KCY - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

KCY - Cytidylate kinase

UniProt:	P38493	Sequences: MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITYAALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIAAKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEENVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEAVEQKSR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	224 (215)
Sequences:	3764 (2664)
Seq/√Len:	181.7

ECOLI - KCY
BACSU - KCY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
182_K	186_E	4.439	1.00
194_K	200_E	3.548	1.00
48_Q	84_T	3.099	1.00
78_K	85_D	2.727	1.00
151_E	174_I	2.543	1.00
134_T	195_A	2.532	1.00
55_D	58_K	2.460	1.00
155_K	159_E	2.443	1.00
152_E	155_K	2.413	1.00
170_Y	174_I	2.258	1.00
158_Y	162_V	2.161	1.00
44_Y	48_Q	2.136	1.00
207_S	210_E	2.116	1.00
6_S	137_L	2.088	1.00
152_E	204_T	2.014	1.00
175_E	179_R	1.970	1.00
56_E	107_S	1.908	1.00
43_T	98_Q	1.903	1.00
145_F	185_S	1.901	1.00
43_T	99_V	1.897	1.00
45_A	82_N	1.875	1.00
142_V	218_A	1.859	1.00
203_T	211_V	1.855	1.00
114_K	118_Q	1.854	1.00
44_Y	81_V	1.851	1.00
120_G	137_L	1.822	1.00
206_L	214_K	1.785	1.00
60_A	107_S	1.762	1.00
214_K	217_E	1.762	1.00
174_I	178_A	1.756	1.00
179_R	183_L	1.753	1.00
56_E	105_H	1.743	1.00
23_I	212_A	1.710	1.00
27_K	216_L	1.708	1.00
46_A	59_L	1.692	1.00
19_T	208_I	1.684	1.00
24_V	215_I	1.681	1.00
8_A	132_I	1.648	1.00
144_I	218_A	1.644	1.00
169_N	172_T	1.629	1.00
111_E	115_R	1.594	1.00
30_Y	124_G	1.567	1.00
23_I	27_K	1.559	1.00
150_V	178_A	1.552	1.00
45_A	49_E	1.551	1.00
47_L	98_Q	1.531	1.00
45_A	66_T	1.528	1.00
135_H	190_S	1.504	1.00
47_L	95_I	1.481	1.00
175_E	178_A	1.478	1.00
213_D	217_E	1.455	1.00
99_V	183_L	1.454	1.00
199_L	218_A	1.433	1.00
106_R	110_E	1.429	1.00
28_K	216_L	1.427	1.00
127_M	132_I	1.422	1.00
33_I	127_M	1.420	1.00
106_R	189_V	1.413	1.00
144_I	215_I	1.402	1.00
20_V	212_A	1.401	1.00
38_M	113_V	1.385	1.00
179_R	182_K	1.372	1.00
115_R	118_Q	1.365	1.00
159_E	162_V	1.364	1.00
159_E	163_K	1.345	1.00
96_S	99_V	1.335	1.00
23_I	26_E	1.307	1.00
134_T	193_R	1.292	1.00
48_Q	89_A	1.286	1.00
27_K	213_D	1.265	1.00
5_L	124_G	1.263	1.00
93_D	96_S	1.261	1.00
41_A	79_V	1.245	1.00
214_K	218_A	1.239	1.00
142_V	219_V	1.234	1.00
187_R	191_P	1.228	1.00
158_Y	168_V	1.225	1.00
46_A	62_L	1.211	1.00
7_I	219_V	1.208	1.00
24_V	216_L	1.199	1.00
201_I	214_K	1.194	1.00
150_V	174_I	1.191	1.00
67_D	82_N	1.188	1.00
61_E	65_R	1.187	1.00
114_K	117_Q	1.185	1.00
111_E	114_K	1.155	1.00
24_V	212_A	1.154	1.00
110_E	189_V	1.153	1.00
28_K	220_E	1.152	1.00
20_V	215_I	1.149	1.00
112_M	116_Q	1.146	1.00
152_E	205_S	1.141	1.00
9_I	21_A	1.140	1.00
113_V	190_S	1.132	1.00
54_T	101_I	1.122	1.00
5_L	141_E	1.120	1.00
69_E	83_G	1.119	1.00
147_L	185_S	1.118	1.00
