YTXE - BACSU - GREMLIN Contacts

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YTXE - Uncharacterized protein YtxE

UniProt:	P39064	Sequences: MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFSMSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYIKDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQVEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDNKTNEHMKENRRVEIVIKKSKTTSS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	242 (210)
Sequences:	4448 (3375)
Seq/√Len:	232.9

ECOLI - MOTB YIAD PAL MBHA YFIB OMPA
BACSU - YTXE MOTB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
131_D	138_L	5.027	1.00
182_S	208_G	3.839	1.00
217_D	223_H	3.665	1.00
216_K	223_H	3.276	1.00
209_Y	213_K	3.258	1.00
218_N	223_H	3.225	1.00
168_R	224_M	3.154	1.00
146_H	192_Y	3.135	1.00
145_L	192_Y	2.802	1.00
132_T	168_R	2.637	1.00
166_D	178_N	2.579	1.00
190_I	206_A	2.574	1.00
164_H	213_K	2.525	1.00
161_V	190_I	2.468	1.00
95_L	99_N	2.376	1.00
220_T	223_H	2.288	1.00
135_A	184_A	2.252	1.00
180_E	191_Q	2.249	1.00
123_V	231_E	2.224	1.00
137_V	192_Y	2.157	1.00
167_S	224_M	2.122	1.00
146_H	197_E	2.081	1.00
162_E	209_Y	2.070	1.00
216_K	226_E	2.043	1.00
28_F	32_I	1.888	1.00
183_A	187_S	1.851	1.00
219_K	223_H	1.828	1.00
172_T	176_P	1.827	1.00
183_A	208_G	1.779	1.00
218_N	224_M	1.768	1.00
194_T	204_F	1.757	1.00
133_G	177_S	1.675	1.00
177_S	180_E	1.659	1.00
38_F	41_L	1.604	1.00
162_E	233_V	1.578	1.00
194_T	201_S	1.574	1.00
28_F	33_T	1.539	1.00
180_E	184_A	1.510	1.00
160_Q	205_I	1.486	1.00
167_S	218_N	1.476	1.00
149_A	193_F	1.473	1.00
175_Y	184_A	1.466	1.00
176_P	184_A	1.462	1.00
135_A	175_Y	1.451	1.00
137_V	141_A	1.447	1.00
142_E	192_Y	1.416	1.00
167_S	223_H	1.402	1.00
48_I	53_F	1.380	1.00
160_Q	207_V	1.378	1.00
187_S	190_I	1.355	1.00
139_K	142_E	1.347	1.00
176_P	180_E	1.329	1.00
32_I	38_F	1.325	1.00
214_P	227_N	1.324	1.00
217_D	220_T	1.320	1.00
145_L	189_V	1.320	1.00
49_D	52_K	1.317	1.00
27_T	31_L	1.310	1.00
148_I	152_L	1.304	1.00
27_T	36_L	1.286	1.00
38_F	42_L	1.278	1.00
166_D	228_R	1.269	1.00
169_N	178_N	1.269	1.00
177_S	191_Q	1.264	1.00
36_L	40_I	1.258	1.00
121_V	231_E	1.253	1.00
88_E	92_D	1.252	1.00
22_S	25_M	1.238	1.00
179_W	210_A	1.230	1.00
184_A	187_S	1.228	1.00
26_V	29_T	1.210	1.00
201_S	212_T	1.192	1.00
114_K	123_V	1.183	1.00
87_Q	90_Q	1.173	1.00
131_D	134_E	1.171	1.00
169_N	177_S	1.169	1.00
19_Q	22_S	1.156	1.00
179_W	183_A	1.150	1.00
200_P	203_R	1.145	1.00
199_L	204_F	1.136	1.00
93_Q	97_K	1.136	1.00
192_Y	197_E	1.133	1.00
205_I	209_Y	1.119	1.00
216_K	224_M	1.103	1.00
170_I	175_Y	1.088	1.00
190_I	204_F	1.087	1.00
132_T	166_D	1.074	1.00
116_D	119_G	1.070	1.00
162_E	207_V	1.066	1.00
89_D	92_D	1.061	1.00
186_A	208_G	1.057	1.00
220_T	224_M	1.049	1.00
