CISY - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

CISY - Citrate synthase 1

UniProt:	P39119	Sequences: MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEEAAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALGENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQPSEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPSAVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGNDRDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMVGWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	366 (351)
Sequences:	4016 (1971)
Seq/√Len:	105.2

ECOLI - CISY PRPC
BACSU - CISY CISY3 CISY2
HALSA - Q9HNH4
SULSO - CISY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
190_T	203_A	8.119	1.00
187_A	204_A	4.195	1.00
53_K	59_E	3.660	1.00
57_T	61_Q	3.502	1.00
32_H	35_D	3.392	1.00
149_E	165_K	3.295	1.00
38_L	267_Q	3.035	1.00
284_H	287_A	2.959	1.00
190_T	207_T	2.901	1.00
146_G	149_E	2.892	1.00
240_K	245_E	2.772	1.00
195_S	209_K	2.720	1.00
56_S	59_E	2.703	1.00
44_E	60_L	2.703	1.00
270_E	283_L	2.681	1.00
232_H	235_A	2.609	1.00
182_A	193_T	2.578	1.00
98_V	205_L	2.562	1.00
225_E	315_R	2.561	1.00
228_G	232_H	2.550	1.00
164_K	317_I	2.519	1.00
189_V	350_F	2.375	1.00
234_E	284_H	2.294	1.00
150_N	154_M	2.270	1.00
267_Q	271_E	2.235	1.00
186_S	207_T	2.232	1.00
7_K	348_M	2.219	1.00
193_T	207_T	2.088	1.00
148_V	169_E	2.075	1.00
115_A	337_C	2.066	1.00
235_A	239_E	1.994	1.00
79_R	82_Q	1.988	1.00
41_S	60_L	1.978	1.00
191_L	200_A	1.954	1.00
126_I	330_A	1.954	1.00
131_R	136_E	1.929	1.00
145_Y	149_E	1.929	1.00
225_E	321_D	1.922	1.00
46_A	334_V	1.892	1.00
107_T	110_P	1.891	1.00
47_Y	53_K	1.882	1.00
319_F	327_T	1.867	1.00
238_K	242_E	1.859	1.00
282_A	312_A	1.851	1.00
166_K	169_E	1.826	1.00
234_E	288_E	1.805	1.00
96_T	99_S	1.804	1.00
95_R	99_S	1.785	1.00
50_L	119_I	1.779	1.00
218_S	222_K	1.769	1.00
155_L	319_F	1.761	1.00
146_G	165_K	1.750	1.00
171_Y	314_M	1.739	1.00
191_L	340_V	1.732	1.00
284_H	288_E	1.717	1.00
95_R	206_G	1.716	1.00
17_S	177_E	1.704	1.00
61_Q	65_D	1.695	1.00
276_D	315_R	1.665	1.00
161_S	164_K	1.661	1.00
75_E	79_R	1.658	1.00
122_T	333_M	1.654	1.00
34_K	263_E	1.648	1.00
170_T	268_K	1.640	1.00
239_E	243_K	1.637	1.00
97_V	125_I	1.594	1.00
127_A	151_Y	1.576	1.00
203_A	207_T	1.576	1.00
239_E	244_G	1.569	1.00
98_V	122_T	1.569	1.00
25_R	32_H	1.537	1.00
47_Y	59_E	1.520	1.00
58_E	62_V	1.506	1.00
45_A	173_I	1.498	1.00
43_E	67_L	1.496	1.00
79_R	83_S	1.495	1.00
171_Y	265_L	1.468	1.00
162_E	166_K	1.464	1.00
267_Q	270_E	1.460	1.00
142_S	145_Y	1.457	1.00
141_P	150_N	1.456	1.00
182_A	207_T	1.453	1.00
70_E	117_R	1.445	1.00
65_D	69_A	1.430	1.00
142_S	153_Y	1.426	1.00
