GREMLIN Database
CISY - Citrate synthase 1
UniProt: P39119 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (351)
Sequences: 4016 (1971)
Seq/√Len: 105.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_T203_A8.1191.00
187_A204_A4.1951.00
53_K59_E3.6601.00
57_T61_Q3.5021.00
32_H35_D3.3921.00
149_E165_K3.2951.00
38_L267_Q3.0351.00
284_H287_A2.9591.00
190_T207_T2.9011.00
146_G149_E2.8921.00
240_K245_E2.7721.00
195_S209_K2.7201.00
56_S59_E2.7031.00
44_E60_L2.7031.00
270_E283_L2.6811.00
232_H235_A2.6091.00
182_A193_T2.5781.00
98_V205_L2.5621.00
225_E315_R2.5611.00
228_G232_H2.5501.00
164_K317_I2.5191.00
189_V350_F2.3751.00
234_E284_H2.2941.00
150_N154_M2.2701.00
267_Q271_E2.2351.00
186_S207_T2.2321.00
7_K348_M2.2191.00
193_T207_T2.0881.00
148_V169_E2.0751.00
115_A337_C2.0661.00
235_A239_E1.9941.00
79_R82_Q1.9881.00
41_S60_L1.9781.00
191_L200_A1.9541.00
126_I330_A1.9541.00
131_R136_E1.9291.00
145_Y149_E1.9291.00
225_E321_D1.9221.00
46_A334_V1.8921.00
107_T110_P1.8911.00
47_Y53_K1.8821.00
319_F327_T1.8671.00
238_K242_E1.8591.00
282_A312_A1.8511.00
166_K169_E1.8261.00
234_E288_E1.8051.00
96_T99_S1.8041.00
95_R99_S1.7851.00
50_L119_I1.7791.00
218_S222_K1.7691.00
155_L319_F1.7611.00
146_G165_K1.7501.00
171_Y314_M1.7391.00
191_L340_V1.7321.00
284_H288_E1.7171.00
95_R206_G1.7161.00
17_S177_E1.7041.00
61_Q65_D1.6951.00
276_D315_R1.6651.00
161_S164_K1.6611.00
75_E79_R1.6581.00
122_T333_M1.6541.00
34_K263_E1.6481.00
170_T268_K1.6401.00
239_E243_K1.6371.00
97_V125_I1.5941.00
127_A151_Y1.5761.00
203_A207_T1.5761.00
239_E244_G1.5691.00
98_V122_T1.5691.00
25_R32_H1.5371.00
47_Y59_E1.5201.00
58_E62_V1.5061.00
45_A173_I1.4981.00
43_E67_L1.4961.00
79_R83_S1.4951.00
171_Y265_L1.4681.00
162_E166_K1.4641.00
267_Q270_E1.4601.00
142_S145_Y1.4571.00
141_P150_N1.4561.00
182_A207_T1.4531.00
70_E117_R1.4451.00
65_D69_A1.4301.00
142_S153_Y1.4261.00
78_E128_Y1.4251.00
93_V129_R1.4201.00
142_S159_Q1.4171.00
176_T334_V1.4151.00
166_K170_T1.4041.00
71_R143_S1.3991.00
66_K116_I1.3971.00
7_K253_R1.3861.00
186_S203_A1.3781.00
239_E245_E1.3731.00
208_M329_S1.3731.00
195_S199_S1.3691.00
110_P114_E1.3651.00
227_I240_K1.3500.99
141_P154_M1.3160.99
269_A312_A1.3150.99
126_I326_P1.3110.99
71_R147_H1.3090.99
213_H216_A1.3090.99
13_E355_Q1.3060.99
258_K263_E1.3040.99
179_G353_S1.3030.99
49_I334_V1.2940.99
186_S190_T1.2870.99
199_S209_K1.2740.99
315_R321_D1.2680.99
133_T322_E1.2680.99
222_K321_D1.2680.99
80_L100_A1.2660.99
31_H54_L1.2600.99
70_E116_I1.2590.99
82_Q137_Q1.2590.99
197_L337_C1.2540.99
186_S189_V1.2350.99
29_R52_G1.2180.99
50_L337_C1.2030.99
34_K264_A1.2020.99
91_M217_P1.1990.99
48_L54_L1.1850.99
233_A284_H1.1740.99
33_A264_A1.1740.99
169_E173_I1.1630.98
28_Y176_T1.1620.98
266_R270_E1.1600.98
35_D39_N1.1570.98
47_Y51_F1.1560.98
