GREMLIN Database
YPEB - Sporulation protein YpeB
UniProt: P38490 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 450 (432)
Sequences: 356 (306)
Seq/√Len: 14.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
428_N435_E6.7281.00
285_R350_A6.4971.00
373_I400_L4.6571.00
285_R352_D4.5201.00
343_E368_H3.9781.00
371_R408_E3.9281.00
50_V146_L3.8881.00
301_A331_Y3.8321.00
334_V337_K3.8251.00
380_E396_T3.7701.00
345_I356_V3.7151.00
368_H371_R3.6370.99
333_P340_M3.5060.99
297_G329_F3.4290.99
332_V339_R3.3330.99
302_L331_Y3.1660.98
41_R89_Q3.1020.98
384_K393_V3.0130.98
293_S296_D2.9060.97
109_D343_E2.8880.97
379_T382_E2.6520.95
338_V400_L2.5660.94
21_G37_N2.5120.94
340_M400_L2.4870.93
32_L161_M2.4630.93
350_A353_D2.4040.92
117_R128_E2.3850.92
232_F308_N2.3820.92
314_D364_F2.3770.91
218_K224_E2.3410.91
398_L410_L2.3260.90
221_S404_E2.3040.90
218_K375_K2.2800.90
85_N303_A2.2520.89
111_S192_F2.1880.88
304_F308_N2.1410.86
372_T382_E2.1360.86
198_L201_S2.0460.84
10_L13_A2.0300.83
409_V428_N2.0090.82
303_A307_K2.0090.82
20_W24_E2.0080.82
285_R353_D2.0040.82
315_L333_P1.9610.81
278_P359_F1.9350.80
383_A414_M1.9220.79
14_I132_L1.9160.79
130_T385_S1.8880.78
279_V365_L1.8460.77
220_I225_A1.8460.77
199_G413_E1.8420.76
163_V167_L1.7650.73
219_Q274_K1.7620.73
220_I271_I1.7610.73
198_L202_F1.7490.73
234_P356_V1.7440.72
262_D338_V1.7370.72
299_N302_L1.7270.72
76_V385_S1.7200.71
311_E382_E1.7060.71
219_Q273_K1.7040.70
21_G24_E1.6930.70
346_R402_T1.6730.69
333_P368_H1.6700.69
222_E244_K1.6450.68
28_K32_L1.6160.66
231_R308_N1.6120.66
319_E344_A1.6050.66
316_E334_V1.5910.65
387_L393_V1.5790.64
193_S200_P1.5780.64
37_N42_A1.5770.64
409_V435_E1.5670.64
281_L349_V1.5470.63
329_F332_V1.5360.62
343_E371_R1.5290.62
311_E314_D1.5280.62
271_I278_P1.5280.62
368_H408_E1.5020.60
111_S273_K1.5000.60
424_R438_E1.4880.60
229_A269_M1.4770.59
225_A271_I1.4720.59
273_K362_R1.4670.58
341_Y413_E1.4550.58
244_K273_K1.4440.57
201_S402_T1.4370.57
303_A393_V1.4260.56
283_Q357_V1.4200.56
88_S395_E1.4150.56
42_A411_C1.4040.55
343_E402_T1.4030.55
316_E397_R1.4000.55
337_K370_K1.3960.55
343_E398_L1.3820.54
16_G22_Y1.3820.54
373_I429_A1.3780.54
332_V363_D1.3700.53
348_K358_G1.3680.53
13_A425_M1.3510.52
94_L179_I1.3510.52
224_E345_I1.3510.52
223_Q226_K1.3490.52
49_Q331_Y1.3410.52
102_E106_K1.3350.51
118_D121_Q1.3260.51
301_A347_M1.3250.51
224_E227_Q1.3180.50
267_I283_Q1.3140.50
331_Y347_M1.3070.50
25_H32_L1.3060.50
271_I356_V1.3050.50
329_F411_C1.2990.49
196_T199_G1.2940.49
377_A430_K1.2820.48
197_D309_G1.2760.48
199_G273_K1.2750.48
226_K230_E1.2670.47
290_Q322_Q1.2610.47
356_V412_Y1.2560.47
105_S325_K1.2390.46
282_I440_L1.2360.46
238_Y356_V1.2330.46
216_K306_K1.2190.45
127_N392_Q1.2050.44
