GREMLIN Database
CISY2 - Citrate synthase 2
UniProt: P39120 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 372 (360)
Sequences: 4167 (2024)
Seq/√Len: 106.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_C208_A7.3491.00
34_D364_K4.0591.00
192_A209_A3.9581.00
52_R58_E3.4561.00
56_K60_E3.3301.00
154_E170_V3.1251.00
39_A365_F3.0951.00
31_D34_D3.0351.00
166_S280_L3.0351.00
292_R295_D3.0351.00
37_E272_E2.8551.00
195_C212_A2.7611.00
245_K250_E2.6831.00
295_D299_S2.6821.00
151_G154_E2.6441.00
55_N58_E2.6361.00
275_K291_I2.6101.00
200_S214_K2.5531.00
237_N240_P2.4861.00
187_A198_T2.4161.00
239_E299_S2.3911.00
43_E59_L2.3681.00
230_T316_H2.3561.00
233_G237_N2.3451.00
169_E318_L2.3401.00
239_E292_R2.2511.00
194_V351_I2.2401.00
52_R363_Q2.2361.00
98_I210_I2.2271.00
272_E276_R2.1171.00
8_E349_R2.1141.00
191_T212_A2.0851.00
155_N159_T2.0821.00
120_A338_L2.0591.00
153_A174_N2.0541.00
198_T212_A2.0031.00
239_E296_I1.9781.00
40_S59_L1.9501.00
240_P244_A1.9311.00
196_V205_G1.8991.00
131_V331_V1.8861.00
45_I335_S1.8611.00
168_I280_L1.8441.00
150_Y154_E1.8311.00
78_E81_K1.8271.00
292_R296_I1.7931.00
290_S313_S1.7921.00
46_Y52_R1.7801.00
96_T99_S1.7791.00
196_V341_I1.7521.00
171_E174_N1.7501.00
275_K279_N1.7281.00
243_R247_E1.7231.00
230_T322_H1.7061.00
151_G170_V1.6951.00
18_S182_D1.6911.00
136_R141_L1.6881.00
30_Y363_Q1.6731.00
320_I328_I1.6601.00
223_E227_K1.6501.00
127_V334_M1.6471.00
74_Q78_E1.6451.00
39_A178_I1.6151.00
176_A315_Y1.6071.00
33_D268_K1.6051.00
175_K273_M1.5971.00
60_E64_Q1.5921.00
244_A248_K1.5911.00
95_R99_S1.5881.00
97_A130_L1.5811.00
57_K61_E1.5681.00
176_A270_L1.5521.00
284_S316_H1.5431.00
95_R211_G1.5381.00
160_L320_I1.5271.00
64_Q68_K1.5211.00
235_V292_R1.5111.00
166_S169_E1.5091.00
49_W124_Q1.4921.00
208_A212_A1.4751.00
132_A156_F1.4731.00
42_E66_L1.4661.00
65_Q121_I1.4651.00
93_A134_F1.4621.00
244_A249_K1.4351.00
24_T31_D1.4331.00
167_P171_E1.4311.00
191_T208_A1.4291.00
144_V159_T1.4261.00
112_N115_A1.4201.00
46_Y58_E1.4051.00
69_E122_R1.3911.00
252_I297_V1.3831.00
44_I178_I1.3811.00
242_I297_V1.3811.00
272_E275_K1.3771.00
146_P155_N1.3741.00
34_D38_N1.3741.00
147_R158_Y1.3731.00
171_E175_K1.3721.00
187_A212_A1.3711.00
147_R164_E1.3611.00
98_I127_V1.3451.00
78_E82_S1.3430.99
244_A250_E1.3410.99
213_L330_A1.3280.99
14_T356_D1.3110.99
263_G268_K1.3070.99
77_I133_A1.3000.99
232_I245_K1.2880.99
147_R150_Y1.2860.99
8_E258_R1.2830.99
271_K294_E1.2780.99
279_N284_S1.2640.99
255_F297_V1.2580.99
30_Y53_L1.2420.99
184_E354_R1.2350.99
65_Q118_R1.2350.99
113_P346_D1.2310.99
200_S204_S1.2300.99
218_H221_A1.2270.99
243_R300_E1.2140.99
181_A335_S1.2110.99
79_H100_L1.2050.99
43_E365_F1.2040.99
33_D269_H1.2000.99
204_S214_K1.1980.99
191_T195_C1.1970.99
70_A152_I1.1890.99
191_T194_V1.1890.99
28_V51_L1.1870.99
192_A341_I1.1720.99
274_S313_S1.1690.99
