GREMLIN Database
RS1H - 30S ribosomal protein S1 homolog
UniProt: P38494 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (332)
Sequences: 910 (501)
Seq/√Len: 27.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_D236_E7.2591.00
192_D238_K5.3511.00
219_L231_V5.1191.00
232_E235_Q4.7861.00
270_V293_L4.6831.00
106_E147_T4.5471.00
277_E322_T4.4781.00
20_K66_E4.4231.00
186_E189_S4.2921.00
83_K87_D4.2331.00
254_S257_D4.2301.00
271_K274_D4.2191.00
102_K151_L4.0271.00
214_V219_L3.5611.00
277_E324_K3.4561.00
278_G290_V3.2741.00
318_E321_Q3.1841.00
331_N334_E3.0881.00
269_K293_L3.0271.00
214_V255_I2.9221.00
280_V290_V2.9101.00
237_V255_I2.9091.00
62_K65_D2.8521.00
107_A150_L2.6410.99
203_A231_V2.5690.99
261_G335_E2.3770.99
22_I66_E2.2970.98
51_S58_S2.2450.98
187_V243_S2.2010.98
198_L203_A2.1890.98
245_D248_N2.1060.97
305_I317_L2.0970.97
23_V61_V2.0820.97
96_E100_E2.0290.96
226_K229_D1.9920.96
20_K68_D1.9410.95
340_S343_E1.9320.95
180_E183_Q1.9240.95
117_L140_F1.8690.94
178_K249_E1.8550.94
26_V59_D1.8530.94
279_T322_T1.8430.94
106_E149_S1.8330.94
125_G164_L1.8110.93
97_K101_T1.7850.93
109_V117_L1.7690.93
206_D209_G1.7600.92
133_E143_Y1.7470.92
218_Q254_S1.7360.92
33_V44_I1.7200.91
105_F150_L1.6920.91
98_K103_E1.6880.91
280_V300_V1.6830.90
90_R93_E1.6810.90
196_Q211_D1.6710.90
194_K236_E1.6710.90
291_E294_P1.6430.89
328_L340_S1.5790.87
176_N180_E1.5250.85
108_E147_T1.4730.83
149_S166_H1.4710.83
134_A174_Q1.4640.83
231_V255_I1.4620.83
190_V238_K1.4400.82
180_E184_S1.4350.82
300_V341_M1.4190.81
307_N342_R1.4140.81
219_L230_V1.4130.81
137_V300_V1.4030.80
34_E41_S1.3960.80
131_L144_K1.3940.80
167_R174_Q1.3920.80
310_I315_E1.3830.79
166_H170_V1.3830.79
327_V330_V1.3100.75
117_L143_Y1.3070.75
31_V44_I1.2910.74
44_I69_L1.2830.74
241_V244_V1.2810.74
21_G33_V1.2790.74
205_V231_V1.2790.74
175_A179_Q1.2780.73
344_L348_P1.2630.73
271_K327_V1.2530.72
109_V143_Y1.2500.72
224_V244_V1.2440.71
270_V292_I1.2400.71
153_V198_L1.2390.71
266_I330_V1.2150.70
307_N348_P1.2150.70
124_R153_V1.2010.69
34_E77_D1.1990.69
342_R348_P1.1880.68
151_L172_S1.1730.67
107_A127_I1.1720.67
181_L210_I1.1720.67
154_E201_F1.1700.67
23_V26_V1.1630.66
97_K100_E1.1560.66
199_T211_D1.1550.66
119_V150_L1.1520.65
94_D103_E1.1430.65
177_K180_E1.1400.65
185_L189_S1.1370.64
305_I340_S1.1340.64
95_L181_L1.1200.63
205_V214_V1.1090.62
193_G205_V1.1010.62
127_I150_L1.1010.62
198_L235_Q1.0970.62
51_S57_A1.0880.61
68_D90_R1.0840.61
186_E246_R1.0800.60
173_E176_N1.0790.60
107_A119_V1.0780.60
203_A230_V1.0760.60
172_S176_N1.0720.60
196_Q199_T1.0680.59
224_V230_V1.0580.59
50_S59_D1.0540.58
49_L67_L1.0420.57
213_L289_F1.0380.57
265_Q300_V1.0300.57
