ACUC - BACSU - GREMLIN Contacts

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ACUC - Acetoin utilization protein AcuC

UniProt:	P39067	Sequences: MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDGDIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAASLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYSARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSFNIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYEEIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIVKWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	387 (310)
Sequences:	4111 (2672)
Seq/√Len:	151.7

BACSU - ACUC
HALSA - Q9HSP7
SULSO - Q981B8 Q97Z24 Q981D8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
156_Q	185_D	3.881	1.00
116_V	295_I	3.474	1.00
164_L	243_A	3.239	1.00
161_A	249_D	3.193	1.00
4_S	123_H	3.122	1.00
112_A	124_A	3.099	1.00
177_Q	207_E	3.081	1.00
109_T	297_V	3.051	1.00
54_E	70_K	2.946	1.00
109_T	151_A	2.744	1.00
180_F	186_V	2.726	1.00
53_S	56_E	2.714	1.00
50_R	56_E	2.647	1.00
153_Q	156_Q	2.631	1.00
155_I	250_V	2.621	1.00
5_V	121_A	2.571	1.00
60_V	179_T	2.525	1.00
236_R	281_L	2.478	1.00
98_M	144_I	2.431	1.00
148_S	252_I	2.316	1.00
58_S	66_I	2.277	1.00
111_T	115_W	2.241	1.00
189_L	239_A	2.187	1.00
112_A	295_I	2.067	1.00
69_V	145_Y	2.066	1.00
113_A	155_I	2.003	1.00
228_D	274_I	1.987	1.00
153_Q	183_N	1.973	1.00
166_I	282_A	1.965	1.00
136_R	178_F	1.952	1.00
148_S	297_V	1.951	1.00
59_L	157_K	1.942	1.00
114_D	154_Y	1.923	1.00
170_A	266_T	1.920	1.00
58_S	63_D	1.915	1.00
11_S	104_L	1.909	1.00
7_I	111_T	1.905	1.00
66_I	145_Y	1.862	1.00
115_W	120_Q	1.851	1.00
227_E	230_S	1.844	1.00
257_A	315_I	1.813	1.00
54_E	67_Q	1.804	1.00
205_I	221_P	1.787	1.00
187_C	218_F	1.783	1.00
140_S	174_D	1.781	1.00
243_A	285_L	1.773	1.00
152_I	252_I	1.772	1.00
113_A	151_A	1.745	1.00
296_A	315_I	1.719	1.00
270_A	274_I	1.677	1.00
52_A	107_G	1.661	1.00
213_G	216_Y	1.658	1.00
135_F	178_F	1.653	1.00
218_F	242_V	1.648	1.00
114_D	159_Y	1.637	1.00
228_D	271_T	1.626	1.00
69_V	144_I	1.624	1.00
50_R	111_T	1.624	1.00
63_D	67_Q	1.620	1.00
54_E	58_S	1.619	1.00
70_K	99_H	1.617	1.00
277_E	280_R	1.594	1.00
106_V	150_V	1.568	1.00
184_P	212_K	1.555	1.00
123_H	283_H	1.553	1.00
51_L	104_L	1.550	1.00
276_E	318_E	1.533	1.00
62_T	136_R	1.524	1.00
172_H	177_Q	1.522	1.00
149_A	179_T	1.522	1.00
232_L	277_E	1.521	1.00
6_F	32_Y	1.502	1.00
