GREMLIN Database
DACF - D-alanyl-D-alanine carboxypeptidase DacF
UniProt: P38422 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (362)
Sequences: 4242 (3349)
Seq/√Len: 176.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_N177_Y3.7651.00
53_N56_S3.7361.00
137_S146_K3.0061.00
113_V132_M2.9481.00
92_S134_E2.9441.00
88_K110_E2.9401.00
74_I132_M2.7901.00
348_T360_E2.7411.00
42_L276_A2.6331.00
55_N58_E2.5741.00
183_A229_V2.5581.00
87_D135_F2.5501.00
227_D251_R2.5411.00
93_E107_P2.4931.00
156_L182_M2.4821.00
150_K153_E2.4461.00
252_A276_A2.4331.00
345_E362_P2.4201.00
118_K198_T2.4111.00
76_E150_K2.3831.00
120_I132_M2.3721.00
225_G247_K2.3391.00
59_R173_Y2.3281.00
72_L185_E2.3181.00
227_D244_S2.2641.00
112_T115_E2.2161.00
119_G125_G2.1901.00
68_I242_T2.1761.00
340_I365_A2.1241.00
57_N158_N2.0821.00
120_I129_S2.0741.00
140_E164_P2.0551.00
40_A52_Y2.0501.00
69_M159_T2.0451.00
284_P287_K2.0321.00
246_K249_N1.9921.00
45_R253_I1.9911.00
90_R110_E1.9641.00
302_Q367_E1.9581.00
177_Y181_I1.9481.00
254_A269_V1.9281.00
142_E145_K1.9111.00
308_T366_K1.8891.00
139_S142_E1.8491.00
336_I346_L1.8151.00
352_K357_V1.8151.00
145_K149_K1.8031.00
59_R158_N1.8021.00
69_M151_A1.7851.00
245_A277_F1.7811.00
268_Q271_K1.7511.00
183_A242_T1.7371.00
89_V135_F1.7291.00
137_S142_E1.7061.00
89_V131_A1.6921.00
91_T131_A1.6861.00
154_L185_E1.6731.00
345_E348_T1.6481.00
357_V360_E1.6441.00
88_K112_T1.6331.00
65_M242_T1.6241.00
86_S114_K1.6211.00
42_L252_A1.6141.00
94_H134_E1.6141.00
92_S95_A1.6101.00
39_S60_L1.6091.00
39_S176_A1.5961.00
344_Q365_A1.5921.00
329_E352_K1.5891.00
156_L181_I1.5881.00
65_M179_M1.5781.00
159_T174_S1.5731.00
70_T129_S1.5721.00
71_M121_A1.5711.00
191_S194_K1.5641.00
310_S362_P1.5611.00
44_E250_M1.5541.00
160_S173_Y1.5451.00
294_K304_F1.5341.00
234_T237_A1.5241.00
346_L365_A1.5161.00
185_E188_K1.5111.00
71_M120_I1.5051.00
184_K253_I1.4981.00
122_I198_T1.4771.00
38_K258_G1.4561.00
350_V360_E1.4461.00
77_A82_K1.4441.00
93_E97_S1.4441.00
223_Y274_D1.4421.00
176_A257_F1.4391.00
149_K153_E1.4311.00
114_K118_K1.4221.00
91_T105_L1.4211.00
168_T236_E1.4151.00
331_K350_V1.4091.00
200_E212_W1.4081.00
162_K171_G1.3891.00
114_K195_F1.3891.00
62_P174_S1.3811.00
119_G128_A1.3801.00
114_K194_K1.3791.00
74_I113_V1.3781.00
84_K87_D1.3781.00
341_Q368_D1.3731.00
305_I365_A1.3701.00
83_I135_F1.3661.00
41_V177_Y1.3341.00
342_K368_D1.3331.00
350_V357_V1.3311.00
162_K169_E1.3311.00
179_M242_T1.3231.00
78_L113_V1.3231.00
341_Q344_Q1.3131.00
118_K201_D1.3031.00
184_K188_K1.3021.00
71_M117_L1.2991.00
65_M257_F1.2961.00
66_T172_H1.2941.00
226_V243_A1.2901.00
85_M117_L1.2901.00
61_A168_T1.2801.00
41_V56_S1.2731.00
95_A134_E1.2561.00
243_A269_V1.2521.00
42_L254_A1.2451.00
329_E350_V1.2431.00
284_P314_S1.2421.00
85_M114_K1.2301.00
202_Y212_W1.2211.00
118_K122_I1.2171.00
98_M130_V1.2171.00
193_T244_S1.2161.00
146_K149_K1.2151.00
