GREMLIN Database
KCY - Cytidylate kinase
UniProt: P38493 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (215)
Sequences: 3764 (2664)
Seq/√Len: 181.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_K186_E4.4391.00
194_K200_E3.5481.00
48_Q84_T3.0991.00
78_K85_D2.7271.00
151_E174_I2.5431.00
134_T195_A2.5321.00
55_D58_K2.4601.00
155_K159_E2.4431.00
152_E155_K2.4131.00
170_Y174_I2.2581.00
158_Y162_V2.1611.00
44_Y48_Q2.1361.00
207_S210_E2.1161.00
6_S137_L2.0881.00
152_E204_T2.0141.00
175_E179_R1.9701.00
56_E107_S1.9081.00
43_T98_Q1.9031.00
145_F185_S1.9011.00
43_T99_V1.8971.00
45_A82_N1.8751.00
142_V218_A1.8591.00
203_T211_V1.8551.00
114_K118_Q1.8541.00
44_Y81_V1.8511.00
120_G137_L1.8221.00
206_L214_K1.7851.00
60_A107_S1.7621.00
214_K217_E1.7621.00
174_I178_A1.7561.00
179_R183_L1.7531.00
56_E105_H1.7431.00
23_I212_A1.7101.00
27_K216_L1.7081.00
46_A59_L1.6921.00
19_T208_I1.6841.00
24_V215_I1.6811.00
8_A132_I1.6481.00
144_I218_A1.6441.00
169_N172_T1.6291.00
111_E115_R1.5941.00
30_Y124_G1.5671.00
23_I27_K1.5591.00
150_V178_A1.5521.00
45_A49_E1.5511.00
47_L98_Q1.5311.00
45_A66_T1.5281.00
135_H190_S1.5041.00
47_L95_I1.4811.00
175_E178_A1.4781.00
213_D217_E1.4551.00
99_V183_L1.4541.00
199_L218_A1.4331.00
106_R110_E1.4291.00
28_K216_L1.4271.00
127_M132_I1.4221.00
33_I127_M1.4201.00
106_R189_V1.4131.00
144_I215_I1.4021.00
20_V212_A1.4011.00
38_M113_V1.3851.00
179_R182_K1.3721.00
115_R118_Q1.3651.00
159_E162_V1.3641.00
159_E163_K1.3451.00
96_S99_V1.3351.00
23_I26_E1.3071.00
134_T193_R1.2921.00
48_Q89_A1.2861.00
27_K213_D1.2651.00
5_L124_G1.2631.00
93_D96_S1.2611.00
41_A79_V1.2451.00
214_K218_A1.2391.00
142_V219_V1.2341.00
187_R191_P1.2281.00
158_Y168_V1.2251.00
46_A62_L1.2111.00
7_I219_V1.2081.00
24_V216_L1.1991.00
201_I214_K1.1941.00
150_V174_I1.1911.00
67_D82_N1.1881.00
61_E65_R1.1871.00
114_K117_Q1.1851.00
111_E114_K1.1551.00
24_V212_A1.1541.00
110_E189_V1.1531.00
28_K220_E1.1521.00
20_V215_I1.1491.00
112_M116_Q1.1461.00
152_E205_S1.1411.00
9_I21_A1.1401.00
113_V190_S1.1321.00
54_T101_I1.1221.00
5_L141_E1.1201.00
69_E83_G1.1191.00
147_L185_S1.1181.00
44_Y86_V1.1021.00
201_I218_A1.0971.00
172_T176_E1.0951.00
84_T89_A1.0901.00
178_A182_K1.0881.00
101_I183_L1.0741.00
61_E64_K1.0701.00
96_S161_N1.0431.00
64_K111_E1.0401.00
42_I63_L1.0391.00
45_A62_L1.0371.00
37_A90_I1.0321.00
42_I66_T1.0311.00
118_Q121_E1.0241.00
81_V86_V1.0140.99
113_V136_V1.0000.99
68_I79_V0.9960.99
210_E213_D0.9940.99
146_L203_T0.9870.99
201_I215_I0.9700.99
39_Y113_V0.9640.99
89_A92_T0.9640.99
5_L30_Y0.9630.99
23_I209_Q0.9540.99
195_A198_A0.9540.99
160_E164_K0.9510.99
60_A105_H0.9490.99
23_I208_I0.9470.99
34_D91_R0.9420.99
71_I80_F0.9290.99
63_L111_E0.9230.99
172_T175_E0.9150.99
38_M112_M0.9140.99
58_K61_E0.9060.99
33_I119_L0.9060.99
217_E221_Q0.9040.99
53_L98_Q0.8960.99
154_A174_I0.8920.99
80_F85_D0.8890.99
193_R196_E0.8860.99
26_E75_D0.8850.99
22_K160_E0.8840.99
43_T183_L0.8820.99
113_V116_Q0.8810.98
43_T95_I0.8770.98
120_G139_N0.8750.98
27_K220_E0.8720.98
38_M116_Q0.8720.98
6_S139_N0.8710.98
168_V173_L0.8700.98
151_E178_A0.8690.98
133_G195_A0.8670.98
171_E174_I0.8670.98
56_E60_A0.8660.98
93_D97_N0.8620.98
101_I104_K0.8540.98
27_K212_A0.8540.98
107_S110_E0.8510.98
21_A126_V0.8500.98
147_L200_E0.8450.98
31_I123_G0.8450.98
104_K183_L0.8290.98
37_A91_R0.8280.98
97_N176_E0.8250.98
162_V165_G0.8240.98
57_E61_E0.8230.98
49_E65_R0.8220.98
44_Y89_A0.8110.97
52_D55_D0.8090.97
34_D37_A0.8060.97
6_S141_E0.8010.97