129_Y394_R1.2010.44
288_K335_E1.1980.44
310_F359_F1.1850.43
394_R417_T1.1820.43
299_N375_K1.1810.43
241_K299_N1.1770.42
340_M357_V1.1730.42
15_V186_E1.1670.42
200_P426_Y1.1670.42
124_L383_A1.1630.42
39_Y46_L1.1630.42
159_R162_D1.1610.42
125_D391_V1.1470.41
333_P343_E1.1450.41
7_I10_L1.1450.41
345_I364_F1.1430.41
42_A76_V1.1420.41
20_W89_Q1.1340.40
252_D273_K1.1210.39
103_L146_L1.1150.39
142_I156_K1.0980.38
183_K392_Q1.0970.38
199_G341_Y1.0930.38
422_T440_L1.0930.38
370_K374_P1.0850.38
269_M337_K1.0820.37
59_T271_I1.0810.37
416_G423_F1.0780.37
57_I310_F1.0780.37
229_A232_F1.0750.37
285_R355_E1.0730.37
74_I441_K1.0720.37
45_E363_D1.0620.36
30_A82_E1.0590.36
46_L182_F1.0570.36
49_Q84_H1.0540.36
198_L203_T1.0530.36
156_K402_T1.0520.36
217_G349_V1.0520.36
76_V240_I1.0470.36
389_K393_V1.0470.36
124_L128_E1.0460.36
232_F304_F1.0460.36
58_G423_F1.0410.35
338_V429_A1.0390.35
99_K145_E1.0360.35
192_F411_C1.0320.35
15_V19_Y1.0270.35
125_D349_V1.0220.34
62_A73_L1.0190.34
259_K293_S1.0190.34
301_A327_G1.0130.34
410_L429_A1.0120.34
155_S337_K1.0110.34
24_E332_V1.0070.34
20_W43_F1.0060.34
22_Y26_Q1.0030.33
197_D360_S1.0020.33
340_M370_K0.9980.33
383_A427_I0.9980.33
297_G351_L0.9970.33
138_Q256_I0.9940.33
306_K311_E0.9940.33
252_D282_I0.9920.33
100_T103_L0.9910.33
260_D340_M0.9890.33
202_F346_R0.9870.33
414_M425_M0.9830.32
374_P430_K0.9820.32
106_K197_D0.9800.32
24_E32_L0.9790.32
299_N381_A0.9790.32
233_A367_S0.9770.32
137_Q306_K0.9750.32
339_R397_R0.9750.32
24_E161_M0.9750.32
110_F128_E0.9700.32
76_V387_L0.9660.32
229_A376_P0.9640.32
99_K176_N0.9640.32
69_L225_A0.9640.32
14_I334_V0.9620.31
106_K109_D0.9620.31
226_K283_Q0.9600.31
155_S387_L0.9560.31
59_T193_S0.9470.31
65_S164_E0.9470.31
125_D226_K0.9450.31
87_V374_P0.9440.31
15_V323_Y0.9430.31
149_V359_F0.9400.30
138_Q192_F0.9400.30
221_S272_T0.9390.30
36_E46_L0.9380.30
351_L416_G0.9380.30
368_H374_P0.9330.30
134_K303_A0.9330.30
417_T422_T0.9310.30
318_D362_R0.9300.30
368_H412_Y0.9290.30
100_T383_A0.9280.30
153_V423_F0.9280.30
85_N272_T0.9280.30
50_V284_N0.9280.30
223_Q306_K0.9270.30
341_Y408_E0.9200.29
335_E368_H0.9200.29
287_V357_V0.9200.29
143_Q439_K0.9180.29
236_D326_I0.9160.29
53_L158_L0.9160.29
7_I14_I0.9160.29
64_N300_R0.9120.29
336_N377_A0.9100.29
370_K392_Q0.9070.29
234_P368_H0.9070.29
134_K137_Q0.9070.29
230_E349_V0.9060.29
32_L168_A0.9050.29
249_T253_V0.9040.29
329_F437_V0.9030.29
173_Q337_K0.9030.29
13_A88_S0.8980.28
403_N407_Q0.8960.28
130_T296_D0.8950.28
57_I196_T0.8950.28
134_K281_L0.8920.28
321_A356_V0.8890.28
124_L409_V0.8830.28
59_T102_E0.8830.28
107_I140_E0.8820.28
367_S391_V0.8820.28
172_K359_F0.8820.28
235_D238_Y0.8810.28
330_S402_T0.8810.28
343_E408_E0.8810.28
31_V161_M0.8810.28
