GREMLIN Database
EXPZ - Nucleotide-binding protein ExpZ
UniProt: P39115 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 547 (475)
Sequences: 221 (204)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
390_M400_W4.2610.99
153_V159_D3.9320.98
156_V159_D3.9290.98
160_R163_L3.8100.98
47_L126_L3.1340.93
294_V297_V3.1160.93
438_D441_S3.0770.92
432_E461_H3.0510.92
151_G157_S2.9790.91
107_G327_G2.9570.91
151_G159_D2.8780.90
47_L156_V2.6700.85
150_N157_S2.6050.84
330_K360_Q2.5480.83
327_G330_K2.5110.82
83_Q90_L2.4740.81
324_G327_G2.4620.80
155_L159_D2.4390.80
163_L167_A2.4260.79
330_K431_D2.4040.79
105_S327_G2.3930.78
327_G431_D2.3860.78
153_V163_L2.3780.78
324_G329_G2.3390.77
327_G408_S2.3120.76
434_T437_L2.2980.75
375_F390_M2.2960.75
37_G43_K2.2390.73
112_A332_T2.1850.71
39_N414_K2.1690.71
107_G329_G2.1600.70
107_G330_K2.1580.70
433_P461_H2.1420.70
151_G155_L2.1410.70
107_G324_G2.1160.69
129_E158_H2.1090.69
431_D461_H2.0730.67
107_G408_S2.0690.67
10_V339_G2.0600.67
107_G431_D2.0390.66
37_G42_G2.0290.65
151_G158_H1.9860.64
90_L93_K1.9790.63
170_I177_T1.9640.63
296_N309_N1.9430.62
321_A470_T1.9250.61
119_S377_N1.9170.61
87_E119_S1.8920.60
434_T438_D1.8590.58
109_K433_P1.8560.58
111_K332_T1.8550.58
152_T158_H1.8510.58
434_T444_Q1.8490.58
159_D163_L1.8030.56
48_H53_D1.8030.56
358_L394_G1.7740.55
12_Y411_E1.7680.54
178_L394_G1.7680.54
360_Q408_S1.7640.54
158_H410_G1.7610.54
155_L171_W1.7370.53
329_G360_Q1.7250.52
372_E383_R1.7240.52
153_V157_S1.7140.52
116_K419_A1.7130.52
360_Q431_D1.7090.52
151_G156_V1.7090.52
186_S212_R1.7050.52
105_S329_G1.7040.52
327_G360_Q1.6910.51
417_L445_L1.6860.51
154_I158_H1.6770.50
27_V33_I1.6760.50
327_G461_H1.6730.50
435_N441_S1.6630.50
324_G330_K1.6570.49
435_N438_D1.6420.49
151_G163_L1.6340.48
331_T429_I1.6320.48
105_S408_S1.6220.48
228_H231_S1.6210.48
54_L411_E1.6170.48
437_L441_S1.6100.47
329_G408_S1.6010.47
409_M414_K1.5970.47
155_L158_H1.5930.47
303_E320_V1.5890.46
158_H438_D1.5840.46
475_V479_N1.5780.46
414_K435_N1.5710.46
108_E116_K1.5630.45
106_G360_Q1.5610.45
438_D444_Q1.5580.45
345_G455_T1.5510.45
324_G408_S1.5490.45
293_E296_N1.5460.45
299_K336_I1.5390.44
13_E24_N1.5340.44
14_V45_T1.5310.44
105_S330_K1.5310.44
330_K408_S1.5280.44
44_S256_Q1.5260.44
293_E427_V1.5250.44
320_V474_L1.5240.44
39_N326_N1.5180.43
105_S324_G1.5070.43
372_E376_E1.5040.43
408_S431_D1.4910.42
289_K292_L1.4840.42
150_N155_L1.4820.42
35_I478_N1.4730.41
275_Y278_R1.4680.41
152_T160_R1.4630.41
107_G360_Q1.4520.40
