BMRU - BACSU - GREMLIN Contacts

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BMRU - Putative lipid kinase BmrU

UniProt:	P39074	Sequences: MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKKKDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVLGIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKISYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGLLDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYTHTPAVIQVLPQHIDMLVPANE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	297 (284)
Sequences:	6937 (5233)
Seq/√Len:	310.5

ECOLI - YEGS
BACSU - BMRU DAGK YTLR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
126_C	133_F	4.295	1.00
259_E	281_V	3.757	1.00
181_K	259_E	3.487	1.00
257_R	281_V	3.464	1.00
127_Q	283_Q	3.396	1.00
257_R	283_Q	3.356	1.00
179_T	261_E	3.249	1.00
122_S	290_D	3.048	1.00
127_Q	285_L	2.892	1.00
64_I	74_C	2.739	1.00
255_A	258_I	2.625	1.00
181_K	261_E	2.566	1.00
44_K	47_D	2.534	1.00
182_I	255_A	2.482	1.00
120_K	290_D	2.461	1.00
124_D	217_G	2.415	1.00
27_V	31_S	2.365	1.00
220_D	254_Q	2.340	1.00
218_L	254_Q	2.330	1.00
225_R	251_S	2.326	1.00
79_S	125_V	2.312	1.00
218_L	256_S	2.258	1.00
65_L	92_G	2.221	1.00
126_C	219_L	2.162	1.00
127_Q	130_D	2.146	1.00
137_W	282_I	2.131	1.00
261_E	279_P	2.129	1.00
61_T	86_A	2.067	1.00
179_T	188_K	2.033	1.00
259_E	279_P	1.986	1.00
121_T	215_E	1.985	1.00
179_T	186_E	1.982	1.00
125_V	288_H	1.970	1.00
197_M	209_L	1.948	1.00
231_A	249_E	1.897	1.00
86_A	120_K	1.861	1.00
138_G	269_D	1.857	1.00
47_D	51_F	1.804	1.00
98_F	123_V	1.798	1.00
107_N	110_K	1.788	1.00
181_K	186_E	1.768	1.00
148_Q	169_T	1.731	1.00
29_V	113_E	1.725	1.00
285_L	288_H	1.721	1.00
47_D	50_H	1.721	1.00
221_V	255_A	1.713	1.00
71_I	89_I	1.681	1.00
42_T	48_A	1.656	1.00
221_V	258_I	1.653	1.00
104_I	111_A	1.642	1.00
7_L	59_V	1.628	1.00
124_D	216_D	1.624	1.00
138_G	142_I	1.622	1.00
76_N	132_Y	1.582	1.00
191_A	223_I	1.556	1.00
61_T	292_L	1.543	1.00
46_D	73_Q	1.511	1.00
183_D	256_S	1.506	1.00
105_P	114_A	1.505	1.00
102_L	291_M	1.503	1.00
178_M	191_A	1.489	1.00
73_Q	77_A	1.459	1.00
120_K	292_L	1.445	1.00
43_K	47_D	1.416	1.00
144_E	169_T	1.406	1.00
122_S	287_Q	1.405	1.00
127_Q	132_Y	1.403	1.00
182_I	253_V	1.402	1.00
53_R	80_A	1.390	1.00
72_H	76_N	1.378	1.00
196_V	219_L	1.364	1.00
62_V	78_I	1.364	1.00
79_S	132_Y	1.354	1.00
223_I	253_V	1.315	1.00
52_C	77_A	1.311	1.00
42_T	73_Q	1.311	1.00
196_V	258_I	1.303	1.00
256_S	286_P	1.290	1.00
177_P	190_E	1.281	1.00
75_I	134_L	1.277	1.00
139_I	260_I	1.257	1.00
262_T	266_K	1.257	1.00
28_P	32_H	1.255	1.00
6_A	61_T	1.243	1.00
182_I	185_E	1.235	1.00
97_D	135_N	1.217	1.00
8_L	63_F	1.216	1.00
72_H	273_E	1.208	1.00
126_C	282_I	1.207	1.00
221_V	253_V	1.203	1.00