302_L406_G0.8800.28
134_K227_Q0.8780.28
51_D364_F0.8770.27
295_N299_N0.8770.27
201_S346_R0.8770.27
15_V337_K0.8770.27
67_K389_K0.8770.27
198_L402_T0.8760.27
227_Q372_T0.8730.27
144_N361_A0.8730.27
62_A423_F0.8710.27
391_V440_L0.8700.27
288_K326_I0.8680.27
24_E89_Q0.8670.27
218_K221_S0.8660.27
8_A75_D0.8660.27
112_Y435_E0.8630.27
43_F88_S0.8630.27
59_T196_T0.8620.27
330_S346_R0.8620.27
20_W136_Y0.8580.27
41_R45_E0.8580.27
253_V279_V0.8550.27
12_I126_K0.8530.26
97_F149_V0.8530.26
109_D214_H0.8520.26
25_H98_N0.8510.26
21_G43_F0.8510.26
130_T227_Q0.8490.26
219_Q228_I0.8490.26
382_E385_S0.8470.26
15_V224_E0.8450.26
78_R112_Y0.8440.26
356_V398_L0.8440.26
15_V309_G0.8440.26
403_N435_E0.8430.26
66_Q129_Y0.8410.26
15_V430_K0.8410.26
15_V18_G0.8380.26
124_L399_A0.8370.26
233_A389_K0.8370.26
169_S404_E0.8340.26
201_S343_E0.8340.26
304_F400_L0.8320.26
365_L411_C0.8310.25
5_I9_V0.8300.25
281_L366_T0.8290.25
336_N431_D0.8270.25
67_K247_K0.8260.25
287_V293_S0.8260.25
421_D439_K0.8220.25
412_Y421_D0.8200.25
216_K277_H0.8180.25
202_F402_T0.8150.25
339_R381_A0.8150.25
33_L37_N0.8140.25
392_Q399_A0.8130.25
7_I38_N0.8120.25
333_P360_S0.8110.25
105_S134_K0.8090.25
109_D155_S0.8080.25
133_N273_K0.8060.24
92_L294_L0.8010.24
92_L159_R0.8010.24
26_Q286_E0.8000.24
161_M166_A0.7980.24
267_I353_D0.7960.24
301_A349_V0.7960.24
87_V102_E0.7960.24
232_F302_L0.7950.24
130_T353_D0.7950.24
272_T279_V0.7930.24
197_D402_T0.7910.24
6_L328_V0.7900.24
372_T391_V0.7900.24
182_F200_P0.7890.24
193_S420_N0.7890.24
288_K337_K0.7870.24
260_D353_D0.7870.24
193_S199_G0.7870.24
209_E362_R0.7840.24
197_D346_R0.7830.24
111_S200_P0.7820.23
27_E32_L0.7800.23
336_N381_A0.7770.23
233_A279_V0.7760.23
249_T273_K0.7760.23
256_I261_P0.7740.23
294_L327_G0.7720.23
179_I183_K0.7720.23
163_V166_A0.7710.23
163_V178_I0.7700.23
126_K378_I0.7680.23
110_F160_W0.7670.23
398_L402_T0.7650.23
244_K249_T0.7620.23
124_L427_I0.7550.22
367_S439_K0.7520.22
241_K379_T0.7480.22
66_Q337_K0.7460.22
236_D296_D0.7460.22
271_I359_F0.7450.22
198_L346_R0.7450.22
224_E262_D0.7440.22
199_G342_P0.7430.22
204_S318_D0.7430.22
18_G415_L0.7420.22
127_N335_E0.7400.22
416_G434_E0.7390.22
80_T192_F0.7360.22
139_S440_L0.7350.22
249_T252_D0.7340.22
253_V387_L0.7340.22
10_L393_V0.7320.22
12_I340_M0.7300.21
99_K334_V0.7300.21
230_E348_K0.7290.21
86_S256_I0.7280.21
416_G419_E0.7260.21
255_S270_D0.7250.21
8_A38_N0.7230.21
196_T346_R0.7230.21
77_W270_D0.7210.21
189_V438_E0.7200.21
287_V335_E0.7200.21
245_S268_Y0.7200.21
63_M249_T0.7190.21
378_I427_I0.7180.21
15_V107_I0.7180.21
38_N300_R0.7180.21
74_I116_V0.7170.21
334_V384_K0.7130.21
57_I253_V0.7120.21
209_E366_T0.7120.21
305_L309_G0.7120.21
156_K279_V0.7110.21
126_K404_E0.7100.21
