GREMLIN Database
BMRR - Multidrug-efflux transporter 1 regulator
UniProt: P39075 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (259)
Sequences: 2408 (2064)
Seq/√Len: 128.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_E106_S4.4151.00
92_R102_E4.1611.00
87_Q90_Q3.9051.00
60_K66_L3.1121.00
95_L99_S3.0391.00
218_A240_I2.9221.00
24_Y28_I2.7101.00
26_D32_K2.7011.00
127_L271_E2.6871.00
37_D40_T2.6071.00
19_I23_R2.5701.00
94_K97_F2.5591.00
222_Y232_N2.5181.00
239_Y243_R2.4521.00
238_K242_D2.4131.00
128_D216_R2.3611.00
88_E102_E2.3081.00
171_G191_F2.2871.00
28_I66_L2.2381.00
240_I247_V2.1961.00
131_E211_T2.1951.00
131_E214_K2.1671.00
264_K267_E2.1461.00
94_K98_L2.1321.00
218_A239_Y2.1161.00
126_V276_I2.0941.00
91_I98_L2.0681.00
88_E109_K2.0651.00
85_T109_K2.0621.00
8_I23_R2.0561.00
24_Y66_L2.0481.00
233_L253_E2.0431.00
7_S10_E2.0311.00
34_A49_Q2.0121.00
128_D214_K2.0121.00
84_Y105_I1.9871.00
53_L57_K1.9821.00
20_K27_K1.9461.00
29_D32_K1.9421.00
239_Y245_L1.8691.00
98_L102_E1.8591.00
95_L98_L1.8591.00
11_V53_L1.7901.00
81_F109_K1.7801.00
17_V53_L1.7731.00
89_R93_E1.7731.00
224_F270_V1.7331.00
31_F56_I1.7031.00
144_P147_V1.6841.00
15_A50_L1.6711.00
34_A48_S1.6691.00
6_Y47_D1.6561.00
95_L102_E1.6461.00
91_I101_L1.6401.00
91_I102_E1.6141.00
15_A53_L1.6091.00
34_A46_T1.6061.00
76_E79_E1.5951.00
21_A24_Y1.5761.00
90_Q94_K1.5371.00
57_K60_K1.5331.00
35_Y44_Y1.5201.00
85_T113_K1.5111.00
220_I232_N1.4251.00
255_I270_V1.4201.00
37_D44_Y1.4161.00
257_P262_P1.4081.00
30_L56_I1.4041.00
96_D99_S1.4011.00
63_G94_K1.3851.00
220_I236_L1.3641.00
11_V15_A1.3251.00
216_R245_L1.3241.00
19_I40_T1.3211.00
9_G19_I1.3161.00
68_E86_E1.3041.00
22_L26_D1.2951.00
148_L152_Y1.2921.00
24_Y27_K1.2861.00
11_V49_Q1.2781.00
22_L28_I1.2761.00
176_F180_T1.2571.00
138_E187_Y1.2491.00
106_S110_K1.2441.00
88_E92_R1.2210.99
8_I19_I1.2170.99
88_E105_I1.2110.99
175_S189_H1.2080.99
26_D43_R1.1920.99
245_L276_I1.1840.99
175_S187_Y1.1760.99
12_S15_A1.1670.99
56_I69_M1.1640.99
46_T49_Q1.1500.99
132_I212_I1.1470.99
222_Y228_H1.1310.99
6_Y49_Q1.1180.99
32_K36_V1.1160.99
84_Y109_K1.1150.99
93_E97_F1.1110.99
189_H210_T1.1050.99
262_P267_E1.1010.99
147_V150_A1.1000.99
91_I105_I1.0990.99
133_R211_T1.0920.99
180_T183_D1.0910.99
28_I60_K1.0870.99
134_I210_T1.0820.99
248_V275_R1.0810.99
124_V218_A1.0790.99
68_E71_K1.0740.99
126_V216_R1.0700.99
12_S18_S1.0660.99
143_G147_V1.0640.99
15_A20_K1.0600.99
233_L272_M1.0560.99
10_E13_K1.0520.98
18_S24_Y1.0460.98
6_Y9_G1.0240.98
149_N153_S1.0090.98
64_T83_F1.0030.98
81_F113_K1.0010.98
140_E154_K1.0000.98
8_I43_R0.9860.98
64_T87_Q0.9850.98
253_E270_V0.9840.98
8_I12_S0.9780.98
171_G174_F0.9740.97
109_K113_K0.9720.97
92_R95_L0.9700.97
8_I40_T0.9690.97
60_K63_G0.9680.97
