GREMLIN Database
PBPF - Penicillin-binding protein 1F
UniProt: P38050 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 714 (603)
Sequences: 8559 (5861)
Seq/√Len: 238.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_K196_E4.8821.00
178_Q188_E4.1421.00
238_A242_V4.0611.00
231_N241_A3.8911.00
237_S240_E3.8641.00
464_A565_A3.7541.00
556_A565_A3.4651.00
487_D491_E3.2951.00
405_V415_K3.2661.00
326_F564_G3.2491.00
77_K81_E3.2361.00
326_F593_I3.0891.00
220_K224_D3.0681.00
307_M322_G2.9081.00
231_N238_A2.9011.00
475_T502_R2.8961.00
513_T558_Y2.7781.00
79_V177_I2.6881.00
265_Y294_P2.6781.00
178_Q189_V2.5841.00
92_Y158_D2.5361.00
228_G245_Q2.4851.00
329_N563_T2.4341.00
90_R98_D2.4021.00
81_E235_Y2.3991.00
54_Q296_D2.3961.00
388_S393_T2.3931.00
101_S104_R2.3811.00
156_S159_K2.3711.00
241_A245_Q2.3431.00
52_V290_T2.3241.00
77_K80_R2.2911.00
53_D57_D2.2881.00
71_S74_E2.2861.00
195_S247_R2.2671.00
72_I80_R2.2641.00
409_D413_Y2.2421.00
328_N331_T2.2291.00
324_A593_I2.2241.00
194_V236_I2.1721.00
408_S514_R2.1231.00
333_G483_S2.1111.00
80_R158_D2.1011.00
333_G480_F2.0971.00
72_I162_E2.0811.00
86_V225_T2.0691.00
334_V481_F2.0631.00
50_K58_E2.0601.00
465_G479_P2.0441.00
292_K484_S2.0431.00
76_P189_V2.0271.00
303_A324_A1.9841.00
408_S518_Q1.9751.00
199_V219_N1.9641.00
72_I158_D1.9571.00
309_E592_D1.9521.00
78_Q197_G1.9461.00
465_G476_Y1.9311.00
108_R117_E1.9201.00
89_K229_M1.9181.00
350_R571_D1.9181.00
74_E190_K1.8841.00
328_N335_E1.8811.00
369_P434_Y1.8811.00
335_E562_I1.8761.00
78_Q81_E1.8551.00
514_R517_Q1.8511.00
83_F201_A1.7991.00
174_V183_Y1.7981.00
470_F512_M1.7961.00
364_L466_A1.7941.00
357_P458_V1.7911.00
194_V244_A1.7841.00
402_E415_K1.7831.00
206_A209_T1.7771.00
94_H152_E1.7691.00
228_G241_A1.7681.00
473_N510_W1.7521.00
397_Y581_A1.7421.00
460_P565_A1.7371.00
372_Q437_A1.7371.00
381_L404_E1.7241.00
366_V450_A1.7231.00
463_L556_A1.7181.00
50_K290_T1.7101.00
86_V229_M1.7071.00
229_M232_D1.7031.00
299_L597_A1.6971.00
378_P515_M1.6961.00
227_L241_A1.6891.00
52_V292_K1.6881.00
79_V197_G1.6871.00
378_P511_N1.6851.00
361_F435_L1.6841.00
325_V460_P1.6821.00
89_K233_Q1.6761.00
188_E191_D1.6701.00
328_N333_G1.6691.00
423_L431_G1.6651.00
325_V461_L1.6591.00
85_A235_Y1.6571.00
433_S437_A1.6431.00
290_T486_I1.6311.00
84_I92_Y1.6251.00
371_M515_M1.6201.00
83_F170_F1.6131.00
127_A151_L1.6091.00
229_M233_Q1.6001.00
382_L425_E1.5991.00
507_Q609_N1.5871.00
363_P470_F1.5861.00
301_K305_Q1.5841.00
590_F594_L1.5821.00
