GREMLIN Database
BMRU - Putative lipid kinase BmrU
UniProt: P39074 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (284)
Sequences: 6937 (5233)
Seq/√Len: 310.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_C133_F4.2951.00
259_E281_V3.7571.00
181_K259_E3.4871.00
257_R281_V3.4641.00
127_Q283_Q3.3961.00
257_R283_Q3.3561.00
179_T261_E3.2491.00
122_S290_D3.0481.00
127_Q285_L2.8921.00
64_I74_C2.7391.00
255_A258_I2.6251.00
181_K261_E2.5661.00
44_K47_D2.5341.00
182_I255_A2.4821.00
120_K290_D2.4611.00
124_D217_G2.4151.00
27_V31_S2.3651.00
220_D254_Q2.3401.00
218_L254_Q2.3301.00
225_R251_S2.3261.00
79_S125_V2.3121.00
218_L256_S2.2581.00
65_L92_G2.2211.00
126_C219_L2.1621.00
127_Q130_D2.1461.00
137_W282_I2.1311.00
261_E279_P2.1291.00
61_T86_A2.0671.00
179_T188_K2.0331.00
259_E279_P1.9861.00
121_T215_E1.9851.00
179_T186_E1.9821.00
125_V288_H1.9701.00
197_M209_L1.9481.00
231_A249_E1.8971.00
86_A120_K1.8611.00
138_G269_D1.8571.00
47_D51_F1.8041.00
98_F123_V1.7981.00
107_N110_K1.7881.00
181_K186_E1.7681.00
148_Q169_T1.7311.00
29_V113_E1.7251.00
285_L288_H1.7211.00
47_D50_H1.7211.00
221_V255_A1.7131.00
71_I89_I1.6811.00
42_T48_A1.6561.00
221_V258_I1.6531.00
104_I111_A1.6421.00
7_L59_V1.6281.00
124_D216_D1.6241.00
138_G142_I1.6221.00
76_N132_Y1.5821.00
191_A223_I1.5561.00
61_T292_L1.5431.00
46_D73_Q1.5111.00
183_D256_S1.5061.00
105_P114_A1.5051.00
102_L291_M1.5031.00
178_M191_A1.4891.00
73_Q77_A1.4591.00
120_K292_L1.4451.00
43_K47_D1.4161.00
144_E169_T1.4061.00
122_S287_Q1.4051.00
127_Q132_Y1.4031.00
182_I253_V1.4021.00
53_R80_A1.3901.00
72_H76_N1.3781.00
196_V219_L1.3641.00
62_V78_I1.3641.00
79_S132_Y1.3541.00
223_I253_V1.3151.00
52_C77_A1.3111.00
42_T73_Q1.3111.00
196_V258_I1.3031.00
256_S286_P1.2901.00
177_P190_E1.2811.00
75_I134_L1.2771.00
139_I260_I1.2571.00
262_T266_K1.2571.00
28_P32_H1.2551.00
6_A61_T1.2431.00
182_I185_E1.2351.00
97_D135_N1.2171.00
8_L63_F1.2161.00
72_H273_E1.2081.00
126_C282_I1.2071.00
221_V253_V1.2031.00
25_A109_A1.2031.00
125_V132_Y1.2011.00
97_D204_T1.1961.00
101_V200_Q1.1961.00
132_Y285_L1.1801.00
52_C56_D1.1651.00
110_K113_E1.1601.00
147_N267_K1.1481.00
219_L284_V1.1471.00
24_G27_V1.1421.00
72_H131_R1.1381.00
105_P110_K1.1381.00
38_I59_V1.1351.00
50_H54_S1.1261.00
154_K161_S1.1241.00
6_A63_F1.1241.00
48_A52_C1.1191.00
98_F135_N1.0931.00
65_L90_L1.0871.00
48_A73_Q1.0861.00
262_T278_T1.0841.00
216_D220_D1.0791.00
64_I87_V1.0751.00
50_H53_R1.0721.00
185_E253_V1.0661.00
237_S242_S1.0661.00
56_D81_L1.0631.00
42_T47_D1.0581.00
268_A280_A1.0551.00
63_F88_G1.0501.00
165_S168_R1.0491.00
209_L212_A1.0491.00
265_A278_T1.0471.00
181_K184_G1.0391.00
146_S269_D1.0391.00
212_A220_D1.0331.00
113_E117_A1.0291.00
98_F102_L1.0291.00
49_Y53_R1.0261.00
184_G257_R1.0241.00
141_L145_T1.0221.00
239_E242_S1.0221.00
142_I202_I1.0211.00
237_S247_T1.0191.00
133_F137_W1.0181.00
136_F195_L1.0181.00
54_S57_D1.0171.00
29_V112_A1.0171.00
7_L40_K1.0151.00
125_V134_L1.0131.00
108_L112_A1.0101.00
97_D203_G1.0051.00
