0.96
50_H	117_Y	0.970	0.96
242_I	296_I	0.970	0.96
235_V	295_D	0.970	0.96
22_D	262_H	0.969	0.95
89_H	223_E	0.967	0.95
206_I	334_M	0.965	0.95
72_V	133_A	0.965	0.95
110_T	115_A	0.964	0.95
232_I	241_Y	0.955	0.95
140_G	144_V	0.951	0.95
239_E	243_R	0.947	0.95
77_I	81_K	0.943	0.95
236_E	240_P	0.941	0.95
76_I	79_H	0.941	0.95
118_R	122_R	0.941	0.95
58_E	61_E	0.938	0.95
342_L	346_D	0.925	0.94
95_R	207_T	0.924	0.94
131_V	327_P	0.923	0.94
57_K	60_E	0.922	0.94
232_I	238_A	0.908	0.94
48_L	181_A	0.908	0.94
52_R	55_N	0.908	0.94
84_S	87_N	0.907	0.94
180_H	307_V	0.907	0.94
117_Y	342_L	0.907	0.94
171_E	276_R	0.903	0.93
291_I	295_D	0.903	0.93
238_A	292_R	0.893	0.93
231_E	250_E	0.892	0.93
221_A	306_N	0.890	0.93
155_N	158_Y	0.890	0.93
171_E	273_M	0.888	0.93
284_S	288_E	0.881	0.93
188_S	218_H	0.881	0.93
332_S	335_S	0.876	0.92
290_S	309_F	0.875	0.92
35_L	44_I	0.875	0.92
235_V	289_M	0.874	0.92
13_T	185_L	0.874	0.92
5_R	347_N	0.871	0.92
274_S	290_S	0.871	0.92
177_L	331_V	0.868	0.92
79_H	83_Y	0.863	0.92
225_V	229_L	0.857	0.92
66_L	121_I	0.856	0.91
7_L	10_V	0.854	0.91
224_G	227_K	0.854	0.91
150_Y	155_N	0.854	0.91
230_T	286_W	0.850	0.91
80_F	137_I	0.849	0.91
42_E	153_A	0.844	0.91
219_G	329_F	0.843	0.91
81_K	137_I	0.842	0.91
234_E	285_K	0.842	0.91
135_S	139_K	0.840	0.91
210_I	330_A	0.838	0.91
199_L	217_L	0.835	0.90
198_T	350_L	0.833	0.90
255_F	305_P	0.832	0.90
69_E	118_R	0.832	0.90
231_E	234_E	0.832	0.90
30_Y	35_L	0.832	0.90
185_L	354_R	0.829	0.90
83_Y	103_L	0.829	0.90
26_T	362_K	0.828	0.90
80_F	97_A	0.828	0.90
245_K	248_K	0.828	0.90
46_Y	62_L	0.826	0.90
116_N	119_K	0.825	0.90
18_S	184_E	0.824	0.90
190_F	194_V	0.823	0.90
129_G	159_T	0.821	0.90
235_V	288_E	0.818	0.90
165_P	170_V	0.813	0.89
151_G	174_N	0.812	0.89
222_N	308_D	0.812	0.89
213_L	219_G	0.810	0.89
72_V	130_L	0.807	0.89
150_Y	170_V	0.805	0.89
16_S	358_T	0.804	0.89
263_G	271_K	0.803	0.89
107_E	110_T	0.796	0.88
124_Q	152_I	0.794	0.88
190_F	351_I	0.791	0.88
224_G	253_M	0.791	0.88
153_A	170_V	0.787	0.88
169_E	277_L	0.787	0.88
40_S	43_E	0.783	0.87
183_H	260_Y	0.783	0.87
218_H	308_D	0.773	0.87
233_G	285_K	0.772	0.87
107_E	118_R	0.771	0.87
205_G	341_I	0.771	0.87
180_H	222_N	0.768	0.86
120_A	342_L	0.767	0.86
213_L	329_F	0.765	0.86
75_E	78_E	0.765	0.86
119_K	203_Y	0.765	0.86
153_A	173_F	0.763	0.86
26_T	361_D	0.762	0.86
45_I	62_L	0.762	0.86
45_I	124_Q	0.761	0.86
49_W	335_S	0.758	0.86
27_Y	47_L	0.755	0.85
136_R	144_V	0.754	0.85
59_L	63_K	0.753	0.85
66_L	125_A	0.752	0.85
71_A	148_E	0.750	0.85
79_H	82_S	0.749	0.85
233_G	236_E	0.746	0.85
240_P	243_R	0.746	0.85
287_Y	291_I	0.743	0.85
125_A	128_P	0.743	0.85
43_E	53_L	0.741	0.84
360_P	363_Q	0.741	0.84
273_M	314_V	0.739	0.84
218_H	329_F	0.739	0.84
163_E	169_E	0.736	0.84
115_A	118_R	0.735	0.84
283_E	288_E	0.732	0.84
32_I	179_L	0.729	0.83
183_H	219_G	0.728	0.83
75_E	104_L	0.723	0.83
274_S	314_V	0.722	0.83