337_A349_N1.5751.00
85_A233_Q1.5731.00
54_Q335_E1.5731.00
268_L481_F1.5711.00
510_W607_P1.5661.00
591_K595_T1.5461.00
535_A558_Y1.5421.00
533_D601_G1.5381.00
536_G555_F1.5381.00
104_R117_E1.5331.00
79_V83_F1.5281.00
327_I464_A1.5201.00
215_H218_K1.5181.00
374_K430_T1.5131.00
231_N236_I1.4881.00
504_F509_S1.4871.00
83_F204_P1.4811.00
299_L335_E1.4771.00
360_T463_L1.4771.00
324_A564_G1.4751.00
182_H186_N1.4751.00
368_G470_F1.4731.00
169_Y173_G1.4641.00
412_T518_Q1.4461.00
155_Y163_M1.4441.00
70_V75_I1.4421.00
302_T596_Q1.4351.00
430_T433_S1.4341.00
168_L204_P1.4321.00
57_D297_S1.4321.00
518_Q522_K1.4241.00
112_A116_V1.4231.00
80_R92_Y1.4101.00
368_G508_T1.4081.00
192_L197_G1.4081.00
561_K602_H1.4061.00
82_A230_M1.3971.00
492_T495_D1.3951.00
193_T247_R1.3921.00
410_A418_P1.3901.00
423_L428_V1.3901.00
72_I75_I1.3891.00
349_N352_T1.3861.00
534_L559_T1.3761.00
72_I92_Y1.3671.00
138_F142_T1.3661.00
368_G504_F1.3611.00
170_F177_I1.3601.00
228_G232_D1.3561.00
434_Y438_N1.3551.00
348_Y353_A1.3551.00
409_D412_T1.3511.00
468_H563_T1.3471.00
395_K399_S1.3451.00
398_D402_E1.3431.00
407_M422_T1.3371.00
442_I462_Q1.3351.00
520_V534_L1.3341.00
159_K162_E1.3321.00
217_D221_E1.3311.00
305_Q596_Q1.3251.00
265_Y295_L1.3181.00
486_I492_T1.3091.00
502_R506_K1.3081.00
484_S495_D1.3081.00
564_G593_I1.3061.00
477_T500_G1.3041.00
90_R93_E1.3021.00
303_A593_I1.2971.00
75_I79_V1.2941.00
302_T306_V1.2921.00
372_Q508_T1.2811.00
195_S244_A1.2771.00
424_N447_L1.2761.00
383_K404_E1.2741.00
568_M589_L1.2691.00
236_I241_A1.2651.00
267_D270_I1.2641.00
97_I145_V1.2641.00
238_A241_A1.2631.00
103_G106_V1.2601.00
242_V246_G1.2591.00
330_K561_K1.2581.00
71_S162_E1.2571.00
368_G512_M1.2571.00
78_Q194_V1.2551.00
371_M511_N1.2541.00
476_Y501_K1.2531.00
415_K418_P1.2461.00
224_D245_Q1.2431.00
242_V245_Q1.2391.00
231_N245_Q1.2381.00
98_D101_S1.2381.00
473_N506_K1.2351.00
372_Q434_Y1.2321.00
382_L418_P1.2311.00
324_A566_V1.2301.00
218_K221_E1.2291.00
470_F558_Y1.2281.00
58_E61_S1.2251.00
552_D567_W1.2241.00
269_V293_V1.2211.00
405_V418_P1.2201.00
70_V189_V1.2171.00
327_I563_T1.2161.00
368_G434_Y1.2161.00
364_L435_L1.2151.00
406_T409_D1.2111.00
216_P220_K1.2081.00
126_L163_M1.2081.00
75_I80_R1.2081.00
305_Q309_E1.2051.00
172_H211_S1.2011.00
438_N469_T1.2001.00
596_Q599_E1.1951.00
306_V592_D1.1891.00
239_K243_T1.1881.00
370_A422_T1.1871.00
303_A338_I1.1861.00
376_F425_E1.1861.00
299_L336_A1.1841.00
557_G590_F1.1831.00
307_M324_A1.1821.00
