GREMLIN Database
ACUB - Acetoin utilization protein AcuB
UniProt: P39066 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 214 (173)
Sequences: 3452 (2248)
Seq/√Len: 170.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_A108_V3.9081.00
110_H113_K3.4141.00
14_L37_V3.3041.00
176_P180_V3.2911.00
72_R76_S3.0011.00
14_L18_D2.9681.00
18_D22_T2.8431.00
156_S160_D2.7521.00
133_A141_E2.6261.00
25_C29_E2.5681.00
21_E25_C2.5041.00
15_T18_D2.4781.00
87_P115_I2.3921.00
16_K45_I2.3521.00
39_D43_H2.2181.00
180_V183_F2.1871.00
23_A74_V2.1501.00
56_A72_R2.1191.00
73_S76_S2.0731.00
41_E113_K2.0631.00
83_V101_H2.0411.00
14_L23_A2.0321.00
151_L181_L2.0081.00
17_T75_D1.9191.00
43_H113_K1.9061.00
89_D93_E1.7901.00
48_I77_I1.7491.00
16_K75_D1.7021.00
15_T40_E1.6911.00
183_F187_T1.6681.00
90_F93_E1.6121.00
87_P110_H1.5941.00
12_I32_I1.5891.00
184_R188_M1.5621.00
27_L35_L1.5561.00
145_N155_S1.5561.00
86_H89_D1.5221.00
85_A89_D1.5081.00
170_V178_V1.4951.00
24_I28_K1.4921.00
23_A48_I1.4841.00
14_L35_L1.4761.00
50_D54_K1.4221.00
94_I98_F1.4141.00
96_A100_E1.3951.00
94_I106_L1.3921.00
34_H105_C1.3881.00
181_L184_R1.3861.00
44_V114_L1.3681.00
20_L56_A1.3611.00
16_K39_D1.3461.00
14_L74_V1.3371.00
23_A35_L1.3181.00
180_V184_R1.3101.00
156_S188_M1.3011.00
155_S166_L1.2931.00
21_E71_T1.2731.00
37_V74_V1.2721.00
155_S185_V1.2671.00
93_E96_A1.2381.00
91_V95_S1.2281.00
15_T39_D1.2231.00
124_L128_V1.1651.00
112_Q115_I1.1641.00
23_A27_L1.1471.00
47_M79_K1.1151.00
11_V117_I1.1131.00
39_D45_I1.1121.00
22_T25_C1.1061.00
52_D79_K1.0971.00
36_P44_V1.0931.00
153_E156_S1.0911.00
57_S96_A1.0711.00
17_T73_S1.0430.99
12_I30_F1.0390.99
168_V185_V1.0380.99
42_R113_K1.0380.99
136_P141_E1.0330.99
107_P114_L1.0310.99
20_L77_I1.0280.99
176_P179_K1.0270.99
99_Y102_G1.0250.99
109_V112_Q1.0110.99
138_S141_E1.0100.99
72_R77_I0.9920.99
82_V107_P0.9850.99
24_I53_M0.9660.99
177_G180_V0.9640.99
91_V123_L0.9560.99
56_A77_I0.9520.99
134_D138_S0.9480.99
150_S153_E0.9460.99
75_D80_K0.9460.99
32_I35_L0.9450.99
184_R187_T0.9360.99
122_D125_R0.9300.99
94_I118_L0.9200.99
149_K153_E0.9160.99
152_A188_M0.9080.98
8_K117_I0.9020.98
9_R137_G0.8990.98
156_S159_Q0.8990.98
166_L170_V0.8960.98
152_A155_S0.8800.98
152_A156_S0.8780.98
43_H111_H0.8770.98
27_L53_M0.8760.98
179_K183_F0.8620.98
120_K124_L0.8520.98
15_T45_I0.8520.98
18_D35_L0.8490.98
34_H104_G0.8440.98
34_H119_T0.8380.97
47_M52_D0.8310.97
46_G78_M0.8280.97
44_V107_P0.8260.97
19_T73_S0.8250.97
174_D178_V0.8240.97
11_V173_H0.8140.97
152_A184_R0.8110.97
53_M56_A0.8010.97
168_V182_V0.7920.96
19_T22_T0.7790.96
23_A95_S0.7720.96
12_I37_V0.7690.96
167_S171_Y0.7690.96
32_I36_P0.7670.96
54_K108_V0.7640.96
147_I151_L0.7620.96
133_A137_G0.7590.95
20_L53_M0.7570.95
12_I26_K0.7570.95
70_L73_S0.7500.95
95_S123_L0.7490.95
148_T151_L0.7490.95
182_V185_V0.7430.95
11_V49_T0.7420.95
31_H50_D0.7390.95