164_H	210_A	1.046	1.00
191_Q	195_S	1.045	1.00
96_K	100_T	1.023	1.00
50_L	54_K	1.022	1.00
189_V	230_V	1.008	1.00
23_S	27_T	1.000	1.00
170_I	177_S	0.999	1.00
129_L	141_A	0.995	1.00
149_A	199_L	0.993	1.00
192_Y	195_S	0.992	1.00
50_L	53_F	0.988	1.00
20_S	23_S	0.983	1.00
18_S	21_S	0.980	1.00
27_T	38_F	0.979	1.00
145_L	193_F	0.976	1.00
118_R	121_V	0.976	1.00
89_D	93_Q	0.958	1.00
215_V	226_E	0.957	1.00
17_N	21_S	0.950	1.00
85_K	88_E	0.945	1.00
220_T	227_N	0.943	1.00
187_S	191_Q	0.940	1.00
100_T	104_D	0.937	1.00
87_Q	91_Q	0.928	1.00
199_L	203_R	0.927	1.00
93_Q	96_K	0.922	1.00
18_S	22_S	0.922	1.00
113_A	120_V	0.921	1.00
170_I	176_P	0.919	1.00
216_K	219_K	0.918	1.00
54_K	58_D	0.917	1.00
183_A	206_A	0.910	1.00
27_T	44_S	0.910	1.00
132_T	178_N	0.908	1.00
47_Q	50_L	0.903	1.00
149_A	197_E	0.903	1.00
150_V	153_Q	0.898	0.99
57_V	60_I	0.894	0.99
164_H	214_P	0.891	0.99
92_D	95_L	0.890	0.99
59_S	63_E	0.888	0.99
56_A	60_I	0.884	0.99
26_V	31_L	0.883	0.99
172_T	175_Y	0.879	0.99
64_G	68_Q	0.871	0.99
85_K	89_D	0.869	0.99
26_V	37_V	0.863	0.99
57_V	61_Q	0.861	0.99
118_R	162_E	0.860	0.99
99_N	103_K	0.857	0.99
41_L	44_S	0.855	0.99
148_I	151_L	0.847	0.99
121_V	233_V	0.839	0.99
21_S	26_V	0.838	0.99
165_T	210_A	0.837	0.99
54_K	57_V	0.825	0.99
83_D	86_K	0.822	0.99
214_P	220_T	0.821	0.99
112_T	125_Q	0.816	0.99
179_W	212_T	0.814	0.99
17_N	22_S	0.813	0.99
25_M	34_L	0.811	0.99
92_D	96_K	0.809	0.99
27_T	34_L	0.805	0.99
40_I	44_S	0.803	0.99
37_V	43_F	0.802	0.99
214_P	223_H	0.798	0.99
143_T	146_H	0.794	0.99
146_H	150_V	0.781	0.99
44_S	48_I	0.780	0.99
166_D	169_N	0.773	0.98
22_S	27_T	0.771	0.98
176_P	191_Q	0.770	0.98
131_D	137_V	0.770	0.98
81_P	88_E	0.765	0.98
140_N	143_T	0.764	0.98
27_T	53_F	0.764	0.98
133_G	178_N	0.761	0.98
163_G	230_V	0.754	0.98
106_H	110_Q	0.752	0.98
90_Q	93_Q	0.751	0.98
23_S	32_I	0.751	0.98
31_L	37_V	0.745	0.98
51_Q	55_A	0.744	0.98
119_G	233_V	0.739	0.98
26_V	41_L	0.736	0.98
114_K	121_V	0.734	0.98
84_T	88_E	0.732	0.98
34_L	40_I	0.729	0.98
148_I	232_I	0.728	0.98
205_I	235_K	0.725	0.98
144_L	147_Q	0.721	0.98
188_G	191_Q	0.716	0.97
153_Q	197_E	0.715	0.97
138_L	143_T	0.712	0.97
214_P	229_R	0.711	0.97
97_K	100_T	0.711	0.97
20_S	25_M	0.710	0.97
96_K	99_N	0.708	0.97
179_W	206_A	0.701	0.97
30_D	39_F	0.700	0.97
34_L	38_F	0.699	0.97
222_E	226_E	0.696	0.97
216_K	220_T	0.696	0.97
24_W	37_V	0.694	0.97
178_N	228_R	0.690	0.97
28_F	37_V	0.690	0.97
179_W	187_S	0.689	0.97
142_E	146_H	0.688	0.97
86_K	89_D	0.687	0.97
19_Q	23_S	0.684	0.97
152_L	199_L	0.683	0.97
40_I	43_F	0.681	0.97
60_I	63_E	0.675	0.96
42_L	45_M	0.674	0.96
37_V	41_L	0.674	0.96
64_G	67_L	0.673	0.96
164_H	212_T	0.663	0.96
138_L	141_A	0.661	0.96
97_K	101_Y	0.657	0.96
129_L	162_E	0.655	0.96
161_V	206_A	0.653	0.96
27_T	32_I	0.653	0.96