310_I313_P1.0300.57
146_K152_V1.0280.56
117_L142_D1.0280.56
131_L153_V1.0220.56
242_L257_D1.0170.56
131_L174_Q1.0110.55
162_V231_V1.0050.55
179_Q183_Q0.9960.54
46_I50_S0.9950.54
44_I296_V0.9900.54
113_V250_R0.9840.53
217_S286_F0.9830.53
212_G253_L0.9790.53
112_V286_F0.9750.52
148_L296_V0.9740.52
104_V149_S0.9690.52
312_T315_E0.9670.52
326_K340_S0.9630.52
221_H261_G0.9600.51
254_S282_R0.9600.51
197_R207_I0.9560.51
98_K152_V0.9520.51
127_I164_L0.9480.50
230_V255_I0.9480.50
88_A201_F0.9470.50
266_I282_R0.9400.50
274_D330_V0.9380.50
104_V169_V0.9350.49
342_R347_T0.9330.49
298_G330_V0.9320.49
161_R166_H0.9320.49
225_E229_D0.9320.49
214_V231_V0.9290.49
218_Q221_H0.9280.49
148_L283_L0.9250.49
100_E195_V0.9170.48
159_K167_R0.9090.47
260_P265_Q0.9090.47
99_F152_V0.9060.47
283_L313_P0.9050.47
290_V300_V0.9030.47
198_L227_P0.8990.47
137_V280_V0.8930.46
194_K268_E0.8860.46
218_Q257_D0.8850.46
35_I48_E0.8830.45
82_S86_V0.8820.45
275_V326_K0.8800.45
270_V327_V0.8800.45
142_D146_K0.8770.45
77_D80_I0.8770.45
136_F197_R0.8770.45
275_V324_K0.8760.45
127_I161_R0.8750.45
22_I34_E0.8750.45
117_L132_V0.8750.45
112_V129_A0.8730.45
75_E92_W0.8730.45
27_E32_D0.8670.44
84_R88_A0.8650.44
138_E205_V0.8600.44
302_I305_I0.8570.44
232_E292_I0.8510.43
25_K185_L0.8510.43
154_E161_R0.8490.43
283_L312_T0.8450.43
300_V325_V0.8440.43
219_L274_D0.8410.42
134_A170_V0.8380.42
204_F213_L0.8340.42
203_A214_V0.8330.42
69_L74_V0.8320.42
285_S327_V0.8300.42
148_L166_H0.8300.42
214_V237_V0.8290.41
196_Q214_V0.8230.41
214_V274_D0.8230.41
107_A136_F0.8230.41
168_A171_E0.8200.41
217_S254_S0.8190.41
299_L303_S0.8180.41
135_H161_R0.8160.40
105_F327_V0.8150.40
123_V245_D0.8120.40
279_T291_E0.8110.40
306_S342_R0.8100.40
113_V134_A0.8100.40
291_E328_L0.8090.40
239_V250_R0.8070.40
272_P329_D0.8030.40
212_G239_V0.8020.39
260_P264_N0.8000.39
30_H43_I0.7980.39
93_E96_E0.7960.39
26_V63_V0.7940.39
183_Q296_V0.7910.39
181_L206_D0.7850.38
200_D228_S0.7840.38
28_D241_V0.7810.38
167_R248_N0.7800.38
288_A317_L0.7790.38
283_L310_I0.7780.38
221_H257_D0.7770.38
76_D243_S0.7770.38
218_Q328_L0.7730.37
167_R294_P0.7710.37
74_V79_L0.7700.37
185_L336_R0.7670.37
78_A167_R0.7650.37
163_I218_Q0.7610.37
281_Q297_E0.7600.36
143_Y149_S0.7590.36
127_I166_H0.7590.36
46_I59_D0.7590.36
181_L184_S0.7590.36
283_L317_L0.7530.36
96_E157_R0.7510.36
156_D159_K0.7490.36
274_D327_V0.7420.35
43_I47_S0.7420.35
23_V31_V0.7410.35
252_S336_R0.7400.35
130_S339_L0.7380.35
329_D338_S0.7340.35
208_G211_D0.7320.34
195_V219_L0.7270.34
283_L286_F0.7270.34
115_G289_F0.7260.34
84_R241_V0.7230.34
204_F211_D0.7230.34
121_I179_Q0.7220.34
82_S85_A0.7200.34
191_L210_I0.7170.33