115_L292_L0.9981.00
84_K122_S0.9951.00
75_I87_V0.9931.00
90_L111_A0.9911.00
223_I251_S0.9851.00
231_A234_E0.9841.00
75_I289_I0.9811.00
142_I269_D0.9801.00
135_N199_G0.9801.00
270_M275_Y0.9771.00
64_I70_T0.9771.00
56_D77_A0.9761.00
190_E226_N0.9701.00
157_L164_T0.9701.00
267_K274_V0.9691.00
128_M282_I0.9691.00
81_L85_P0.9681.00
196_V282_I0.9671.00
49_Y77_A0.9611.00
128_M270_M0.9561.00
10_H41_Q0.9551.00
154_K157_L0.9551.00
148_Q165_S0.9541.00
183_D255_A0.9521.00
99_S104_I0.9471.00
265_A277_H0.9411.00
128_M137_W0.9371.00
165_S169_T0.9361.00
220_D252_Y0.9331.00
40_K54_S0.9291.00
29_V32_H0.9281.00
44_K73_Q0.9251.00
147_N274_V0.9221.00
118_G292_L0.9191.00
71_I98_F0.9191.00
154_K158_G0.9171.00
63_F115_L0.9151.00
29_V109_A0.9111.00
194_L223_I0.9071.00
81_L84_K0.9071.00
90_L108_L0.9071.00
33_H113_E0.9031.00
228_N231_A0.9011.00
222_L252_Y0.8981.00
131_R275_Y0.8971.00
136_F197_M0.8851.00
52_C55_I0.8801.00
23_L27_V0.8771.00
97_D205_N0.8771.00
91_P111_A0.8761.00
164_T168_R0.8721.00
100_R201_Y0.8701.00
10_H39_I0.8691.00
177_P188_K0.8521.00
31_S37_V0.8511.00
183_D257_R0.8481.00
184_G187_I0.8461.00
123_V214_I0.8451.00
202_I208_P0.8401.00
84_K290_D0.8391.00
123_V291_M0.8371.00
95_C162_Y0.8341.00
189_E225_R0.8301.00
98_F134_L0.8281.00
86_A290_D0.8191.00
9_I52_C0.8191.00
59_V85_P0.8151.00
95_C142_I0.8121.00
56_D85_P0.8111.00
25_A28_P0.8091.00
64_I71_I0.8091.00
105_P111_A0.8061.00
10_H19_I0.8031.00
161_S165_S0.8021.00
178_M262_T0.7971.00
238_M243_I0.7961.00
88_G292_L0.7951.00
195_L202_I0.7931.00
89_I98_F0.7901.00
182_I258_I0.7901.00
240_Q243_I0.7861.00
177_P263_D0.7861.00
133_F270_M0.7851.00
46_D50_H0.7811.00
124_D198_N0.7760.99
112_A116_M0.7740.99
149_I161_S0.7730.99
49_Y76_N0.7720.99
114_A118_G0.7710.99
241_G244_D0.7700.99
10_H65_L0.7700.99
31_S34_L0.7670.99
44_K50_H0.7660.99
146_S149_I0.7630.99
189_E251_S0.7590.99
125_V285_L0.7590.99
137_W270_M0.7580.99
147_N151_E0.7570.99
167_L171_S0.7570.99
106_Q111_A0.7570.99
46_D49_Y0.7550.99
199_G214_I0.7540.99
61_T115_L0.7520.99
196_V221_V0.7470.99
66_G70_T0.7440.99
75_I132_Y0.7440.99
33_H116_M0.7410.99
206_R238_M0.7370.99
109_A112_A0.7330.99
198_N220_D0.7300.99
128_M280_A0.7280.99
153_E158_G0.7260.99
107_N111_A0.7250.99
148_Q168_R0.7250.99
200_Q207_I0.7230.99
111_A116_M0.7220.99
78_I81_L0.7210.99
24_G28_P0.7180.99
72_H132_Y0.7180.99
268_A277_H0.7180.99
104_I114_A0.7140.99
53_R77_A0.7120.99
40_K51_F0.7110.99
173_A192_V0.7020.99
135_N269_D0.7010.99
124_D215_E0.7010.99
234_E237_S0.7000.99
53_R81_L0.6950.99
229_L232_L0.6900.99
61_T88_G0.6870.99
158_G162_Y0.6850.99
29_V33_H0.6850.99
267_K277_H0.6850.99
238_M244_D0.6850.99
215_E287_Q0.6830.99
168_R171_S0.6830.99
97_D136_F0.6820.99
49_Y80_A0.6790.99
101_V199_G0.6770.99
115_L118_G0.6770.99
179_T263_D0.6770.99
62_V74_C0.6760.99
191_A194_L0.6740.99
60_D86_A0.6730.99
187_I251_S0.6720.99
64_I89_I0.6680.98
7_L38_I0.6660.98
101_V214_I0.6650.98
139_I194_L0.6640.98
110_K114_A0.6620.98
158_G161_S0.6610.98
160_I163_F0.6600.98
9_I74_C0.6600.98
23_L41_Q0.6580.98