57_L	150_V	1.471	1.00
7_I	115_W	1.465	1.00
280_R	318_E	1.451	1.00
222_L	234_A	1.441	1.00
54_E	103_S	1.427	1.00
5_V	115_W	1.423	1.00
60_V	153_Q	1.414	1.00
176_V	254_Q	1.411	1.00
31_T	312_W	1.410	1.00
253_S	282_A	1.388	1.00
26_Q	29_L	1.385	1.00
12_Y	108_G	1.380	1.00
102_A	145_Y	1.374	1.00
65_Y	139_A	1.371	1.00
117_M	159_Y	1.365	1.00
243_A	251_I	1.364	1.00
32_Y	36_K	1.360	1.00
165_Y	186_V	1.330	1.00
170_A	268_L	1.328	1.00
226_T	230_S	1.310	1.00
222_L	268_L	1.307	1.00
231_F	278_I	1.303	1.00
9_S	48_T	1.301	1.00
153_Q	157_K	1.296	1.00
99_H	145_Y	1.293	1.00
43_D	322_I	1.286	1.00
136_R	179_T	1.286	1.00
296_A	319_M	1.285	1.00
56_E	110_L	1.285	1.00
236_R	277_E	1.272	1.00
156_Q	183_N	1.271	1.00
164_L	187_C	1.268	1.00
50_R	104_L	1.256	1.00
193_E	267_H	1.250	1.00
208_K	214_Y	1.247	1.00
54_E	63_D	1.238	1.00
135_F	174_D	1.227	1.00
168_T	278_I	1.227	1.00
34_L	313_A	1.224	1.00
188_T	254_Q	1.213	1.00
62_T	137_G	1.206	1.00
152_I	165_Y	1.200	1.00
11_S	14_T	1.196	1.00
271_T	274_I	1.185	1.00
14_T	97_G	1.182	1.00
153_Q	185_D	1.181	1.00
281_L	284_T	1.180	1.00
165_Y	176_V	1.178	1.00
279_P	315_I	1.175	1.00
140_S	199_F	1.150	1.00
23_F	130_G	1.147	1.00
191_I	235_Y	1.137	1.00
52_A	56_E	1.133	1.00
286_A	292_G	1.129	1.00
181_Y	217_S	1.126	1.00
148_S	254_Q	1.125	1.00
259_A	270_A	1.122	0.99
47_V	115_W	1.120	0.99
272_I	310_R	1.117	0.99
145_Y	150_V	1.116	0.99
106_V	147_D	1.111	0.99
251_I	282_A	1.109	0.99
56_E	59_L	1.107	0.99
114_D	158_K	1.107	0.99
182_D	210_S	1.100	0.99
259_A	275_Y	1.097	0.99
11_S	100_E	1.095	0.99
261_Y	271_T	1.092	0.99
13_Q	29_L	1.091	0.99
168_T	255_N	1.065	0.99
57_L	103_S	1.059	0.99
189_L	220_I	1.057	0.99
33_D	36_K	1.054	0.99
253_S	296_A	1.050	0.99
109_T	127_L	1.050	0.99
283_H	318_E	1.043	0.99
164_L	251_I	1.042	0.99
67_Q	70_K	1.041	0.99
283_H	294_W	1.038	0.99
135_F	140_S	1.038	0.99
111_T	114_D	1.029	0.99
114_D	118_S	1.027	0.99
188_T	217_S	1.026	0.99
165_Y	180_F	1.024	0.99
181_Y	210_S	1.018	0.99
56_E	154_Y	1.016	0.99
7_I	108_G	1.015	0.99
7_I	47_V	1.014	0.99
115_W	121_A	1.013	0.99
135_F	138_R	1.009	0.99
110_L	154_Y	0.998	0.99
177_Q	181_Y	0.997	0.99
233_E	237_T	0.996	0.99
154_Y	158_K	0.990	0.99
261_Y	269_S	0.989	0.99
113_A	295_I	0.989	0.99
67_Q	71_L	0.976	0.99
252_I	297_V	0.970	0.99
262_Y	303_D	0.970	0.99
52_A	57_L	0.965	0.98
260_H	272_I	0.964	0.98
60_V	149_A	0.960	0.98
173_G	188_T	0.960	0.98
286_A	293_K	0.958	0.98