44_Y	86_V	1.102	1.00
201_I	218_A	1.097	1.00
172_T	176_E	1.095	1.00
84_T	89_A	1.090	1.00
178_A	182_K	1.088	1.00
101_I	183_L	1.074	1.00
61_E	64_K	1.070	1.00
96_S	161_N	1.043	1.00
64_K	111_E	1.040	1.00
42_I	63_L	1.039	1.00
45_A	62_L	1.037	1.00
37_A	90_I	1.032	1.00
42_I	66_T	1.031	1.00
118_Q	121_E	1.024	1.00
81_V	86_V	1.014	0.99
113_V	136_V	1.000	0.99
68_I	79_V	0.996	0.99
210_E	213_D	0.994	0.99
146_L	203_T	0.987	0.99
201_I	215_I	0.970	0.99
39_Y	113_V	0.964	0.99
89_A	92_T	0.964	0.99
5_L	30_Y	0.963	0.99
23_I	209_Q	0.954	0.99
195_A	198_A	0.954	0.99
160_E	164_K	0.951	0.99
60_A	105_H	0.949	0.99
23_I	208_I	0.947	0.99
34_D	91_R	0.942	0.99
71_I	80_F	0.929	0.99
63_L	111_E	0.923	0.99
172_T	175_E	0.915	0.99
38_M	112_M	0.914	0.99
58_K	61_E	0.906	0.99
33_I	119_L	0.906	0.99
217_E	221_Q	0.904	0.99
53_L	98_Q	0.896	0.99
154_A	174_I	0.892	0.99
80_F	85_D	0.889	0.99
193_R	196_E	0.886	0.99
26_E	75_D	0.885	0.99
22_K	160_E	0.884	0.99
43_T	183_L	0.882	0.99
113_V	116_Q	0.881	0.98
43_T	95_I	0.877	0.98
120_G	139_N	0.875	0.98
27_K	220_E	0.872	0.98
38_M	116_Q	0.872	0.98
6_S	139_N	0.871	0.98
168_V	173_L	0.870	0.98
151_E	178_A	0.869	0.98
133_G	195_A	0.867	0.98
171_E	174_I	0.867	0.98
56_E	60_A	0.866	0.98
93_D	97_N	0.862	0.98
101_I	104_K	0.854	0.98
27_K	212_A	0.854	0.98
107_S	110_E	0.851	0.98
21_A	126_V	0.850	0.98
147_L	200_E	0.845	0.98
31_I	123_G	0.845	0.98
104_K	183_L	0.829	0.98
37_A	91_R	0.828	0.98
97_N	176_E	0.825	0.98
162_V	165_G	0.824	0.98
57_E	61_E	0.823	0.98
49_E	65_R	0.822	0.98
44_Y	89_A	0.811	0.97
52_D	55_D	0.809	0.97
34_D	37_A	0.806	0.97
6_S	141_E	0.801	0.97
33_I	125_V	0.792	0.97
208_I	212_A	0.791	0.97
206_L	210_E	0.790	0.97
151_E	155_K	0.789	0.97
150_V	177_I	0.789	0.97
149_S	205_S	0.789	0.97
62_L	65_R	0.787	0.97
49_E	82_N	0.786	0.97
48_Q	94_E	0.776	0.97
203_T	215_I	0.772	0.97
34_D	90_I	0.766	0.96
67_D	83_G	0.761	0.96
20_V	208_I	0.758	0.96
149_S	204_T	0.757	0.96
209_Q	213_D	0.755	0.96
170_Y	173_L	0.752	0.96
47_L	94_E	0.751	0.96
70_L	79_V	0.748	0.96
206_L	211_V	0.746	0.96
158_Y	173_L	0.739	0.96
43_T	96_S	0.739	0.96
118_Q	122_K	0.733	0.95
53_L	102_A	0.731	0.95
28_K	219_V	0.731	0.95
187_R	190_S	0.730	0.95
6_S	120_G	0.730	0.95
45_A	81_V	0.723	0.95
14_A	203_T	0.721	0.95
42_I	112_M	0.718	0.95
35_T	112_M	0.714	0.95
24_V	219_V	0.714	0.95
57_E	107_S	0.712	0.95
132_I	136_V	0.710	0.94
154_A	170_Y	0.707	0.94
66_T	82_N	0.704	0.94
78_K	88_E	0.703	0.94
27_K	209_Q	0.703	0.94
96_S	183_L	0.701	0.94
169_N	173_L	0.695	0.94
14_A	147_L	0.691	0.94
78_K	87_T	0.691	0.94
71_I	78_K	0.689	0.94
161_N	166_F	0.688	0.94
144_I	201_I	0.686	0.93
161_N	168_V	0.685	0.93
67_D	118_Q	0.683	0.93
162_V	167_D	0.682	0.93
144_I	199_L	0.677	0.93
43_T	47_L	0.675	0.93
173_L	177_I	0.673	0.93
113_V	117_Q	0.673	0.93