291_K373_I0.7100.21
18_G266_V0.7090.21
21_G89_Q0.7090.21
340_M373_I0.7080.21
135_L139_S0.7050.21
223_Q244_K0.7040.21
59_T343_E0.7030.20
349_V400_L0.7030.20
225_A344_A0.7020.20
200_P402_T0.7010.20
341_Y399_A0.7000.20
235_D345_I0.7000.20
201_S273_K0.7000.20
128_E423_F0.6990.20
109_D133_N0.6980.20
350_A355_E0.6970.20
87_V267_I0.6970.20
127_N373_I0.6970.20
91_P305_L0.6960.20
344_A363_D0.6960.20
25_H161_M0.6940.20
245_S253_V0.6940.20
335_E390_N0.6940.20
8_A34_H0.6940.20
200_P360_S0.6890.20
145_E361_A0.6880.20
365_L442_N0.6860.20
5_I172_K0.6850.20
202_F343_E0.6840.20
48_Y110_F0.6810.20
326_I435_E0.6810.20
203_T346_R0.6800.20
300_R303_A0.6800.20
230_E240_I0.6800.20
59_T344_A0.6800.20
106_K424_R0.6800.20
93_T347_M0.6790.20
227_Q361_A0.6790.20
251_R280_Y0.6780.20
130_T134_K0.6780.20
241_K272_T0.6770.20
230_E390_N0.6770.20
249_T426_Y0.6750.19
66_Q120_D0.6740.19
24_E27_E0.6720.19
373_I412_Y0.6710.19
236_D239_S0.6690.19
235_D281_L0.6680.19
162_D179_I0.6670.19
11_G126_K0.6660.19
235_D377_A0.6620.19
45_E86_S0.6610.19
292_I379_T0.6600.19
158_L163_V0.6550.19
148_H359_F0.6530.19
133_N419_E0.6530.19
222_E226_K0.6530.19
218_K289_D0.6520.19
174_S387_L0.6510.19
78_R110_F0.6510.19
112_Y416_G0.6510.19
86_S108_G0.6500.19
128_E132_L0.6490.19
168_A178_I0.6490.19
121_Q360_S0.6490.19
326_I440_L0.6490.19
346_R442_N0.6470.19
357_V398_L0.6460.18
103_L360_S0.6450.18
417_T420_N0.6450.18
62_A416_G0.6440.18
196_T360_S0.6440.18
212_F315_L0.6430.18
16_G27_E0.6420.18
80_T278_P0.6410.18
131_S308_N0.6410.18
242_V272_T0.6410.18
15_V431_D0.6400.18
73_L76_V0.6390.18
319_E402_T0.6350.18
318_D387_L0.6320.18
282_I346_R0.6310.18
281_L309_G0.6310.18
234_P315_L0.6240.18
75_D321_A0.6240.18
278_P295_N0.6240.18
110_F186_E0.6230.18
103_L361_A0.6220.18
24_E162_D0.6210.18
74_I80_T0.6190.18
318_D360_S0.6170.18
94_L178_I0.6150.17
343_E433_S0.6140.17
339_R400_L0.6130.17
311_E431_D0.6130.17
12_I291_K0.6130.17
110_F149_V0.6120.17
331_Y425_M0.6120.17
232_F366_T0.6110.17
94_L163_V0.6100.17
112_Y160_W0.6100.17
227_Q231_R0.6100.17
287_V352_D0.6090.17
75_D366_T0.6090.17
153_V331_Y0.6090.17
328_V367_S0.6090.17
108_G225_A0.6080.17
94_L175_D0.6080.17
75_D339_R0.6080.17
372_T384_K0.6070.17
324_D357_V0.6050.17
22_Y32_L0.6030.17
258_M355_E0.6010.17
144_N232_F0.6010.17
45_E380_E0.5990.17
332_V344_A0.5980.17
372_T385_S0.5980.17
239_S391_V0.5970.17
6_L157_N0.5950.17
101_E119_L0.5940.17
131_S280_Y0.5910.17
194_T331_Y0.5910.17
319_E438_E0.5900.17
376_P398_L0.5880.17
44_H123_P0.5880.17
397_R440_L0.5880.17
414_M434_E0.5870.17
54_H140_E0.5860.17
250_N356_V0.5860.17
42_A117_R0.5850.17
281_L330_S0.5850.17
196_T395_E0.5840.16
148_H356_V0.5830.16
98_N181_S0.5820.16
23_K213_S0.5800.16
9_V377_A0.5800.16
71_P320_S0.5790.16
