GREMLIN Database
GERM - Spore germination protein GerM
UniProt: P39072 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (282)
Sequences: 335 (289)
Seq/√Len: 17.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_V296_D7.5921.00
258_A323_T6.7741.00
230_Y245_K5.3441.00
148_D184_R4.6821.00
299_Q338_N4.6381.00
139_I178_I4.4251.00
326_E357_R4.2801.00
185_I190_L4.2531.00
139_I145_A4.1361.00
245_K261_E3.7661.00
358_P362_N3.6571.00
128_V167_S3.3920.99
256_T260_N3.1650.99
148_D187_G2.7530.98
230_Y265_G2.4830.96
282_L297_F2.4450.95
135_V147_A2.2990.93
275_D319_S2.2620.93
169_T181_V2.2170.92
137_V145_A2.2030.92
332_S335_V2.0980.89
284_S296_D2.0680.89
154_K185_I1.9280.85
111_L316_V1.8810.83
196_G323_T1.8510.82
173_T206_R1.8360.82
162_Q166_Q1.7760.80
296_D336_K1.7480.79
296_D339_G1.7310.78
282_L295_L1.6850.76
107_A171_T1.6720.75
169_T199_P1.6680.75
136_N359_S1.6650.75
108_L172_L1.6260.73
182_K189_E1.6020.72
302_F316_V1.6020.72
146_I184_R1.5960.72
168_V183_L1.5900.71
343_L352_T1.5650.70
349_E355_V1.5430.69
149_F168_V1.5410.69
259_I320_I1.5170.68
167_S230_Y1.5120.67
153_F165_V1.5030.67
108_L111_L1.5020.67
187_G241_V1.4900.66
192_E201_S1.4890.66
167_S316_V1.4710.65
153_F169_T1.4650.65
147_A184_R1.4470.64
178_I229_Y1.4440.64
67_T71_D1.4360.63
147_A253_D1.4300.63
226_L354_P1.4270.63
327_Q330_V1.4170.62
295_L334_S1.3820.60
335_V351_L1.3780.60
135_V323_T1.3740.60
149_F161_E1.3630.59
296_D323_T1.3630.59
99_K176_S1.3510.58
116_P337_V1.3490.58
211_N243_V1.3470.58
150_S312_I1.3420.58
257_A323_T1.3370.58
168_V340_K1.3220.57
113_Q178_I1.3040.56
261_E264_K1.2930.55
160_D163_K1.2880.55
168_V213_E1.2880.55
111_L167_S1.2730.54
86_K89_Y1.2600.53
156_Y164_I1.2470.52
136_N148_D1.2460.52
323_T351_L1.2290.51
97_L103_T1.2260.51
129_L168_V1.2230.51
193_M199_P1.2140.50
75_S178_I1.2130.50
183_L335_V1.1960.49
169_T193_M1.1750.48
139_I185_I1.1680.48
93_Q174_Q1.1660.47
263_A279_D1.1610.47
152_E155_N1.1490.46
80_E313_S1.1470.46
111_L171_T1.1450.46
186_N200_I1.1430.46
213_E230_Y1.1390.46
163_K321_V1.1390.46
297_F337_V1.1330.45
238_E296_D1.1330.45
104_A198_T1.1230.45
102_S143_G1.1140.44
110_Y116_P1.1140.44
107_A177_S1.0970.43
136_N288_I1.0950.43
143_G179_D1.0920.43
83_L87_N1.0790.42
156_Y193_M1.0780.42
262_L335_V1.0770.42
293_V318_N1.0710.42
258_A315_E1.0700.42
150_S324_L1.0680.42
183_L204_L1.0640.41
265_G321_V1.0630.41
112_V124_G1.0560.41
147_A181_V1.0510.41
273_L330_V1.0410.40
240_Y322_L1.0410.40
226_L243_V1.0390.40
211_N244_T1.0340.40
211_N242_P1.0300.39
228_V339_G1.0290.39
226_L298_N1.0250.39
71_D101_E1.0230.39
135_V256_T1.0140.38
145_A172_L1.0100.38
133_T187_G1.0080.38
113_Q203_D1.0050.38
289_K294_T1.0050.38
99_K143_G1.0040.38
286_P334_S1.0040.38
230_Y263_A1.0010.38
170_W206_R0.9990.38
276_F297_F0.9940.37
102_S136_N0.9880.37
231_L234_N0.9870.37
263_A297_F0.9850.37
163_K293_V0.9840.37
320_I346_E0.9770.36
166_Q253_D0.9670.36
236_D252_K0.9640.36
137_V178_I0.9640.36
90_V138_D0.9570.35
187_G259_I0.9550.35
226_L233_E0.9540.35
92_A272_L0.9540.35
88_G244_T0.9510.35
157_K350_K0.9500.35
227_T244_T0.9490.35