36_P122_D0.7370.95
176_P183_F0.7340.95
89_D97_V0.7270.94
163_V166_L0.7270.94
58_P71_T0.7260.94
146_D150_S0.7230.94
151_L155_S0.7220.94
124_L141_E0.7200.94
143_K147_I0.7160.94
33_R102_G0.7150.94
97_V101_H0.7140.94
95_S126_T0.7060.93
153_E157_L0.7030.93
47_M117_I0.7010.93
27_L30_F0.6950.93
33_R120_K0.6950.93
143_K146_D0.6930.93
20_L72_R0.6910.93
135_Q139_Q0.6830.92
157_L160_D0.6820.92
26_K35_L0.6810.92
147_I150_S0.6810.92
39_D113_K0.6810.92
13_T42_R0.6800.92
175_D179_K0.6780.92
35_L124_L0.6750.92
24_I108_V0.6740.92
99_Y125_R0.6740.92
34_H117_I0.6730.92
144_V148_T0.6620.91
50_D117_I0.6620.91
105_C117_I0.6620.91
85_A94_I0.6600.91
15_T38_V0.6580.91
58_P72_R0.6550.90
24_I35_L0.6500.90
53_M95_S0.6490.90
169_L172_P0.6430.90
47_M105_C0.6390.89
8_K122_D0.6390.89
92_E95_S0.6390.89
55_Q99_Y0.6390.89
133_A136_P0.6370.89
155_S159_Q0.6370.89
34_H107_P0.6370.89
164_K172_P0.6340.89
145_N148_T0.6340.89
16_K38_V0.6340.89
51_R54_K0.6340.89
166_L169_L0.6330.89
35_L74_V0.6300.89
12_I35_L0.6300.89
185_V188_M0.6260.88
150_S154_I0.6210.88
71_T80_K0.6210.88
15_T75_D0.6190.88
21_E136_P0.6180.88
98_F105_C0.6120.87
151_L170_V0.6100.87
159_Q163_V0.6080.87
146_D155_S0.5950.86
33_R52_D0.5920.86
27_L123_L0.5890.85
38_V45_I0.5890.85
26_K30_F0.5890.85
86_H90_F0.5880.85
135_Q173_H0.5860.85
23_A127_F0.5850.85
98_F106_L0.5850.85
103_I106_L0.5830.85
144_V147_I0.5790.84
147_I170_V0.5780.84
34_H51_R0.5720.84
39_D42_R0.5720.84
18_D26_K0.5700.83
78_M84_C0.5640.83
47_M51_R0.5640.83
158_C163_V0.5610.82
158_C161_L0.5600.82
53_M91_V0.5590.82
48_I56_A0.5570.82
104_G121_T0.5570.82
158_C165_I0.5570.82
111_H187_T0.5550.82
158_C169_L0.5530.81
137_G141_E0.5510.81
27_L31_H0.5510.81
163_V178_V0.5480.81
15_T25_C0.5460.81
78_M119_T0.5450.81
7_M36_P0.5450.81
95_S102_G0.5410.80
8_K11_V0.5410.80
168_V181_L0.5400.80
18_D75_D0.5380.80
51_R104_G0.5380.80
18_D74_V0.5370.80
149_K184_R0.5360.79
17_T40_E0.5340.79
90_F97_V0.5340.79
47_M82_V0.5310.79
16_K72_R0.5270.78
43_H112_Q0.5270.78
20_L24_I0.5260.78
7_M98_F0.5260.78
27_L37_V0.5260.78
152_A181_L0.5200.77
124_L127_F0.5140.77
172_P175_D0.5140.77
178_V182_V0.5140.77
176_P181_L0.5130.76
88_L108_V0.5110.76
83_V103_I0.5110.76
91_V126_T0.5100.76
85_A97_V0.5080.76
132_G154_I0.5070.76
95_S120_K0.5060.75
12_I74_V0.5050.75
17_T39_D0.5040.75
25_C31_H0.5040.75
143_K148_T0.5010.75
13_T115_I0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vr9A 1 0.5561 100 0.366 Contact Map
3l2bA 2 0.5654 100 0.417 Contact Map
3orgA 2 0.5374 99.9 0.443 Contact Map
4cooA 2 0.5794 99.9 0.445 Contact Map
3pc3A 2 0.5841 99.9 0.45 Contact Map
4nocA 2 0.6075 99.9 0.459 Contact Map
4esyA 2 0.6075 99.9 0.461 Contact Map
3fhmA 2 0.5841 99.9 0.464 Contact Map
2j9lA 3 0.6729 99.9 0.464 Contact Map
2d4zA 3 0.5935 99.9 0.465 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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