182_D	212_K	0.957	0.98
303_D	306_R	0.953	0.98
253_S	294_W	0.952	0.98
203_G	219_N	0.946	0.98
260_H	311_A	0.945	0.98
89_T	92_T	0.939	0.98
52_A	110_L	0.936	0.98
272_I	311_A	0.932	0.98
60_V	150_V	0.931	0.98
231_F	270_A	0.913	0.98
23_F	128_G	0.911	0.98
168_T	279_P	0.911	0.98
191_I	222_L	0.904	0.98
187_C	246_F	0.898	0.98
162_R	249_D	0.898	0.98
51_L	103_S	0.895	0.98
84_S	87_L	0.895	0.98
250_V	295_I	0.891	0.97
57_L	66_I	0.888	0.97
62_T	65_Y	0.887	0.97
38_I	313_A	0.886	0.97
35_L	316_W	0.885	0.97
28_V	126_N	0.884	0.97
128_G	131_L	0.879	0.97
193_E	224_A	0.877	0.97
259_A	268_L	0.868	0.97
59_L	106_V	0.867	0.97
193_E	266_T	0.866	0.97
191_I	234_A	0.864	0.97
183_N	246_F	0.863	0.97
160_S	249_D	0.859	0.97
177_Q	219_N	0.856	0.97
54_E	99_H	0.852	0.97
235_Y	239_A	0.850	0.97
5_V	47_V	0.842	0.96
194_T	204_Q	0.837	0.96
57_L	106_V	0.836	0.96
56_E	107_G	0.832	0.96
99_H	103_S	0.832	0.96
164_L	189_L	0.831	0.96
254_Q	299_G	0.829	0.96
149_A	180_F	0.825	0.96
105_L	128_G	0.820	0.96
157_K	185_D	0.813	0.96
181_Y	207_E	0.812	0.96
279_P	296_A	0.811	0.96
230_S	233_E	0.810	0.96
191_I	239_A	0.809	0.96
69_V	99_H	0.809	0.96
34_L	310_R	0.808	0.95
146_N	179_T	0.807	0.95
59_L	150_V	0.802	0.95
50_R	53_S	0.797	0.95
51_L	100_E	0.793	0.95
50_R	114_D	0.790	0.95
224_A	267_H	0.790	0.95
21_H	142_F	0.789	0.95
129_G	147_D	0.788	0.95
55_E	58_S	0.787	0.95
68_A	72_A	0.784	0.95
121_A	124_A	0.784	0.95
108_G	125_A	0.781	0.95
184_P	216_Y	0.780	0.95
277_E	281_L	0.778	0.94
251_I	286_A	0.775	0.94
13_Q	28_V	0.774	0.94
181_Y	213_G	0.773	0.94
193_E	198_L	0.773	0.94
36_K	46_I	0.773	0.94
313_A	317_L	0.772	0.94
282_A	294_W	0.772	0.94
23_F	131_L	0.771	0.94
83_E	87_L	0.770	0.94
306_R	311_A	0.767	0.94
218_F	238_A	0.767	0.94
31_T	35_L	0.766	0.94
153_Q	180_F	0.763	0.94
191_I	231_F	0.759	0.94
232_L	236_R	0.757	0.94
276_E	317_L	0.755	0.94
164_L	242_V	0.754	0.93
151_A	252_I	0.753	0.93
240_S	285_L	0.753	0.93
17_F	95_F	0.752	0.93
243_A	292_G	0.750	0.93
12_Y	28_V	0.749	0.93
262_Y	306_R	0.748	0.93
240_S	281_L	0.747	0.93
152_I	163_V	0.743	0.93
166_I	239_A	0.742	0.93
129_G	299_G	0.741	0.93
149_A	176_V	0.739	0.93
59_L	153_Q	0.735	0.93
130_G	147_D	0.734	0.93
109_T	295_I	0.733	0.93
240_S	244_A	0.733	0.93
59_L	154_Y	0.732	0.92
235_Y	278_I	0.731	0.92
154_Y	159_Y	0.730	0.92
279_P	318_E	0.721	0.92
45_D	121_A	0.721	0.92
53_S	107_G	0.715	0.92
187_C	242_V	0.710	0.91
308_V	311_A	0.705	0.91