160_Q	233_V	0.648	0.95
97_K	154_T	0.647	0.95
143_T	147_Q	0.647	0.95
31_L	43_F	0.645	0.95
82_S	85_K	0.644	0.95
123_V	215_V	0.642	0.95
17_N	20_S	0.640	0.95
133_G	166_D	0.638	0.95
25_M	31_L	0.638	0.95
147_Q	150_V	0.637	0.95
34_L	37_V	0.633	0.95
131_D	136_K	0.631	0.95
201_S	211_D	0.630	0.95
82_S	86_K	0.629	0.95
214_P	224_M	0.620	0.94
47_Q	51_Q	0.615	0.94
223_H	226_E	0.615	0.94
52_K	55_A	0.615	0.94
160_Q	235_K	0.612	0.94
41_L	48_I	0.612	0.94
173_Y	176_P	0.609	0.94
218_N	227_N	0.608	0.94
25_M	33_T	0.608	0.94
162_E	213_K	0.608	0.94
22_S	26_V	0.606	0.94
88_E	91_Q	0.605	0.93
79_T	83_D	0.602	0.93
162_E	231_E	0.600	0.93
25_M	44_S	0.599	0.93
39_F	42_L	0.596	0.93
124_L	129_L	0.595	0.93
134_E	174_R	0.592	0.93
88_E	96_K	0.591	0.93
133_G	170_I	0.585	0.92
121_V	234_I	0.585	0.92
53_F	56_A	0.583	0.92
43_F	46_S	0.581	0.92
194_T	198_K	0.581	0.92
80_S	85_K	0.581	0.92
94_L	99_N	0.580	0.92
183_A	210_A	0.578	0.92
215_V	229_R	0.577	0.92
214_P	218_N	0.577	0.92
22_S	32_I	0.575	0.92
81_P	85_K	0.572	0.91
69_P	86_K	0.571	0.91
170_I	173_Y	0.570	0.91
183_A	207_V	0.567	0.91
110_Q	113_A	0.567	0.91
153_Q	198_K	0.564	0.91
31_L	45_M	0.559	0.91
162_E	205_I	0.557	0.90
126_E	129_L	0.553	0.90
189_V	232_I	0.552	0.90
120_V	234_I	0.552	0.90
150_V	154_T	0.552	0.90
22_S	34_L	0.551	0.90
128_V	141_A	0.551	0.90
161_V	186_A	0.550	0.90
62_K	68_Q	0.550	0.90
159_I	232_I	0.548	0.90
47_Q	53_F	0.546	0.90
187_S	206_A	0.542	0.89
29_T	32_I	0.542	0.89
179_W	230_V	0.542	0.89
113_A	116_D	0.540	0.89
60_I	64_G	0.539	0.89
137_V	189_V	0.539	0.89
118_R	233_V	0.538	0.89
79_T	82_S	0.535	0.89
58_D	65_N	0.534	0.88
22_S	41_L	0.533	0.88
172_T	177_S	0.531	0.88
153_Q	199_L	0.527	0.88
29_T	36_L	0.525	0.88
58_D	61_Q	0.521	0.87
118_R	235_K	0.520	0.87
37_V	44_S	0.517	0.87
26_V	36_L	0.517	0.87
177_S	207_V	0.517	0.87
128_V	232_I	0.514	0.87
174_R	184_A	0.513	0.86
20_S	27_T	0.513	0.86
34_L	46_S	0.512	0.86
102_I	106_H	0.512	0.86
24_W	46_S	0.512	0.86
220_T	225_K	0.510	0.86
80_S	84_T	0.509	0.86
175_Y	178_N	0.509	0.86
156_P	208_G	0.508	0.86
101_Y	104_D	0.508	0.86
22_S	38_F	0.507	0.86
171_S	174_R	0.507	0.86
223_H	227_N	0.506	0.86
28_F	42_L	0.504	0.85
43_F	48_I	0.504	0.85
62_K	65_N	0.502	0.85
32_I	36_L	0.501	0.85
146_H	149_A	0.500	0.85
112_T	123_V	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wpwA	2	0.6157	100	0.39	Contact Map
3s0yA	4	0.7149	100	0.429	Contact Map
3khnA	2	0.6488	100	0.43	Contact Map
4b62A	1	0.5909	100	0.432	Contact Map
2zovA	2	0.595	100	0.448	Contact Map
2zvyA	2	0.6694	100	0.449	Contact Map
2k1sA	1	0.5992	100	0.45	Contact Map
3ldtA	2	0.5909	100	0.454	Contact Map
3s06A	3	0.6033	100	0.456	Contact Map
1r1mA	1	0.4917	100	0.467	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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