48_L335_S1.1630.99
202_I338_L1.1630.99
27_Y181_A1.1620.99
316_H322_H1.1610.99
138_R323_D1.1570.98
47_L53_L1.1470.98
91_M222_N1.1450.98
81_K142_E1.1410.98
146_P159_T1.1410.98
46_Y50_H1.1370.98
70_A148_E1.1350.98
69_E121_I1.1290.98
227_K322_H1.1200.98
119_K202_I1.1190.98
115_A119_K1.1100.98
273_M276_R1.1080.98
296_I299_S1.1070.98
49_W338_L1.0960.98
270_L314_V1.0940.98
32_I269_H1.0850.98
161_N169_E1.0820.98
61_E65_Q1.0800.98
234_E237_N1.0790.98
63_K67_A1.0720.98
271_K275_K1.0690.97
217_L251_K1.0660.97
30_Y47_L1.0510.97
39_A43_E1.0500.97
202_I341_I1.0490.97
14_T358_T1.0420.97
40_S174_N1.0410.97
154_E167_P1.0320.97
94_L131_V1.0310.97
34_D37_E1.0290.97
174_N178_I1.0250.97
288_E291_I1.0140.97
60_E63_K1.0120.96
65_Q69_E1.0110.96
123_L206_I1.0080.96
168_I276_R1.0070.96
228_M245_K0.9980.96
206_I338_L0.9950.96
290_S312_A0.9940.96
144_V162_G0.9930.96
144_V158_Y0.9930.96
142_E145_E0.9920.96
71_A145_E0.9910.96
241_Y245_K0.9900.96
229_L293_I0.9860.96
41_F335_S0.9850.96
129_G146_P0.9820.96
271_K291_I0.9820.96
193_R344_Q0.9810.96
200_S205_G0.9720.96
27_Y44_I0.9710.96
50_H117_Y0.9700.96
242_I296_I0.9700.96
235_V295_D0.9700.96
22_D262_H0.9690.95
89_H223_E0.9670.95
206_I334_M0.9650.95
72_V133_A0.9650.95
110_T115_A0.9640.95
232_I241_Y0.9550.95
140_G144_V0.9510.95
239_E243_R0.9470.95
77_I81_K0.9430.95
236_E240_P0.9410.95
76_I79_H0.9410.95
118_R122_R0.9410.95
58_E61_E0.9380.95
342_L346_D0.9250.94
95_R207_T0.9240.94
131_V327_P0.9230.94
57_K60_E0.9220.94
232_I238_A0.9080.94
48_L181_A0.9080.94
52_R55_N0.9080.94
84_S87_N0.9070.94
180_H307_V0.9070.94
117_Y342_L0.9070.94
171_E276_R0.9030.93
291_I295_D0.9030.93
238_A292_R0.8930.93
231_E250_E0.8920.93
221_A306_N0.8900.93
155_N158_Y0.8900.93
171_E273_M0.8880.93
284_S288_E0.8810.93
188_S218_H0.8810.93
332_S335_S0.8760.92
290_S309_F0.8750.92
35_L44_I0.8750.92
235_V289_M0.8740.92
13_T185_L0.8740.92
5_R347_N0.8710.92
274_S290_S0.8710.92
177_L331_V0.8680.92
79_H83_Y0.8630.92
225_V229_L0.8570.92
66_L121_I0.8560.91
7_L10_V0.8540.91
224_G227_K0.8540.91
150_Y155_N0.8540.91
230_T286_W0.8500.91
80_F137_I0.8490.91
42_E153_A0.8440.91
219_G329_F0.8430.91
81_K137_I0.8420.91
234_E285_K0.8420.91
135_S139_K0.8400.91
210_I330_A0.8380.91
199_L217_L0.8350.90
198_T350_L0.8330.90
255_F305_P0.8320.90
69_E118_R0.8320.90
231_E234_E0.8320.90
30_Y35_L0.8320.90
185_L354_R0.8290.90
83_Y103_L0.8290.90
26_T362_K0.8280.90
80_F97_A0.8280.90
245_K248_K0.8280.90
46_Y62_L0.8260.90
116_N119_K0.8250.90
18_S184_E0.8240.90
190_F194_V0.8230.90
129_G159_T0.8210.90
235_V288_E0.8180.90
165_P170_V0.8130.89
151_G174_N0.8120.89
222_N308_D0.8120.89
213_L219_G0.8100.89
72_V130_L0.8070.89
150_Y170_V0.8050.89
16_S358_T0.8040.89
263_G271_K0.8030.89
107_E110_T0.7960.88
124_Q152_I0.7940.88
190_F351_I0.7910.88
224_G253_M0.7910.88
153_A170_V0.7870.88
169_E277_L0.7870.88
40_S43_E0.7830.87
183_H260_Y0.7830.87
