GREMLIN Database
YTXE - Uncharacterized protein YtxE
UniProt: P39064 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (210)
Sequences: 4448 (3375)
Seq/√Len: 232.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_D138_L5.0271.00
182_S208_G3.8391.00
217_D223_H3.6651.00
216_K223_H3.2761.00
209_Y213_K3.2581.00
218_N223_H3.2251.00
168_R224_M3.1541.00
146_H192_Y3.1351.00
145_L192_Y2.8021.00
132_T168_R2.6371.00
166_D178_N2.5791.00
190_I206_A2.5741.00
164_H213_K2.5251.00
161_V190_I2.4681.00
95_L99_N2.3761.00
220_T223_H2.2881.00
135_A184_A2.2521.00
180_E191_Q2.2491.00
123_V231_E2.2241.00
137_V192_Y2.1571.00
167_S224_M2.1221.00
146_H197_E2.0811.00
162_E209_Y2.0701.00
216_K226_E2.0431.00
28_F32_I1.8881.00
183_A187_S1.8511.00
219_K223_H1.8281.00
172_T176_P1.8271.00
183_A208_G1.7791.00
218_N224_M1.7681.00
194_T204_F1.7571.00
133_G177_S1.6751.00
177_S180_E1.6591.00
38_F41_L1.6041.00
162_E233_V1.5781.00
194_T201_S1.5741.00
28_F33_T1.5391.00
180_E184_A1.5101.00
160_Q205_I1.4861.00
167_S218_N1.4761.00
149_A193_F1.4731.00
175_Y184_A1.4661.00
176_P184_A1.4621.00
135_A175_Y1.4511.00
137_V141_A1.4471.00
142_E192_Y1.4161.00
167_S223_H1.4021.00
48_I53_F1.3801.00
160_Q207_V1.3781.00
187_S190_I1.3551.00
139_K142_E1.3471.00
176_P180_E1.3291.00
32_I38_F1.3251.00
214_P227_N1.3241.00
217_D220_T1.3201.00
145_L189_V1.3201.00
49_D52_K1.3171.00
27_T31_L1.3101.00
148_I152_L1.3041.00
27_T36_L1.2861.00
38_F42_L1.2781.00
166_D228_R1.2691.00
169_N178_N1.2691.00
177_S191_Q1.2641.00
36_L40_I1.2581.00
121_V231_E1.2531.00
88_E92_D1.2521.00
22_S25_M1.2381.00
179_W210_A1.2301.00
184_A187_S1.2281.00
26_V29_T1.2101.00
201_S212_T1.1921.00
114_K123_V1.1831.00
87_Q90_Q1.1731.00
131_D134_E1.1711.00
169_N177_S1.1691.00
19_Q22_S1.1561.00
179_W183_A1.1501.00
200_P203_R1.1451.00
199_L204_F1.1361.00
93_Q97_K1.1361.00
192_Y197_E1.1331.00
205_I209_Y1.1191.00
216_K224_M1.1031.00
170_I175_Y1.0881.00
190_I204_F1.0871.00
132_T166_D1.0741.00
116_D119_G1.0701.00
162_E207_V1.0661.00
89_D92_D1.0611.00
186_A208_G1.0571.00
220_T224_M1.0491.00
164_H210_A1.0461.00
191_Q195_S1.0451.00
96_K100_T1.0231.00
50_L54_K1.0221.00
189_V230_V1.0081.00
23_S27_T1.0001.00
170_I177_S0.9991.00
129_L141_A0.9951.00
149_A199_L0.9931.00
192_Y195_S0.9921.00
50_L53_F0.9881.00
20_S23_S0.9831.00
18_S21_S0.9801.00
27_T38_F0.9791.00
145_L193_F0.9761.00
118_R121_V0.9761.00
89_D93_Q0.9581.00
215_V226_E0.9571.00
17_N21_S0.9501.00
85_K88_E0.9451.00
220_T227_N0.9431.00
187_S191_Q0.9401.00
100_T104_D0.9371.00
87_Q91_Q0.9281.00
199_L203_R0.9271.00
93_Q96_K0.9221.00
18_S22_S0.9221.00
113_A120_V0.9211.00
170_I176_P0.9191.00
216_K219_K0.9181.00
54_K58_D0.9171.00
183_A206_A0.9101.00
27_T44_S0.9101.00
132_T178_N0.9081.00
47_Q50_L0.9031.00
149_A197_E0.9031.00
150_V153_Q0.8980.99
57_V60_I0.8940.99
164_H214_P0.8910.99
92_D95_L0.8900.99
59_S63_E0.8880.99
56_A60_I0.8840.99
26_V31_L0.8830.99
172_T175_Y0.8790.99
64_G68_Q0.8710.99
85_K89_D0.8690.99
26_V37_V0.8630.99
57_V61_Q0.8610.99
118_R162_E0.8600.99
99_N103_K0.8570.99
41_L44_S0.8550.99
148_I151_L0.8470.99
121_V233_V0.8390.99
21_S26_V0.8380.99
165_T210_A0.8370.99
54_K57_V0.8250.99
83_D86_K0.8220.99
214_P220_T0.8210.99
112_T125_Q0.8160.99
179_W212_T0.8140.99
17_N22_S0.8130.99
25_M34_L0.8110.99
92_D96_K0.8090.99
27_T34_L0.8050.99
40_I44_S0.8030.99
37_V43_F0.8020.99
214_P223_H0.7980.99
143_T146_H0.7940.99
146_H150_V0.7810.99
44_S48_I0.7800.99
166_D169_N0.7730.98
22_S27_T0.7710.98