87_E376_E1.4490.40
39_N435_N1.4410.40
257_K260_E1.4180.39
118_L429_I1.4180.39
238_K241_H1.4150.39
20_F176_Q1.4140.39
324_G431_D1.4110.39
40_G43_K1.4030.38
292_L427_V1.3970.38
170_I334_L1.3950.38
155_L167_A1.3930.38
111_K117_G1.3920.38
24_N50_I1.3920.38
157_S161_Y1.3890.38
209_M224_S1.3840.38
433_P459_V1.3830.38
427_V481_I1.3820.38
107_G461_H1.3780.37
153_V160_R1.3760.37
105_S135_D1.3750.37
9_N24_N1.3740.37
160_R164_D1.3720.37
20_F41_A1.3700.37
119_S376_E1.3700.37
277_V280_S1.3670.37
105_S431_D1.3660.37
33_I455_T1.3600.37
339_G365_L1.3530.36
17_Q384_G1.3240.35
113_R409_M1.3240.35
336_I423_E1.3230.35
437_L444_Q1.3200.35
135_D330_K1.3160.35
275_Y281_I1.3000.34
135_D327_G1.2980.34
290_R293_E1.2900.34
329_G431_D1.2850.34
49_L129_E1.2820.33
131_T433_P1.2700.33
134_L462_D1.2680.33
114_L395_F1.2660.33
153_V156_V1.2570.32
109_K319_K1.2560.32
185_Y188_Y1.2540.32
131_T376_E1.2500.32
322_I447_E1.2490.32
119_S453_S1.2460.32
40_G360_Q1.2460.32
68_L308_K1.2430.32
79_S429_I1.2390.32
220_L224_S1.2390.32
142_L430_L1.2370.32
107_G111_K1.2290.31
372_E422_L1.2280.31
190_K198_T1.2180.31
164_D167_A1.2110.31
239_E243_V1.2070.31
105_S432_E1.2040.30
219_G225_E1.2000.30
208_K212_R1.1980.30
331_T469_T1.1980.30
211_E222_S1.1950.30
117_G332_T1.1940.30
448_T451_Q1.1930.30
129_E414_K1.1930.30
152_T159_D1.1910.30
213_I218_N1.1910.30
187_G429_I1.1830.30
54_L417_L1.1820.30
135_D461_H1.1780.29
154_I159_D1.1690.29
215_A221_A1.1670.29
35_I71_V1.1630.29
292_L445_L1.1590.29
156_V162_F1.1570.29
158_H408_S1.1550.29
90_L94_W1.1500.28
410_G438_D1.1480.28
174_E186_S1.1460.28
430_L434_T1.1420.28
330_K432_E1.1410.28
10_V49_L1.1380.28
213_I224_S1.1370.28
333_L449_L1.1330.28
192_R196_R1.1320.28
44_S146_L1.1300.28
154_I164_D1.1290.28
327_G432_E1.1290.28
10_V14_V1.1280.28
215_A222_S1.1280.28
188_Y195_K1.1280.28
108_E143_I1.1270.28
101_F320_V1.1270.28
154_I167_A1.1260.28
212_R223_W1.1250.28
101_F337_I1.1150.27
37_G40_G1.1100.27
107_G135_D1.1090.27
158_H163_L1.1070.27
435_N439_L1.1040.27
41_A426_D1.1000.27
131_T326_N1.0950.27
151_G160_R1.0950.27
40_G73_Q1.0920.26
43_K128_D1.0910.26
155_L161_Y1.0870.26
356_G420_Y1.0850.26
375_F388_N1.0850.26
410_G434_T1.0810.26
106_G332_T1.0780.26
135_D431_D1.0690.26
298_T314_I1.0680.26
413_V433_P1.0680.26
173_L333_L1.0570.25
106_G408_S1.0530.25
294_V312_F1.0480.25
27_V61_I1.0430.25
51_H70_L1.0420.25
209_M212_R1.0410.25
371_P375_F1.0350.24
434_T441_S1.0330.24
160_R167_A1.0320.24
7_L10_V1.0240.24
331_T417_L1.0190.24
52_N422_L1.0180.24