218_H308_D0.7730.87
233_G285_K0.7720.87
107_E118_R0.7710.87
205_G341_I0.7710.87
180_H222_N0.7680.86
120_A342_L0.7670.86
213_L329_F0.7650.86
75_E78_E0.7650.86
119_K203_Y0.7650.86
153_A173_F0.7630.86
26_T361_D0.7620.86
45_I62_L0.7620.86
45_I124_Q0.7610.86
49_W335_S0.7580.86
27_Y47_L0.7550.85
136_R144_V0.7540.85
59_L63_K0.7530.85
66_L125_A0.7520.85
71_A148_E0.7500.85
79_H82_S0.7490.85
233_G236_E0.7460.85
240_P243_R0.7460.85
287_Y291_I0.7430.85
125_A128_P0.7430.85
43_E53_L0.7410.84
360_P363_Q0.7410.84
273_M314_V0.7390.84
218_H329_F0.7390.84
163_E169_E0.7360.84
115_A118_R0.7350.84
283_E288_E0.7320.84
32_I179_L0.7290.83
183_H219_G0.7280.83
75_E104_L0.7230.83
274_S314_V0.7220.83
76_I100_L0.7210.83
184_E355_A0.7170.82
188_S219_G0.7150.82
105_D122_R0.7150.82
221_A256_G0.7140.82
228_M241_Y0.7130.82
44_I181_A0.7120.82
99_S211_G0.7110.82
168_I172_A0.7080.82
80_F134_F0.7070.81
25_L32_I0.7060.81
94_L210_I0.7060.81
12_A190_F0.7050.81
232_I293_I0.7040.81
18_S26_T0.7040.81
72_V77_I0.7020.81
199_L216_P0.7020.81
222_N326_T0.6990.81
107_E122_R0.6970.81
105_D119_K0.6960.80
201_D204_S0.6930.80
237_N244_A0.6900.80
26_T31_D0.6900.80
180_H311_S0.6870.80
35_L53_L0.6850.79
99_S207_T0.6840.79
68_K148_E0.6830.79
226_M325_F0.6820.79
132_A159_T0.6810.79
41_F45_I0.6800.79
76_I84_S0.6790.79
286_W316_H0.6740.78
213_L222_N0.6730.78
230_T234_E0.6670.78
225_V307_V0.6670.78
61_E64_Q0.6650.77
7_L190_F0.6630.77
225_V289_M0.6630.77
199_L345_Y0.6610.77
270_L311_S0.6590.77
122_R126_K0.6550.76
288_E292_R0.6540.76
83_Y100_L0.6530.76
81_K133_A0.6520.76
67_A148_E0.6480.76
175_K178_I0.6470.75
139_K321_D0.6460.75
320_I324_L0.6450.75
132_A136_R0.6430.75
171_E178_I0.6420.75
229_L290_S0.6410.75
330_A337_W0.6400.75
116_N345_Y0.6380.74
17_V28_V0.6380.74
260_Y337_W0.6370.74
183_H329_F0.6350.74
285_K288_E0.6340.74
76_I97_A0.6330.74
30_Y52_R0.6330.74
7_L11_V0.6330.74
75_E86_E0.6320.74
246_L300_E0.6320.74
7_L12_A0.6310.74
195_C205_G0.6300.74
176_A180_H0.6290.73
133_A143_P0.6250.73
238_A289_M0.6240.73
41_F174_N0.6240.73
150_Y165_P0.6230.73
74_Q145_E0.6230.73
239_E242_I0.6220.73
183_H186_N0.6220.73
169_E281_T0.6210.72
36_T178_I0.6200.72
235_V238_A0.6200.72
153_A157_L0.6200.72
256_G306_N0.6160.72
73_P101_L0.6150.72
28_V45_I0.6110.71
147_R155_N0.6100.71
227_K230_T0.6100.71
252_I301_K0.6100.71
334_M338_L0.6080.71
243_R296_I0.6080.71
140_G143_P0.6070.71
242_I293_I0.6070.71
150_Y158_Y0.6070.71
124_Q335_S0.6060.71
189_T340_H0.6050.71
120_A202_I0.6040.70
177_L332_S0.6040.70
226_M322_H0.6040.70
69_E209_A0.6020.70
77_I145_E0.6020.70
261_K302_K0.6020.70
153_A177_L0.6010.70
114_E118_R0.6000.70
244_A247_E0.5980.70
251_K350_L0.5970.69
76_I80_F0.5970.69
175_K276_R0.5950.69
201_D214_K0.5950.69
231_E245_K0.5930.69
186_N260_Y0.5920.69
275_K287_Y0.5910.69
242_I289_M0.5910.69
124_Q338_L0.5910.69
340_H348_N0.5890.68
245_K249_K0.5880.68