304_Y308_K1.1811.00
268_L272_E1.1811.00
513_T535_A1.1801.00
460_P464_A1.1741.00
387_Q421_W1.1701.00
423_L450_A1.1691.00
517_Q533_D1.1661.00
139_L143_K1.1581.00
513_T516_L1.1571.00
448_A453_G1.1551.00
268_L271_K1.1541.00
240_E243_T1.1521.00
12_P16_L1.1501.00
292_K486_I1.1411.00
187_K191_D1.1391.00
472_A477_T1.1391.00
165_L177_I1.1361.00
376_F407_M1.1351.00
355_R552_D1.1341.00
412_T522_K1.1321.00
54_Q333_G1.1311.00
119_G128_K1.1281.00
525_A528_G1.1271.00
407_M515_M1.1241.00
209_T218_K1.1241.00
464_A556_A1.1221.00
534_L590_F1.1211.00
521_K529_T1.1191.00
194_V227_L1.1151.00
440_I458_V1.1131.00
289_Y493_I1.1121.00
419_A422_T1.1111.00
392_Y420_V1.1051.00
364_L438_N1.1011.00
564_G594_L1.1001.00
533_D603_V1.0961.00
109_D115_K1.0951.00
53_D297_S1.0901.00
429_E445_E1.0881.00
417_A421_W1.0841.00
90_R94_H1.0811.00
356_Q541_T1.0801.00
429_E433_S1.0801.00
385_E421_W1.0771.00
78_Q240_E1.0701.00
262_F265_Y1.0691.00
471_A558_Y1.0651.00
79_V165_L1.0641.00
83_F165_L1.0621.00
437_A501_K1.0601.00
568_M586_P1.0601.00
372_Q505_S1.0581.00
150_N154_D1.0551.00
438_N504_F1.0501.00
269_V273_A1.0491.00
103_G107_Y1.0491.00
304_Y338_I1.0491.00
475_T500_G1.0461.00
102_V124_Q1.0461.00
16_L20_A1.0451.00
115_K136_K1.0451.00
398_D415_K1.0431.00
562_I597_A1.0401.00
228_G231_N1.0381.00
376_F380_S1.0351.00
411_I419_A1.0311.00
169_Y175_Y1.0271.00
329_N562_I1.0261.00
82_A201_A1.0261.00
51_I62_L1.0221.00
51_I59_V1.0211.00
606_K612_E1.0211.00
90_R100_K1.0181.00
307_M338_I1.0171.00
507_Q610_V1.0141.00
423_L449_L1.0121.00
325_V337_A1.0111.00
357_P361_F1.0111.00
434_Y504_F1.0111.00
99_A103_G1.0021.00
510_W606_K1.0011.00
102_V119_G1.0011.00
377_K380_S1.0011.00
401_Y417_A0.9991.00
195_S223_R0.9961.00
268_L337_A0.9951.00
277_Y494_A0.9911.00
518_Q521_K0.9841.00
178_Q182_H0.9821.00
220_K223_R0.9811.00
49_S291_I0.9801.00
115_K138_F0.9791.00
109_D138_F0.9771.00
616_P620_K0.9761.00
553_A586_P0.9751.00
299_L593_I0.9741.00
243_T247_R0.9741.00
106_V109_D0.9731.00
371_M512_M0.9721.00
294_P333_G0.9651.00
202_A219_N0.9621.00
56_G483_S0.9601.00
434_Y437_A0.9601.00
108_R116_V0.9581.00
615_S620_K0.9561.00
112_A115_K0.9551.00
517_Q603_V0.9541.00
470_F513_T0.9491.00
27_Y31_I0.9491.00
205_K210_Y0.9481.00
30_I34_G0.9471.00
325_V464_A0.9451.00
367_Y419_A0.9441.00
273_A485_I0.9421.00
265_Y481_F0.9421.00
509_S512_M0.9421.00
520_V525_A0.9401.00
310_G592_D0.9381.00
459_S462_Q0.9341.00
72_I161_L0.9321.00
519_V525_A0.9311.00
433_S436_K0.9291.00
142_T146_I0.9291.00
150_N153_R0.9291.00