12_S19_I0.9680.97
130_E214_K0.9600.97
17_V21_A0.9590.97
98_L101_L0.9540.97
189_H192_T0.9530.97
79_E82_A0.9500.97
218_A245_L0.9500.97
7_S44_Y0.9470.97
233_L251_V0.9460.97
234_Q238_K0.9440.97
188_R191_F0.9420.97
22_L31_F0.9390.97
20_K24_Y0.9330.97
218_A236_L0.9280.97
88_E91_I0.9240.97
11_V50_L0.9240.97
154_K157_K0.9220.97
89_R92_R0.9220.97
15_A31_F0.9190.96
30_L66_L0.9190.96
133_R137_T0.9160.96
241_A244_Q0.9140.96
18_S21_A0.9100.96
219_C273_K0.9080.96
151_S154_K0.9030.96
22_L45_Y0.9010.96
187_Y192_T0.9000.96
132_I193_P0.8920.96
132_I273_K0.8890.96
188_R193_P0.8840.96
236_L274_I0.8800.95
247_V274_I0.8800.95
36_V49_Q0.8780.95
22_L49_Q0.8770.95
226_P270_V0.8730.95
64_T72_A0.8710.95
174_F188_R0.8700.95
90_Q93_E0.8640.95
44_Y49_Q0.8630.95
52_H55_L0.8570.95
157_K161_S0.8560.95
240_I274_I0.8550.95
254_L271_E0.8540.95
230_F234_Q0.8460.94
60_K69_M0.8450.94
20_K23_R0.8450.94
103_Q106_S0.8430.94
78_E116_M0.8410.94
70_K73_Q0.8410.94
86_E89_R0.8400.94
65_P68_E0.8400.94
9_G23_R0.8340.94
171_G175_S0.8290.94
68_E87_Q0.8280.94
155_L159_I0.8250.94
252_Y273_K0.8230.94
238_K241_A0.8210.93
61_Y101_L0.8180.93
82_A86_E0.8180.93
97_F101_L0.8120.93
15_A26_D0.8080.93
221_A271_E0.8010.93
60_K65_P0.7980.92
223_N267_E0.7870.92
154_K158_F0.7840.92
149_N152_Y0.7820.92
222_Y270_V0.7800.92
84_Y88_E0.7790.92
87_Q94_K0.7760.91
22_L66_L0.7730.91
132_I252_Y0.7660.91
251_V274_I0.7650.91
159_I192_T0.7590.90
70_K74_D0.7520.90
151_S155_L0.7490.90
141_G145_E0.7460.90
25_Y53_L0.7450.90
6_Y64_T0.7420.89
7_S26_D0.7420.89
85_T89_R0.7410.89
11_V17_V0.7380.89
26_D60_K0.7380.89
136_Q189_H0.7380.89
158_F162_A0.7360.89
108_V258_I0.7360.89
258_I262_P0.7310.89
228_H231_L0.7230.88
45_Y69_M0.7190.88
257_P269_R0.7180.88
259_H268_Y0.7180.88
178_P183_D0.7150.88
212_I252_Y0.7100.87
174_F179_Y0.7080.87
31_F49_Q0.7010.87
40_T49_Q0.7010.87
9_G12_S0.6960.86
23_R31_F0.6950.86
226_P255_I0.6940.86
131_E213_P0.6940.86
255_I259_H0.6890.86
53_L60_K0.6880.86
229_Y233_L0.6850.85
99_S102_E0.6840.85
8_I108_V0.6820.85
127_L219_C0.6810.85
218_A276_I0.6690.84
143_G186_T0.6680.84
15_A24_Y0.6670.84
67_E71_K0.6640.84
251_V272_M0.6630.83
31_F53_L0.6630.83
174_F181_S0.6630.83
257_P268_Y0.6610.83
63_G87_Q0.6600.83
40_T213_P0.6600.83
127_L132_I0.6600.83
92_R106_S0.6560.83
122_G235_K0.6550.83
6_Y11_V0.6480.82
92_R96_D0.6480.82
92_R99_S0.6470.82
175_S183_D0.6470.82
156_K192_T0.6470.82
106_S235_K0.6410.81
96_D100_A0.6390.81
178_P181_S0.6370.81
125_F219_C0.6350.81
26_D31_F0.6350.81
110_K114_R0.6310.80
87_Q101_L0.6280.80
93_E96_D0.6280.80
93_E100_A0.6260.80
264_K268_Y0.6260.80
58_S170_Y0.6250.80
6_Y50_L0.6250.80
179_Y182_I0.6240.80
129_E132_I0.6230.79
55_L58_S0.6200.79
262_P265_Q0.6200.79
225_S270_V0.6170.79
19_I24_Y0.6160.79
218_A243_R0.6150.79