192_E228_V0.9460.35
106_Q116_P0.9430.35
216_G356_S0.9420.34
250_S260_N0.9410.34
275_D315_E0.9410.34
322_L358_P0.9350.34
108_L299_Q0.9330.34
71_D306_D0.9310.34
141_K176_S0.9290.34
300_S335_V0.9290.34
74_S300_S0.9280.34
230_Y258_A0.9280.34
141_K179_D0.9220.33
111_L321_V0.9200.33
95_L191_K0.9160.33
216_G282_L0.9120.33
165_V169_T0.9110.33
211_N272_L0.9060.33
211_N355_V0.9030.32
126_R160_D0.9000.32
169_T204_L0.8990.32
137_V168_V0.8950.32
81_L299_Q0.8940.32
264_K348_G0.8850.31
143_G178_I0.8840.31
100_S168_V0.8800.31
169_T302_F0.8800.31
232_A238_E0.8800.31
74_S78_M0.8790.31
210_I243_V0.8750.31
125_F199_P0.8740.31
286_P295_L0.8730.31
275_D318_N0.8720.31
282_L319_S0.8700.31
111_L295_L0.8650.30
149_F181_V0.8630.30
124_G143_G0.8630.30
112_V242_P0.8620.30
72_Q85_D0.8610.30
102_S340_K0.8570.30
292_R295_L0.8570.30
92_A242_P0.8470.29
273_L316_V0.8460.29
80_E92_A0.8420.29
173_T211_N0.8420.29
146_I182_K0.8410.29
232_A295_L0.8410.29
146_I271_G0.8400.29
133_T246_R0.8340.29
132_D187_G0.8320.29
207_K216_G0.8310.29
224_H300_S0.8280.29
286_P312_I0.8280.29
81_L254_D0.8270.29
244_T272_L0.8230.28
147_A197_G0.8200.28
158_K335_V0.8150.28
293_V322_L0.8150.28
265_G326_E0.8130.28
216_G253_D0.8120.28
168_V177_S0.8110.28
243_V272_L0.8060.27
178_I347_K0.8060.27
281_K300_S0.8050.27
104_A175_F0.8040.27
109_E210_I0.8040.27
294_T318_N0.8030.27
145_A171_T0.7990.27
255_I328_P0.7920.27
259_I297_F0.7890.27
283_V318_N0.7870.27
138_D186_N0.7860.27
322_L362_N0.7800.26
75_S335_V0.7800.26
133_T156_Y0.7760.26
240_Y293_V0.7730.26
92_A244_T0.7710.26
72_Q290_D0.7700.26
228_V254_D0.7680.26
162_Q323_T0.7610.25
324_L361_V0.7580.25
250_S264_K0.7580.25
104_A337_V0.7570.25
104_A137_V0.7560.25
247_I261_E0.7530.25
263_A273_L0.7510.25
114_G126_R0.7480.25
186_N247_I0.7480.25
108_L289_K0.7460.25
81_L317_L0.7430.25
114_G158_K0.7390.24
125_F239_Y0.7380.24
358_P361_V0.7380.24
102_S359_S0.7320.24
88_G253_D0.7250.24
205_S208_D0.7230.24
174_Q298_N0.7220.24
89_Y165_V0.7220.24
207_K221_T0.7210.24
259_I283_V0.7190.24
149_F183_L0.7160.23
237_S319_S0.7150.23
78_M96_P0.7120.23
129_L199_P0.7100.23
206_R242_P0.7100.23
292_R332_S0.7100.23
133_T242_P0.7100.23
176_S310_K0.7080.23
321_V354_P0.7070.23
88_G187_G0.7060.23
71_D183_L0.7050.23
199_P239_Y0.7040.23
228_V258_A0.7040.23
155_N188_H0.7030.23
145_A261_E0.7020.23
280_V297_F0.7000.23
79_R97_L0.6990.23
190_L226_L0.6970.23
314_S318_N0.6960.23
105_K187_G0.6920.22
170_W231_L0.6920.22
318_N351_L0.6920.22
113_Q136_N0.6910.22
104_A177_S0.6860.22
103_T106_Q0.6840.22
81_L246_R0.6800.22
93_Q286_P0.6800.22
187_G242_P0.6790.22
170_W210_I0.6760.22
183_L333_V0.6760.22
138_D142_D0.6740.22
91_V199_P0.6720.22
148_D353_E0.6710.22
71_D155_N0.6690.21
103_T320_I0.6680.21
81_L223_T0.6660.21
170_W322_L0.6650.21
217_V246_R0.6640.21
109_E337_V0.6630.21
83_L209_G0.6610.21
250_S300_S0.6580.21
278_E320_I0.6580.21
306_D335_V0.6560.21
108_L210_I0.6530.21
92_A172_L0.6510.21
68_A278_E0.6500.21
268_K271_G0.6490.21
345_N356_S0.6490.21
112_V129_L0.6490.21
178_I331_K0.6470.21
160_D361_V0.6460.21
180_K196_G0.6440.20
