ENGB - BACSU - GREMLIN Contacts

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ENGB - Probable GTP-binding protein EngB

UniProt:	P38424	Sequences: MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLINRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITTREELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVRQTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	195 (164)
Sequences:	28799 (17546)
Seq/√Len:	1370.1

ECOLI - ENGB DER ERA MNME YFJP YKFA HFLX FEOB OBG CRFC EFTU1 EFTU2 SELB YEEP CYSN
BACSU - ENGB ERA DER MNME HFLX YPBR OBG EFTU YCHF
HALSA - ENGB Q9HQ88 Q9HMD6 Q9HMC2 Y1111 Q9HRX2 IF2P Q9HP92 IF2G EF1A
SULSO - Q7LXR6 HFLX Q7LXL0 IF2P IF2G Q97W17

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_S	179_K	3.176	1.00
172_I	188_A	2.882	1.00
110_V	140_I	2.840	1.00
188_A	191_K	2.767	1.00
38_S	176_S	2.491	1.00
115_L	141_A	2.328	1.00
170_E	188_A	2.281	1.00
64_F	72_H	2.218	1.00
144_A	173_L	2.182	1.00
27_A	106_L	2.009	1.00
25_E	72_H	1.958	1.00
188_A	192_M	1.914	1.00
69_D	190_K	1.912	1.00
41_N	52_T	1.896	1.00
113_V	139_V	1.868	1.00
66_I	70_E	1.832	1.00
39_F	112_I	1.750	1.00
108_A	138_I	1.739	1.00
141_A	173_L	1.735	1.00
42_S	182_K	1.696	1.00
112_I	142_T	1.686	1.00
44_I	49_L	1.636	1.00
156_A	173_L	1.636	1.00
156_A	160_R	1.626	1.00
129_F	133_Y	1.618	1.00
110_V	189_I	1.611	1.00
100_I	129_F	1.553	1.00
138_I	188_A	1.546	1.00
158_V	162_T	1.527	1.00
66_I	72_H	1.486	1.00
140_I	174_F	1.485	1.00
123_D	127_Y	1.467	1.00
28_L	110_V	1.463	1.00
127_Y	130_L	1.452	1.00
39_F	185_A	1.441	1.00
155_H	158_V	1.441	1.00
46_R	49_L	1.425	1.00
127_Y	131_K	1.410	1.00
50_A	63_N	1.406	1.00
28_L	40_I	1.405	1.00
142_T	176_S	1.384	1.00
44_I	65_Y	1.367	1.00
140_I	185_A	1.358	1.00
40_I	50_A	1.357	1.00
94_R	97_E	1.345	1.00
130_L	133_Y	1.337	1.00
111_Q	137_V	1.337	1.00
141_A	171_L	1.325	1.00
110_V	138_I	1.322	1.00
64_F	74_V	1.298	1.00
124_V	128_E	1.272	1.00
148_P	151_K	1.260	1.00
157_K	161_Q	1.257	1.00
138_I	172_I	1.254	1.00
125_Q	129_F	1.249	1.00
181_G	184_E	1.224	1.00
62_L	74_V	1.219	1.00
117_H	120_S	1.211	1.00
111_Q	127_Y	1.200	1.00
31_R	123_D	1.192	1.00
37_S	50_A	1.186	1.00
51_R	58_K	1.177	1.00
143_K	146_K	1.170	1.00
157_K	160_R	1.169	1.00
124_V	162_T	1.164	1.00
149_K	152_W	1.164	1.00
126_M	130_L	1.153	1.00
53_S	58_K	1.145	1.00
26_I	108_A	1.144	1.00
183_D	187_G	1.139	1.00
71_L	190_K	1.138	1.00
114_D	117_H	1.132	1.00
129_F	132_Y	1.122	1.00
108_A	192_M	1.120	1.00
33_N	54_S	1.120	1.00
39_F	43_L	1.118	1.00
139_V	171_L	1.101	1.00
154_K	158_V	1.090	1.00
26_I	189_I	1.088	1.00
187_G	191_K	1.088	1.00
128_E	131_K	1.082	1.00
23_L	72_H	1.077	1.00
128_E	132_Y	1.070	1.00
182_K	186_W	1.069	1.00
116_R	146_K	1.052	1.00
170_E	192_M	1.049	1.00
186_W	189_I	1.044	1.00
32_S	56_P	1.040	1.00
184_E	188_A	1.030	1.00
184_E	187_G	1.028	1.00
97_E	101_T	1.020	1.00
29_A	103_R	1.020	1.00
123_D	131_K	1.004	1.00
123_D	126_M	1.003	1.00
125_Q	128_E	1.000	1.00
41_N	50_A	0.989	1.00
153_D	157_K	0.965	1.00
170_E	173_L	0.959	1.00
43_L	186_W	0.950	1.00
90_E	93_G	0.948	1.00
186_W	190_K	0.948	1.00
121_N	125_Q	0.942	1.00
174_F	185_A	0.936	1.00
122_D	125_Q	0.935	1.00
43_L	73_F	0.931	1.00
147_I	152_W	0.922	1.00
158_V	161_Q	0.920	1.00
123_D	133_Y	0.915	1.00
123_D	130_L	0.909	1.00
98_T	101_T	0.903	1.00
39_F	176_S	0.902	1.00
80_G	92_W	0.899	1.00
155_H	159_V	0.894	1.00
89_R	92_W	0.889	1.00
178_T	181_G	0.887	1.00
154_K	157_K	0.885	1.00
42_S	176_S	0.885	1.00