24_Y60_K0.6150.79
258_I268_Y0.6120.78
247_V250_D0.6110.78
162_A194_V0.6110.78
128_D131_E0.6110.78
129_E252_Y0.6060.78
53_L273_K0.6050.77
126_V239_Y0.6040.77
189_H226_P0.6040.77
137_T190_I0.6030.77
262_P268_Y0.6020.77
18_S66_L0.6010.77
15_A54_D0.6010.77
30_L59_L0.6000.77
259_H262_P0.6000.77
149_N156_K0.5970.77
192_T195_L0.5960.76
133_R209_I0.5960.76
52_H74_D0.5950.76
220_I235_K0.5950.76
255_I258_I0.5910.76
237_I274_I0.5880.75
82_A238_K0.5860.75
19_I26_D0.5840.75
9_G13_K0.5840.75
23_R40_T0.5830.75
10_E190_I0.5830.75
26_D36_V0.5820.75
72_A83_F0.5820.75
96_D167_N0.5780.74
144_P148_L0.5770.74
40_T44_Y0.5710.73
165_F168_N0.5680.73
173_T177_Q0.5680.73
262_P269_R0.5680.73
260_Y271_E0.5670.73
160_E195_L0.5670.73
67_E73_Q0.5660.73
66_L87_Q0.5630.72
256_I269_R0.5630.72
120_A123_E0.5620.72
20_K256_I0.5610.72
56_I124_V0.5580.72
67_E70_K0.5560.71
240_I276_I0.5550.71
203_I209_I0.5540.71
18_S68_E0.5540.71
122_G183_D0.5520.71
212_I215_G0.5510.71
49_Q56_I0.5510.71
49_Q64_T0.5470.70
71_K74_D0.5470.70
205_P208_E0.5470.70
12_S41_S0.5470.70
188_R194_V0.5460.70
21_A31_F0.5440.70
26_D49_Q0.5430.70
111_R169_S0.5430.70
226_P268_Y0.5430.70
135_I207_M0.5420.69
29_D74_D0.5420.69
254_L273_K0.5410.69
122_G232_N0.5400.69
107_L111_R0.5390.69
222_Y253_E0.5380.69
252_Y258_I0.5370.69
11_V31_F0.5370.69
21_A53_L0.5370.69
12_S17_V0.5360.69
35_Y71_K0.5350.68
41_S45_Y0.5350.68
260_Y267_E0.5340.68
6_Y10_E0.5330.68
243_R247_V0.5330.68
6_Y44_Y0.5330.68
65_P87_Q0.5300.68
129_E134_I0.5290.68
19_I31_F0.5260.67
121_L140_E0.5260.67
149_N276_I0.5250.67
33_P49_Q0.5230.67
113_K116_M0.5210.66
124_V220_I0.5210.66
116_M166_T0.5200.66
186_T190_I0.5190.66
66_L69_M0.5180.66
129_E273_K0.5170.66
94_K99_S0.5170.66
129_E217_Y0.5150.66
82_A113_K0.5150.66
75_L79_E0.5130.65
142_I148_L0.5120.65
173_T240_I0.5100.65
222_Y225_S0.5090.65
9_G24_Y0.5090.65
250_D276_I0.5080.65
203_I206_D0.5060.64
249_S276_I0.5060.64
138_E189_H0.5050.64
249_S275_R0.5050.64
14_L191_F0.5050.64
21_A207_M0.5050.64
54_D217_Y0.5040.64
181_S186_T0.5040.64
156_K160_E0.5040.64
234_Q248_V0.5040.64
122_G229_Y0.5030.64
8_I37_D0.5020.64
131_E241_A0.5020.64
5_Y46_T0.5020.64
69_M138_E0.5020.64
207_M211_T0.5010.63
16_N41_S0.5000.63
178_P186_T0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r8eA 2 0.9892 100 0.239 Contact Map
3gpvA 2 0.3957 99.9 0.542 Contact Map
3qaoA 2 0.5 99.9 0.544 Contact Map
1r8dA 2 0.3921 99.9 0.559 Contact Map
2vz4A 2 0.3597 99.9 0.563 Contact Map
3gp4A 4 0.4532 99.9 0.564 Contact Map
2zhgA 2 0.4281 99.9 0.567 Contact Map
3hh0A 4 0.4712 99.9 0.568 Contact Map
1q06A 2 0.4353 99.9 0.576 Contact Map
4ua1A 2 0.4281 99.9 0.59 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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