185_L193_R0.5880.68
7_L351_I0.5870.68
79_H84_S0.5870.68
258_R261_K0.5860.68
108_A119_K0.5860.68
182_D338_L0.5860.68
80_F143_P0.5850.68
62_L66_L0.5840.68
71_A118_R0.5830.68
263_G304_P0.5830.68
133_A159_T0.5810.67
243_R246_L0.5810.67
129_G132_A0.5790.67
184_E303_L0.5780.67
129_G155_N0.5770.67
193_R229_L0.5760.67
189_T326_T0.5760.67
31_D364_K0.5740.66
258_R350_L0.5740.66
98_I123_L0.5730.66
69_E126_K0.5720.66
307_V311_S0.5720.66
240_P247_E0.5720.66
189_T193_R0.5720.66
298_T302_K0.5710.66
281_T317_S0.5690.66
41_F84_S0.5690.66
30_Y34_D0.5690.66
73_P76_I0.5680.66
40_S171_E0.5670.66
101_L130_L0.5670.66
271_K310_Y0.5670.66
188_S329_F0.5670.66
278_T287_Y0.5670.66
358_T361_D0.5660.65
19_S22_D0.5660.65
65_Q68_K0.5650.65
218_H256_G0.5630.65
188_S308_D0.5610.65
235_V239_E0.5600.65
186_N257_H0.5590.64
306_N312_A0.5590.64
133_A137_I0.5580.64
227_K231_E0.5580.64
105_D345_Y0.5560.64
39_A174_N0.5550.64
172_A273_M0.5540.64
216_P221_A0.5530.64
116_N120_A0.5510.63
102_G201_D0.5500.63
42_E152_I0.5500.63
236_E239_E0.5480.63
270_L307_V0.5480.63
141_L144_V0.5480.63
117_Y121_I0.5480.63
72_V80_F0.5450.63
274_S287_Y0.5450.63
176_A328_I0.5430.62
15_S18_S0.5430.62
71_A75_E0.5410.62
186_N307_V0.5410.62
312_A329_F0.5390.62
288_E299_S0.5380.62
238_A293_I0.5370.61
238_A296_I0.5360.61
183_H188_S0.5330.61
180_H308_D0.5330.61
157_L170_V0.5320.61
315_Y325_F0.5300.60
172_A277_L0.5300.60
303_L309_F0.5270.60
156_F324_L0.5270.60
186_N329_F0.5260.60
40_S45_I0.5260.60
137_I143_P0.5250.60
116_N342_L0.5250.60
127_V130_L0.5230.59
30_Y38_N0.5230.59
40_S63_K0.5220.59
39_A59_L0.5210.59
275_K295_D0.5210.59
121_I125_A0.5210.59
300_E303_L0.5200.59
226_M316_H0.5190.59
226_M313_S0.5190.59
38_N365_F0.5190.59
186_N218_H0.5190.59
341_I355_A0.5180.59
99_S102_G0.5180.59
15_S355_A0.5170.59
193_R255_F0.5160.58
172_A314_V0.5150.58
188_S213_L0.5150.58
131_V195_C0.5150.58
9_G20_I0.5150.58
19_S26_T0.5130.58
294_E305_P0.5130.58
232_I242_I0.5120.58
257_H329_F0.5110.58
64_Q67_A0.5100.57
45_I49_W0.5100.57
222_N325_F0.5090.57
239_E275_K0.5080.57
35_L47_L0.5080.57
83_Y88_V0.5070.57
11_V356_D0.5070.57
25_L29_G0.5070.57
15_S340_H0.5060.57
245_K301_K0.5060.57
75_E79_H0.5060.57
251_K290_S0.5060.57
228_M253_M0.5040.57
271_K287_Y0.5040.57
135_S321_D0.5040.57
102_G200_S0.5040.57
81_K86_E0.5010.56
74_Q167_P0.5000.56
179_L269_H0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h12A 4 0.9946 100 0.038 Contact Map
4xghA 5 0.9113 100 0.04 Contact Map
1iomA 2 0.9892 100 0.047 Contact Map
2ibpA 2 0.9919 100 0.053 Contact Map
3o8jA 3 0.9704 100 0.054 Contact Map
4jadA 5 0.9946 100 0.056 Contact Map
1vgpA 2 0.9839 100 0.056 Contact Map
1o7xA 2 0.9731 100 0.059 Contact Map
4tvmA 2 0.8925 100 0.06 Contact Map
3tqgA 2 0.9651 100 0.061 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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