187_A340_V1.1460.98
41_S169_E1.1430.98
265_L313_V1.1400.98
31_H48_L1.1370.98
40_H44_E1.1320.98
156_T164_K1.1130.98
89_D218_S1.1060.98
20_D23_K1.1050.98
226_D230_K1.1020.98
212_L246_R1.1000.98
136_E139_I1.1000.98
42_F334_V1.0990.98
201_V333_M1.0950.98
268_K271_E1.0940.98
139_I154_M1.0890.98
13_E357_T1.0880.98
28_Y45_A1.0860.98
62_V66_K1.0790.98
35_D38_L1.0750.97
73_L128_Y1.0690.97
197_L340_V1.0670.97
139_I153_Y1.0650.97
163_A271_E1.0630.97
61_Q64_K1.0620.97
64_K68_A1.0610.97
66_K113_E1.0590.97
132_W138_A1.0540.97
229_E232_H1.0510.97
266_R286_E1.0480.97
341_L345_E1.0420.97
114_E197_L1.0410.97
72_N140_A1.0390.97
149_E162_E1.0370.97
18_H21_G1.0360.97
231_E235_A1.0350.97
58_E61_Q1.0330.97
110_P113_E1.0280.97
236_Y240_K1.0240.97
108_F345_E1.0190.96
234_E238_K1.0170.96
94_L126_I1.0110.96
21_G24_G1.0070.96
227_I236_Y1.0070.96
188_R343_Q1.0060.96
195_S200_A1.0050.96
113_E117_R1.0040.96
78_E82_Q1.0040.96
130_K134_R0.9980.96
223_M240_K0.9970.96
201_V337_C0.9900.96
266_R283_L0.9840.96
81_I97_V0.9840.96
230_K281_L0.9840.96
331_S334_V0.9820.96
166_K271_E0.9710.95
283_L287_A0.9710.95
135_G138_A0.9530.95
53_K56_S0.9530.95
12_V180_M0.9530.95
226_D245_E0.9500.95
51_F112_T0.9500.95
49_I176_T0.9460.95
150_N153_Y0.9450.95
59_E62_V0.9400.94
227_I233_A0.9380.94
31_H36_I0.9370.94
193_T349_I0.9350.94
14_T17_S0.9350.94
43_E148_V0.9330.94
183_S213_H0.9310.94
279_L283_L0.9260.94
224_L285_V0.9250.94
95_R202_T0.9240.94
111_K114_E0.9210.94
296_Y299_G0.9210.94
226_D229_E0.9180.94
274_G280_D0.9160.94
166_K268_K0.9140.94
146_G169_E0.9130.94
175_A306_V0.9130.94
17_S179_G0.9120.94
280_D283_L0.9090.93
70_E113_E0.9090.93
15_S357_T0.9010.93
4_Y346_N0.8980.93
237_L288_E0.8950.93
250_F304_T0.8930.93
84_L100_A0.8910.93
145_Y150_N0.8900.93
67_L116_I0.8880.93
139_I157_G0.8830.92
216_A305_N0.8830.92
36_I45_A0.8760.92
205_L329_S0.8700.92
148_V165_K0.8670.92
27_I361_P0.8650.92
44_E54_L0.8560.91
172_M330_A0.8550.91
208_M214_G0.8540.91
112_T341_L0.8520.91
117_R121_I0.8510.91
258_K266_R0.8450.91
41_S44_E0.8430.91
194_E212_L0.8420.91
185_F189_V0.8360.90
276_D280_D0.8350.90
178_H255_Y0.8350.90
180_M353_S0.8350.90
50_L334_V0.8330.90
225_E278_D0.8320.90
99_S206_G0.8320.90
214_G328_F0.8300.90
217_P307_E0.8300.90
164_K272_V0.8290.90
148_V168_L0.8280.90
175_A217_P0.8270.90
185_F350_F0.8250.90
11_C185_F0.8240.90
213_H307_E0.8240.90
228_G277_R0.8170.89
208_M328_F0.8140.89
47_Y63_F0.8130.89
60_L64_K0.8130.89
219_A222_K0.8070.89
118_L201_V0.8070.89
6_L9_I0.8040.88
72_N143_S0.7900.88
145_Y165_K0.7900.88
66_K70_E0.7850.87
179_G354_A0.7830.87
75_E140_A0.7790.87
77_I100_A0.7780.87
200_A340_V0.7770.87
28_Y48_L0.7730.86
235_A238_K0.7720.86
213_H328_F0.7710.86
221_T324_F0.7710.86
120_A123_P0.7680.86
148_V152_Y0.7670.86
163_A167_A0.7660.86
115_A341_L0.7660.86