76_I	100_L	0.721	0.83
184_E	355_A	0.717	0.82
188_S	219_G	0.715	0.82
105_D	122_R	0.715	0.82
221_A	256_G	0.714	0.82
228_M	241_Y	0.713	0.82
44_I	181_A	0.712	0.82
99_S	211_G	0.711	0.82
168_I	172_A	0.708	0.82
80_F	134_F	0.707	0.81
25_L	32_I	0.706	0.81
94_L	210_I	0.706	0.81
12_A	190_F	0.705	0.81
232_I	293_I	0.704	0.81
18_S	26_T	0.704	0.81
72_V	77_I	0.702	0.81
199_L	216_P	0.702	0.81
222_N	326_T	0.699	0.81
107_E	122_R	0.697	0.81
105_D	119_K	0.696	0.80
201_D	204_S	0.693	0.80
237_N	244_A	0.690	0.80
26_T	31_D	0.690	0.80
180_H	311_S	0.687	0.80
35_L	53_L	0.685	0.79
99_S	207_T	0.684	0.79
68_K	148_E	0.683	0.79
226_M	325_F	0.682	0.79
132_A	159_T	0.681	0.79
41_F	45_I	0.680	0.79
76_I	84_S	0.679	0.79
286_W	316_H	0.674	0.78
213_L	222_N	0.673	0.78
230_T	234_E	0.667	0.78
225_V	307_V	0.667	0.78
61_E	64_Q	0.665	0.77
7_L	190_F	0.663	0.77
225_V	289_M	0.663	0.77
199_L	345_Y	0.661	0.77
270_L	311_S	0.659	0.77
122_R	126_K	0.655	0.76
288_E	292_R	0.654	0.76
83_Y	100_L	0.653	0.76
81_K	133_A	0.652	0.76
67_A	148_E	0.648	0.76
175_K	178_I	0.647	0.75
139_K	321_D	0.646	0.75
320_I	324_L	0.645	0.75
132_A	136_R	0.643	0.75
171_E	178_I	0.642	0.75
229_L	290_S	0.641	0.75
330_A	337_W	0.640	0.75
116_N	345_Y	0.638	0.74
17_V	28_V	0.638	0.74
260_Y	337_W	0.637	0.74
183_H	329_F	0.635	0.74
285_K	288_E	0.634	0.74
76_I	97_A	0.633	0.74
30_Y	52_R	0.633	0.74
7_L	11_V	0.633	0.74
75_E	86_E	0.632	0.74
246_L	300_E	0.632	0.74
7_L	12_A	0.631	0.74
195_C	205_G	0.630	0.74
176_A	180_H	0.629	0.73
133_A	143_P	0.625	0.73
238_A	289_M	0.624	0.73
41_F	174_N	0.624	0.73
150_Y	165_P	0.623	0.73
74_Q	145_E	0.623	0.73
239_E	242_I	0.622	0.73
183_H	186_N	0.622	0.73
169_E	281_T	0.621	0.72
36_T	178_I	0.620	0.72
235_V	238_A	0.620	0.72
153_A	157_L	0.620	0.72
256_G	306_N	0.616	0.72
73_P	101_L	0.615	0.72
28_V	45_I	0.611	0.71
147_R	155_N	0.610	0.71
227_K	230_T	0.610	0.71
252_I	301_K	0.610	0.71
334_M	338_L	0.608	0.71
243_R	296_I	0.608	0.71
140_G	143_P	0.607	0.71
242_I	293_I	0.607	0.71
150_Y	158_Y	0.607	0.71
124_Q	335_S	0.606	0.71
189_T	340_H	0.605	0.71
120_A	202_I	0.604	0.70
177_L	332_S	0.604	0.70
226_M	322_H	0.604	0.70
69_E	209_A	0.602	0.70
77_I	145_E	0.602	0.70
261_K	302_K	0.602	0.70
153_A	177_L	0.601	0.70
114_E	118_R	0.600	0.70
244_A	247_E	0.598	0.70
251_K	350_L	0.597	0.69
76_I	80_F	0.597	0.69
175_K	276_R	0.595	0.69
201_D	214_K	0.595	0.69
231_E	245_K	0.593	0.69
186_N	260_Y	0.592	0.69
275_K	287_Y	0.591	0.69
242_I	289_M	0.591	0.69
124_Q	338_L	0.591	0.69
340_H	348_N	0.589	0.68
245_K	249_K	0.588	0.68
185_L	193_R	0.588	0.68
7_L	351_I	0.587	0.68
79_H	84_S	0.587	0.68
258_R	261_K	0.586	0.68
108_A	119_K	0.586	0.68
182_D	338_L	0.586	0.68
80_F	143_P	0.585	0.68
62_L	66_L	0.584	0.68
71_A	118_R	0.583	0.68
263_G	304_P	0.583	0.68
133_A	159_T	0.581	0.67
243_R	246_L	0.581	0.67
129_G	132_A	0.579	0.67
184_E	303_L	0.578	0.67
129_G	155_N	0.577	0.67