176_V	188_T	0.705	0.91
220_I	238_A	0.704	0.91
147_D	299_G	0.703	0.91
194_T	198_L	0.702	0.91
239_A	282_A	0.700	0.91
172_H	203_G	0.699	0.91
220_I	234_A	0.698	0.91
172_H	202_T	0.697	0.91
137_G	178_F	0.694	0.90
70_K	103_S	0.692	0.90
131_L	299_G	0.691	0.90
54_E	66_I	0.689	0.90
49_P	108_G	0.687	0.90
203_G	207_E	0.686	0.90
8_Y	32_Y	0.685	0.90
168_T	282_A	0.683	0.90
276_E	314_R	0.683	0.90
57_L	145_Y	0.682	0.90
130_G	299_G	0.678	0.89
178_F	181_Y	0.676	0.89
152_I	176_V	0.676	0.89
82_G	86_G	0.676	0.89
118_S	159_Y	0.675	0.89
181_Y	209_G	0.671	0.89
105_L	127_L	0.664	0.88
244_A	247_E	0.663	0.88
166_I	189_L	0.662	0.88
135_F	179_T	0.659	0.88
117_M	160_S	0.658	0.88
177_Q	203_G	0.655	0.88
36_K	41_F	0.654	0.88
165_Y	254_Q	0.653	0.87
276_E	280_R	0.652	0.87
32_Y	41_F	0.651	0.87
60_V	180_F	0.649	0.87
151_A	297_V	0.643	0.87
108_G	128_G	0.641	0.86
280_R	284_T	0.638	0.86
260_H	306_R	0.638	0.86
198_L	267_H	0.638	0.86
9_S	12_Y	0.637	0.86
113_A	252_I	0.636	0.86
32_Y	46_I	0.636	0.86
94_V	98_M	0.635	0.86
253_S	279_P	0.635	0.86
60_V	136_R	0.633	0.86
128_G	299_G	0.630	0.86
117_M	250_V	0.630	0.86
109_T	113_A	0.630	0.86
113_A	154_Y	0.628	0.85
126_N	129_G	0.622	0.85
159_Y	249_D	0.622	0.85
170_A	259_A	0.620	0.85
209_G	214_Y	0.619	0.85
255_N	315_I	0.618	0.84
98_M	129_G	0.618	0.84
226_T	268_L	0.618	0.84
166_I	243_A	0.616	0.84
226_T	231_F	0.614	0.84
227_E	269_S	0.613	0.84
262_Y	310_R	0.612	0.84
257_A	299_G	0.612	0.84
162_R	246_F	0.612	0.84
40_A	320_K	0.612	0.84
142_F	265_L	0.606	0.83
168_T	235_Y	0.605	0.83
241_E	245_Y	0.605	0.83
64_D	67_Q	0.605	0.83
139_A	144_I	0.604	0.83
180_F	217_S	0.603	0.83
209_G	216_Y	0.602	0.83
252_I	295_I	0.602	0.83
18_H	93_P	0.602	0.83
179_T	186_V	0.602	0.83
103_S	107_G	0.602	0.83
251_I	294_W	0.601	0.83
97_G	101_A	0.601	0.83
6_F	44_G	0.597	0.82
130_G	298_G	0.596	0.82
127_L	147_D	0.596	0.82
108_G	111_T	0.595	0.82
7_I	112_A	0.595	0.82
242_V	245_Y	0.594	0.82
210_S	213_G	0.593	0.82
168_T	253_S	0.590	0.82
273_N	276_E	0.590	0.82
91_D	201_G	0.590	0.82
129_G	257_A	0.589	0.82
33_D	37_T	0.588	0.81
223_D	226_T	0.587	0.81
52_A	106_V	0.585	0.81
16_M	25_Q	0.584	0.81
154_Y	160_S	0.582	0.81
315_I	319_M	0.580	0.81
187_C	216_Y	0.579	0.80
209_G	212_K	0.579	0.80
308_V	312_W	0.577	0.80
113_A	250_V	0.576	0.80
98_M	102_A	0.576	0.80
151_A	295_I	0.576	0.80
23_F	129_G	0.573	0.80
23_F	299_G	0.572	0.80
218_F	221_P	0.572	0.80
116_V	121_A	0.570	0.79