42_T77_A0.6560.98
23_L37_V0.6540.98
10_H23_L0.6520.98
178_M194_L0.6510.98
231_A247_T0.6500.98
52_C74_C0.6490.98
94_T135_N0.6490.98
136_F269_D0.6480.98
153_E157_L0.6460.98
71_I291_M0.6430.98
216_D254_Q0.6380.98
88_G114_A0.6340.98
97_D100_R0.6330.98
46_D77_A0.6330.98
206_R239_E0.6330.98
88_G115_L0.6320.98
79_S288_H0.6280.98
153_E164_T0.6270.98
258_I282_I0.6230.98
47_D52_C0.6210.98
137_W260_I0.6210.98
146_S150_N0.6200.98
228_N249_E0.6180.97
97_D101_V0.6170.97
99_S106_Q0.6160.97
180_L260_I0.6160.97
230_T233_R0.6140.97
9_I48_A0.6130.97
135_N146_S0.6120.97
168_R172_S0.6110.97
52_C62_V0.6100.97
196_V260_I0.6080.97
40_K47_D0.6070.97
48_A77_A0.6070.97
153_E161_S0.6060.97
97_D146_S0.6060.97
79_S285_L0.6060.97
88_G111_A0.6050.97
193_M197_M0.6010.97
139_I268_A0.5990.97
197_M202_I0.5970.97
102_L214_I0.5950.97
89_I99_S0.5930.97
229_L233_R0.5920.97
137_W268_A0.5910.97
78_I87_V0.5890.97
48_A74_C0.5880.97
97_D269_D0.5860.97
235_L247_T0.5850.96
238_M241_G0.5850.96
55_I58_S0.5840.96
141_L192_V0.5840.96
97_D142_I0.5840.96
197_M220_D0.5830.96
72_H75_I0.5810.96
225_R249_E0.5810.96
169_T173_A0.5810.96
108_L111_A0.5770.96
76_N131_R0.5740.96
95_C205_N0.5740.96
144_E267_K0.5720.96
47_D73_Q0.5710.96
19_I22_A0.5700.96
51_F54_S0.5680.96
135_N142_I0.5660.96
237_S241_G0.5660.96
42_T46_D0.5650.96
143_A269_D0.5610.96
151_E154_K0.5610.96
8_L37_V0.5610.96
182_I187_I0.5610.96
44_K48_A0.5580.95
123_V289_I0.5560.95
20_E41_Q0.5560.95
234_E247_T0.5550.95
149_I165_S0.5540.95
14_A17_K0.5540.95
15_G94_T0.5520.95
138_G195_L0.5490.95
107_N114_A0.5490.95
242_S246_F0.5480.95
109_A113_E0.5480.95
48_A51_F0.5470.95
95_C149_I0.5470.95
234_E248_G0.5460.95
125_V289_I0.5450.95
12_G42_T0.5450.95
45_K48_A0.5440.95
51_F55_I0.5440.95
98_F198_N0.5430.95
205_N208_P0.5410.95
142_I204_T0.5390.94
162_Y204_T0.5360.94
113_E116_M0.5360.94
108_L116_M0.5360.94
136_F199_G0.5340.94
20_E24_G0.5320.94
208_P222_L0.5320.94
274_V277_H0.5310.94
95_C100_R0.5310.94
175_S226_N0.5310.94
237_S240_Q0.5280.94
70_T138_G0.5280.94
88_G116_M0.5280.94
91_P104_I0.5280.94
18_N22_A0.5270.94
111_A114_A0.5230.94
176_F266_K0.5210.93
55_I59_V0.5200.93
40_K55_I0.5200.93
158_G204_T0.5200.93
44_K51_F0.5190.93
139_I266_K0.5170.93
160_I164_T0.5160.93
268_A278_T0.5140.93
209_L222_L0.5120.93
25_A29_V0.5120.93
211_D252_Y0.5110.93
56_D78_I0.5100.93
74_C77_A0.5090.93
149_I157_L0.5070.93
121_T213_S0.5060.92
28_P31_S0.5050.92
30_L33_H0.5040.92
75_I79_S0.5040.92
139_I262_T0.5040.92
138_G143_A0.5030.92
144_E147_N0.5030.92
42_T45_K0.5010.92
103_G121_T0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4v24A 1 0.9764 100 0.199 Contact Map
3s40A 3 0.9933 100 0.205 Contact Map
4werA 2 0.9461 100 0.209 Contact Map
2qv7A 2 0.9529 100 0.212 Contact Map
2bonA 1 0.9293 100 0.233 Contact Map
1u0tA 4 0.798 100 0.574 Contact Map
1z0sA 4 0.7576 100 0.578 Contact Map
2an1A 4 0.8081 100 0.584 Contact Map
2i2cA 3 0.8047 100 0.594 Contact Map
1yt5A 4 0.7778 100 0.597 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.