193_R	229_L	0.576	0.67
189_T	326_T	0.576	0.67
31_D	364_K	0.574	0.66
258_R	350_L	0.574	0.66
98_I	123_L	0.573	0.66
69_E	126_K	0.572	0.66
307_V	311_S	0.572	0.66
240_P	247_E	0.572	0.66
189_T	193_R	0.572	0.66
298_T	302_K	0.571	0.66
281_T	317_S	0.569	0.66
41_F	84_S	0.569	0.66
30_Y	34_D	0.569	0.66
73_P	76_I	0.568	0.66
40_S	171_E	0.567	0.66
101_L	130_L	0.567	0.66
271_K	310_Y	0.567	0.66
188_S	329_F	0.567	0.66
278_T	287_Y	0.567	0.66
358_T	361_D	0.566	0.65
19_S	22_D	0.566	0.65
65_Q	68_K	0.565	0.65
218_H	256_G	0.563	0.65
188_S	308_D	0.561	0.65
235_V	239_E	0.560	0.65
186_N	257_H	0.559	0.64
306_N	312_A	0.559	0.64
133_A	137_I	0.558	0.64
227_K	231_E	0.558	0.64
105_D	345_Y	0.556	0.64
39_A	174_N	0.555	0.64
172_A	273_M	0.554	0.64
216_P	221_A	0.553	0.64
116_N	120_A	0.551	0.63
102_G	201_D	0.550	0.63
42_E	152_I	0.550	0.63
236_E	239_E	0.548	0.63
270_L	307_V	0.548	0.63
141_L	144_V	0.548	0.63
117_Y	121_I	0.548	0.63
72_V	80_F	0.545	0.63
274_S	287_Y	0.545	0.63
176_A	328_I	0.543	0.62
15_S	18_S	0.543	0.62
71_A	75_E	0.541	0.62
186_N	307_V	0.541	0.62
312_A	329_F	0.539	0.62
288_E	299_S	0.538	0.62
238_A	293_I	0.537	0.61
238_A	296_I	0.536	0.61
183_H	188_S	0.533	0.61
180_H	308_D	0.533	0.61
157_L	170_V	0.532	0.61
315_Y	325_F	0.530	0.60
172_A	277_L	0.530	0.60
303_L	309_F	0.527	0.60
156_F	324_L	0.527	0.60
186_N	329_F	0.526	0.60
40_S	45_I	0.526	0.60
137_I	143_P	0.525	0.60
116_N	342_L	0.525	0.60
127_V	130_L	0.523	0.59
30_Y	38_N	0.523	0.59
40_S	63_K	0.522	0.59
39_A	59_L	0.521	0.59
275_K	295_D	0.521	0.59
121_I	125_A	0.521	0.59
300_E	303_L	0.520	0.59
226_M	316_H	0.519	0.59
226_M	313_S	0.519	0.59
38_N	365_F	0.519	0.59
186_N	218_H	0.519	0.59
341_I	355_A	0.518	0.59
99_S	102_G	0.518	0.59
15_S	355_A	0.517	0.59
193_R	255_F	0.516	0.58
172_A	314_V	0.515	0.58
188_S	213_L	0.515	0.58
131_V	195_C	0.515	0.58
9_G	20_I	0.515	0.58
19_S	26_T	0.513	0.58
294_E	305_P	0.513	0.58
232_I	242_I	0.512	0.58
257_H	329_F	0.511	0.58
64_Q	67_A	0.510	0.57
45_I	49_W	0.510	0.57
222_N	325_F	0.509	0.57
239_E	275_K	0.508	0.57
35_L	47_L	0.508	0.57
83_Y	88_V	0.507	0.57
11_V	356_D	0.507	0.57
25_L	29_G	0.507	0.57
15_S	340_H	0.506	0.57
245_K	301_K	0.506	0.57
75_E	79_H	0.506	0.57
251_K	290_S	0.506	0.57
228_M	253_M	0.504	0.57
271_K	287_Y	0.504	0.57
135_S	321_D	0.504	0.57
102_G	200_S	0.504	0.57
81_K	86_E	0.501	0.56
74_Q	167_P	0.500	0.56
179_L	269_H	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2h12A	4	0.9946	100	0.038	Contact Map
4xghA	5	0.9113	100	0.04	Contact Map
1iomA	2	0.9892	100	0.047	Contact Map
2ibpA	2	0.9919	100	0.053	Contact Map
3o8jA	3	0.9704	100	0.054	Contact Map
4jadA	5	0.9946	100	0.056	Contact Map
1vgpA	2	0.9839	100	0.056	Contact Map
1o7xA	2	0.9731	100	0.059	Contact Map
4tvmA	2	0.8925	100	0.06	Contact Map
3tqgA	2	0.9651	100	0.061	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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