GREMLIN Database
ACUA - Acetoin utilization protein AcuA
UniProt: P39065 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (210)
Sequences: 249 (161)
Seq/√Len: 11.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_N190_N6.0401.00
124_E190_N5.2181.00
27_P57_G4.3381.00
14_T17_G4.2651.00
121_M163_G4.1780.99
36_H104_A3.5080.98
94_D192_S3.4900.98
92_M195_S2.7510.91
22_E67_R2.7240.91
116_L120_S2.6880.90
19_L112_V2.5490.88
78_Y120_S2.4650.86
79_L83_P2.4000.84
76_V116_L2.3200.82
167_W176_S2.2410.80
119_V145_M2.1540.77
21_I119_V2.0660.74
148_D151_E2.0450.73
124_E128_N1.9970.71
121_M162_A1.9860.71
168_F185_A1.9740.70
159_M163_G1.8970.67
113_G133_T1.8900.67
94_D195_S1.8740.66
36_H71_T1.8710.66
22_E65_I1.8030.63
27_P56_A1.7940.63
153_R157_E1.7860.62
38_D105_P1.7840.62
66_A103_V1.7400.60
49_H53_V1.7310.60
121_M159_M1.7050.59
121_M131_V1.6940.58
47_E107_Y1.6250.55
6_T164_G1.6130.54
122_M145_M1.6030.54
55_I77_T1.6000.54
54_D58_L1.5060.49
113_G159_M1.4940.49
7_Y25_V1.4890.48
64_I103_V1.4590.47
26_S70_R1.4050.44
21_I146_K1.3950.44
73_V89_E1.3890.44
90_G96_I1.3650.42
156_M160_M1.3590.42
38_D106_D1.3490.42
159_M162_A1.3360.41
157_E182_C1.3310.41
58_L169_A1.3260.41
79_L159_M1.3160.40
10_A122_M1.3120.40
25_V65_I1.3110.40
17_G68_D1.3020.39
47_E145_M1.2970.39
158_K165_L1.2940.39
68_D107_Y1.2860.39
52_L59_P1.2830.39
27_P53_V1.2820.39
129_Y143_K1.2800.38
134_T137_Y1.2720.38
55_I116_L1.2650.38
144_G153_R1.2560.37
8_H91_N1.2470.37
104_A167_W1.2420.37
8_H13_K1.2360.36
133_T208_Y1.2340.36
134_T174_E1.1940.35
44_P105_P1.1910.34
38_D104_A1.1780.34
36_H210_Y1.1720.34
151_E154_K1.1700.34
95_L130_I1.1530.33
127_E189_K1.1510.33
192_S195_S1.1390.32
109_G205_Y1.1380.32
167_W209_M1.1340.32
95_L177_S1.1300.32
177_S182_C1.1300.32
111_A115_T1.1230.32
34_E70_R1.1060.31
137_Y157_E1.1020.31
161_N209_M1.0880.30
35_F72_I1.0840.30
171_D177_S1.0780.30
55_I61_G1.0740.30
144_G164_G1.0600.29
19_L73_V1.0590.29
111_A114_K1.0530.29
95_L182_C1.0500.29
85_E160_M1.0500.29
105_P202_L1.0480.28
90_G202_L1.0320.28
153_R167_W1.0130.27
30_L72_I1.0010.27
117_L193_Q0.9980.27
161_N176_S0.9870.26
104_A210_Y0.9860.26
30_L49_H0.9830.26
36_H92_M0.9620.25
95_L165_L0.9570.25
6_T185_A0.9570.25
10_A202_L0.9530.25
34_E37_K0.9510.25
38_D92_M0.9490.25
31_A56_A0.9440.25
187_I203_R0.9430.25
52_L209_M0.9340.24
55_I76_V0.9290.24
40_T105_P0.9220.24
150_W157_E0.9180.24
2_E205_Y0.9130.23
120_S146_K0.9120.23
111_A121_M0.9080.23
64_I116_L0.9060.23
96_I131_V0.9050.23
9_S20_L0.9030.23
52_L56_A0.9000.23
85_E177_S0.8960.23
195_S207_R0.8910.23
78_Y146_K0.8900.23
153_R195_S0.8860.23
50_E190_N0.8830.22
95_L174_E0.8800.22
91_N106_D0.8780.22
105_P165_L0.8770.22
69_G115_T0.8720.22
53_V106_D0.8680.22
83_P159_M0.8610.22
92_M210_Y0.8590.22
33_Y196_I0.8550.22
157_E167_W0.8520.21
34_E54_D0.8370.21
13_K17_G0.8350.21
103_V120_S0.8310.21
73_V168_F0.8280.21
92_M95_L0.8230.21
25_V53_V0.8230.21
28_E201_R0.8180.20
66_A116_L0.8170.20
25_V32_G0.8100.20
8_H117_L0.8020.20
79_L121_M0.8010.20
48_Q135_E0.8000.20
169_A208_Y0.7990.20
176_S209_M0.7960.20
85_E156_M0.7960.20
126_M150_W0.7950.20
149_V169_A0.7950.20
77_T82_D0.7940.20
56_A191_V0.7930.20
11_N18_S0.7920.20
147_K172_E0.7890.19
20_L67_R0.7880.19
8_H21_I0.7880.19
18_S69_G0.7870.19
84_L151_E0.7850.19
62_R156_M0.7740.19
100_A174_E0.7710.19
200_D210_Y0.7690.19
24_P135_E0.7650.19
33_Y168_F0.7630.19
165_L197_E0.7590.19