322_I429_I1.0080.24
116_K415_I1.0050.24
49_L377_N0.9960.23
91_L94_W0.9930.23
430_L460_S0.9930.23
254_S259_L0.9910.23
153_V158_H0.9900.23
329_G461_H0.9830.23
206_Q216_Q0.9810.23
17_Q27_V0.9810.23
312_F458_A0.9810.23
195_K198_T0.9760.23
233_K249_D0.9730.23
154_I314_I0.9720.22
22_H454_G0.9720.22
203_Y212_R0.9710.22
269_E274_E0.9710.22
109_K347_V0.9700.22
105_S360_Q0.9660.22
254_S260_E0.9620.22
73_Q466_L0.9580.22
326_N465_F0.9580.22
239_E244_K0.9580.22
439_L444_Q0.9560.22
83_Q87_E0.9550.22
156_V375_F0.9540.22
410_G414_K0.9530.22
134_L321_A0.9530.22
7_L332_T0.9530.22
158_H437_L0.9480.22
45_T410_G0.9460.22
214_E221_A0.9450.22
54_L358_L0.9440.22
329_G332_T0.9430.22
105_S461_H0.9430.22
274_E280_S0.9400.22
34_G326_N0.9400.22
111_K327_G0.9400.22
131_T377_N0.9380.21
39_N129_E0.9350.21
307_F310_A0.9330.21
393_L457_L0.9280.21
119_S173_L0.9280.21
226_K246_K0.9270.21
216_Q220_L0.9260.21
99_R429_I0.9260.21
428_L464_Y0.9260.21
213_I220_L0.9230.21
383_R390_M0.9230.21
334_L429_I0.9180.21
324_G461_H0.9170.21
39_N465_F0.9160.21
161_Y165_E0.9080.21
107_G432_E0.9070.21
40_G44_S0.9070.21
42_G128_D0.9060.21
435_N462_D0.9060.21
114_L296_N0.9040.20
131_T393_L0.9030.20
37_G128_D0.9010.20
334_L459_V0.9000.20
323_I362_V0.8960.20
203_Y206_Q0.8930.20
40_G105_S0.8900.20
44_S126_L0.8860.20
191_F194_K0.8840.20
15_K425_K0.8840.20
477_S482_E0.8830.20
20_F419_A0.8820.20
87_E377_N0.8810.20
207_Q216_Q0.8800.20
365_L449_L0.8760.20
252_I255_K0.8750.20
327_G332_T0.8750.20
216_Q227_A0.8740.20
330_K461_H0.8740.20
331_T426_D0.8730.20
83_Q147_K0.8720.20
35_I456_L0.8670.19
211_E229_A0.8670.19
126_L156_V0.8670.19
318_E471_N0.8660.19
27_V345_G0.8630.19
139_L159_D0.8620.19
64_K333_L0.8620.19
323_I479_N0.8570.19
28_Q65_D0.8570.19
238_K245_A0.8560.19
111_K432_E0.8550.19
40_G330_K0.8550.19
258_R279_F0.8530.19
206_Q213_I0.8530.19
182_K481_I0.8470.19
135_D432_E0.8460.19
441_S444_Q0.8450.19
190_K193_E0.8440.19
282_D309_N0.8400.19
113_R414_K0.8380.19
49_L158_H0.8380.19
36_I183_G0.8370.19
223_W231_S0.8370.19
128_D329_G0.8370.19
40_G327_G0.8360.19
217_M221_A0.8360.19
267_K275_Y0.8340.19
435_N444_Q0.8320.18
183_G188_Y0.8320.18
152_T156_V0.8320.18
233_K427_V0.8300.18
253_K256_Q0.8290.18
153_V164_D0.8260.18
116_K413_V0.8260.18
233_K322_I0.8240.18
322_I385_H0.8230.18
255_K258_R0.8220.18
87_E368_E0.8210.18
309_N480_G0.8180.18
44_S231_S0.8180.18
131_T357_Y0.8170.18
133_H436_H0.8150.18
152_T155_L0.8130.18
391_R444_Q0.8120.18
105_S111_K0.8070.18
211_E224_S0.8020.18