25_A	109_A	1.203	1.00
125_V	132_Y	1.201	1.00
97_D	204_T	1.196	1.00
101_V	200_Q	1.196	1.00
132_Y	285_L	1.180	1.00
52_C	56_D	1.165	1.00
110_K	113_E	1.160	1.00
147_N	267_K	1.148	1.00
219_L	284_V	1.147	1.00
24_G	27_V	1.142	1.00
72_H	131_R	1.138	1.00
105_P	110_K	1.138	1.00
38_I	59_V	1.135	1.00
50_H	54_S	1.126	1.00
154_K	161_S	1.124	1.00
6_A	63_F	1.124	1.00
48_A	52_C	1.119	1.00
98_F	135_N	1.093	1.00
65_L	90_L	1.087	1.00
48_A	73_Q	1.086	1.00
262_T	278_T	1.084	1.00
216_D	220_D	1.079	1.00
64_I	87_V	1.075	1.00
50_H	53_R	1.072	1.00
185_E	253_V	1.066	1.00
237_S	242_S	1.066	1.00
56_D	81_L	1.063	1.00
42_T	47_D	1.058	1.00
268_A	280_A	1.055	1.00
63_F	88_G	1.050	1.00
165_S	168_R	1.049	1.00
209_L	212_A	1.049	1.00
265_A	278_T	1.047	1.00
181_K	184_G	1.039	1.00
146_S	269_D	1.039	1.00
212_A	220_D	1.033	1.00
113_E	117_A	1.029	1.00
98_F	102_L	1.029	1.00
49_Y	53_R	1.026	1.00
184_G	257_R	1.024	1.00
141_L	145_T	1.022	1.00
239_E	242_S	1.022	1.00
142_I	202_I	1.021	1.00
237_S	247_T	1.019	1.00
133_F	137_W	1.018	1.00
136_F	195_L	1.018	1.00
54_S	57_D	1.017	1.00
29_V	112_A	1.017	1.00
7_L	40_K	1.015	1.00
125_V	134_L	1.013	1.00
108_L	112_A	1.010	1.00
97_D	203_G	1.005	1.00
115_L	292_L	0.998	1.00
84_K	122_S	0.995	1.00
75_I	87_V	0.993	1.00
90_L	111_A	0.991	1.00
223_I	251_S	0.985	1.00
231_A	234_E	0.984	1.00
75_I	289_I	0.981	1.00
142_I	269_D	0.980	1.00
135_N	199_G	0.980	1.00
270_M	275_Y	0.977	1.00
64_I	70_T	0.977	1.00
56_D	77_A	0.976	1.00
190_E	226_N	0.970	1.00
157_L	164_T	0.970	1.00
267_K	274_V	0.969	1.00
128_M	282_I	0.969	1.00
81_L	85_P	0.968	1.00
196_V	282_I	0.967	1.00
49_Y	77_A	0.961	1.00
128_M	270_M	0.956	1.00
10_H	41_Q	0.955	1.00
154_K	157_L	0.955	1.00
148_Q	165_S	0.954	1.00
183_D	255_A	0.952	1.00
99_S	104_I	0.947	1.00
265_A	277_H	0.941	1.00
128_M	137_W	0.937	1.00
165_S	169_T	0.936	1.00
220_D	252_Y	0.933	1.00
40_K	54_S	0.929	1.00
29_V	32_H	0.928	1.00
44_K	73_Q	0.925	1.00
147_N	274_V	0.922	1.00
118_G	292_L	0.919	1.00
71_I	98_F	0.919	1.00
154_K	158_G	0.917	1.00
63_F	115_L	0.915	1.00
29_V	109_A	0.911	1.00
194_L	223_I	0.907	1.00
81_L	84_K	0.907	1.00
90_L	108_L	0.907	1.00
33_H	113_E	0.903	1.00
228_N	231_A	0.901	1.00
222_L	252_Y	0.898	1.00
131_R	275_Y	0.897	1.00
136_F	197_M	0.885	1.00
52_C	55_I	0.880	1.00
23_L	27_V	0.877	1.00
97_D	205_N	0.877	1.00
91_P	111_A	0.876	1.00
164_T	168_R	0.872	1.00
100_R	201_Y	0.870	1.00
10_H	39_I	0.869	1.00
177_P	188_K	0.852	1.00
31_S	37_V	0.851	1.00
183_D	257_R	0.848	1.00
184_G	187_I	0.846	1.00
123_V	214_I	0.845	1.00
202_I	208_P	0.840	1.00
84_K	290_D	0.839	1.00
123_V	291_M	0.837	1.00
95_C	162_Y	0.834	1.00
189_E	225_R	0.830	1.00
98_F	134_L	0.828	1.00
86_A	290_D	0.819	1.00
9_I	52_C	0.819	1.00
59_V	85_P	0.815	1.00
95_C	142_I	0.812	1.00