249_D	291_G	0.570	0.79
73_G	94_V	0.570	0.79
222_L	227_E	0.569	0.79
166_I	251_I	0.569	0.79
129_G	254_Q	0.568	0.79
26_Q	304_I	0.566	0.79
7_I	124_A	0.565	0.79
65_Y	69_V	0.565	0.79
63_D	66_I	0.565	0.79
191_I	220_I	0.564	0.79
188_T	192_H	0.563	0.79
148_S	188_T	0.563	0.79
281_L	285_L	0.562	0.78
317_L	324_P	0.560	0.78
294_W	319_M	0.559	0.78
12_Y	104_L	0.557	0.78
155_I	160_S	0.557	0.78
231_F	268_L	0.556	0.78
154_Y	157_K	0.555	0.78
34_L	309_P	0.554	0.77
16_M	26_Q	0.554	0.77
166_I	235_Y	0.553	0.77
130_G	257_A	0.553	0.77
237_T	241_E	0.553	0.77
31_T	309_P	0.552	0.77
168_T	275_Y	0.552	0.77
279_P	283_H	0.552	0.77
255_N	312_W	0.550	0.77
58_S	67_Q	0.550	0.77
98_M	130_G	0.550	0.77
82_G	85_Y	0.549	0.77
34_L	38_I	0.547	0.77
172_H	219_N	0.547	0.77
161_A	185_D	0.546	0.76
123_H	292_G	0.546	0.76
103_S	137_G	0.545	0.76
113_A	116_V	0.545	0.76
15_Y	23_F	0.544	0.76
105_L	147_D	0.542	0.76
180_F	213_G	0.541	0.76
5_V	45_D	0.538	0.75
70_K	74_A	0.534	0.75
213_G	217_S	0.533	0.75
130_G	254_Q	0.532	0.75
314_R	318_E	0.532	0.75
209_G	213_G	0.531	0.74
109_T	126_N	0.531	0.74
135_F	199_F	0.530	0.74
181_Y	208_K	0.527	0.74
97_G	100_E	0.522	0.73
87_L	142_F	0.521	0.73
117_M	155_I	0.519	0.73
167_D	171_H	0.517	0.73
222_L	226_T	0.516	0.72
189_L	242_V	0.515	0.72
152_I	186_V	0.515	0.72
103_S	145_Y	0.515	0.72
103_S	106_V	0.514	0.72
209_G	215_G	0.514	0.72
65_Y	135_F	0.514	0.72
66_I	99_H	0.513	0.72
118_S	158_K	0.512	0.72
170_A	265_L	0.512	0.72
170_A	193_E	0.511	0.72
30_L	33_D	0.511	0.72
192_H	239_A	0.510	0.72
220_I	239_A	0.509	0.71
27_R	298_G	0.509	0.71
192_H	203_G	0.509	0.71
72_A	94_V	0.507	0.71
194_T	201_G	0.507	0.71
131_L	254_Q	0.506	0.71
255_N	279_P	0.506	0.71
239_A	243_A	0.506	0.71
234_A	268_L	0.503	0.70
134_G	139_A	0.503	0.70
22_P	142_F	0.503	0.70
75_G	81_E	0.503	0.70
188_T	199_F	0.501	0.70
55_E	59_L	0.501	0.70
109_T	125_A	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4bkxB	1	0.9457	100	0.152	Contact Map
4a69A	1	0.9406	100	0.153	Contact Map
4ly1A	2	0.938	100	0.162	Contact Map
2vqmA	1	0.9457	100	0.164	Contact Map
1c3pA	1	0.9328	100	0.168	Contact Map
4qa5A	1	0.9457	100	0.168	Contact Map
4bz7A	3	0.9509	100	0.174	Contact Map
1zz1A	4	0.8941	100	0.178	Contact Map
3menA	3	0.7984	100	0.215	Contact Map
4zurA	2	0.7933	100	0.215	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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