GREMLIN Database
ENGB - Probable GTP-binding protein EngB
UniProt: P38424 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (164)
Sequences: 28799 (17546)
Seq/√Len: 1370.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_S179_K3.1761.00
172_I188_A2.8821.00
110_V140_I2.8401.00
188_A191_K2.7671.00
38_S176_S2.4911.00
115_L141_A2.3281.00
170_E188_A2.2811.00
64_F72_H2.2181.00
144_A173_L2.1821.00
27_A106_L2.0091.00
25_E72_H1.9581.00
188_A192_M1.9141.00
69_D190_K1.9121.00
41_N52_T1.8961.00
113_V139_V1.8681.00
66_I70_E1.8321.00
39_F112_I1.7501.00
108_A138_I1.7391.00
141_A173_L1.7351.00
42_S182_K1.6961.00
112_I142_T1.6861.00
44_I49_L1.6361.00
156_A173_L1.6361.00
156_A160_R1.6261.00
129_F133_Y1.6181.00
110_V189_I1.6111.00
100_I129_F1.5531.00
138_I188_A1.5461.00
158_V162_T1.5271.00
66_I72_H1.4861.00
140_I174_F1.4851.00
123_D127_Y1.4671.00
28_L110_V1.4631.00
127_Y130_L1.4521.00
39_F185_A1.4411.00
155_H158_V1.4411.00
46_R49_L1.4251.00
127_Y131_K1.4101.00
50_A63_N1.4061.00
28_L40_I1.4051.00
142_T176_S1.3841.00
44_I65_Y1.3671.00
140_I185_A1.3581.00
40_I50_A1.3571.00
94_R97_E1.3451.00
130_L133_Y1.3371.00
111_Q137_V1.3371.00
141_A171_L1.3251.00
110_V138_I1.3221.00
64_F74_V1.2981.00
124_V128_E1.2721.00
148_P151_K1.2601.00
157_K161_Q1.2571.00
138_I172_I1.2541.00
125_Q129_F1.2491.00
181_G184_E1.2241.00
62_L74_V1.2191.00
117_H120_S1.2111.00
111_Q127_Y1.2001.00
31_R123_D1.1921.00
37_S50_A1.1861.00
51_R58_K1.1771.00
143_K146_K1.1701.00
157_K160_R1.1691.00
124_V162_T1.1641.00
149_K152_W1.1641.00
126_M130_L1.1531.00
53_S58_K1.1451.00
26_I108_A1.1441.00
183_D187_G1.1391.00
71_L190_K1.1381.00
114_D117_H1.1321.00
129_F132_Y1.1221.00
108_A192_M1.1201.00
33_N54_S1.1201.00
39_F43_L1.1181.00
139_V171_L1.1011.00
154_K158_V1.0901.00
26_I189_I1.0881.00
187_G191_K1.0881.00
128_E131_K1.0821.00
23_L72_H1.0771.00
128_E132_Y1.0701.00
182_K186_W1.0691.00
116_R146_K1.0521.00
170_E192_M1.0491.00
186_W189_I1.0441.00
32_S56_P1.0401.00
184_E188_A1.0301.00
184_E187_G1.0281.00
97_E101_T1.0201.00
29_A103_R1.0201.00
123_D131_K1.0041.00
123_D126_M1.0031.00
125_Q128_E1.0001.00
41_N50_A0.9891.00
153_D157_K0.9651.00
170_E173_L0.9591.00
43_L186_W0.9501.00
90_E93_G0.9481.00
186_W190_K0.9481.00
121_N125_Q0.9421.00
174_F185_A0.9361.00
122_D125_Q0.9351.00
43_L73_F0.9311.00
147_I152_W0.9221.00
158_V161_Q0.9201.00
123_D133_Y0.9151.00
123_D130_L0.9091.00
98_T101_T0.9031.00
39_F176_S0.9021.00
80_G92_W0.8991.00
155_H159_V0.8941.00
89_R92_W0.8891.00
178_T181_G0.8871.00
154_K157_K0.8851.00
42_S176_S0.8851.00
94_R98_T0.8831.00
110_V185_A0.8821.00
90_E94_R0.8791.00
113_V141_A0.8731.00
27_A76_V0.8591.00
153_D156_A0.8561.00
114_D143_K0.8471.00
115_L144_A0.8451.00
174_F182_K0.8421.00
187_G190_K0.8391.00
144_A180_K0.8341.00
26_I71_L0.8341.00
116_R119_P0.8281.00