78_E	128_Y	1.425	1.00
93_V	129_R	1.420	1.00
142_S	159_Q	1.417	1.00
176_T	334_V	1.415	1.00
166_K	170_T	1.404	1.00
71_R	143_S	1.399	1.00
66_K	116_I	1.397	1.00
7_K	253_R	1.386	1.00
186_S	203_A	1.378	1.00
239_E	245_E	1.373	1.00
208_M	329_S	1.373	1.00
195_S	199_S	1.369	1.00
110_P	114_E	1.365	1.00
227_I	240_K	1.350	0.99
141_P	154_M	1.316	0.99
269_A	312_A	1.315	0.99
126_I	326_P	1.311	0.99
71_R	147_H	1.309	0.99
213_H	216_A	1.309	0.99
13_E	355_Q	1.306	0.99
258_K	263_E	1.304	0.99
179_G	353_S	1.303	0.99
49_I	334_V	1.294	0.99
186_S	190_T	1.287	0.99
199_S	209_K	1.274	0.99
315_R	321_D	1.268	0.99
133_T	322_E	1.268	0.99
222_K	321_D	1.268	0.99
80_L	100_A	1.266	0.99
31_H	54_L	1.260	0.99
70_E	116_I	1.259	0.99
82_Q	137_Q	1.259	0.99
197_L	337_C	1.254	0.99
186_S	189_V	1.235	0.99
29_R	52_G	1.218	0.99
50_L	337_C	1.203	0.99
34_K	264_A	1.202	0.99
91_M	217_P	1.199	0.99
48_L	54_L	1.185	0.99
233_A	284_H	1.174	0.99
33_A	264_A	1.174	0.99
169_E	173_I	1.163	0.98
28_Y	176_T	1.162	0.98
266_R	270_E	1.160	0.98
35_D	39_N	1.157	0.98
47_Y	51_F	1.156	0.98
187_A	340_V	1.146	0.98
41_S	169_E	1.143	0.98
265_L	313_V	1.140	0.98
31_H	48_L	1.137	0.98
40_H	44_E	1.132	0.98
156_T	164_K	1.113	0.98
89_D	218_S	1.106	0.98
20_D	23_K	1.105	0.98
226_D	230_K	1.102	0.98
212_L	246_R	1.100	0.98
136_E	139_I	1.100	0.98
42_F	334_V	1.099	0.98
201_V	333_M	1.095	0.98
268_K	271_E	1.094	0.98
139_I	154_M	1.089	0.98
13_E	357_T	1.088	0.98
28_Y	45_A	1.086	0.98
62_V	66_K	1.079	0.98
35_D	38_L	1.075	0.97
73_L	128_Y	1.069	0.97
197_L	340_V	1.067	0.97
139_I	153_Y	1.065	0.97
163_A	271_E	1.063	0.97
61_Q	64_K	1.062	0.97
64_K	68_A	1.061	0.97
66_K	113_E	1.059	0.97
132_W	138_A	1.054	0.97
229_E	232_H	1.051	0.97
266_R	286_E	1.048	0.97
341_L	345_E	1.042	0.97
114_E	197_L	1.041	0.97
72_N	140_A	1.039	0.97
149_E	162_E	1.037	0.97
18_H	21_G	1.036	0.97
231_E	235_A	1.035	0.97
58_E	61_Q	1.033	0.97
110_P	113_E	1.028	0.97
236_Y	240_K	1.024	0.97
108_F	345_E	1.019	0.96
234_E	238_K	1.017	0.96
94_L	126_I	1.011	0.96
21_G	24_G	1.007	0.96
227_I	236_Y	1.007	0.96
188_R	343_Q	1.006	0.96
195_S	200_A	1.005	0.96
113_E	117_R	1.004	0.96
78_E	82_Q	1.004	0.96
130_K	134_R	0.998	0.96
223_M	240_K	0.997	0.96
201_V	337_C	0.990	0.96
266_R	283_L	0.984	0.96
81_I	97_V	0.984	0.96
230_K	281_L	0.984	0.96
331_S	334_V	0.982	0.96
166_K	271_E	0.971	0.95
283_L	287_A	0.971	0.95
135_G	138_A	0.953	0.95
53_K	56_S	0.953	0.95
12_V	180_M	0.953	0.95
226_D	245_E	0.950	0.95
51_F	112_T	0.950	0.95
49_I	176_T	0.946	0.95
150_N	153_Y	0.945	0.95
59_E	62_V	0.940	0.94
227_I	233_A	0.938	0.94
31_H	36_I	0.937	0.94
193_T	349_I	0.935	0.94
14_T	17_S	0.935	0.94
43_E	148_V	0.933	0.94
183_S	213_H	0.931	0.94