379_T387_L0.5780.16
191_A404_E0.5770.16
187_K385_S0.5760.16
218_K307_K0.5750.16
122_K287_V0.5750.16
243_V269_M0.5730.16
110_F331_Y0.5710.16
386_K392_Q0.5710.16
20_W388_N0.5700.16
45_E144_N0.5690.16
199_G315_L0.5690.16
381_A431_D0.5670.16
258_M280_Y0.5660.16
89_Q145_E0.5640.16
172_K337_K0.5640.16
269_M374_P0.5640.16
346_R360_S0.5640.16
12_I304_F0.5630.16
5_I134_K0.5630.16
82_E85_N0.5620.16
12_I188_N0.5590.16
70_S88_S0.5570.16
24_E31_V0.5560.16
92_L388_N0.5560.16
219_Q224_E0.5560.16
68_S272_T0.5550.16
97_F180_N0.5550.16
258_M394_R0.5530.16
232_F359_F0.5530.16
146_L358_G0.5520.16
15_V267_I0.5520.16
136_Y414_M0.5520.16
13_A381_A0.5510.16
289_D381_A0.5510.16
67_K120_D0.5500.15
319_E346_R0.5500.15
59_T318_D0.5460.15
7_I317_I0.5460.15
129_Y393_V0.5450.15
31_V162_D0.5450.15
310_F365_L0.5430.15
198_L330_S0.5430.15
130_T293_S0.5420.15
282_I299_N0.5410.15
100_T146_L0.5380.15
73_L160_W0.5370.15
15_V393_V0.5370.15
192_F273_K0.5370.15
57_I212_F0.5360.15
310_F344_A0.5360.15
415_L426_Y0.5340.15
395_E415_L0.5330.15
67_K385_S0.5330.15
374_P391_V0.5320.15
319_E343_E0.5320.15
389_K419_E0.5320.15
12_I431_D0.5310.15
338_V432_G0.5310.15
298_S317_I0.5300.15
59_T199_G0.5290.15
91_P104_L0.5280.15
97_F158_L0.5280.15
323_Y327_G0.5260.15
59_T82_E0.5260.15
428_N434_E0.5260.15
22_Y137_Q0.5250.15
122_K281_L0.5250.15
105_S437_V0.5230.15
145_E325_K0.5230.15
261_P268_Y0.5230.15
59_T202_F0.5220.15
301_A309_G0.5220.15
217_G388_N0.5220.15
294_L429_A0.5210.15
384_K396_T0.5200.15
345_I373_I0.5200.15
192_F279_V0.5190.15
292_I354_G0.5180.15
199_G309_G0.5180.15
132_L388_N0.5180.15
288_K369_R0.5170.15
35_A44_H0.5170.15
22_Y123_P0.5160.15
228_I271_I0.5160.15
277_H322_Q0.5150.14
53_L221_S0.5140.14
49_Q194_T0.5140.14
223_Q364_F0.5140.14
326_I356_V0.5130.14
173_Q314_D0.5130.14
104_L350_A0.5120.14
266_V302_L0.5120.14
120_D386_K0.5120.14
12_I102_E0.5110.14
51_D69_L0.5100.14
108_G245_S0.5100.14
289_D356_V0.5090.14
45_E153_V0.5090.14
230_E237_N0.5080.14
36_E40_Q0.5080.14
273_K314_D0.5070.14
88_S434_E0.5070.14
296_D377_A0.5050.14
62_A407_Q0.5040.14
56_K75_D0.5030.14
84_H328_V0.5020.14
370_K377_A0.5020.14
271_I420_N0.5020.14
231_R239_S0.5020.14
426_Y434_E0.5010.14
41_R94_L0.5010.14
212_F402_T0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k90B 1 0.3667 99.8 0.861 Contact Map
3nqzA 1 0.3511 99.8 0.87 Contact Map
2o3oA 2 0.4667 97.5 0.947 Contact Map
4exrA 2 0.3 96.2 0.955 Contact Map
4cgkA 3 0.6422 91.9 0.964 Contact Map
2gu3A 1 0.2689 72.4 0.972 Contact Map
3zg1A 2 0.2244 65.8 0.973 Contact Map
2fgtA 1 0.7578 55 0.975 Contact Map
4ipbA 1 0.2933 44.7 0.976 Contact Map
3db7A 2 0.2756 20.8 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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