114_D142_T0.8251.00
104_E133_Y0.8251.00
106_L109_V0.8251.00
152_W173_L0.8221.00
136_P192_M0.8181.00
31_R122_D0.8171.00
62_L102_T0.8091.00
119_P124_V0.8091.00
49_L65_Y0.8051.00
183_D186_W0.8041.00
88_E91_A0.8011.00
92_W95_M0.7931.00
39_F182_K0.7901.00
23_L66_I0.7871.00
115_L147_I0.7871.00
172_I184_E0.7871.00
185_A189_I0.7861.00
160_R164_N0.7821.00
26_I73_F0.7771.00
170_E191_K0.7731.00
39_F140_I0.7721.00
25_E105_E0.7711.00
50_A65_Y0.7691.00
152_W156_A0.7651.00
40_I65_Y0.7601.00
138_I170_E0.7571.00
96_I100_I0.7551.00
67_I186_W0.7541.00
126_M133_Y0.7531.00
25_E74_V0.7521.00
101_T104_E0.7481.00
39_F174_F0.7451.00
121_N124_V0.7441.00
108_A189_I0.7401.00
29_A109_V0.7391.00
96_I99_Y0.7391.00
91_A94_R0.7351.00
127_Y137_V0.7351.00
79_Y99_Y0.7341.00
179_K182_K0.7331.00
111_Q139_V0.7321.00
23_L70_E0.7311.00
28_L39_F0.7241.00
93_G97_E0.7241.00
25_E107_K0.7171.00
92_W96_I0.7131.00
108_A136_P0.7111.00
126_M129_F0.7111.00
130_L137_V0.7081.00
77_P95_M0.7071.00
38_S52_T0.7061.00
127_Y133_Y0.7031.00
91_A95_M0.7031.00
77_P99_Y0.6901.00
67_I71_L0.6861.00
123_D129_F0.6861.00
93_G96_I0.6761.00
160_R171_L0.6611.00
161_Q164_N0.6591.00
151_K154_K0.6571.00
80_G96_I0.6471.00
67_I73_F0.6401.00
164_N168_E0.6351.00
31_R117_H0.6331.00
50_A53_S0.6271.00
119_P123_D0.6251.00
86_K89_R0.6231.00
152_W155_H0.6211.00
98_T102_T0.6181.00
137_V169_D0.6171.00
80_G99_Y0.6121.00
44_I67_I0.6111.00
42_S177_E0.6081.00
144_A152_W0.5991.00
119_P122_D0.5991.00
175_S178_T0.5951.00
140_I172_I0.5941.00
42_S174_F0.5921.00
64_F105_E0.5871.00
177_E180_K0.5831.00
109_V135_I0.5811.00
111_Q130_L0.5811.00
168_E171_L0.5801.00
156_A159_V0.5781.00
172_I181_G0.5711.00
174_F177_E0.5711.00
146_K149_K0.5671.00
116_R120_S0.5621.00
138_I192_M0.5601.00
89_R93_G0.5591.00
25_E64_F0.5581.00
60_Q88_E0.5571.00
26_I110_V0.5561.00
28_L50_A0.5531.00
139_V169_D0.5531.00
45_N186_W0.5481.00
76_V99_Y0.5421.00
59_T62_L0.5351.00
46_R65_Y0.5341.00
148_P173_L0.5331.00
180_K184_E0.5331.00
176_S179_K0.5311.00
40_I44_I0.5311.00
40_I63_N0.5311.00
24_P71_L0.5231.00
124_V131_K0.5191.00
61_T77_P0.5171.00
38_S174_F0.5131.00
103_R109_V0.5101.00
169_D173_L0.5071.00
147_I151_K0.5051.00
162_T167_P0.5041.00
159_V163_L0.5021.00
164_N167_P0.5011.00
101_T105_E0.5011.00
139_V168_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sviA 1 0.9333 100 0.295 Contact Map
1mkyA 1 0.9026 100 0.319 Contact Map
3pqcA 1 0.9897 100 0.325 Contact Map
3j8gX 1 0.9538 100 0.326 Contact Map
4dcuA 1 0.9333 100 0.331 Contact Map
3ievA 1 0.8718 100 0.332 Contact Map
1puiA 1 0.8667 100 0.337 Contact Map
3geeA 2 0.7333 100 0.345 Contact Map
1egaA 2 0.8615 100 0.346 Contact Map
4dheA 1 0.9949 100 0.352 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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