484_S492_T0.9281.00
382_L422_T0.9271.00
81_E92_Y0.9271.00
376_F422_T0.9261.00
382_L407_M0.9261.00
426_I430_T0.9241.00
620_K623_K0.9241.00
127_A131_F0.9231.00
123_T152_E0.9221.00
616_P619_L0.9221.00
84_I235_Y0.9211.00
327_I479_P0.9191.00
384_D401_Y0.9191.00
432_K436_K0.9171.00
122_I168_L0.9151.00
52_V58_E0.9131.00
88_D94_H0.9131.00
310_G589_L0.9121.00
480_F496_H0.9111.00
152_E160_L0.9081.00
268_L334_V0.9021.00
469_T476_Y0.9011.00
128_K134_H0.9001.00
109_D112_A0.9001.00
272_E276_K0.9001.00
460_P554_W0.8981.00
86_V222_R0.8971.00
69_P162_E0.8961.00
366_V431_G0.8961.00
426_I431_G0.8941.00
592_D596_Q0.8941.00
368_G438_N0.8931.00
189_V192_L0.8921.00
583_S587_T0.8921.00
303_A336_A0.8890.99
57_D298_K0.8890.99
509_S513_T0.8870.99
417_A420_V0.8870.99
76_P79_V0.8860.99
357_P454_L0.8860.99
384_D403_G0.8860.99
405_V410_A0.8850.99
444_D454_L0.8850.99
80_R161_L0.8820.99
360_T556_A0.8810.99
402_E413_Y0.8800.99
411_I515_M0.8760.99
383_K421_W0.8760.99
102_V145_V0.8740.99
322_G589_L0.8740.99
152_E157_K0.8740.99
99_A102_V0.8730.99
261_W264_S0.8690.99
522_K526_T0.8680.99
420_V451_L0.8680.99
520_V555_F0.8640.99
566_V589_L0.8630.99
326_F562_I0.8610.99
86_V205_K0.8600.99
402_E405_V0.8600.99
526_T529_T0.8590.99
427_G430_T0.8580.99
283_Q287_G0.8560.99
342_D345_S0.8560.99
423_L447_L0.8560.99
517_Q521_K0.8530.99
432_K445_E0.8530.99
26_G30_I0.8530.99
129_N168_L0.8530.99
68_E178_Q0.8510.99
172_H183_Y0.8480.99
95_H99_A0.8430.99
296_D299_L0.8430.99
334_V461_L0.8390.99
297_S301_K0.8390.99
292_K483_S0.8380.99
217_D220_K0.8350.99
299_L326_F0.8350.99
560_P604_F0.8340.99
368_G509_S0.8330.99
76_P197_G0.8310.99
432_K449_L0.8300.99
458_V463_L0.8300.99
70_V178_Q0.8300.99
553_A582_G0.8280.99
109_D117_E0.8260.99
68_E182_H0.8260.99
199_V223_R0.8240.99
267_D343_Y0.8230.99
615_S623_K0.8210.99
619_L622_V0.8200.99
513_T604_F0.8200.99
264_S267_D0.8190.99
273_A291_I0.8180.99
551_K573_T0.8110.99
329_N471_A0.8100.99
384_D402_E0.8090.99
369_P431_G0.8080.99
199_V202_A0.8080.99
438_N466_A0.8080.99
109_D119_G0.8070.99
325_V351_V0.8070.99
206_A210_Y0.8060.99
460_P556_A0.8050.99
386_L401_Y0.8040.99
83_F177_I0.8030.99
186_N252_H0.8020.99
11_I15_I0.8010.99
382_L421_W0.8010.99
337_A351_V0.8010.99
371_M508_T0.7990.99
30_I33_L0.7970.99
464_A563_T0.7970.99
80_R84_I0.7970.99
263_D266_I0.7960.99
328_N561_K0.7960.99
593_I597_A0.7940.99
321_E350_R0.7930.99
294_P480_F0.7930.99
231_N242_V0.7920.99
516_L558_Y0.7920.99
363_P366_V0.7920.99
511_N610_V0.7910.99
