GREMLIN Database
YTXD - Uncharacterized protein YtxD
UniProt: P39063 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (249)
Sequences: 2330 (1540)
Seq/√Len: 97.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_G206_N3.7731.00
137_I227_V3.7431.00
92_H104_Q3.3491.00
92_H100_S3.2621.00
22_G43_I3.0561.00
69_K73_I3.0131.00
48_L154_A2.9001.00
151_F208_I2.7861.00
14_L50_A2.7471.00
171_V192_L2.7061.00
110_D223_K2.5971.00
116_G230_I2.5871.00
179_D182_M2.5241.00
144_H219_E2.4241.00
78_N81_D2.3811.00
137_I220_I2.3341.00
152_E209_A2.2881.00
53_F61_L2.2511.00
200_L205_F2.1901.00
115_K136_E2.1711.00
45_T200_L2.1651.00
15_G203_M2.1631.00
64_A151_F2.1581.00
140_M220_I2.1551.00
86_F242_L2.0661.00
48_L158_A2.0611.00
31_G172_L2.0451.00
37_D40_S2.0141.00
8_T211_K1.9201.00
55_S210_A1.9191.00
62_K66_S1.9091.00
71_A208_I1.9001.00
158_A200_L1.8911.00
57_P60_E1.8591.00
144_H216_T1.8521.00
229_G246_L1.8141.00
141_E220_I1.8001.00
34_S175_K1.7811.00
67_V147_G1.7431.00
113_L226_M1.7341.00
58_P62_K1.7091.00
232_G237_K1.7001.00
140_M144_H1.6471.00
32_F36_L1.6391.00
26_G172_L1.6221.00
13_V17_I1.6111.00
130_R134_D1.5861.00
16_T20_V1.5811.00
19_I47_G1.5501.00
41_F45_T1.5421.00
136_E255_W1.5211.00
66_S69_K1.5161.00
130_R228_E1.5151.00
228_E249_F1.5111.00
173_M191_L1.4881.00
84_K243_E1.4871.00
160_A191_L1.4851.00
8_T71_A1.4851.00
61_L64_A1.4641.00
23_I35_F1.4451.00
158_A205_F1.4451.00
8_T54_I1.4441.00
60_E214_E1.4321.00
152_E213_E1.4231.00
52_V154_A1.4030.99
17_I21_I1.4020.99
243_E247_V1.3910.99
240_R243_E1.3900.99
15_G50_A1.3870.99
9_P13_V1.3720.99
88_S91_D1.3660.99
40_S193_T1.3370.99
133_M230_I1.3200.99
19_I199_L1.3130.99
10_V17_I1.2960.99
86_F229_G1.2720.99
104_Q107_E1.2620.99
154_A205_F1.2440.99
182_M185_P1.2430.99
21_I25_S1.2310.99
93_A101_L1.2190.99
92_H96_H1.2130.99
23_I28_G1.2100.98
52_V61_L1.2030.98
163_M193_T1.1920.98
163_M187_M1.1900.98
128_T237_K1.1880.98
64_A68_L1.1870.98
115_K244_S1.1860.98
64_A150_V1.1750.98
167_L187_M1.1740.98
106_R118_L1.1670.98
82_L226_M1.1560.98
144_H212_L1.1410.98
25_S42_F1.1400.98
187_M198_S1.1180.97
17_I20_V1.1110.97
105_A118_L1.1100.97
172_L186_N1.1070.97
160_A187_M1.1040.97
148_R216_T1.1030.97
18_I50_A1.0990.97
166_T195_L1.0920.97
19_I203_M1.0860.97
140_M216_T1.0740.97
187_M191_L1.0670.97
35_F172_L1.0670.97
135_S139_A1.0640.97
120_A129_I1.0620.97
125_D128_T1.0590.96
182_M186_N1.0400.96
16_T204_V1.0310.96
85_T108_I1.0270.96
222_I226_M1.0230.96
183_L187_M1.0230.96
51_A157_F1.0200.96
116_G133_M1.0090.95
199_L203_M1.0050.95
81_D85_T0.9950.95
37_D189_I0.9950.95
10_V14_L0.9940.95
60_E150_V0.9910.95
187_M193_T0.9870.95
68_L151_F0.9780.94
166_T174_L0.9770.94
56_F149_R0.9770.94
92_H101_L0.9760.94