251_E343_L0.6410.20
298_N320_I0.6400.20
174_Q286_P0.6390.20
70_A151_N0.6330.20
87_N222_A0.6320.20
188_H200_I0.6310.20
126_R168_V0.6310.20
133_T153_F0.6290.20
99_K340_K0.6290.20
162_Q165_V0.6270.20
356_S359_S0.6260.20
279_D323_T0.6250.20
98_P348_G0.6250.20
69_K281_K0.6240.20
150_S325_T0.6240.20
171_T175_F0.6230.20
187_G244_T0.6230.20
258_A293_V0.6220.20
135_V148_D0.6220.20
89_Y100_S0.6200.20
211_N346_E0.6200.20
141_K264_K0.6190.19
92_A245_K0.6190.19
151_N186_N0.6170.19
324_L327_Q0.6160.19
88_G227_T0.6160.19
148_D185_I0.6150.19
213_E325_T0.6140.19
83_L117_V0.6130.19
265_G286_P0.6120.19
101_E341_S0.6110.19
246_R351_L0.6110.19
70_A268_K0.6100.19
277_S319_S0.6070.19
144_T180_K0.6060.19
130_P227_T0.6050.19
167_S273_L0.6040.19
198_T259_I0.6040.19
93_Q203_D0.5990.19
101_E113_Q0.5990.19
127_A174_Q0.5980.19
67_T250_S0.5970.19
164_I168_V0.5960.19
170_W209_G0.5960.19
160_D192_E0.5940.19
161_E165_V0.5930.19
98_P112_V0.5920.18
228_V253_D0.5880.18
280_V300_S0.5880.18
283_V335_V0.5880.18
301_I345_N0.5880.18
128_V172_L0.5870.18
226_L257_A0.5860.18
258_A350_K0.5860.18
145_A181_V0.5860.18
234_N297_F0.5840.18
111_L152_E0.5830.18
135_V157_K0.5830.18
88_G92_A0.5810.18
81_L258_A0.5780.18
80_E174_Q0.5770.18
167_S302_F0.5760.18
168_V181_V0.5750.18
85_D89_Y0.5710.18
87_N129_L0.5700.18
222_A359_S0.5690.18
166_Q351_L0.5690.18
297_F334_S0.5690.18
193_M198_T0.5680.18
275_D351_L0.5670.18
136_N258_A0.5660.18
232_A292_R0.5660.18
92_A210_I0.5650.18
132_D275_D0.5640.17
280_V298_N0.5640.17
217_V234_N0.5620.17
75_S136_N0.5600.17
72_Q146_I0.5590.17
186_N284_S0.5580.17
215_A258_A0.5580.17
81_L331_K0.5570.17
232_A235_E0.5560.17
233_E238_E0.5550.17
82_Y279_D0.5550.17
205_S330_V0.5540.17
73_A236_D0.5530.17
217_V295_L0.5520.17
98_P178_I0.5520.17
142_D289_K0.5500.17
101_E260_N0.5490.17
152_E168_V0.5480.17
130_P244_T0.5470.17
235_E318_N0.5470.17
135_V191_K0.5460.17
292_R319_S0.5440.17
93_Q150_S0.5440.17
344_V347_K0.5420.17
276_F337_V0.5400.17
162_Q260_N0.5400.17
165_V302_F0.5400.17
230_Y337_V0.5380.17
232_A236_D0.5370.17
143_G180_K0.5360.17
83_L293_V0.5360.17
259_I302_F0.5340.16
340_K347_K0.5320.16
70_A138_D0.5300.16
170_W212_L0.5300.16
75_S197_G0.5300.16
291_G324_L0.5300.16
143_G148_D0.5290.16
102_S145_A0.5240.16
184_R189_E0.5240.16
161_E244_T0.5230.16
91_V168_V0.5220.16
141_K248_D0.5210.16
330_V349_E0.5180.16
139_I352_T0.5180.16
130_P242_P0.5140.16
157_K252_K0.5130.16
266_P321_V0.5130.16
263_A280_V0.5120.16
155_N284_S0.5110.16
270_S361_V0.5060.16
109_E353_E0.5050.16
70_A177_S0.5040.15
254_D350_K0.5030.15
130_P178_I0.5020.15
206_R355_V0.5010.15
144_T258_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cq1A 2 0.2705 33 0.968 Contact Map
3lnoA 1 0.2923 32.3 0.969 Contact Map
1uwdA 1 0.2787 26.3 0.97 Contact Map
3zbiC 1 0.0601 22.9 0.971 Contact Map
4jwoA 1 0.5683 19.3 0.972 Contact Map
2ca6A 1 0.1066 11.4 0.975 Contact Map
2dafA 1 0.3197 7.7 0.976 Contact Map
4fybB 1 0.4044 7 0.977 Contact Map
3qxiA 3 0.2104 6.4 0.977 Contact Map
1m56D 1 0.0574 6.2 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.