94_R	98_T	0.883	1.00
110_V	185_A	0.882	1.00
90_E	94_R	0.879	1.00
113_V	141_A	0.873	1.00
27_A	76_V	0.859	1.00
153_D	156_A	0.856	1.00
114_D	143_K	0.847	1.00
115_L	144_A	0.845	1.00
174_F	182_K	0.842	1.00
187_G	190_K	0.839	1.00
144_A	180_K	0.834	1.00
26_I	71_L	0.834	1.00
116_R	119_P	0.828	1.00
114_D	142_T	0.825	1.00
104_E	133_Y	0.825	1.00
106_L	109_V	0.825	1.00
152_W	173_L	0.822	1.00
136_P	192_M	0.818	1.00
31_R	122_D	0.817	1.00
62_L	102_T	0.809	1.00
119_P	124_V	0.809	1.00
49_L	65_Y	0.805	1.00
183_D	186_W	0.804	1.00
88_E	91_A	0.801	1.00
92_W	95_M	0.793	1.00
39_F	182_K	0.790	1.00
23_L	66_I	0.787	1.00
115_L	147_I	0.787	1.00
172_I	184_E	0.787	1.00
185_A	189_I	0.786	1.00
160_R	164_N	0.782	1.00
26_I	73_F	0.777	1.00
170_E	191_K	0.773	1.00
39_F	140_I	0.772	1.00
25_E	105_E	0.771	1.00
50_A	65_Y	0.769	1.00
152_W	156_A	0.765	1.00
40_I	65_Y	0.760	1.00
138_I	170_E	0.757	1.00
96_I	100_I	0.755	1.00
67_I	186_W	0.754	1.00
126_M	133_Y	0.753	1.00
25_E	74_V	0.752	1.00
101_T	104_E	0.748	1.00
39_F	174_F	0.745	1.00
121_N	124_V	0.744	1.00
108_A	189_I	0.740	1.00
29_A	109_V	0.739	1.00
96_I	99_Y	0.739	1.00
91_A	94_R	0.735	1.00
127_Y	137_V	0.735	1.00
79_Y	99_Y	0.734	1.00
179_K	182_K	0.733	1.00
111_Q	139_V	0.732	1.00
23_L	70_E	0.731	1.00
28_L	39_F	0.724	1.00
93_G	97_E	0.724	1.00
25_E	107_K	0.717	1.00
92_W	96_I	0.713	1.00
108_A	136_P	0.711	1.00
126_M	129_F	0.711	1.00
130_L	137_V	0.708	1.00
77_P	95_M	0.707	1.00
38_S	52_T	0.706	1.00
127_Y	133_Y	0.703	1.00
91_A	95_M	0.703	1.00
77_P	99_Y	0.690	1.00
67_I	71_L	0.686	1.00
123_D	129_F	0.686	1.00
93_G	96_I	0.676	1.00
160_R	171_L	0.661	1.00
161_Q	164_N	0.659	1.00
151_K	154_K	0.657	1.00
80_G	96_I	0.647	1.00
67_I	73_F	0.640	1.00
164_N	168_E	0.635	1.00
31_R	117_H	0.633	1.00
50_A	53_S	0.627	1.00
119_P	123_D	0.625	1.00
86_K	89_R	0.623	1.00
152_W	155_H	0.621	1.00
98_T	102_T	0.618	1.00
137_V	169_D	0.617	1.00
80_G	99_Y	0.612	1.00
44_I	67_I	0.611	1.00
42_S	177_E	0.608	1.00
144_A	152_W	0.599	1.00
119_P	122_D	0.599	1.00
175_S	178_T	0.595	1.00
140_I	172_I	0.594	1.00
42_S	174_F	0.592	1.00
64_F	105_E	0.587	1.00
177_E	180_K	0.583	1.00
109_V	135_I	0.581	1.00
111_Q	130_L	0.581	1.00
168_E	171_L	0.580	1.00
156_A	159_V	0.578	1.00
172_I	181_G	0.571	1.00
174_F	177_E	0.571	1.00
146_K	149_K	0.567	1.00
116_R	120_S	0.562	1.00
138_I	192_M	0.560	1.00
89_R	93_G	0.559	1.00
25_E	64_F	0.558	1.00
60_Q	88_E	0.557	1.00
26_I	110_V	0.556	1.00
28_L	50_A	0.553	1.00
139_V	169_D	0.553	1.00
45_N	186_W	0.548	1.00
76_V	99_Y	0.542	1.00
59_T	62_L	0.535	1.00
46_R	65_Y	0.534	1.00
148_P	173_L	0.533	1.00
180_K	184_E	0.533	1.00
176_S	179_K	0.531	1.00
40_I	44_I	0.531	1.00
40_I	63_N	0.531	1.00
24_P	71_L	0.523	1.00
124_V	131_K	0.519	1.00
61_T	77_P	0.517	1.00
38_S	174_F	0.513	1.00
103_R	109_V	0.510	1.00
169_D	173_L	0.507	1.00
147_I	151_K	0.505	1.00
162_T	167_P	0.504	1.00
159_V	163_L	0.502	1.00
164_N	167_P	0.501	1.00
101_T	105_E	0.501	1.00
139_V	168_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sviA	1	0.9333	100	0.295	Contact Map
1mkyA	1	0.9026	100	0.319	Contact Map
3pqcA	1	0.9897	100	0.325	Contact Map
3j8gX	1	0.9538	100	0.326	Contact Map
4dcuA	1	0.9333	100	0.331	Contact Map
3ievA	1	0.8718	100	0.332	Contact Map
1puiA	1	0.8667	100	0.337	Contact Map
3geeA	2	0.7333	100	0.345	Contact Map
1egaA	2	0.8615	100	0.346	Contact Map
4dheA	1	0.9949	100	0.352	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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