GREMLIN Database
CLPQ - ATP-dependent protease subunit ClpQ
UniProt: P39070 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (174)
Sequences: 1205 (484)
Seq/√Len: 36.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_S158_R4.2641.00
152_S155_E4.1651.00
21_S157_A3.9291.00
146_H159_A3.8241.00
166_E173_D3.5681.00
154_S179_E3.5041.00
57_V118_E3.3541.00
9_I22_G3.2641.00
112_L127_L2.9261.00
137_L141_R2.7341.00
17_R179_E2.5801.00
26_V38_A2.4471.00
145_K159_A2.3671.00
66_K88_E2.2360.99
43_K178_E2.0800.99
103_I127_L2.0720.99
50_L180_L1.9990.98
11_A110_L1.9980.98
145_K166_E1.9760.98
13_Q110_L1.9570.98
14_H147_A1.9010.98
46_N72_E1.8820.98
103_I110_L1.8680.98
124_D141_R1.8220.97
27_T169_V1.8180.97
165_G173_D1.8100.97
110_L127_L1.8100.97
21_S175_I1.8050.97
158_R162_E1.7820.97
67_F104_V1.7800.97
51_A64_F1.7540.96
82_A113_V1.7240.96
34_M120_I1.7120.96
28_F101_M1.7100.96
103_I126_I1.6500.95
162_E173_D1.6190.94
21_S161_L1.5890.94
51_A104_V1.5700.94
93_K97_K1.5580.93
14_H144_K1.5340.93
159_A162_E1.5060.92
57_V60_A1.5020.92
27_T31_A1.4750.91
45_F76_G1.4540.91
82_A111_L1.4450.90
28_F34_M1.4340.90
128_A133_G1.4130.89
18_S110_L1.3900.88
10_F161_L1.3870.88
10_F140_G1.3490.87
41_V176_I1.3450.87
30_Q169_V1.3200.86
36_H123_D1.2980.85
48_K106_N1.2840.84
17_R152_S1.2780.84
101_M120_I1.2640.83
18_S105_M1.2580.83
37_T123_D1.2150.81
142_A163_T1.1970.80
70_K88_E1.1780.78
114_S120_I1.1720.78
31_A170_Y1.1620.78
49_V71_L1.1570.77
64_F104_V1.1440.76
70_K73_E1.1270.75
146_H150_S1.1200.75
162_E165_G1.1110.74
6_A57_V1.1110.74
44_L51_A1.1090.74
16_G153_A1.0990.73
103_I112_L1.0790.72
79_K109_T1.0310.69
49_V81_A1.0170.67
48_K107_Q1.0100.67
12_V153_A1.0030.66
141_R166_E1.0020.66
66_K69_A0.9910.65
124_D137_L0.9900.65
126_I144_K0.9800.65
18_S180_L0.9780.64
20_M50_L0.9760.64
62_T65_E0.9710.64
165_G175_I0.9630.63
157_A160_A0.9550.63
66_K94_V0.9340.61
9_I169_V0.9290.60
138_A167_I0.9160.59
44_L64_F0.9120.59
74_Y84_E0.9100.59
87_K95_L0.9100.59
124_D145_K0.9080.59
135_Y138_A0.9060.58
73_E123_D0.9020.58
91_S94_V0.8910.57
67_F82_A0.8910.57
77_N123_D0.8860.57
134_N169_V0.8840.57
15_K153_A0.8790.56
147_A150_S0.8720.55
12_V19_A0.8660.55
13_Q18_S0.8530.54
91_S170_Y0.8500.54
47_G56_S0.8450.53
65_E122_P0.8430.53
36_H174_Q0.8430.53
147_A159_A0.8420.53
154_S177_L0.8270.52
30_Q170_Y0.8240.51
87_K102_L0.8220.51
155_E158_R0.8140.50
49_V93_K0.8080.50
139_A160_A0.8060.50
64_F83_V0.8020.49
104_V113_V0.7950.49
6_A176_I0.7920.48
19_A154_S0.7910.48
118_E169_V0.7820.48
144_K156_I0.7780.47
11_A103_I0.7770.47
19_A179_E0.7700.47
61_F102_L0.7640.46
49_V109_T0.7610.46
79_K111_L0.7610.46
51_A141_R0.7580.45
36_H161_L0.7570.45
34_M112_L0.7520.45
93_K173_D0.7490.45
45_F48_K0.7470.45
128_A168_C0.7440.44
143_L146_H0.7440.44
4_F120_I0.7390.44
138_A160_A0.7350.43
75_N114_S0.7340.43
158_R175_I0.7320.43
158_R177_L0.7300.43
112_L134_N0.7300.43
125_G141_R0.7280.43