330_I363_V1.2131.00
281_E319_K1.2101.00
61_A236_E1.2071.00
103_I119_G1.2041.00
79_D191_S1.2041.00
151_A156_L1.1981.00
244_S251_R1.1901.00
331_K348_T1.1811.00
72_L150_K1.1811.00
246_K251_R1.1781.00
41_V50_V1.1721.00
142_E146_K1.1641.00
39_S55_N1.1571.00
199_Y221_K1.1571.00
77_A146_K1.1561.00
124_S230_K1.1481.00
40_A54_K1.1401.00
306_E366_K1.1361.00
372_A376_T1.1281.00
68_I229_V1.1261.00
223_Y226_V1.1201.00
237_A240_C1.1191.00
256_V269_V1.1091.00
56_S177_Y1.1081.00
150_K185_E1.1051.00
261_T264_E1.1021.00
365_A368_D1.1021.00
287_K290_Q1.1001.00
73_L77_A1.0941.00
74_I120_I1.0921.00
287_K312_P1.0911.00
144_V164_P1.0861.00
57_N175_S1.0861.00
68_I183_A1.0811.00
48_G184_K1.0641.00
259_A268_Q1.0601.00
270_T274_D1.0591.00
327_K352_K1.0581.00
43_I180_A1.0531.00
301_K370_K1.0511.00
83_I113_V1.0491.00
144_V148_N1.0400.99
295_V307_L1.0390.99
162_K172_H1.0320.99
37_A259_A1.0210.99
321_E325_D1.0200.99
94_H141_E1.0170.99
83_I132_M1.0150.99
284_P312_P1.0100.99
245_A273_L1.0100.99
226_V273_L1.0090.99
129_S164_P0.9970.99
196_T229_V0.9970.99
243_A273_L0.9950.99
300_G338_A0.9930.99
77_A136_I0.9930.99
373_G376_T0.9900.99
310_S364_A0.9830.99
318_K321_E0.9830.99
193_T251_R0.9790.99
247_K277_F0.9750.99
294_K306_E0.9650.99
74_I83_I0.9630.99
282_T316_L0.9620.99
96_A107_P0.9580.99
91_T111_M0.9570.99
187_L193_T0.9520.99
62_P257_F0.9510.99
124_S231_T0.9480.99
46_D282_T0.9460.99
59_R175_S0.9420.99
38_K60_L0.9400.99
75_M192_I0.9360.99
151_A182_M0.9360.99
79_D87_D0.9340.99
307_L346_L0.9330.99
372_A380_R0.9320.99
158_N175_S0.9290.99
286_Y309_T0.9280.99
73_L150_K0.9270.99
73_L136_I0.9260.99
44_E282_T0.9220.99
86_S112_T0.9210.99
180_A255_V0.9190.99
46_D251_R0.9180.99
223_Y245_A0.9090.99
89_V113_V0.9060.99
94_H140_E0.9030.99
157_K177_Y0.9020.99
68_I186_L0.9020.99
194_K197_G0.9010.99
247_K274_D0.8960.98
136_I146_K0.8960.98
242_T255_V0.8960.98
130_V140_E0.8930.98
106_E109_E0.8920.98
225_G274_D0.8910.98
275_F280_Y0.8910.98
305_I340_I0.8910.98
306_E367_E0.8880.98
260_S264_E0.8850.98
149_K152_K0.8850.98
160_S171_G0.8830.98
78_L192_I0.8790.98
72_L189_Y0.8790.98
179_M257_F0.8770.98
78_L83_I0.8740.98
44_E316_L0.8740.98
305_I369_M0.8720.98
282_T314_S0.8710.98
79_D189_Y0.8710.98
125_G128_A0.8680.98
46_D314_S0.8640.98
204_R210_K0.8600.98
352_K355_G0.8570.98
91_T116_M0.8530.98
313_I359_A0.8520.98
288_R312_P0.8500.98
13_M16_T0.8500.98
371_K377_F0.8480.98
223_Y270_T0.8470.98
246_K277_F0.8470.98
90_R135_F0.8450.98
121_A196_T0.8420.98
229_V244_S0.8420.98
105_L131_A0.8410.98
328_K351_L0.8410.98
168_T234_T0.8390.98
111_M115_E0.8380.98
36_E268_Q0.8360.98
203_L213_L0.8350.98
85_M195_F0.8340.98
111_M116_M0.8320.98
74_I136_I0.8280.97
275_F279_Q0.8270.97
192_I196_T0.8240.97
34_A54_K0.8230.97
344_Q368_D0.8230.97
63_A237_A0.8220.97
148_N160_S0.8200.97
313_I361_S0.8190.97
193_T196_T0.8170.97
68_I121_A0.8160.97
64_S230_K0.8150.97