278_G338_S0.7160.33
184_S191_L0.7160.33
44_I67_L0.7150.33
298_G301_H0.7140.33
213_L252_S0.7130.33
301_H313_P0.7120.33
47_S164_L0.7110.33
102_K106_E0.7090.33
181_L185_L0.7080.33
89_D93_E0.7070.33
185_L205_V0.7040.33
43_I160_N0.7010.32
34_E122_G0.7000.32
92_W155_L0.6990.32
234_G241_V0.6990.32
120_D335_E0.6970.32
222_S282_R0.6960.32
275_V344_L0.6960.32
243_S277_E0.6950.32
199_T282_R0.6930.32
27_E30_H0.6920.32
139_D142_D0.6890.32
242_L254_S0.6890.32
176_N179_Q0.6880.32
13_P38_V0.6860.31
113_V166_H0.6850.31
124_R160_N0.6850.31
125_G150_L0.6850.31
154_E286_F0.6840.31
219_L227_P0.6820.31
276_L325_V0.6810.31
27_E67_L0.6780.31
150_L164_L0.6780.31
158_D285_S0.6770.31
13_P41_S0.6770.31
142_D205_V0.6760.31
118_V187_V0.6760.31
14_E17_D0.6760.31
155_L162_V0.6750.31
215_H227_P0.6740.31
90_R156_D0.6740.31
94_D97_K0.6740.31
236_E251_I0.6730.31
261_G264_N0.6720.31
292_I337_I0.6710.30
30_H46_I0.6710.30
97_K180_E0.6700.30
71_V205_V0.6690.30
84_R247_D0.6660.30
282_R330_V0.6640.30
249_E292_I0.6620.30
250_R270_V0.6610.30
205_V290_V0.6590.30
175_A296_V0.6580.30
305_I313_P0.6570.30
77_D183_Q0.6560.29
98_K105_F0.6560.29
80_I236_E0.6550.29
23_V46_I0.6550.29
250_R258_T0.6550.29
206_D211_D0.6510.29
144_K163_I0.6500.29
308_K342_R0.6500.29
304_Q340_S0.6490.29
197_R328_L0.6470.29
224_V278_G0.6440.29
133_E166_H0.6420.29
131_L160_N0.6420.29
104_V151_L0.6400.28
70_K75_E0.6400.28
266_I270_V0.6400.28
118_V254_S0.6390.28
291_E295_G0.6350.28
76_D231_V0.6340.28
101_T205_V0.6340.28
191_L239_V0.6330.28
127_I286_F0.6330.28
124_R233_E0.6310.28
105_F163_I0.6300.28
207_I225_E0.6300.28
139_D279_T0.6290.28
131_L168_A0.6290.28
286_F301_H0.6290.28
137_V291_E0.6280.28
51_S60_V0.6280.28
197_R282_R0.6250.28
150_L166_H0.6230.27
221_H247_D0.6220.27
319_E327_V0.6210.27
155_L292_I0.6210.27
284_V289_F0.6200.27
278_G328_L0.6200.27
125_G160_N0.6190.27
230_V274_D0.6190.27
162_V255_I0.6180.27
102_K121_I0.6170.27
308_K315_E0.6160.27
308_K340_S0.6160.27
156_D325_V0.6160.27
211_D227_P0.6160.27
131_L299_L0.6160.27
164_L283_L0.6150.27
240_K257_D0.6140.27
304_Q328_L0.6140.27
25_K266_I0.6130.27
107_A161_R0.6120.27
283_L319_E0.6110.27
153_V270_V0.6090.27
82_S92_W0.6080.27
18_V34_E0.6040.26
104_V184_S0.6040.26
243_S256_K0.6020.26
140_F153_V0.5990.26
153_V293_L0.5980.26
309_H315_E0.5970.26
278_G288_A0.5970.26
216_I299_L0.5970.26
223_H309_H0.5970.26
14_E25_K0.5960.26
31_V317_L0.5960.26
289_F299_L0.5950.26
320_G334_E0.5950.26
121_I317_L0.5940.26
210_I247_D0.5940.26
129_A197_R0.5940.26
84_R201_F0.5920.26
19_V210_I0.5920.26
277_E280_V0.5910.26
197_R254_S0.5900.25
29_K41_S0.5900.25
56_K59_D0.5880.25
95_L156_D0.5840.25
300_V323_V0.5840.25
223_H227_P0.5830.25