124_Q144_E0.7900.99
363_P411_I0.7900.99
357_P453_G0.7900.99
33_L36_Y0.7860.99
337_A481_F0.7860.99
129_N167_Q0.7850.99
20_A24_L0.7850.99
32_F36_Y0.7830.99
520_V536_G0.7820.99
525_A555_F0.7790.99
508_T512_M0.7790.99
240_E244_A0.7770.99
236_I240_E0.7770.99
441_D462_Q0.7770.99
264_S340_G0.7750.99
505_S508_T0.7750.99
182_H188_E0.7720.99
594_L598_G0.7710.99
476_Y503_V0.7700.99
75_I177_I0.7700.99
329_N468_H0.7700.99
470_F504_F0.7690.99
542_S549_A0.7680.99
205_K209_T0.7680.99
193_T197_G0.7650.98
294_P483_S0.7620.98
323_S350_R0.7620.98
97_I149_I0.7600.98
247_R250_G0.7590.98
177_I200_L0.7590.98
95_H149_I0.7560.98
261_W265_Y0.7560.98
28_I32_F0.7540.98
239_K242_V0.7540.98
510_W610_V0.7530.98
138_F145_V0.7530.98
273_A289_Y0.7520.98
395_K401_Y0.7510.98
83_F122_I0.7510.98
370_A376_F0.7500.98
428_V445_E0.7490.98
576_N579_L0.7480.98
528_G587_T0.7460.98
367_Y411_I0.7460.98
262_F266_I0.7390.98
105_A109_D0.7380.98
55_N297_S0.7380.98
108_R112_A0.7370.98
478_E499_E0.7360.98
354_V462_Q0.7350.98
181_S197_G0.7350.98
436_K443_P0.7330.98
357_P463_L0.7320.98
376_F382_L0.7270.98
189_V197_G0.7270.98
186_N254_K0.7260.98
47_A69_P0.7250.98
99_A149_I0.7250.98
23_A27_Y0.7250.98
364_L463_L0.7230.98
19_T23_A0.7220.98
430_T434_Y0.7210.98
340_G350_R0.7200.98
132_L140_R0.7200.98
396_N401_Y0.7190.98
553_A580_K0.7180.98
9_L12_P0.7160.98
471_A535_A0.7160.98
84_I161_L0.7160.98
553_A585_Y0.7160.98
615_S619_L0.7140.98
220_K249_L0.7130.98
465_G478_E0.7120.98
321_E345_S0.7110.98
366_V451_L0.7110.98
558_Y563_T0.7080.97
323_S460_P0.7070.97
50_K61_S0.7070.97
274_E281_G0.7070.97
331_T480_F0.7060.97
514_R518_Q0.7060.97
564_G590_F0.7060.97
440_I466_A0.7060.97
225_T228_G0.7050.97
528_G591_K0.7050.97
552_D569_G0.7040.97
446_G453_G0.7000.97
436_K441_D0.7000.97
79_V192_L0.6990.97
301_K304_Y0.6990.97
463_L554_W0.6980.97
506_K609_N0.6980.97
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90_R152_E0.5590.91
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330_K602_H0.5590.91
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115_K119_G0.5550.91
28_I36_Y0.5540.91
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471_A563_T0.5540.91
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397_Y550_T0.5520.91
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619_L623_K0.5500.90
386_L395_K0.5500.90
411_I512_M0.5490.90
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181_S185_F0.5390.89
75_I162_E0.5390.89
108_R114_G0.5380.89
15_I19_T0.5380.89
260_P264_S0.5370.89