73_Q127_L0.8010.18
297_V310_A0.7990.18
116_K340_Q0.7980.18
111_K413_V0.7970.18
187_G334_L0.7960.18
45_T414_K0.7960.18
240_Y248_T0.7950.17
326_N435_N0.7950.17
230_Q233_K0.7940.17
216_Q223_W0.7910.17
216_Q232_T0.7900.17
390_M395_F0.7890.17
270_P273_P0.7890.17
318_E474_L0.7880.17
373_E424_E0.7870.17
252_I257_K0.7870.17
142_L389_L0.7870.17
13_E428_L0.7860.17
83_Q119_S0.7850.17
119_S147_K0.7850.17
108_E375_F0.7830.17
49_L99_R0.7820.17
184_N193_E0.7800.17
91_L418_M0.7800.17
43_K59_G0.7780.17
325_P368_E0.7780.17
318_E472_S0.7770.17
182_K202_E0.7750.17
151_G429_I0.7750.17
133_H465_F0.7740.17
214_E226_K0.7730.17
278_R283_T0.7730.17
269_E272_T0.7730.17
337_I370_T0.7720.17
285_H347_V0.7670.17
11_S173_L0.7660.17
46_L61_I0.7620.17
212_R220_L0.7620.17
128_D330_K0.7620.17
133_H395_F0.7610.17
326_N393_L0.7600.17
37_G44_S0.7600.17
332_T432_E0.7590.17
14_V377_N0.7580.17
34_G377_N0.7560.17
230_Q297_V0.7560.17
207_Q218_N0.7520.16
147_K377_N0.7510.16
445_L449_L0.7510.16
327_G331_T0.7510.16
225_E243_V0.7510.16
292_L417_L0.7500.16
454_G462_D0.7500.16
32_I322_I0.7490.16
128_D431_D0.7460.16
215_A226_K0.7410.16
128_D324_G0.7410.16
49_L371_P0.7410.16
128_D327_G0.7400.16
90_L326_N0.7400.16
108_E376_E0.7390.16
314_I336_I0.7380.16
131_T414_K0.7380.16
478_N483_K0.7360.16
9_N22_H0.7340.16
324_G360_Q0.7330.16
132_N413_V0.7320.16
358_L420_Y0.7310.16
243_V249_D0.7310.16
224_S227_A0.7310.16
130_P133_H0.7300.16
114_L432_E0.7300.16
305_T449_L0.7210.16
259_L262_E0.7190.16
159_D462_D0.7180.16
20_F39_N0.7180.16
207_Q210_V0.7170.16
135_D360_Q0.7160.16
223_W244_K0.7150.16
75_T446_E0.7150.16
150_N154_I0.7140.16
119_S143_I0.7140.16
127_L430_L0.7140.16
113_R125_L0.7120.15
382_A385_H0.7120.15
458_A470_T0.7110.15
154_I174_E0.7100.15
44_S338_L0.7090.15
76_A129_E0.7090.15
118_L138_S0.7080.15
222_S240_Y0.7080.15
270_P279_F0.7070.15
277_V282_D0.7060.15
434_T443_E0.7050.15
155_L163_L0.7050.15
24_N102_H0.7050.15
273_P284_T0.7050.15
133_H414_K0.7050.15
179_I427_V0.7040.15
131_T138_S0.7030.15
224_S245_A0.7010.15
321_A372_E0.7010.15
332_T461_H0.7000.15
114_L135_D0.7000.15
126_L137_K0.6990.15
129_E438_D0.6990.15
105_S128_D0.6960.15
223_W232_T0.6960.15
157_S449_L0.6920.15
152_T167_A0.6920.15
142_L478_N0.6910.15
17_Q61_I0.6910.15
438_D442_R0.6900.15
171_W455_T0.6900.15
301_F459_V0.6890.15
157_S163_L0.6870.15
35_I178_L0.6870.15
128_D135_D0.6860.15
50_I183_G0.6850.15
410_G437_L0.6840.15
158_H168_T0.6830.15
40_G431_D0.6810.15
264_E273_P0.6810.15
22_H112_A0.6800.15
112_A294_V0.6800.15
