GREMLIN Database
ACUC - Acetoin utilization protein AcuC
UniProt: P39067 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (310)
Sequences: 4111 (2672)
Seq/√Len: 151.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_Q185_D3.8811.00
116_V295_I3.4741.00
164_L243_A3.2391.00
161_A249_D3.1931.00
4_S123_H3.1221.00
112_A124_A3.0991.00
177_Q207_E3.0811.00
109_T297_V3.0511.00
54_E70_K2.9461.00
109_T151_A2.7441.00
180_F186_V2.7261.00
53_S56_E2.7141.00
50_R56_E2.6471.00
153_Q156_Q2.6311.00
155_I250_V2.6211.00
5_V121_A2.5711.00
60_V179_T2.5251.00
236_R281_L2.4781.00
98_M144_I2.4311.00
148_S252_I2.3161.00
58_S66_I2.2771.00
111_T115_W2.2411.00
189_L239_A2.1871.00
112_A295_I2.0671.00
69_V145_Y2.0661.00
113_A155_I2.0031.00
228_D274_I1.9871.00
153_Q183_N1.9731.00
166_I282_A1.9651.00
136_R178_F1.9521.00
148_S297_V1.9511.00
59_L157_K1.9421.00
114_D154_Y1.9231.00
170_A266_T1.9201.00
58_S63_D1.9151.00
11_S104_L1.9091.00
7_I111_T1.9051.00
66_I145_Y1.8621.00
115_W120_Q1.8511.00
227_E230_S1.8441.00
257_A315_I1.8131.00
54_E67_Q1.8041.00
205_I221_P1.7871.00
187_C218_F1.7831.00
140_S174_D1.7811.00
243_A285_L1.7731.00
152_I252_I1.7721.00
113_A151_A1.7451.00
296_A315_I1.7191.00
270_A274_I1.6771.00
52_A107_G1.6611.00
213_G216_Y1.6581.00
135_F178_F1.6531.00
218_F242_V1.6481.00
114_D159_Y1.6371.00
228_D271_T1.6261.00
69_V144_I1.6241.00
50_R111_T1.6241.00
63_D67_Q1.6201.00
54_E58_S1.6191.00
70_K99_H1.6171.00
277_E280_R1.5941.00
106_V150_V1.5681.00
184_P212_K1.5551.00
123_H283_H1.5531.00
51_L104_L1.5501.00
276_E318_E1.5331.00
62_T136_R1.5241.00
172_H177_Q1.5221.00
149_A179_T1.5221.00
232_L277_E1.5211.00
6_F32_Y1.5021.00
57_L150_V1.4711.00
7_I115_W1.4651.00
280_R318_E1.4511.00
222_L234_A1.4411.00
54_E103_S1.4271.00
5_V115_W1.4231.00
60_V153_Q1.4141.00
176_V254_Q1.4111.00
31_T312_W1.4101.00
253_S282_A1.3881.00
26_Q29_L1.3851.00
12_Y108_G1.3801.00
102_A145_Y1.3741.00
65_Y139_A1.3711.00
117_M159_Y1.3651.00
243_A251_I1.3641.00
32_Y36_K1.3601.00
165_Y186_V1.3301.00
170_A268_L1.3281.00
226_T230_S1.3101.00
222_L268_L1.3071.00
231_F278_I1.3031.00
9_S48_T1.3011.00
153_Q157_K1.2961.00
99_H145_Y1.2931.00
43_D322_I1.2861.00
136_R179_T1.2861.00
296_A319_M1.2851.00
56_E110_L1.2851.00
236_R277_E1.2721.00
156_Q183_N1.2711.00
164_L187_C1.2681.00
50_R104_L1.2561.00
193_E267_H1.2501.00
208_K214_Y1.2471.00
54_E63_D1.2381.00
135_F174_D1.2271.00
168_T278_I1.2271.00
34_L313_A1.2241.00
188_T254_Q1.2131.00
62_T137_G1.2061.00
152_I165_Y1.2001.00
11_S14_T1.1961.00