183_S214_G0.7640.86
109_H113_E0.7620.86
275_N280_D0.7590.85
31_H53_K0.7580.85
280_D284_H0.7570.85
124_S154_M0.7560.85
282_A311_A0.7550.85
124_S141_P0.7490.85
216_A251_G0.7480.85
36_I54_L0.7480.85
137_Q140_A0.7470.84
170_T173_I0.7470.84
238_K299_G0.7470.84
94_L205_L0.7450.84
226_D240_K0.7450.84
127_A131_R0.7450.84
40_H173_I0.7440.84
77_I97_V0.7410.84
77_I80_L0.7400.84
80_L83_S0.7390.84
99_S202_T0.7390.84
81_I138_A0.7380.84
190_T200_A0.7370.84
227_I285_V0.7360.84
329_S336_W0.7360.84
223_M236_Y0.7360.84
27_I32_H0.7310.83
217_P325_T0.7310.83
234_E237_L0.7310.83
298_P301_K0.7270.83
268_K313_V0.7250.83
62_V65_D0.7220.82
228_G231_E0.7220.82
208_M217_P0.7220.82
274_G277_R0.7220.82
282_A308_F0.7200.82
227_I237_L0.7190.82
145_Y153_Y0.7140.82
26_L33_A0.7130.82
233_A288_E0.7110.81
221_T321_D0.7100.81
220_V224_L0.7100.81
45_A176_T0.7080.81
265_L310_A0.7070.81
76_H79_R0.7060.81
160_P165_K0.7050.81
46_A119_I0.7050.81
148_V172_M0.7030.81
72_N113_E0.7020.81
81_I129_R0.7010.80
42_F169_E0.6990.80
175_A310_A0.6970.80
178_H214_G0.6940.80
40_H169_E0.6920.80
33_A174_L0.6870.79
172_M331_S0.6820.79
269_A282_A0.6810.79
220_V306_V0.6810.79
18_H23_K0.6800.78
82_Q128_Y0.6760.78
111_K344_A0.6720.78
114_E198_V0.6710.78
145_Y160_P0.6690.77
119_I147_H0.6670.77
42_F46_A0.6670.77
27_I360_I0.6660.77
16_I29_R0.6660.77
225_E229_E0.6650.77
18_H356_Y0.6640.77
81_I132_W0.6630.77
269_A313_V0.6610.76
196_D199_S0.6600.76
111_K115_A0.6570.76
247_L296_Y0.6570.76
17_S27_I0.6560.76
237_L281_L0.6540.76
6_L185_F0.6530.76
240_K244_G0.6510.75
171_Y175_A0.6500.75
46_A63_F0.6490.75
133_T136_E0.6480.75
183_S307_E0.6460.75
194_E344_A0.6450.75
229_E277_R0.6400.74
73_L125_I0.6400.74
158_E164_K0.6380.74
240_K243_K0.6360.74
297_K302_L0.6330.73
319_F323_L0.6320.73
6_L11_C0.6320.73
21_G257_T0.6300.73
37_A173_I0.6280.73
178_H328_F0.6280.73
333_M337_C0.6270.73
122_T125_I0.6260.73
132_W137_Q0.6260.73
119_I337_C0.6260.73
251_G305_N0.6250.72
278_D315_R0.6250.72
142_S150_N0.6250.72
246_R349_I0.6240.72
166_K173_I0.6230.72
6_L10_T0.6230.72
196_D209_K0.6220.72
232_H239_E0.6210.72
69_A143_S0.6210.72
184_T325_T0.6190.72
80_L84_L0.6180.72
273_A279_L0.6150.71
255_Y336_W0.6140.71
169_E348_M0.6140.71
339_H347_N0.6140.71
102_G196_D0.6120.71
179_G302_L0.6090.70
174_L264_A0.6080.70
224_L282_A0.6070.70
238_K298_P0.6070.70
178_H181_N0.6060.70
278_D282_A0.6060.70
175_A307_E0.6030.70
296_Y300_R0.6030.70
41_S64_K0.6010.69
188_R224_L0.6010.69
219_A248_M0.6010.69
222_K225_E0.6010.69
17_S21_G0.6010.69
84_L88_M0.5980.69
57_T158_E0.5960.69
183_S328_F0.5950.69
180_M188_R0.5920.68
266_R309_Y0.5890.68
68_A143_S0.5890.68
48_L176_T0.5890.68
297_K301_K0.5860.68
99_S102_G0.5860.68
184_T339_H0.5830.67
134_R320_D0.5830.67
306_V310_A0.5820.67
258_K303_Y0.5820.67
230_K284_H0.5820.67