56_D	85_P	0.811	1.00
25_A	28_P	0.809	1.00
64_I	71_I	0.809	1.00
105_P	111_A	0.806	1.00
10_H	19_I	0.803	1.00
161_S	165_S	0.802	1.00
178_M	262_T	0.797	1.00
238_M	243_I	0.796	1.00
88_G	292_L	0.795	1.00
195_L	202_I	0.793	1.00
89_I	98_F	0.790	1.00
182_I	258_I	0.790	1.00
240_Q	243_I	0.786	1.00
177_P	263_D	0.786	1.00
133_F	270_M	0.785	1.00
46_D	50_H	0.781	1.00
124_D	198_N	0.776	0.99
112_A	116_M	0.774	0.99
149_I	161_S	0.773	0.99
49_Y	76_N	0.772	0.99
114_A	118_G	0.771	0.99
241_G	244_D	0.770	0.99
10_H	65_L	0.770	0.99
31_S	34_L	0.767	0.99
44_K	50_H	0.766	0.99
146_S	149_I	0.763	0.99
189_E	251_S	0.759	0.99
125_V	285_L	0.759	0.99
137_W	270_M	0.758	0.99
147_N	151_E	0.757	0.99
167_L	171_S	0.757	0.99
106_Q	111_A	0.757	0.99
46_D	49_Y	0.755	0.99
199_G	214_I	0.754	0.99
61_T	115_L	0.752	0.99
196_V	221_V	0.747	0.99
66_G	70_T	0.744	0.99
75_I	132_Y	0.744	0.99
33_H	116_M	0.741	0.99
206_R	238_M	0.737	0.99
109_A	112_A	0.733	0.99
198_N	220_D	0.730	0.99
128_M	280_A	0.728	0.99
153_E	158_G	0.726	0.99
107_N	111_A	0.725	0.99
148_Q	168_R	0.725	0.99
200_Q	207_I	0.723	0.99
111_A	116_M	0.722	0.99
78_I	81_L	0.721	0.99
24_G	28_P	0.718	0.99
72_H	132_Y	0.718	0.99
268_A	277_H	0.718	0.99
104_I	114_A	0.714	0.99
53_R	77_A	0.712	0.99
40_K	51_F	0.711	0.99
173_A	192_V	0.702	0.99
135_N	269_D	0.701	0.99
124_D	215_E	0.701	0.99
234_E	237_S	0.700	0.99
53_R	81_L	0.695	0.99
229_L	232_L	0.690	0.99
61_T	88_G	0.687	0.99
158_G	162_Y	0.685	0.99
29_V	33_H	0.685	0.99
267_K	277_H	0.685	0.99
238_M	244_D	0.685	0.99
215_E	287_Q	0.683	0.99
168_R	171_S	0.683	0.99
97_D	136_F	0.682	0.99
49_Y	80_A	0.679	0.99
101_V	199_G	0.677	0.99
115_L	118_G	0.677	0.99
179_T	263_D	0.677	0.99
62_V	74_C	0.676	0.99
191_A	194_L	0.674	0.99
60_D	86_A	0.673	0.99
187_I	251_S	0.672	0.99
64_I	89_I	0.668	0.98
7_L	38_I	0.666	0.98
101_V	214_I	0.665	0.98
139_I	194_L	0.664	0.98
110_K	114_A	0.662	0.98
158_G	161_S	0.661	0.98
160_I	163_F	0.660	0.98
9_I	74_C	0.660	0.98
23_L	41_Q	0.658	0.98
42_T	77_A	0.656	0.98
23_L	37_V	0.654	0.98
10_H	23_L	0.652	0.98
178_M	194_L	0.651	0.98
231_A	247_T	0.650	0.98
52_C	74_C	0.649	0.98
94_T	135_N	0.649	0.98
136_F	269_D	0.648	0.98
153_E	157_L	0.646	0.98
71_I	291_M	0.643	0.98
216_D	254_Q	0.638	0.98
88_G	114_A	0.634	0.98
97_D	100_R	0.633	0.98
46_D	77_A	0.633	0.98
206_R	239_E	0.633	0.98
88_G	115_L	0.632	0.98
79_S	288_H	0.628	0.98
153_E	164_T	0.627	0.98
258_I	282_I	0.623	0.98
47_D	52_C	0.621	0.98
137_W	260_I	0.621	0.98
146_S	150_N	0.620	0.98
228_N	249_E	0.618	0.97
97_D	101_V	0.617	0.97
99_S	106_Q	0.616	0.97
180_L	260_I	0.616	0.97
230_T	233_R	0.614	0.97
9_I	48_A	0.613	0.97
135_N	146_S	0.612	0.97
168_R	172_S	0.611	0.97
52_C	62_V	0.610	0.97
196_V	260_I	0.608	0.97
40_K	47_D	0.607	0.97