143_I362_V0.6800.15
138_S146_L0.6790.15
130_P173_L0.6760.15
183_G421_I0.6740.15
61_I306_L0.6740.15
367_L375_F0.6720.15
253_K259_L0.6710.15
213_I233_K0.6710.15
436_H441_S0.6710.15
116_K339_G0.6690.14
131_T158_H0.6680.14
238_K242_R0.6670.14
129_E331_T0.6670.14
449_L458_A0.6670.14
12_Y17_Q0.6660.14
80_F143_I0.6650.14
34_G54_L0.6650.14
303_E337_I0.6640.14
106_G423_E0.6640.14
135_D329_G0.6630.14
254_S261_K0.6590.14
374_L413_V0.6590.14
107_G128_D0.6580.14
115_A422_L0.6560.14
449_L476_I0.6550.14
182_K455_T0.6540.14
148_H451_Q0.6530.14
40_G135_D0.6530.14
68_L373_E0.6500.14
324_G332_T0.6490.14
217_M226_K0.6470.14
228_H234_K0.6470.14
318_E347_V0.6460.14
213_I223_W0.6440.14
321_A461_H0.6440.14
23_V417_L0.6420.14
222_S229_A0.6380.14
101_F370_T0.6370.14
177_T240_Y0.6370.14
214_E233_K0.6370.14
19_V417_L0.6360.14
208_K220_L0.6350.14
376_E453_S0.6330.14
68_L73_Q0.6330.14
186_S225_E0.6330.14
337_I452_Y0.6320.14
153_V170_I0.6320.14
42_G360_Q0.6310.14
15_K45_T0.6310.14
40_G408_S0.6290.14
408_S461_H0.6250.14
334_L474_L0.6250.14
25_A354_N0.6250.14
56_P61_I0.6250.14
106_G117_G0.6230.14
348_W457_L0.6230.14
455_T462_D0.6220.13
218_N231_S0.6210.13
23_V198_T0.6210.13
273_P282_D0.6200.13
125_L133_H0.6190.13
332_T458_A0.6190.13
357_Y365_L0.6190.13
218_N225_E0.6170.13
173_L464_Y0.6160.13
437_L443_E0.6160.13
128_D432_E0.6130.13
292_L299_K0.6130.13
438_D443_E0.6110.13
250_A287_T0.6110.13
254_S257_K0.6090.13
157_S433_P0.6090.13
264_E268_A0.6070.13
47_L50_I0.6070.13
215_A244_K0.6070.13
40_G107_G0.6050.13
237_F243_V0.6050.13
22_H320_V0.6040.13
229_A238_K0.6040.13
292_L374_L0.6010.13
111_K324_G0.6010.13
25_A297_V0.6000.13
212_R217_M0.5990.13
45_T124_L0.5980.13
210_V234_K0.5970.13
7_L386_V0.5960.13
390_M448_T0.5960.13
146_L432_E0.5950.13
129_E132_N0.5930.13
407_M418_M0.5920.13
76_A131_T0.5910.13
362_V457_L0.5900.13
218_N223_W0.5880.13
243_V246_K0.5880.13
331_T431_D0.5870.13
435_N442_R0.5870.13
39_N433_P0.5870.13
213_I222_S0.5860.13
226_K238_K0.5860.13
180_E188_Y0.5850.13
186_S190_K0.5830.13
214_E224_S0.5820.13
308_K338_L0.5820.13
20_F465_F0.5820.13
311_N358_L0.5810.13
170_I188_Y0.5800.13
76_A142_L0.5790.13
153_V415_I0.5780.13
136_E143_I0.5760.13
188_Y191_F0.5760.13
96_V362_V0.5750.13
69_A122_A0.5750.13
146_L461_H0.5740.13
226_K232_T0.5730.13
250_A261_K0.5710.12
159_D442_R0.5680.12
209_M229_A0.5680.12
192_R195_K0.5680.12
50_I156_V0.5670.12
219_G235_E0.5670.12
46_L430_L0.5620.12
157_S462_D0.5610.12
297_V311_N0.5600.12
164_D186_S0.5600.12