271_T274_I1.1851.00
14_T97_G1.1821.00
153_Q185_D1.1811.00
281_L284_T1.1801.00
165_Y176_V1.1781.00
279_P315_I1.1751.00
140_S199_F1.1501.00
23_F130_G1.1471.00
191_I235_Y1.1371.00
52_A56_E1.1331.00
286_A292_G1.1291.00
181_Y217_S1.1261.00
148_S254_Q1.1251.00
259_A270_A1.1220.99
47_V115_W1.1200.99
272_I310_R1.1170.99
145_Y150_V1.1160.99
106_V147_D1.1110.99
251_I282_A1.1090.99
56_E59_L1.1070.99
114_D158_K1.1070.99
182_D210_S1.1000.99
259_A275_Y1.0970.99
11_S100_E1.0950.99
261_Y271_T1.0920.99
13_Q29_L1.0910.99
168_T255_N1.0650.99
57_L103_S1.0590.99
189_L220_I1.0570.99
33_D36_K1.0540.99
253_S296_A1.0500.99
109_T127_L1.0500.99
283_H318_E1.0430.99
164_L251_I1.0420.99
67_Q70_K1.0410.99
283_H294_W1.0380.99
135_F140_S1.0380.99
111_T114_D1.0290.99
114_D118_S1.0270.99
188_T217_S1.0260.99
165_Y180_F1.0240.99
181_Y210_S1.0180.99
56_E154_Y1.0160.99
7_I108_G1.0150.99
7_I47_V1.0140.99
115_W121_A1.0130.99
135_F138_R1.0090.99
110_L154_Y0.9980.99
177_Q181_Y0.9970.99
233_E237_T0.9960.99
154_Y158_K0.9900.99
261_Y269_S0.9890.99
113_A295_I0.9890.99
67_Q71_L0.9760.99
252_I297_V0.9700.99
262_Y303_D0.9700.99
52_A57_L0.9650.98
260_H272_I0.9640.98
60_V149_A0.9600.98
173_G188_T0.9600.98
286_A293_K0.9580.98
182_D212_K0.9570.98
303_D306_R0.9530.98
253_S294_W0.9520.98
203_G219_N0.9460.98
260_H311_A0.9450.98
89_T92_T0.9390.98
52_A110_L0.9360.98
272_I311_A0.9320.98
60_V150_V0.9310.98
231_F270_A0.9130.98
23_F128_G0.9110.98
168_T279_P0.9110.98
191_I222_L0.9040.98
187_C246_F0.8980.98
162_R249_D0.8980.98
51_L103_S0.8950.98
84_S87_L0.8950.98
250_V295_I0.8910.97
57_L66_I0.8880.97
62_T65_Y0.8870.97
38_I313_A0.8860.97
35_L316_W0.8850.97
28_V126_N0.8840.97
128_G131_L0.8790.97
193_E224_A0.8770.97
259_A268_L0.8680.97
59_L106_V0.8670.97
193_E266_T0.8660.97
191_I234_A0.8640.97
183_N246_F0.8630.97
160_S249_D0.8590.97
177_Q219_N0.8560.97
54_E99_H0.8520.97
235_Y239_A0.8500.97
5_V47_V0.8420.96
194_T204_Q0.8370.96
57_L106_V0.8360.96
56_E107_G0.8320.96
99_H103_S0.8320.96
164_L189_L0.8310.96
254_Q299_G0.8290.96
149_A180_F0.8250.96
105_L128_G0.8200.96
157_K185_D0.8130.96
181_Y207_E0.8120.96
279_P296_A0.8110.96
230_S233_E0.8100.96
191_I239_A0.8090.96
69_V99_H0.8090.96
34_L310_R0.8080.95
146_N179_T0.8070.95
59_L150_V0.8020.95
50_R53_S0.7970.95
51_L100_E0.7930.95
50_R114_D0.7900.95
224_A267_H0.7900.95
21_H142_F0.7890.95
129_G147_D0.7880.95
55_E58_S0.7870.95
68_A72_A0.7840.95
121_A124_A0.7840.95
108_G125_A0.7810.95
184_P216_Y0.7800.95
277_E281_L0.7780.94