279_L	283_L	0.926	0.94
224_L	285_V	0.925	0.94
95_R	202_T	0.924	0.94
111_K	114_E	0.921	0.94
296_Y	299_G	0.921	0.94
226_D	229_E	0.918	0.94
274_G	280_D	0.916	0.94
166_K	268_K	0.914	0.94
146_G	169_E	0.913	0.94
175_A	306_V	0.913	0.94
17_S	179_G	0.912	0.94
280_D	283_L	0.909	0.93
70_E	113_E	0.909	0.93
15_S	357_T	0.901	0.93
4_Y	346_N	0.898	0.93
237_L	288_E	0.895	0.93
250_F	304_T	0.893	0.93
84_L	100_A	0.891	0.93
145_Y	150_N	0.890	0.93
67_L	116_I	0.888	0.93
139_I	157_G	0.883	0.92
216_A	305_N	0.883	0.92
36_I	45_A	0.876	0.92
205_L	329_S	0.870	0.92
148_V	165_K	0.867	0.92
27_I	361_P	0.865	0.92
44_E	54_L	0.856	0.91
172_M	330_A	0.855	0.91
208_M	214_G	0.854	0.91
112_T	341_L	0.852	0.91
117_R	121_I	0.851	0.91
258_K	266_R	0.845	0.91
41_S	44_E	0.843	0.91
194_E	212_L	0.842	0.91
185_F	189_V	0.836	0.90
276_D	280_D	0.835	0.90
178_H	255_Y	0.835	0.90
180_M	353_S	0.835	0.90
50_L	334_V	0.833	0.90
225_E	278_D	0.832	0.90
99_S	206_G	0.832	0.90
214_G	328_F	0.830	0.90
217_P	307_E	0.830	0.90
164_K	272_V	0.829	0.90
148_V	168_L	0.828	0.90
175_A	217_P	0.827	0.90
185_F	350_F	0.825	0.90
11_C	185_F	0.824	0.90
213_H	307_E	0.824	0.90
228_G	277_R	0.817	0.89
208_M	328_F	0.814	0.89
47_Y	63_F	0.813	0.89
60_L	64_K	0.813	0.89
219_A	222_K	0.807	0.89
118_L	201_V	0.807	0.89
6_L	9_I	0.804	0.88
72_N	143_S	0.790	0.88
145_Y	165_K	0.790	0.88
66_K	70_E	0.785	0.87
179_G	354_A	0.783	0.87
75_E	140_A	0.779	0.87
77_I	100_A	0.778	0.87
200_A	340_V	0.777	0.87
28_Y	48_L	0.773	0.86
235_A	238_K	0.772	0.86
213_H	328_F	0.771	0.86
221_T	324_F	0.771	0.86
120_A	123_P	0.768	0.86
148_V	152_Y	0.767	0.86
163_A	167_A	0.766	0.86
115_A	341_L	0.766	0.86
183_S	214_G	0.764	0.86
109_H	113_E	0.762	0.86
275_N	280_D	0.759	0.85
31_H	53_K	0.758	0.85
280_D	284_H	0.757	0.85
124_S	154_M	0.756	0.85
282_A	311_A	0.755	0.85
124_S	141_P	0.749	0.85
216_A	251_G	0.748	0.85
36_I	54_L	0.748	0.85
137_Q	140_A	0.747	0.84
170_T	173_I	0.747	0.84
238_K	299_G	0.747	0.84
94_L	205_L	0.745	0.84
226_D	240_K	0.745	0.84
127_A	131_R	0.745	0.84
40_H	173_I	0.744	0.84
77_I	97_V	0.741	0.84
77_I	80_L	0.740	0.84
80_L	83_S	0.739	0.84
99_S	202_T	0.739	0.84
81_I	138_A	0.738	0.84
190_T	200_A	0.737	0.84
227_I	285_V	0.736	0.84
329_S	336_W	0.736	0.84
223_M	236_Y	0.736	0.84
27_I	32_H	0.731	0.83
217_P	325_T	0.731	0.83
234_E	237_L	0.731	0.83
298_P	301_K	0.727	0.83
268_K	313_V	0.725	0.83
62_V	65_D	0.722	0.82
228_G	231_E	0.722	0.82
208_M	217_P	0.722	0.82
274_G	277_R	0.722	0.82
282_A	308_F	0.720	0.82
227_I	237_L	0.719	0.82
145_Y	153_Y	0.714	0.82
26_L	33_A	0.713	0.82
233_A	288_E	0.711	0.81
221_T	321_D	0.710	0.81
220_V	224_L	0.710	0.81
45_A	176_T	0.708	0.81
265_L	310_A	0.707	0.81