33_I125_V0.7920.97
208_I212_A0.7910.97
206_L210_E0.7900.97
151_E155_K0.7890.97
150_V177_I0.7890.97
149_S205_S0.7890.97
62_L65_R0.7870.97
49_E82_N0.7860.97
48_Q94_E0.7760.97
203_T215_I0.7720.97
34_D90_I0.7660.96
67_D83_G0.7610.96
20_V208_I0.7580.96
149_S204_T0.7570.96
209_Q213_D0.7550.96
170_Y173_L0.7520.96
47_L94_E0.7510.96
70_L79_V0.7480.96
206_L211_V0.7460.96
158_Y173_L0.7390.96
43_T96_S0.7390.96
118_Q122_K0.7330.95
53_L102_A0.7310.95
28_K219_V0.7310.95
187_R190_S0.7300.95
6_S120_G0.7300.95
45_A81_V0.7230.95
14_A203_T0.7210.95
42_I112_M0.7180.95
35_T112_M0.7140.95
24_V219_V0.7140.95
57_E107_S0.7120.95
132_I136_V0.7100.94
154_A170_Y0.7070.94
66_T82_N0.7040.94
78_K88_E0.7030.94
27_K209_Q0.7030.94
96_S183_L0.7010.94
169_N173_L0.6950.94
14_A147_L0.6910.94
78_K87_T0.6910.94
71_I78_K0.6890.94
161_N166_F0.6880.94
144_I201_I0.6860.93
161_N168_V0.6850.93
67_D118_Q0.6830.93
162_V167_D0.6820.93
144_I199_L0.6770.93
43_T47_L0.6750.93
173_L177_I0.6730.93
113_V117_Q0.6730.93
142_V199_L0.6720.93
127_M137_L0.6720.93
132_I137_L0.6720.93
93_D176_E0.6710.93
15_A177_I0.6700.93
143_K198_A0.6680.93
97_N183_L0.6650.92
185_S192_L0.6650.92
158_Y169_N0.6630.92
41_A90_I0.6600.92
51_V62_L0.6570.92
158_Y170_Y0.6540.92
155_K170_Y0.6530.92
8_A195_A0.6500.91
133_G198_A0.6470.91
44_Y95_I0.6460.91
149_S152_E0.6450.91
51_V58_K0.6420.91
90_I95_I0.6400.91
46_A53_L0.6390.91
218_A221_Q0.6380.91
8_A127_M0.6370.91
41_A68_I0.6340.90
135_H189_V0.6340.90
211_V214_K0.6330.90
149_S177_I0.6330.90
93_D161_N0.6320.90
35_T116_Q0.6290.90
7_I28_K0.6240.90
121_E139_N0.6230.90
20_V211_V0.6210.90
94_E97_N0.6170.89
70_L119_L0.6160.89
173_L176_E0.6130.89
59_L105_H0.6100.89
14_A146_L0.6090.89
35_T127_M0.6080.89
201_I211_V0.6010.88
151_E170_Y0.6010.88
13_A177_I0.5990.88
24_V126_V0.5940.87
35_T38_M0.5920.87
216_L220_E0.5920.87
12_P15_A0.5910.87
92_T95_I0.5860.87
117_Q121_E0.5860.87
194_K197_D0.5850.87
15_A203_T0.5820.86
8_A133_G0.5810.86
182_K185_S0.5770.86
141_E219_V0.5770.86
44_Y84_T0.5760.86
145_F191_P0.5760.86
117_Q137_L0.5720.85
213_D216_L0.5710.85
89_A94_E0.5680.85
120_G125_V0.5670.85
53_L59_L0.5640.85
151_E171_E0.5640.85
165_G168_V0.5630.84
134_T194_K0.5630.84
9_I126_V0.5620.84
176_E179_R0.5570.84
8_A137_L0.5540.84
63_L107_S0.5540.84
145_F192_L0.5520.83
166_F169_N0.5500.83
41_A86_V0.5500.83
125_V137_L0.5500.83
11_G17_K0.5500.83
110_E114_K0.5490.83
64_K114_K0.5470.83
143_K197_D0.5450.83
69_E122_K0.5440.82
134_T197_D0.5420.82
95_I99_V0.5410.82
21_A32_Y0.5410.82
46_A102_A0.5410.82
85_D90_I0.5400.82
18_S38_M0.5370.82
186_E189_V0.5360.81
49_E62_L0.5320.81
30_Y219_V0.5310.81
41_A81_V0.5310.81
60_A64_K0.5240.80
51_V55_D0.5210.80
113_V189_V0.5210.80
59_L62_L0.5200.80
69_E80_F0.5180.79
18_S41_A0.5160.79
110_E113_V0.5150.79
51_V59_L0.5150.79
60_A108_V0.5140.79
191_P198_A0.5110.78
42_I62_L0.5080.78
6_S125_V0.5080.78
92_T166_F0.5070.78
7_I24_V0.5060.78
15_A147_L0.5050.78
52_D58_K0.5050.78
124_G141_E0.5040.77
99_V104_K0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r20A 3 0.9643 100 0.485 Contact Map
1ckeA 1 0.9375 100 0.501 Contact Map
2h92A 1 0.9598 100 0.552 Contact Map
1q3tA 1 0.9821 100 0.556 Contact Map
4e22A 1 0.9464 100 0.558 Contact Map
3akeA 1 0.9196 100 0.56 Contact Map
1a7jA 5 0.8571 100 0.656 Contact Map
3fdiA 3 0.7589 99.9 0.72 Contact Map
3hdtA 2 0.6964 99.9 0.72 Contact Map
2grjA 2 0.7902 99.8 0.742 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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