142_V	199_L	0.672	0.93
127_M	137_L	0.672	0.93
132_I	137_L	0.672	0.93
93_D	176_E	0.671	0.93
15_A	177_I	0.670	0.93
143_K	198_A	0.668	0.93
97_N	183_L	0.665	0.92
185_S	192_L	0.665	0.92
158_Y	169_N	0.663	0.92
41_A	90_I	0.660	0.92
51_V	62_L	0.657	0.92
158_Y	170_Y	0.654	0.92
155_K	170_Y	0.653	0.92
8_A	195_A	0.650	0.91
133_G	198_A	0.647	0.91
44_Y	95_I	0.646	0.91
149_S	152_E	0.645	0.91
51_V	58_K	0.642	0.91
90_I	95_I	0.640	0.91
46_A	53_L	0.639	0.91
218_A	221_Q	0.638	0.91
8_A	127_M	0.637	0.91
41_A	68_I	0.634	0.90
135_H	189_V	0.634	0.90
211_V	214_K	0.633	0.90
149_S	177_I	0.633	0.90
93_D	161_N	0.632	0.90
35_T	116_Q	0.629	0.90
7_I	28_K	0.624	0.90
121_E	139_N	0.623	0.90
20_V	211_V	0.621	0.90
94_E	97_N	0.617	0.89
70_L	119_L	0.616	0.89
173_L	176_E	0.613	0.89
59_L	105_H	0.610	0.89
14_A	146_L	0.609	0.89
35_T	127_M	0.608	0.89
201_I	211_V	0.601	0.88
151_E	170_Y	0.601	0.88
13_A	177_I	0.599	0.88
24_V	126_V	0.594	0.87
35_T	38_M	0.592	0.87
216_L	220_E	0.592	0.87
12_P	15_A	0.591	0.87
92_T	95_I	0.586	0.87
117_Q	121_E	0.586	0.87
194_K	197_D	0.585	0.87
15_A	203_T	0.582	0.86
8_A	133_G	0.581	0.86
182_K	185_S	0.577	0.86
141_E	219_V	0.577	0.86
44_Y	84_T	0.576	0.86
145_F	191_P	0.576	0.86
117_Q	137_L	0.572	0.85
213_D	216_L	0.571	0.85
89_A	94_E	0.568	0.85
120_G	125_V	0.567	0.85
53_L	59_L	0.564	0.85
151_E	171_E	0.564	0.85
165_G	168_V	0.563	0.84
134_T	194_K	0.563	0.84
9_I	126_V	0.562	0.84
176_E	179_R	0.557	0.84
8_A	137_L	0.554	0.84
63_L	107_S	0.554	0.84
145_F	192_L	0.552	0.83
166_F	169_N	0.550	0.83
41_A	86_V	0.550	0.83
125_V	137_L	0.550	0.83
11_G	17_K	0.550	0.83
110_E	114_K	0.549	0.83
64_K	114_K	0.547	0.83
143_K	197_D	0.545	0.83
69_E	122_K	0.544	0.82
134_T	197_D	0.542	0.82
95_I	99_V	0.541	0.82
21_A	32_Y	0.541	0.82
46_A	102_A	0.541	0.82
85_D	90_I	0.540	0.82
18_S	38_M	0.537	0.82
186_E	189_V	0.536	0.81
49_E	62_L	0.532	0.81
30_Y	219_V	0.531	0.81
41_A	81_V	0.531	0.81
60_A	64_K	0.524	0.80
51_V	55_D	0.521	0.80
113_V	189_V	0.521	0.80
59_L	62_L	0.520	0.80
69_E	80_F	0.518	0.79
18_S	41_A	0.516	0.79
110_E	113_V	0.515	0.79
51_V	59_L	0.515	0.79
60_A	108_V	0.514	0.79
191_P	198_A	0.511	0.78
42_I	62_L	0.508	0.78
6_S	125_V	0.508	0.78
92_T	166_F	0.507	0.78
7_I	24_V	0.506	0.78
15_A	147_L	0.505	0.78
52_D	58_K	0.505	0.78
124_G	141_E	0.504	0.77
99_V	104_K	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3r20A	3	0.9643	100	0.485	Contact Map
1ckeA	1	0.9375	100	0.501	Contact Map
2h92A	1	0.9598	100	0.552	Contact Map
1q3tA	1	0.9821	100	0.556	Contact Map
4e22A	1	0.9464	100	0.558	Contact Map
3akeA	1	0.9196	100	0.56	Contact Map
1a7jA	5	0.8571	100	0.656	Contact Map
3fdiA	3	0.7589	99.9	0.72	Contact Map
3hdtA	2	0.6964	99.9	0.72	Contact Map
2grjA	2	0.7902	99.8	0.742	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.