48_A	77_A	0.607	0.97
153_E	161_S	0.606	0.97
97_D	146_S	0.606	0.97
79_S	285_L	0.606	0.97
88_G	111_A	0.605	0.97
193_M	197_M	0.601	0.97
139_I	268_A	0.599	0.97
197_M	202_I	0.597	0.97
102_L	214_I	0.595	0.97
89_I	99_S	0.593	0.97
229_L	233_R	0.592	0.97
137_W	268_A	0.591	0.97
78_I	87_V	0.589	0.97
48_A	74_C	0.588	0.97
97_D	269_D	0.586	0.97
235_L	247_T	0.585	0.96
238_M	241_G	0.585	0.96
55_I	58_S	0.584	0.96
141_L	192_V	0.584	0.96
97_D	142_I	0.584	0.96
197_M	220_D	0.583	0.96
72_H	75_I	0.581	0.96
225_R	249_E	0.581	0.96
169_T	173_A	0.581	0.96
108_L	111_A	0.577	0.96
76_N	131_R	0.574	0.96
95_C	205_N	0.574	0.96
144_E	267_K	0.572	0.96
47_D	73_Q	0.571	0.96
19_I	22_A	0.570	0.96
51_F	54_S	0.568	0.96
135_N	142_I	0.566	0.96
237_S	241_G	0.566	0.96
42_T	46_D	0.565	0.96
143_A	269_D	0.561	0.96
151_E	154_K	0.561	0.96
8_L	37_V	0.561	0.96
182_I	187_I	0.561	0.96
44_K	48_A	0.558	0.95
123_V	289_I	0.556	0.95
20_E	41_Q	0.556	0.95
234_E	247_T	0.555	0.95
149_I	165_S	0.554	0.95
14_A	17_K	0.554	0.95
15_G	94_T	0.552	0.95
138_G	195_L	0.549	0.95
107_N	114_A	0.549	0.95
242_S	246_F	0.548	0.95
109_A	113_E	0.548	0.95
48_A	51_F	0.547	0.95
95_C	149_I	0.547	0.95
234_E	248_G	0.546	0.95
125_V	289_I	0.545	0.95
12_G	42_T	0.545	0.95
45_K	48_A	0.544	0.95
51_F	55_I	0.544	0.95
98_F	198_N	0.543	0.95
205_N	208_P	0.541	0.95
142_I	204_T	0.539	0.94
162_Y	204_T	0.536	0.94
113_E	116_M	0.536	0.94
108_L	116_M	0.536	0.94
136_F	199_G	0.534	0.94
20_E	24_G	0.532	0.94
208_P	222_L	0.532	0.94
274_V	277_H	0.531	0.94
95_C	100_R	0.531	0.94
175_S	226_N	0.531	0.94
237_S	240_Q	0.528	0.94
70_T	138_G	0.528	0.94
88_G	116_M	0.528	0.94
91_P	104_I	0.528	0.94
18_N	22_A	0.527	0.94
111_A	114_A	0.523	0.94
176_F	266_K	0.521	0.93
55_I	59_V	0.520	0.93
40_K	55_I	0.520	0.93
158_G	204_T	0.520	0.93
44_K	51_F	0.519	0.93
139_I	266_K	0.517	0.93
160_I	164_T	0.516	0.93
268_A	278_T	0.514	0.93
209_L	222_L	0.512	0.93
25_A	29_V	0.512	0.93
211_D	252_Y	0.511	0.93
56_D	78_I	0.510	0.93
74_C	77_A	0.509	0.93
149_I	157_L	0.507	0.93
121_T	213_S	0.506	0.92
28_P	31_S	0.505	0.92
30_L	33_H	0.504	0.92
75_I	79_S	0.504	0.92
139_I	262_T	0.504	0.92
138_G	143_A	0.503	0.92
144_E	147_N	0.503	0.92
42_T	45_K	0.501	0.92
103_G	121_T	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4v24A	1	0.9764	100	0.199	Contact Map
3s40A	3	0.9933	100	0.205	Contact Map
4werA	2	0.9461	100	0.209	Contact Map
2qv7A	2	0.9529	100	0.212	Contact Map
2bonA	1	0.9293	100	0.233	Contact Map
1u0tA	4	0.798	100	0.574	Contact Map
1z0sA	4	0.7576	100	0.578	Contact Map
2an1A	4	0.8081	100	0.584	Contact Map
2i2cA	3	0.8047	100	0.594	Contact Map
1yt5A	4	0.7778	100	0.597	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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