166_T173_M0.9740.94
86_F124_W0.9660.94
211_K215_K0.9630.94
36_L41_F0.9620.94
60_E146_K0.9590.94
68_L208_I0.9550.94
164_I199_L0.9520.94
129_I234_Q0.9480.94
71_A211_K0.9410.93
134_D227_V0.9360.93
119_L132_V0.9360.93
184_G188_A0.9330.93
124_W132_V0.9310.93
185_P188_A0.9290.93
173_M187_M0.9190.92
89_L117_L0.9170.92
25_S39_T0.9170.92
163_M173_M0.9170.92
111_P114_K0.9110.92
91_D95_K0.9080.92
55_S153_K0.9060.92
43_I168_V0.8980.92
82_L222_I0.8970.92
251_S254_E0.8960.91
148_R213_E0.8890.91
74_R215_K0.8830.91
161_W186_N0.8770.91
232_G245_Q0.8760.91
216_T220_I0.8750.90
118_L244_S0.8720.90
62_K65_P0.8680.90
157_F202_N0.8640.90
24_I32_F0.8610.90
185_P189_I0.8580.90
177_L184_G0.8560.90
56_F153_K0.8550.89
252_R255_W0.8550.89
174_L195_L0.8530.89
228_E245_Q0.8530.89
163_M198_S0.8500.89
120_A234_Q0.8500.89
153_K157_F0.8480.89
85_T113_L0.8350.88
151_F205_F0.8290.88
23_I195_L0.8260.88
89_L101_L0.8240.88
179_D183_L0.8230.88
63_K146_K0.8210.87
67_V71_A0.8200.87
33_R36_L0.8190.87
77_D81_D0.8170.87
166_T192_L0.8150.87
87_V243_E0.8150.87
14_L53_F0.8100.87
26_G191_L0.8070.87
232_G242_L0.8060.87
79_V222_I0.8050.86
44_V199_L0.8020.86
151_F212_L0.8020.86
94_R238_N0.8000.86
45_T49_C0.7990.86
160_A173_M0.7970.86
7_L14_L0.7920.86
124_W129_I0.7890.85
77_D222_I0.7870.85
35_F173_M0.7830.85
40_S166_T0.7810.85
200_L204_V0.7810.85
26_G193_T0.7770.84
137_I223_K0.7750.84
183_L186_N0.7700.84
18_I46_G0.7700.84
12_F16_T0.7680.84
180_P183_L0.7680.84
167_L198_S0.7670.84
160_A193_T0.7670.84
54_I71_A0.7660.84
51_A203_M0.7600.83
38_L41_F0.7600.83
148_R152_E0.7590.83
131_L135_S0.7580.83
163_M167_L0.7560.83
143_R219_E0.7550.83
126_E235_S0.7540.83
58_P61_L0.7530.83
88_S104_Q0.7530.83
120_A230_I0.7510.82
237_K245_Q0.7470.82
141_E216_T0.7460.82
109_K226_M0.7450.82
12_F54_I0.7430.82
123_G236_G0.7410.82
160_A167_L0.7400.81
42_F155_G0.7380.81
153_K156_E0.7340.81
52_V64_A0.7270.80
167_L191_L0.7270.80
90_S229_G0.7260.80
137_I224_Q0.7240.80
138_A141_E0.7230.80
87_V239_P0.7210.80
27_S186_N0.7200.80
89_L230_I0.7190.80
16_T78_N0.7190.80
56_F150_V0.7180.79
163_M191_L0.7170.79
31_G34_S0.7160.79
161_W164_I0.7150.79
161_W185_P0.7080.79
180_P185_P0.7060.78
181_H185_P0.7040.78
160_A163_M0.6940.77
66_S253_E0.6890.77
65_P68_L0.6820.76
119_L237_K0.6800.76
155_G191_L0.6800.76
182_M188_A0.6800.76
23_I163_M0.6790.76
161_W175_K0.6790.76
51_A161_W0.6770.75
52_V150_V0.6760.75
48_L205_F0.6750.75
117_L121_I0.6730.75
85_T104_Q0.6650.74
66_S149_R0.6650.74
212_L219_E0.6600.74
59_S63_K0.6600.74
53_F58_P0.6590.73
143_R212_L0.6580.73
166_T202_N0.6540.73
173_M202_N0.6530.73
225_V249_F0.6520.73
128_T131_L0.6490.72
67_V212_L0.6400.71
233_V242_L0.6400.71
60_E218_S0.6380.71