181_I184_K0.8150.97
339_P369_M0.8130.97
38_K58_E0.8070.97
43_I184_K0.8070.97
200_E214_V0.8030.97
179_M183_A0.8010.97
116_M128_A0.8000.97
349_L361_S0.8000.97
254_A273_L0.7990.97
69_M147_M0.7960.97
174_S179_M0.7940.97
81_G84_K0.7930.97
75_M189_Y0.7930.97
41_V53_N0.7920.97
186_L229_V0.7920.97
73_L76_E0.7920.97
41_V255_V0.7910.97
41_V180_A0.7900.97
241_L269_V0.7840.97
115_E204_R0.7810.96
340_I346_L0.7800.96
233_Y239_Y0.7770.96
102_Q105_L0.7750.96
115_E118_K0.7720.96
291_T306_E0.7700.96
326_V353_K0.7680.96
161_F179_M0.7680.96
109_E211_F0.7680.96
283_H322_D0.7620.96
51_L280_Y0.7610.96
218_R266_N0.7570.96
147_M151_A0.7530.96
256_V259_A0.7530.96
217_N243_A0.7500.96
325_D354_D0.7490.95
234_T240_C0.7480.95
14_L17_F0.7460.95
297_V338_A0.7440.95
141_E145_K0.7440.95
152_K157_K0.7430.95
204_R211_F0.7410.95
101_S125_G0.7410.95
183_A228_G0.7340.95
148_N161_F0.7340.95
187_L227_D0.7310.95
187_L251_R0.7310.95
259_A264_E0.7290.95
201_D213_L0.7290.95
336_I340_I0.7280.95
151_A154_L0.7270.95
117_L195_F0.7240.95
217_N241_L0.7200.94
69_M73_L0.7190.94
213_L216_T0.7190.94
151_A161_F0.7180.94
111_M203_L0.7170.94
69_M161_F0.7170.94
82_K146_K0.7170.94
118_K195_F0.7130.94
146_K150_K0.7130.94
75_M117_L0.7120.94
65_M240_C0.7110.94
297_V300_G0.7100.94
69_M156_L0.7100.94
309_T363_V0.7080.94
64_S67_K0.7060.94
202_Y210_K0.7020.94
186_L192_I0.7000.94
39_S257_F0.7000.94
300_G369_M0.6990.94
78_L132_M0.6960.93
123_A216_T0.6930.93
223_Y273_L0.6900.93
61_A169_E0.6890.93
78_L85_M0.6890.93
64_S124_S0.6870.93
353_K356_E0.6860.93
154_L182_M0.6840.93
89_V116_M0.6830.93
254_A272_M0.6810.93
71_M75_M0.6800.93
374_F378_L0.6790.93
71_M196_T0.6780.92
73_L147_M0.6780.92
60_L257_F0.6780.92
100_G127_D0.6720.92
186_L189_Y0.6710.92
103_I123_A0.6700.92
343_G365_A0.6690.92
264_E267_A0.6620.92
103_I111_M0.6590.91
250_M282_T0.6570.91
53_N177_Y0.6560.91
158_N178_D0.6560.91
85_M88_K0.6550.91
250_M280_Y0.6540.91
18_A21_A0.6540.91
92_S131_A0.6540.91
353_K358_L0.6500.91
121_A192_I0.6500.91
192_I229_V0.6480.91
307_L363_V0.6480.91
98_M167_L0.6460.91
64_S232_G0.6450.90
243_A254_A0.6450.90
159_T178_D0.6430.90
83_I89_V0.6420.90
69_M182_M0.6410.90
225_G245_A0.6400.90
35_H40_A0.6390.90
68_I182_M0.6370.90
327_K355_G0.6370.90
115_E201_D0.6340.90
144_V159_T0.6330.90
76_E153_E0.6310.90
123_A213_L0.6290.89
63_A66_T0.6270.89
49_K316_L0.6260.89
328_K349_L0.6260.89
330_I349_L0.6250.89
148_N152_K0.6240.89
53_N57_N0.6240.89
94_H98_M0.6220.89
122_I201_D0.6220.89
162_K170_E0.6210.89
43_I253_I0.6200.89
26_D29_R0.6190.89
49_K356_E0.6170.88
78_L136_I0.6170.88
73_L159_T0.6140.88
271_K274_D0.6130.88
300_G339_P0.6110.88
99_G102_Q0.6100.88
116_M132_M0.6100.88
83_I87_D0.6070.88
196_T244_S0.6060.88
264_E268_Q0.6050.87
196_T228_G0.6040.87
157_K181_I0.6030.87
43_I181_I0.5990.87
44_E47_T0.5990.87
67_K126_N0.5960.87
75_M191_S0.5950.87
309_T313_I0.5950.87
73_L146_K0.5940.87
233_Y262_P0.5940.87