76_H	79_R	0.706	0.81
160_P	165_K	0.705	0.81
46_A	119_I	0.705	0.81
148_V	172_M	0.703	0.81
72_N	113_E	0.702	0.81
81_I	129_R	0.701	0.80
42_F	169_E	0.699	0.80
175_A	310_A	0.697	0.80
178_H	214_G	0.694	0.80
40_H	169_E	0.692	0.80
33_A	174_L	0.687	0.79
172_M	331_S	0.682	0.79
269_A	282_A	0.681	0.79
220_V	306_V	0.681	0.79
18_H	23_K	0.680	0.78
82_Q	128_Y	0.676	0.78
111_K	344_A	0.672	0.78
114_E	198_V	0.671	0.78
145_Y	160_P	0.669	0.77
119_I	147_H	0.667	0.77
42_F	46_A	0.667	0.77
27_I	360_I	0.666	0.77
16_I	29_R	0.666	0.77
225_E	229_E	0.665	0.77
18_H	356_Y	0.664	0.77
81_I	132_W	0.663	0.77
269_A	313_V	0.661	0.76
196_D	199_S	0.660	0.76
111_K	115_A	0.657	0.76
247_L	296_Y	0.657	0.76
17_S	27_I	0.656	0.76
237_L	281_L	0.654	0.76
6_L	185_F	0.653	0.76
240_K	244_G	0.651	0.75
171_Y	175_A	0.650	0.75
46_A	63_F	0.649	0.75
133_T	136_E	0.648	0.75
183_S	307_E	0.646	0.75
194_E	344_A	0.645	0.75
229_E	277_R	0.640	0.74
73_L	125_I	0.640	0.74
158_E	164_K	0.638	0.74
240_K	243_K	0.636	0.74
297_K	302_L	0.633	0.73
319_F	323_L	0.632	0.73
6_L	11_C	0.632	0.73
21_G	257_T	0.630	0.73
37_A	173_I	0.628	0.73
178_H	328_F	0.628	0.73
333_M	337_C	0.627	0.73
122_T	125_I	0.626	0.73
132_W	137_Q	0.626	0.73
119_I	337_C	0.626	0.73
251_G	305_N	0.625	0.72
278_D	315_R	0.625	0.72
142_S	150_N	0.625	0.72
246_R	349_I	0.624	0.72
166_K	173_I	0.623	0.72
6_L	10_T	0.623	0.72
196_D	209_K	0.622	0.72
232_H	239_E	0.621	0.72
69_A	143_S	0.621	0.72
184_T	325_T	0.619	0.72
80_L	84_L	0.618	0.72
273_A	279_L	0.615	0.71
255_Y	336_W	0.614	0.71
169_E	348_M	0.614	0.71
339_H	347_N	0.614	0.71
102_G	196_D	0.612	0.71
179_G	302_L	0.609	0.70
174_L	264_A	0.608	0.70
224_L	282_A	0.607	0.70
238_K	298_P	0.607	0.70
178_H	181_N	0.606	0.70
278_D	282_A	0.606	0.70
175_A	307_E	0.603	0.70
296_Y	300_R	0.603	0.70
41_S	64_K	0.601	0.69
188_R	224_L	0.601	0.69
219_A	248_M	0.601	0.69
222_K	225_E	0.601	0.69
17_S	21_G	0.601	0.69
84_L	88_M	0.598	0.69
57_T	158_E	0.596	0.69
183_S	328_F	0.595	0.69
180_M	188_R	0.592	0.68
266_R	309_Y	0.589	0.68
68_A	143_S	0.589	0.68
48_L	176_T	0.589	0.68
297_K	301_K	0.586	0.68
99_S	102_G	0.586	0.68
184_T	339_H	0.583	0.67
134_R	320_D	0.583	0.67
306_V	310_A	0.582	0.67
258_K	303_Y	0.582	0.67
230_K	284_H	0.582	0.67
235_A	242_E	0.580	0.67
230_K	280_D	0.579	0.67
270_E	279_L	0.579	0.67
170_T	271_E	0.578	0.66
181_N	255_Y	0.577	0.66
281_L	284_H	0.577	0.66
110_P	197_L	0.576	0.66
97_V	100_A	0.576	0.66
132_W	136_E	0.576	0.66
135_G	139_I	0.574	0.66
194_E	211_P	0.573	0.66
253_R	256_K	0.573	0.66
6_L	350_F	0.573	0.66
277_R	280_D	0.573	0.66
270_E	287_A	0.572	0.66
247_L	300_R	0.571	0.66
70_E	121_I	0.571	0.66
171_Y	327_T	0.569	0.65
152_Y	165_K	0.569	0.65