71_T191_V0.7580.19
13_K18_S0.7570.19
63_I136_Y0.7570.19
117_L196_I0.7520.18
169_A176_S0.7510.18
29_D202_L0.7460.18
83_P126_M0.7460.18
12_I16_T0.7400.18
126_M129_Y0.7350.18
50_E59_P0.7340.18
127_E143_K0.7330.18
169_A209_M0.7330.18
38_D164_G0.7330.18
40_T45_P0.7300.18
92_M130_I0.7270.18
55_I82_D0.7230.18
13_K29_D0.7230.18
124_E127_E0.7230.18
18_S115_T0.7220.18
2_E111_A0.7200.17
13_K118_T0.7170.17
11_N194_E0.7150.17
106_D185_A0.7150.17
176_S185_A0.7140.17
10_A115_T0.7130.17
55_I108_R0.7110.17
116_L202_L0.7100.17
135_E180_A0.7100.17
34_E71_T0.7070.17
108_R130_I0.7060.17
64_I122_M0.7050.17
59_P189_K0.7020.17
111_A165_L0.7010.17
46_R50_E0.6980.17
34_E112_V0.6960.17
23_G135_E0.6960.17
13_K38_D0.6960.17
130_I195_S0.6950.17
150_W191_V0.6940.17
60_E80_Y0.6900.17
79_L117_L0.6900.17
62_R160_M0.6900.17
14_T112_V0.6850.16
36_H73_V0.6840.16
7_Y22_E0.6790.16
153_R176_S0.6780.16
143_K206_H0.6760.16
39_L117_L0.6680.16
21_I184_M0.6630.16
19_L198_Q0.6600.16
119_V122_M0.6600.16
17_G26_S0.6560.16
78_Y90_G0.6550.16
44_P132_M0.6550.16
9_S46_R0.6550.16
13_K189_K0.6530.16
112_V208_Y0.6460.15
4_H65_I0.6430.15
19_L210_Y0.6420.15
93_E185_A0.6420.15
7_Y16_T0.6390.15
135_E178_H0.6370.15
26_S69_G0.6360.15
59_P106_D0.6350.15
19_L31_A0.6340.15
10_A106_D0.6320.15
6_T11_N0.6320.15
77_T108_R0.6270.15
4_H9_S0.6270.15
101_I106_D0.6250.15
40_T120_S0.6250.15
121_M155_I0.6210.15
38_D69_G0.6180.15
125_Q206_H0.6140.15
194_E198_Q0.6140.15
4_H124_E0.6140.15
2_E91_N0.6090.15
4_H190_N0.6080.15
61_G76_V0.6070.15
12_I46_R0.6020.14
2_E10_A0.6020.14
35_F79_L0.6020.14
20_L31_A0.6010.14
85_E203_R0.6000.14
14_T65_I0.5980.14
63_I83_P0.5970.14
157_E177_S0.5960.14
41_A85_E0.5950.14
134_T182_C0.5910.14
120_S185_A0.5910.14
84_L204_F0.5900.14
48_Q99_G0.5890.14
49_H73_V0.5880.14
37_K146_K0.5880.14
159_M165_L0.5860.14
41_A156_M0.5840.14
30_L53_V0.5800.14
14_T202_L0.5790.14
137_Y182_C0.5770.14
118_T122_M0.5760.14
41_A160_M0.5750.14
60_E149_V0.5740.14
158_K163_G0.5690.14
23_G178_H0.5680.14
2_E154_K0.5680.14
109_G112_V0.5660.14
51_A60_E0.5650.14
128_N205_Y0.5630.13
2_E9_S0.5590.13
4_H33_Y0.5530.13
91_N202_L0.5520.13
86_R129_Y0.5510.13
133_T206_H0.5500.13
124_E192_S0.5490.13
193_Q202_L0.5480.13
191_V195_S0.5470.13
62_R85_E0.5470.13
47_E58_L0.5460.13
94_D153_R0.5450.13
13_K106_D0.5420.13
125_Q131_V0.5410.13
21_I41_A0.5410.13
35_F132_M0.5400.13
205_Y209_M0.5400.13
104_A145_M0.5360.13
123_D159_M0.5360.13
189_K194_E0.5350.13
2_E13_K0.5300.13
205_Y208_Y0.5300.13
65_I132_M0.5300.13
16_T202_L0.5300.13
143_K146_K0.5290.13
160_M182_C0.5260.13
62_R82_D0.5230.13
25_V93_E0.5220.13
112_V197_E0.5220.13
85_E182_C0.5170.12
137_Y177_S0.5170.12
9_S32_G0.5160.12
31_A53_V0.5160.12
91_N117_L0.5150.12
82_D160_M0.5140.12
129_Y148_D0.5140.12
13_K26_S0.5110.12
195_S204_F0.5090.12
110_C115_T0.5070.12
41_A64_I0.5060.12
11_N69_G0.5050.12
126_M154_K0.5040.12
9_S69_G0.5040.12
166_V210_Y0.5020.12
85_E136_Y0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q04A 5 0.9952 100 0.653 Contact Map
3lodA 1 0.6667 98.4 0.907 Contact Map
3pp9A 2 0.7333 98.3 0.908 Contact Map
2oh1A 1 0.7619 98.3 0.909 Contact Map
2q7bA 2 0.7095 98.3 0.909 Contact Map
1s3zA 2 0.6952 98.3 0.91 Contact Map
2fl4A 2 0.6857 98.3 0.91 Contact Map
3exnA 1 0.6905 98.2 0.911 Contact Map
1yx0A 1 0.6905 98.2 0.912 Contact Map
3fynA 2 0.6952 98.2 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.