251_I286_A0.7750.94
13_Q28_V0.7740.94
181_Y213_G0.7730.94
193_E198_L0.7730.94
36_K46_I0.7730.94
313_A317_L0.7720.94
282_A294_W0.7720.94
23_F131_L0.7710.94
83_E87_L0.7700.94
306_R311_A0.7670.94
218_F238_A0.7670.94
31_T35_L0.7660.94
153_Q180_F0.7630.94
191_I231_F0.7590.94
232_L236_R0.7570.94
276_E317_L0.7550.94
164_L242_V0.7540.93
151_A252_I0.7530.93
240_S285_L0.7530.93
17_F95_F0.7520.93
243_A292_G0.7500.93
12_Y28_V0.7490.93
262_Y306_R0.7480.93
240_S281_L0.7470.93
152_I163_V0.7430.93
166_I239_A0.7420.93
129_G299_G0.7410.93
149_A176_V0.7390.93
59_L153_Q0.7350.93
130_G147_D0.7340.93
109_T295_I0.7330.93
240_S244_A0.7330.93
59_L154_Y0.7320.92
235_Y278_I0.7310.92
154_Y159_Y0.7300.92
279_P318_E0.7210.92
45_D121_A0.7210.92
53_S107_G0.7150.92
187_C242_V0.7100.91
308_V311_A0.7050.91
176_V188_T0.7050.91
220_I238_A0.7040.91
147_D299_G0.7030.91
194_T198_L0.7020.91
239_A282_A0.7000.91
172_H203_G0.6990.91
220_I234_A0.6980.91
172_H202_T0.6970.91
137_G178_F0.6940.90
70_K103_S0.6920.90
131_L299_G0.6910.90
54_E66_I0.6890.90
49_P108_G0.6870.90
203_G207_E0.6860.90
8_Y32_Y0.6850.90
168_T282_A0.6830.90
276_E314_R0.6830.90
57_L145_Y0.6820.90
130_G299_G0.6780.89
178_F181_Y0.6760.89
152_I176_V0.6760.89
82_G86_G0.6760.89
118_S159_Y0.6750.89
181_Y209_G0.6710.89
105_L127_L0.6640.88
244_A247_E0.6630.88
166_I189_L0.6620.88
135_F179_T0.6590.88
117_M160_S0.6580.88
177_Q203_G0.6550.88
36_K41_F0.6540.88
165_Y254_Q0.6530.87
276_E280_R0.6520.87
32_Y41_F0.6510.87
60_V180_F0.6490.87
151_A297_V0.6430.87
108_G128_G0.6410.86
280_R284_T0.6380.86
260_H306_R0.6380.86
198_L267_H0.6380.86
9_S12_Y0.6370.86
113_A252_I0.6360.86
32_Y46_I0.6360.86
94_V98_M0.6350.86
253_S279_P0.6350.86
60_V136_R0.6330.86
128_G299_G0.6300.86
117_M250_V0.6300.86
109_T113_A0.6300.86
113_A154_Y0.6280.85
126_N129_G0.6220.85
159_Y249_D0.6220.85
170_A259_A0.6200.85
209_G214_Y0.6190.85
255_N315_I0.6180.84
98_M129_G0.6180.84
226_T268_L0.6180.84
166_I243_A0.6160.84
226_T231_F0.6140.84
227_E269_S0.6130.84
262_Y310_R0.6120.84
257_A299_G0.6120.84
162_R246_F0.6120.84
40_A320_K0.6120.84
142_F265_L0.6060.83
168_T235_Y0.6050.83
241_E245_Y0.6050.83
64_D67_Q0.6050.83
139_A144_I0.6040.83
180_F217_S0.6030.83
209_G216_Y0.6020.83
252_I295_I0.6020.83
18_H93_P0.6020.83
179_T186_V0.6020.83
103_S107_G0.6020.83
251_I294_W0.6010.83
97_G101_A0.6010.83
6_F44_G0.5970.82
130_G298_G0.5960.82
127_L147_D0.5960.82
108_G111_T0.5950.82
7_I112_A0.5950.82
242_V245_Y0.5940.82
210_S213_G0.5930.82
168_T253_S0.5900.82