458_A475_V0.5600.12
251_Q261_K0.5590.12
310_A473_K0.5590.12
332_T431_D0.5580.12
45_T367_L0.5570.12
28_Q61_I0.5570.12
302_G444_Q0.5550.12
288_G428_L0.5550.12
308_K355_I0.5540.12
413_V420_Y0.5540.12
27_V146_L0.5530.12
132_N371_P0.5520.12
87_E143_I0.5510.12
177_T186_S0.5500.12
321_A332_T0.5490.12
116_K345_G0.5480.12
399_Q404_I0.5470.12
410_G425_K0.5470.12
262_E265_K0.5460.12
214_E222_S0.5450.12
113_R331_T0.5450.12
56_P422_L0.5450.12
326_N414_K0.5440.12
33_I36_I0.5440.12
269_E276_T0.5430.12
218_N221_A0.5430.12
139_L337_I0.5430.12
96_V101_F0.5420.12
244_K253_K0.5420.12
338_L459_V0.5380.12
13_E417_L0.5380.12
44_S47_L0.5370.12
5_V9_N0.5360.12
434_T439_L0.5350.12
163_L169_K0.5350.12
69_A338_L0.5350.12
176_Q183_G0.5340.12
98_L144_Q0.5340.12
91_L430_L0.5340.12
109_K389_L0.5320.12
110_L331_T0.5310.12
425_K452_Y0.5310.12
339_G374_L0.5310.12
135_D408_S0.5290.12
162_F391_R0.5290.12
331_T473_K0.5290.12
45_T158_H0.5290.12
132_N358_L0.5270.12
192_R198_T0.5270.12
172_S180_E0.5260.12
251_Q256_Q0.5260.12
408_S438_D0.5260.12
111_K115_A0.5250.12
31_D124_L0.5240.12
107_G332_T0.5240.12
270_P284_T0.5220.12
383_R422_L0.5220.12
209_M247_R0.5220.12
326_N332_T0.5220.12
125_L423_E0.5210.12
340_Q470_T0.5210.12
155_L160_R0.5210.12
133_H433_P0.5200.12
142_L373_E0.5190.11
174_E178_L0.5190.11
171_W178_L0.5180.11
207_Q228_H0.5180.11
272_T277_V0.5180.11
152_T413_V0.5180.11
173_L358_L0.5180.11
212_R235_E0.5180.11
152_T404_I0.5180.11
109_K148_H0.5170.11
172_S459_V0.5160.11
38_K421_I0.5150.11
157_S171_W0.5150.11
381_K424_E0.5150.11
323_I328_S0.5150.11
108_E326_N0.5130.11
76_A377_N0.5120.11
312_F406_H0.5120.11
427_V437_L0.5120.11
296_N349_V0.5110.11
106_G445_L0.5100.11
79_S445_L0.5100.11
16_D34_G0.5100.11
300_A305_T0.5090.11
53_D93_K0.5090.11
168_T476_I0.5070.11
147_K325_P0.5070.11
163_L185_Y0.5060.11
124_L294_V0.5050.11
31_D478_N0.5030.11
427_V434_T0.5030.11
42_G59_G0.5030.11
464_Y483_K0.5020.11
143_I377_N0.5020.11
215_A231_S0.5020.11
39_N54_L0.5010.11
212_R224_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9hA 1 0.8537 100 0.375 Contact Map
4f4cA 1 0.8647 100 0.378 Contact Map
4finA 2 0.8775 100 0.414 Contact Map
2iw3A 2 0.766 100 0.458 Contact Map
1yqtA 1 0.83 100 0.493 Contact Map
3ozxA 1 0.841 100 0.495 Contact Map
3bk7A 1 0.8446 100 0.498 Contact Map
3j16B 1 0.8391 100 0.514 Contact Map
3ux8A 2 0.7441 100 0.536 Contact Map
2vf7A 2 0.7697 100 0.61 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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