21_I32_F0.6380.71
44_V203_M0.6380.71
139_A142_E0.6330.70
77_D110_D0.6310.70
18_I35_F0.6310.70
166_T182_M0.6310.70
166_T193_T0.6300.70
23_I168_V0.6280.70
146_K149_R0.6270.70
26_G173_M0.6230.69
172_L175_K0.6230.69
193_T199_L0.6220.69
111_P252_R0.6220.69
166_T187_M0.6190.69
231_I235_S0.6140.68
57_P63_K0.6140.68
241_N244_S0.6120.68
91_D242_L0.6120.68
151_F154_A0.6110.68
124_W248_V0.6100.68
99_L121_I0.6100.68
196_Y202_N0.6090.67
152_E156_E0.6080.67
161_W172_L0.6080.67
180_P184_G0.6080.67
131_L134_D0.6070.67
37_D163_M0.6070.67
130_R235_S0.6060.67
44_V48_L0.6060.67
161_W187_M0.6060.67
210_A213_E0.6030.67
93_A100_S0.6030.67
44_V180_P0.6010.66
14_L17_I0.5980.66
135_S248_V0.5980.66
83_V225_V0.5970.66
86_F233_V0.5970.66
71_A151_F0.5970.66
121_I238_N0.5960.66
165_G193_T0.5950.66
76_E253_E0.5930.65
68_L72_F0.5930.65
189_I196_Y0.5910.65
7_L55_S0.5840.64
54_I57_P0.5830.64
205_F208_I0.5770.63
23_I37_D0.5770.63
11_G53_F0.5750.63
167_L173_M0.5740.63
157_F206_N0.5730.63
231_I245_Q0.5700.62
40_S163_M0.5700.62
119_L248_V0.5690.62
233_V245_Q0.5680.62
129_I246_L0.5680.62
120_A244_S0.5670.62
160_A199_L0.5670.62
144_H147_G0.5650.62
139_A154_A0.5650.62
117_L167_L0.5620.61
75_Q215_K0.5620.61
229_G245_Q0.5620.61
96_H236_G0.5570.61
237_K242_L0.5560.60
70_Q212_L0.5560.60
191_L199_L0.5550.60
91_D240_R0.5530.60
68_L77_D0.5530.60
61_L65_P0.5530.60
26_G39_T0.5530.60
105_A121_I0.5530.60
38_L42_F0.5520.60
7_L211_K0.5520.60
93_A99_L0.5510.60
219_E223_K0.5500.60
156_E172_L0.5500.60
90_S99_L0.5500.60
161_W167_L0.5490.60
201_A206_N0.5480.59
173_M193_T0.5450.59
108_I116_G0.5430.59
85_T109_K0.5420.59
68_L205_F0.5410.58
156_E160_A0.5410.58
126_E231_I0.5400.58
70_Q216_T0.5400.58
28_G168_V0.5380.58
226_M230_I0.5370.58
95_K124_W0.5320.57
26_G156_E0.5320.57
19_I192_L0.5320.57
44_V154_A0.5300.57
86_F246_L0.5280.57
70_Q74_R0.5280.57
92_H125_D0.5270.56
102_D183_L0.5250.56
136_E248_V0.5240.56
113_L231_I0.5210.56
161_W199_L0.5200.55
166_T196_Y0.5200.55
71_A212_L0.5150.55
14_L18_I0.5130.54
98_L236_G0.5130.54
24_I42_F0.5120.54
168_V173_M0.5100.54
18_I22_G0.5090.54
127_E246_L0.5080.54
93_A231_I0.5070.54
34_S172_L0.5050.53
15_G51_A0.5040.53
93_A98_L0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i5pA 1 0.5074 72.6 0.949 Contact Map
4il3A 1 0.9118 68.6 0.951 Contact Map
4aw6A 2 0.9154 42.4 0.958 Contact Map
3h90A 3 0.4926 18.5 0.965 Contact Map
2qk1A 1 0.7904 15.2 0.966 Contact Map
4m70A 1 0.3603 13.9 0.967 Contact Map
2gyqA 2 0.5368 12.6 0.967 Contact Map
3wozA 1 0.6838 12.2 0.968 Contact Map
3b5dA 2 0.1912 8.5 0.97 Contact Map
1ji6A 1 0.3787 7.7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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