179_M240_C0.5900.86
131_A135_F0.5880.86
136_I144_V0.5880.86
78_L87_D0.5880.86
62_P66_T0.5870.86
283_H317_T0.5870.86
326_V358_L0.5860.86
256_V272_M0.5850.86
63_A231_T0.5830.85
299_K337_S0.5800.85
37_A268_Q0.5800.85
65_M68_I0.5780.85
223_Y247_K0.5770.85
241_L256_V0.5760.85
301_K376_T0.5760.85
140_E144_V0.5750.85
66_T174_S0.5750.85
241_L254_A0.5740.85
186_L196_T0.5740.85
217_N220_I0.5740.85
231_T265_R0.5730.85
174_S178_D0.5730.85
289_N309_T0.5730.85
150_K154_L0.5710.84
33_L275_F0.5710.84
239_Y262_P0.5700.84
10_I16_T0.5690.84
50_V53_N0.5690.84
49_K321_E0.5680.84
376_T379_K0.5670.84
156_L178_D0.5670.84
42_L272_M0.5650.84
285_L315_I0.5650.84
226_V245_A0.5650.84
16_T20_S0.5650.84
62_P179_M0.5640.84
216_T233_Y0.5630.83
64_S231_T0.5630.83
98_M102_Q0.5630.83
272_M276_A0.5610.83
9_L12_I0.5600.83
75_M196_T0.5600.83
376_T380_R0.5590.83
160_S172_H0.5590.83
279_Q318_K0.5590.83
9_L16_T0.5570.83
222_F270_T0.5550.83
10_I18_A0.5540.83
348_T362_P0.5530.82
168_T237_A0.5530.82
72_L154_L0.5530.82
273_L276_A0.5510.82
133_A140_E0.5510.82
114_K191_S0.5510.82
45_R184_K0.5490.82
219_L241_L0.5490.82
119_G213_L0.5470.82
76_E189_Y0.5470.82
100_G104_F0.5440.81
63_A124_S0.5430.81
172_H240_C0.5430.81
62_P172_H0.5420.81
286_Y351_L0.5410.81
59_R174_S0.5410.81
63_A232_G0.5410.81
192_I195_F0.5400.81
241_L266_N0.5400.81
239_Y265_R0.5370.81
45_R188_K0.5360.80
227_D246_K0.5350.80
223_Y277_F0.5350.80
109_E204_R0.5350.80
286_Y349_L0.5330.80
77_A83_I0.5320.80
55_N60_L0.5320.80
103_I125_G0.5320.80
286_Y289_N0.5310.80
165_T168_T0.5300.80
117_L121_A0.5300.80
111_M119_G0.5270.79
338_A369_M0.5270.79
193_T227_D0.5270.79
181_I185_E0.5240.79
317_T324_N0.5240.79
35_H268_Q0.5240.79
102_Q127_D0.5230.79
373_G377_F0.5230.79
321_E353_K0.5220.79
12_I19_P0.5210.79
285_L351_L0.5210.79
317_T326_V0.5200.78
163_N168_T0.5200.78
75_M195_F0.5190.78
101_S230_K0.5180.78
103_I213_L0.5180.78
345_E364_A0.5170.78
187_L229_V0.5170.78
143_F147_M0.5170.78
43_I48_G0.5140.78
179_M182_M0.5140.78
283_H286_Y0.5130.77
68_I75_M0.5120.77
375_I379_K0.5110.77
297_V305_I0.5100.77
197_G227_D0.5090.77
298_K335_N0.5090.77
289_N308_T0.5090.77
101_S231_T0.5070.77
29_R33_L0.5060.77
71_M186_L0.5060.77
193_T197_G0.5060.77
357_V361_S0.5050.76
122_I195_F0.5050.76
250_M316_L0.5050.76
199_Y214_V0.5040.76
70_T143_F0.5040.76
14_L20_S0.5030.76
109_E203_L0.5020.76
147_M161_F0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mzfA 1 0.8895 100 0.248 Contact Map
3itaA 1 0.8766 100 0.263 Contact Map
4k91A 1 0.8792 100 0.265 Contact Map
3a3jA 1 0.8663 100 0.277 Contact Map
3mfdA 1 0.8226 100 0.286 Contact Map
1xp4A 3 0.8483 100 0.287 Contact Map
3hunA 1 0.8072 100 0.379 Contact Map
1tvfA 1 0.8355 100 0.41 Contact Map
4pprA 1 0.7481 100 0.482 Contact Map
4ryeA 1 0.6658 100 0.488 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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