272_E481_F0.5370.89
421_W425_E0.5370.89
209_T215_H0.5370.89
327_I465_G0.5370.89
230_M235_Y0.5360.89
75_I83_F0.5360.89
111_L115_K0.5360.89
525_A587_T0.5360.89
406_T412_T0.5350.89
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23_A30_I0.5340.89
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31_I142_T0.5340.89
102_V138_F0.5330.89
362_K416_N0.5330.89
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181_S189_V0.5310.89
310_G588_R0.5300.89
519_V524_T0.5300.89
72_I76_P0.5300.89
278_S282_E0.5290.89
513_T517_Q0.5280.89
70_V76_P0.5280.89
419_A426_I0.5280.89
525_A536_G0.5280.89
273_A284_L0.5280.89
384_D417_A0.5270.88
411_I516_L0.5270.88
199_V213_I0.5260.88
79_V201_A0.5260.88
86_V226_I0.5250.88
374_K380_S0.5240.88
282_E286_Q0.5240.88
130_I163_M0.5230.88
295_L481_F0.5230.88
418_P421_W0.5230.88
616_P623_K0.5230.88
381_L406_T0.5220.88
386_L393_T0.5220.88
140_R144_E0.5210.88
55_N298_K0.5200.88
348_Y571_D0.5200.88
21_F24_L0.5190.88
67_R288_G0.5180.88
360_T565_A0.5180.88
483_S495_D0.5180.88
315_G319_N0.5180.88
59_V295_L0.5170.87
506_K510_W0.5170.87
266_I270_I0.5160.87
48_S66_N0.5160.87
230_M236_I0.5160.87
195_S199_V0.5160.87
206_A218_K0.5160.87
361_F431_G0.5150.87
202_A222_R0.5150.87
357_P360_T0.5150.87
587_T591_K0.5150.87
261_W266_I0.5150.87
527_S587_T0.5140.87
68_E179_A0.5140.87
198_A227_L0.5140.87
311_S341_R0.5140.87
361_F364_L0.5140.87
265_Y270_I0.5140.87
515_M518_Q0.5120.87
51_I270_I0.5120.87
311_S322_G0.5110.87
352_T461_L0.5110.87
117_E136_K0.5110.87
342_D346_K0.5110.87
289_Y485_I0.5100.87
530_Y534_L0.5090.87
49_S52_V0.5090.87
70_V177_I0.5090.87
434_Y508_T0.5080.87
36_Y39_D0.5080.87
228_G238_A0.5080.87
343_Y346_K0.5070.86
512_M515_M0.5060.86
470_F516_L0.5050.86
9_L13_I0.5040.86
100_K103_G0.5030.86
269_V274_E0.5020.86
349_N355_R0.5020.86
25_I28_I0.5020.86
116_V119_G0.5020.86
28_I31_I0.5020.86
102_V106_V0.5010.86
392_Y447_L0.5010.86
438_N470_F0.5010.86
133_T147_I0.5010.86
309_E599_E0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oonA 1 0.5308 100 0.171 Contact Map
3vmaA 1 0.8529 100 0.212 Contact Map
2jchA 1 0.584 100 0.218 Contact Map
3udfA 2 0.6765 100 0.222 Contact Map
2olvA 1 0.8151 100 0.254 Contact Map
3zg9B 1 0.619 100 0.423 Contact Map
2y2mA 2 0.6204 100 0.582 Contact Map
2v2fF 1 0.4888 100 0.644 Contact Map
3un7A 1 0.5042 100 0.644 Contact Map
2oqoA 2 0.2535 100 0.651 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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