29_R	46_A	0.568	0.65
36_I	48_L	0.568	0.65
141_P	145_Y	0.567	0.65
256_K	301_K	0.566	0.65
40_H	45_A	0.565	0.65
269_A	279_L	0.565	0.65
92_S	102_G	0.564	0.65
70_E	204_A	0.562	0.64
79_R	84_L	0.561	0.64
23_K	257_T	0.561	0.64
181_N	213_H	0.561	0.64
114_E	118_L	0.560	0.64
213_H	251_G	0.558	0.64
131_R	139_I	0.557	0.64
278_D	281_L	0.556	0.64
191_L	344_A	0.554	0.63
66_K	69_A	0.554	0.63
118_L	197_L	0.554	0.63
181_N	252_H	0.552	0.63
178_H	183_S	0.551	0.63
297_K	303_Y	0.550	0.63
181_N	306_V	0.550	0.63
183_S	208_M	0.549	0.63
282_A	285_V	0.549	0.63
340_V	354_A	0.548	0.62
63_F	67_L	0.547	0.62
167_A	268_K	0.547	0.62
286_E	304_T	0.546	0.62
181_N	328_F	0.543	0.62
101_L	125_I	0.543	0.62
67_L	120_A	0.542	0.62
115_A	197_L	0.542	0.62
14_T	339_H	0.541	0.61
112_T	116_I	0.541	0.61
46_A	188_R	0.540	0.61
221_T	315_R	0.540	0.61
269_A	273_A	0.540	0.61
272_V	320_D	0.539	0.61
92_S	95_R	0.538	0.61
234_E	298_P	0.537	0.61
234_E	270_E	0.535	0.61
117_R	120_A	0.535	0.61
76_H	85_P	0.535	0.61
152_Y	168_L	0.534	0.60
233_A	281_L	0.532	0.60
175_A	331_S	0.530	0.60
46_A	50_L	0.530	0.60
43_E	147_H	0.529	0.60
221_T	282_A	0.529	0.60
240_K	300_R	0.528	0.60
305_N	311_A	0.526	0.59
306_V	313_V	0.526	0.59
102_G	195_S	0.526	0.59
26_L	255_Y	0.524	0.59
357_T	360_I	0.524	0.59
41_S	46_A	0.523	0.59
177_E	337_C	0.521	0.59
9_I	12_V	0.521	0.59
112_T	115_A	0.520	0.58
10_T	355_Q	0.520	0.58
151_Y	330_A	0.520	0.58
220_V	281_L	0.519	0.58
311_A	328_F	0.519	0.58
301_K	304_T	0.518	0.58
77_I	81_I	0.518	0.58
181_N	350_F	0.518	0.58
302_L	308_F	0.517	0.58
241_L	297_K	0.517	0.58
184_T	188_R	0.517	0.58
24_G	260_P	0.516	0.58
217_P	324_F	0.514	0.58
230_K	239_E	0.513	0.57
42_F	339_H	0.513	0.57
26_L	30_G	0.513	0.57
307_E	328_F	0.512	0.57
272_V	313_V	0.512	0.57
127_A	141_P	0.512	0.57
113_E	116_I	0.511	0.57
239_E	242_E	0.510	0.57
314_M	324_F	0.509	0.57
221_T	312_A	0.509	0.57
240_K	247_L	0.507	0.57
103_E	106_Y	0.507	0.57
251_G	307_E	0.507	0.57
70_E	136_E	0.506	0.56
211_P	216_A	0.506	0.56
343_Q	347_N	0.506	0.56
194_E	347_N	0.503	0.56
68_A	71_R	0.502	0.56
133_T	137_Q	0.502	0.56
121_I	124_S	0.502	0.56
265_L	306_V	0.501	0.56
325_T	328_F	0.501	0.56
73_L	78_E	0.501	0.56
233_A	285_V	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2c6xA	2	0.9918	100	0.046	Contact Map
3hwkA	5	0.9809	100	0.047	Contact Map
2h12A	4	0.9945	100	0.053	Contact Map
4xghA	5	0.9044	100	0.053	Contact Map
2p2wA	2	0.9563	100	0.058	Contact Map
3msuA	2	0.9891	100	0.061	Contact Map
1o7xA	2	0.9863	100	0.064	Contact Map
2ibpA	2	0.9918	100	0.065	Contact Map
1aj8A	2	0.9836	100	0.065	Contact Map
1a59A	2	0.9781	100	0.066	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.