5_H180_L0.7260.43
39_R178_E0.7230.42
61_F118_E0.7220.42
41_V175_I0.7160.42
30_Q135_Y0.7140.42
56_S137_L0.7130.42
13_Q125_G0.7110.41
92_D96_R0.7080.41
144_K147_A0.7060.41
74_Y80_R0.7050.41
106_N109_T0.7040.41
19_A67_F0.7020.41
21_S177_L0.6950.40
20_M140_G0.6940.40
60_A101_M0.6910.40
11_A20_M0.6880.39
22_G41_V0.6870.39
34_M97_K0.6860.39
31_A118_E0.6770.39
11_A105_M0.6740.38
6_A65_E0.6690.38
146_H151_M0.6640.37
26_V61_F0.6630.37
27_T36_H0.6620.37
11_A18_S0.6600.37
121_E168_C0.6580.37
5_H120_I0.6580.37
146_H163_T0.6580.37
34_M41_V0.6560.37
114_S167_I0.6400.36
103_I107_Q0.6350.35
94_V165_G0.6350.35
41_V169_V0.6280.35
41_V166_E0.6240.34
64_F87_K0.6210.34
157_A177_L0.6210.34
20_M41_V0.6210.34
76_G171_T0.6200.34
77_N114_S0.6180.34
44_L134_N0.6150.34
101_M129_I0.6130.33
16_G108_D0.6130.33
61_F67_F0.6120.33
69_A87_K0.6120.33
147_A156_I0.6110.33
57_V62_T0.6100.33
114_S175_I0.6090.33
101_M113_V0.6080.33
46_N51_A0.6070.33
9_I101_M0.6070.33
162_E175_I0.6050.33
39_R176_I0.6030.33
85_L113_V0.6010.32
72_E81_A0.6000.32
134_N137_L0.6000.32
34_M133_G0.5940.32
31_A167_I0.5900.32
50_L67_F0.5880.31
102_L167_I0.5880.31
79_K121_E0.5860.31
10_F144_K0.5830.31
31_A134_N0.5820.31
51_A102_L0.5800.31
72_E156_I0.5790.31
51_A88_E0.5790.31
74_Y85_L0.5780.31
19_A177_L0.5780.31
6_A9_I0.5780.31
5_H129_I0.5760.31
74_Y77_N0.5730.30
145_K163_T0.5640.30
70_K86_A0.5640.30
10_F105_M0.5640.30
147_A151_M0.5620.30
33_V172_N0.5610.29
150_S155_E0.5600.29
15_K18_S0.5580.29
93_K162_E0.5570.29
60_A67_F0.5560.29
27_T122_P0.5530.29
78_L106_N0.5520.29
164_A171_T0.5510.29
39_R129_I0.5500.29
18_S125_G0.5470.28
22_G38_A0.5470.28
129_I133_G0.5460.28
51_A56_S0.5450.28
45_F72_E0.5450.28
80_R94_V0.5440.28
70_K85_L0.5430.28
41_V62_T0.5420.28
158_R179_E0.5380.28
33_V165_G0.5370.28
66_K83_V0.5370.28
29_G101_M0.5360.28
27_T134_N0.5360.28
61_F128_A0.5340.28
134_N138_A0.5320.27
33_V38_A0.5290.27
43_K135_Y0.5280.27
165_G174_Q0.5270.27
114_S123_D0.5260.27
37_T174_Q0.5260.27
11_A114_S0.5250.27
80_R97_K0.5240.27
159_A163_T0.5240.27
56_S174_Q0.5220.27
106_N161_L0.5210.27
43_K180_L0.5180.26
106_N110_L0.5170.26
65_E165_G0.5160.26
4_F28_F0.5150.26
66_K114_S0.5150.26
50_L93_K0.5150.26
56_S116_T0.5140.26
80_R121_E0.5130.26
91_S97_K0.5110.26
44_L47_G0.5110.26
92_D125_G0.5110.26
30_Q168_C0.5050.26
13_Q16_G0.5010.25
29_G102_L0.5010.25
20_M178_E0.5000.25
93_K99_E0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g3kA 5 0.9503 100 0.659 Contact Map
1m4yA 5 0.9448 100 0.676 Contact Map
2z3bA 5 0.989 100 0.679 Contact Map
4hnzA 5 0.9448 100 0.694 Contact Map
4r3oJ 1 0.9669 99.9 0.744 Contact Map
1rypJ 1 0.9613 99.9 0.744 Contact Map
1rypH 2 0.9613 99.9 0.747 Contact Map
4r3oN 1 0.9724 99.9 0.749 Contact Map
1yarH 5 0.9227 99.9 0.75 Contact Map
1g0uM 1 0.9779 99.9 0.751 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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