235_A242_E0.5800.67
230_K280_D0.5790.67
270_E279_L0.5790.67
170_T271_E0.5780.66
181_N255_Y0.5770.66
281_L284_H0.5770.66
110_P197_L0.5760.66
97_V100_A0.5760.66
132_W136_E0.5760.66
135_G139_I0.5740.66
194_E211_P0.5730.66
253_R256_K0.5730.66
6_L350_F0.5730.66
277_R280_D0.5730.66
270_E287_A0.5720.66
247_L300_R0.5710.66
70_E121_I0.5710.66
171_Y327_T0.5690.65
152_Y165_K0.5690.65
29_R46_A0.5680.65
36_I48_L0.5680.65
141_P145_Y0.5670.65
256_K301_K0.5660.65
40_H45_A0.5650.65
269_A279_L0.5650.65
92_S102_G0.5640.65
70_E204_A0.5620.64
79_R84_L0.5610.64
23_K257_T0.5610.64
181_N213_H0.5610.64
114_E118_L0.5600.64
213_H251_G0.5580.64
131_R139_I0.5570.64
278_D281_L0.5560.64
191_L344_A0.5540.63
66_K69_A0.5540.63
118_L197_L0.5540.63
181_N252_H0.5520.63
178_H183_S0.5510.63
297_K303_Y0.5500.63
181_N306_V0.5500.63
183_S208_M0.5490.63
282_A285_V0.5490.63
340_V354_A0.5480.62
63_F67_L0.5470.62
167_A268_K0.5470.62
286_E304_T0.5460.62
181_N328_F0.5430.62
101_L125_I0.5430.62
67_L120_A0.5420.62
115_A197_L0.5420.62
14_T339_H0.5410.61
112_T116_I0.5410.61
46_A188_R0.5400.61
221_T315_R0.5400.61
269_A273_A0.5400.61
272_V320_D0.5390.61
92_S95_R0.5380.61
234_E298_P0.5370.61
234_E270_E0.5350.61
117_R120_A0.5350.61
76_H85_P0.5350.61
152_Y168_L0.5340.60
233_A281_L0.5320.60
175_A331_S0.5300.60
46_A50_L0.5300.60
43_E147_H0.5290.60
221_T282_A0.5290.60
240_K300_R0.5280.60
305_N311_A0.5260.59
306_V313_V0.5260.59
102_G195_S0.5260.59
26_L255_Y0.5240.59
357_T360_I0.5240.59
41_S46_A0.5230.59
177_E337_C0.5210.59
9_I12_V0.5210.59
112_T115_A0.5200.58
10_T355_Q0.5200.58
151_Y330_A0.5200.58
220_V281_L0.5190.58
311_A328_F0.5190.58
301_K304_T0.5180.58
77_I81_I0.5180.58
181_N350_F0.5180.58
302_L308_F0.5170.58
241_L297_K0.5170.58
184_T188_R0.5170.58
24_G260_P0.5160.58
217_P324_F0.5140.58
230_K239_E0.5130.57
42_F339_H0.5130.57
26_L30_G0.5130.57
307_E328_F0.5120.57
272_V313_V0.5120.57
127_A141_P0.5120.57
113_E116_I0.5110.57
239_E242_E0.5100.57
314_M324_F0.5090.57
221_T312_A0.5090.57
240_K247_L0.5070.57
103_E106_Y0.5070.57
251_G307_E0.5070.57
70_E136_E0.5060.56
211_P216_A0.5060.56
343_Q347_N0.5060.56
194_E347_N0.5030.56
68_A71_R0.5020.56
133_T137_Q0.5020.56
121_I124_S0.5020.56
265_L306_V0.5010.56
325_T328_F0.5010.56
73_L78_E0.5010.56
233_A285_V0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c6xA 2 0.9918 100 0.046 Contact Map
3hwkA 5 0.9809 100 0.047 Contact Map
2h12A 4 0.9945 100 0.053 Contact Map
4xghA 5 0.9044 100 0.053 Contact Map
2p2wA 2 0.9563 100 0.058 Contact Map
3msuA 2 0.9891 100 0.061 Contact Map
1o7xA 2 0.9863 100 0.064 Contact Map
2ibpA 2 0.9918 100 0.065 Contact Map
1aj8A 2 0.9836 100 0.065 Contact Map
1a59A 2 0.9781 100 0.066 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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