96_E155_L0.5800.25
218_Q258_T0.5800.25
132_V182_L0.5790.25
201_F302_I0.5770.25
26_V46_I0.5770.25
226_K331_N0.5760.25
130_S299_L0.5740.25
117_L150_L0.5700.24
125_G162_V0.5700.24
307_N347_T0.5700.24
20_K62_K0.5690.24
242_L297_E0.5670.24
237_V258_T0.5670.24
201_F208_G0.5620.24
25_K32_D0.5600.24
151_L168_A0.5600.24
308_K347_T0.5600.24
178_K241_V0.5590.24
129_A207_I0.5570.24
95_L144_K0.5560.24
201_F304_Q0.5550.24
154_E284_V0.5530.23
91_A210_I0.5530.23
259_L279_T0.5520.23
214_V258_T0.5510.23
21_G198_L0.5500.23
162_V321_Q0.5490.23
216_I223_H0.5480.23
145_G276_L0.5480.23
156_D282_R0.5470.23
34_E68_D0.5470.23
311_G341_M0.5460.23
43_I327_V0.5460.23
199_T227_P0.5460.23
261_G330_V0.5440.23
102_K183_Q0.5430.23
312_T335_E0.5420.23
172_S235_Q0.5420.23
191_L255_I0.5400.23
48_E198_L0.5400.23
90_R222_S0.5400.23
91_A184_S0.5390.23
183_Q186_E0.5390.23
133_E178_K0.5380.23
85_A311_G0.5380.23
183_Q277_E0.5360.22
168_A336_R0.5360.22
177_K220_S0.5360.22
271_K330_V0.5350.22
96_E132_V0.5350.22
137_V142_D0.5340.22
109_V132_V0.5320.22
22_I139_D0.5320.22
184_S241_V0.5310.22
113_V169_V0.5290.22
310_I345_E0.5290.22
282_R286_F0.5290.22
84_R167_R0.5270.22
268_E274_D0.5270.22
311_G343_E0.5260.22
14_E327_V0.5260.22
343_E347_T0.5260.22
75_E182_L0.5260.22
133_E137_V0.5250.22
201_F213_L0.5240.22
207_I251_I0.5240.22
265_Q269_K0.5240.22
190_V240_K0.5230.22
143_Y152_V0.5210.22
124_R203_A0.5200.22
203_A227_P0.5200.22
139_D164_L0.5180.22
129_A217_S0.5180.22
132_V139_D0.5180.22
153_V179_Q0.5180.22
278_G339_L0.5180.22
99_F189_S0.5180.22
127_I307_N0.5170.22
136_F159_K0.5150.21
25_K47_S0.5150.21
325_V328_L0.5150.21
237_V246_R0.5140.21
281_Q335_E0.5140.21
70_K174_Q0.5140.21
90_R249_E0.5140.21
219_L247_D0.5130.21
298_G331_N0.5120.21
316_V337_I0.5100.21
133_E170_V0.5100.21
131_L309_H0.5090.21
296_V332_E0.5080.21
299_L339_L0.5070.21
253_L289_F0.5070.21
46_I56_K0.5060.21
187_V260_P0.5060.21
141_T195_V0.5060.21
159_K270_V0.5050.21
79_L139_D0.5050.21
195_V267_G0.5040.21
182_L241_V0.5040.21
19_V28_D0.5040.21
189_S246_R0.5030.21
23_V60_V0.5030.21
105_F166_H0.5020.21
31_V46_I0.5020.21
35_I42_G0.5020.21
99_F155_L0.5010.21
224_V280_V0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q7jD 1 0.445 100 0.55 Contact Map
3go5A 1 0.7173 100 0.64 Contact Map
1q8kA 1 0.5131 100 0.739 Contact Map
1hh2P 2 0.7775 100 0.755 Contact Map
2k4kA 1 0.3325 100 0.758 Contact Map
4aidA 3 0.3089 100 0.763 Contact Map
3cdiA 3 0.233 100 0.765 Contact Map
4nngA 1 0.4058 100 0.769 Contact Map
3aevA 1 0.3141 100 0.77 Contact Map
4nbqA 3 0.5916 100 0.77 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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