273_N276_E0.5900.82
91_D201_G0.5900.82
129_G257_A0.5890.82
33_D37_T0.5880.81
223_D226_T0.5870.81
52_A106_V0.5850.81
16_M25_Q0.5840.81
154_Y160_S0.5820.81
315_I319_M0.5800.81
187_C216_Y0.5790.80
209_G212_K0.5790.80
308_V312_W0.5770.80
113_A250_V0.5760.80
98_M102_A0.5760.80
151_A295_I0.5760.80
23_F129_G0.5730.80
23_F299_G0.5720.80
218_F221_P0.5720.80
116_V121_A0.5700.79
249_D291_G0.5700.79
73_G94_V0.5700.79
222_L227_E0.5690.79
166_I251_I0.5690.79
129_G254_Q0.5680.79
26_Q304_I0.5660.79
7_I124_A0.5650.79
65_Y69_V0.5650.79
63_D66_I0.5650.79
191_I220_I0.5640.79
188_T192_H0.5630.79
148_S188_T0.5630.79
281_L285_L0.5620.78
317_L324_P0.5600.78
294_W319_M0.5590.78
12_Y104_L0.5570.78
155_I160_S0.5570.78
231_F268_L0.5560.78
154_Y157_K0.5550.78
34_L309_P0.5540.77
16_M26_Q0.5540.77
166_I235_Y0.5530.77
130_G257_A0.5530.77
237_T241_E0.5530.77
31_T309_P0.5520.77
168_T275_Y0.5520.77
279_P283_H0.5520.77
255_N312_W0.5500.77
58_S67_Q0.5500.77
98_M130_G0.5500.77
82_G85_Y0.5490.77
34_L38_I0.5470.77
172_H219_N0.5470.77
161_A185_D0.5460.76
123_H292_G0.5460.76
103_S137_G0.5450.76
113_A116_V0.5450.76
15_Y23_F0.5440.76
105_L147_D0.5420.76
180_F213_G0.5410.76
5_V45_D0.5380.75
70_K74_A0.5340.75
213_G217_S0.5330.75
130_G254_Q0.5320.75
314_R318_E0.5320.75
209_G213_G0.5310.74
109_T126_N0.5310.74
135_F199_F0.5300.74
181_Y208_K0.5270.74
97_G100_E0.5220.73
87_L142_F0.5210.73
117_M155_I0.5190.73
167_D171_H0.5170.73
222_L226_T0.5160.72
189_L242_V0.5150.72
152_I186_V0.5150.72
103_S145_Y0.5150.72
103_S106_V0.5140.72
209_G215_G0.5140.72
65_Y135_F0.5140.72
66_I99_H0.5130.72
118_S158_K0.5120.72
170_A265_L0.5120.72
170_A193_E0.5110.72
30_L33_D0.5110.72
192_H239_A0.5100.72
220_I239_A0.5090.71
27_R298_G0.5090.71
192_H203_G0.5090.71
72_A94_V0.5070.71
194_T201_G0.5070.71
131_L254_Q0.5060.71
255_N279_P0.5060.71
239_A243_A0.5060.71
234_A268_L0.5030.70
134_G139_A0.5030.70
22_P142_F0.5030.70
75_G81_E0.5030.70
188_T199_F0.5010.70
55_E59_L0.5010.70
109_T125_A0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bkxB 1 0.9457 100 0.152 Contact Map
4a69A 1 0.9406 100 0.153 Contact Map
4ly1A 2 0.938 100 0.162 Contact Map
2vqmA 1 0.9457 100 0.164 Contact Map
1c3pA 1 0.9328 100 0.168 Contact Map
4qa5A 1 0.9457 100 0.168 Contact Map
4bz7A 3 0.9509 100 0.174 Contact Map
1zz1A 4 0.8941 100 0.178 Contact Map
3menA 3 0.7984 100 0.215 Contact Map
4zurA 2 0.7933 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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