176_P191_Q0.7700.98
131_D137_V0.7700.98
81_P88_E0.7650.98
140_N143_T0.7640.98
27_T53_F0.7640.98
133_G178_N0.7610.98
163_G230_V0.7540.98
106_H110_Q0.7520.98
90_Q93_Q0.7510.98
23_S32_I0.7510.98
31_L37_V0.7450.98
51_Q55_A0.7440.98
119_G233_V0.7390.98
26_V41_L0.7360.98
114_K121_V0.7340.98
84_T88_E0.7320.98
34_L40_I0.7290.98
148_I232_I0.7280.98
205_I235_K0.7250.98
144_L147_Q0.7210.98
188_G191_Q0.7160.97
153_Q197_E0.7150.97
138_L143_T0.7120.97
214_P229_R0.7110.97
97_K100_T0.7110.97
20_S25_M0.7100.97
96_K99_N0.7080.97
179_W206_A0.7010.97
30_D39_F0.7000.97
34_L38_F0.6990.97
222_E226_E0.6960.97
216_K220_T0.6960.97
24_W37_V0.6940.97
178_N228_R0.6900.97
28_F37_V0.6900.97
179_W187_S0.6890.97
142_E146_H0.6880.97
86_K89_D0.6870.97
19_Q23_S0.6840.97
152_L199_L0.6830.97
40_I43_F0.6810.97
60_I63_E0.6750.96
42_L45_M0.6740.96
37_V41_L0.6740.96
64_G67_L0.6730.96
164_H212_T0.6630.96
138_L141_A0.6610.96
97_K101_Y0.6570.96
129_L162_E0.6550.96
161_V206_A0.6530.96
27_T32_I0.6530.96
160_Q233_V0.6480.95
97_K154_T0.6470.95
143_T147_Q0.6470.95
31_L43_F0.6450.95
82_S85_K0.6440.95
123_V215_V0.6420.95
17_N20_S0.6400.95
133_G166_D0.6380.95
25_M31_L0.6380.95
147_Q150_V0.6370.95
34_L37_V0.6330.95
131_D136_K0.6310.95
201_S211_D0.6300.95
82_S86_K0.6290.95
214_P224_M0.6200.94
47_Q51_Q0.6150.94
223_H226_E0.6150.94
52_K55_A0.6150.94
160_Q235_K0.6120.94
41_L48_I0.6120.94
173_Y176_P0.6090.94
218_N227_N0.6080.94
25_M33_T0.6080.94
162_E213_K0.6080.94
22_S26_V0.6060.94
88_E91_Q0.6050.93
79_T83_D0.6020.93
162_E231_E0.6000.93
25_M44_S0.5990.93
39_F42_L0.5960.93
124_L129_L0.5950.93
134_E174_R0.5920.93
88_E96_K0.5910.93
133_G170_I0.5850.92
121_V234_I0.5850.92
53_F56_A0.5830.92
43_F46_S0.5810.92
194_T198_K0.5810.92
80_S85_K0.5810.92
94_L99_N0.5800.92
183_A210_A0.5780.92
215_V229_R0.5770.92
214_P218_N0.5770.92
22_S32_I0.5750.92
81_P85_K0.5720.91
69_P86_K0.5710.91
170_I173_Y0.5700.91
183_A207_V0.5670.91
110_Q113_A0.5670.91
153_Q198_K0.5640.91
31_L45_M0.5590.91
162_E205_I0.5570.90
126_E129_L0.5530.90
189_V232_I0.5520.90
120_V234_I0.5520.90
150_V154_T0.5520.90
22_S34_L0.5510.90
128_V141_A0.5510.90
161_V186_A0.5500.90
62_K68_Q0.5500.90
159_I232_I0.5480.90
47_Q53_F0.5460.90
187_S206_A0.5420.89
29_T32_I0.5420.89
179_W230_V0.5420.89
113_A116_D0.5400.89
60_I64_G0.5390.89
137_V189_V0.5390.89
118_R233_V0.5380.89
79_T82_S0.5350.89
58_D65_N0.5340.88
22_S41_L0.5330.88
172_T177_S0.5310.88
153_Q199_L0.5270.88
29_T36_L0.5250.88
58_D61_Q0.5210.87
118_R235_K0.5200.87
37_V44_S0.5170.87
26_V36_L0.5170.87
177_S207_V0.5170.87
128_V232_I0.5140.87
174_R184_A0.5130.86
20_S27_T0.5130.86
34_L46_S0.5120.86
102_I106_H0.5120.86
24_W46_S0.5120.86
220_T225_K0.5100.86
80_S84_T0.5090.86
175_Y178_N0.5090.86
156_P208_G0.5080.86
101_Y104_D0.5080.86
22_S38_F0.5070.86
171_S174_R0.5070.86
223_H227_N0.5060.86
28_F42_L0.5040.85
43_F48_I0.5040.85
62_K65_N0.5020.85
32_I36_L0.5010.85
146_H149_A0.5000.85
112_T123_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wpwA 2 0.6157 100 0.39 Contact Map
3s0yA 4 0.7149 100 0.429 Contact Map
3khnA 2 0.6488 100 0.43 Contact Map
4b62A 1 0.5909 100 0.432 Contact Map
2zovA 2 0.595 100 0.448 Contact Map
2zvyA 2 0.6694 100 0.449 Contact Map
2k1sA 1 0.5992 100 0.45 Contact Map
3ldtA 2 0.5909 100 0.454 Contact Map
3s06A 3 0.6033 100 0.456 Contact Map
1r1mA 1 0.4917 100 0.467 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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