GREMLIN Database
HMOB - Heme-degrading monooxygenase HmoB
UniProt: P38049 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 166 (160)
Sequences: 174 (134)
Seq/√Len: 10.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_Y141_R2.9670.93
85_R125_F2.8180.91
23_E38_H2.8150.91
40_T44_T2.7500.90
134_Y143_T2.6630.89
121_T124_A2.3930.83
115_I129_Q2.0910.73
54_V57_Q2.0840.73
66_F114_V2.0300.71
134_Y146_G1.9950.69
59_G104_V1.9860.69
12_F48_A1.9140.66
38_H49_P1.8740.64
15_T20_H1.8370.63
143_T146_G1.8240.62
70_N89_R1.8230.62
36_L40_T1.7690.60
86_F89_R1.7630.59
6_T46_F1.7580.59
36_L46_F1.7490.59
73_A112_T1.7450.59
134_Y148_D1.7380.58
22_S60_E1.6990.56
28_M37_I1.6780.55
122_E161_T1.6470.54
56_D79_R1.6240.53
83_E107_P1.6190.53
86_F125_F1.6110.52
70_N138_H1.6050.52
75_T78_G1.6040.52
115_I148_D1.6030.52
6_T9_T1.5980.52
11_D34_A1.5970.52
131_S138_H1.5590.50
119_W128_W1.5570.50
7_Y50_H1.5520.50
9_T13_L1.5450.49
23_E36_L1.5230.48
89_R138_H1.5220.48
40_T158_Y1.5120.48
143_T148_D1.5060.47
59_G111_D1.5020.47
10_A61_I1.4610.45
102_I129_Q1.4600.45
111_D155_R1.4530.45
129_Q148_D1.4450.45
134_Y142_D1.4250.44
9_T46_F1.4220.43
9_T12_F1.4080.43
103_R107_P1.3920.42
27_L95_N1.3820.42
83_E103_R1.3600.41
69_L116_L1.3490.40
10_A14_K1.3470.40
136_E139_K1.3410.40
55_I58_V1.3390.40
69_L109_D1.3200.39
100_E118_L1.3150.39
13_L32_E1.2850.37
129_Q134_Y1.2400.35
47_Q115_I1.2310.35
4_Y57_Q1.2110.34
8_G46_F1.1930.33
103_R113_Y1.1860.33
53_E158_Y1.1750.33
6_T13_L1.1680.32
142_D148_D1.1660.32
85_R89_R1.1490.31
3_V125_F1.1200.30
66_F135_K1.1160.30
134_Y147_I1.1020.30
25_I45_V1.0860.29
105_L113_Y1.0640.28
87_K91_G1.0630.28
5_I136_E1.0600.28
97_P125_F1.0550.28
38_H158_Y1.0450.27
140_K157_S1.0370.27
126_Q156_P1.0290.27
86_F138_H1.0200.26
70_N74_V1.0030.26
98_G131_S0.9980.26
129_Q141_R0.9900.25
83_E105_L0.9900.25
13_L67_A0.9890.25
32_E158_Y0.9890.25
23_E42_G0.9860.25
70_N86_F0.9810.25
134_Y159_V0.9780.25
40_T45_V0.9700.25
21_P61_I0.9680.25
85_R91_G0.9650.24
132_G135_K0.9640.24
141_R146_G0.9630.24
49_P158_Y0.9570.24
120_E124_A0.9540.24
13_L48_A0.9530.24
50_H110_S0.9500.24
75_T133_S0.9480.24
60_E95_N0.9480.24
90_A137_A0.9450.24
7_Y69_L0.9410.24
38_H44_T0.9400.24
54_V76_Q0.9310.23
9_T49_P0.9300.23
107_P112_T0.9300.23
70_N137_A0.9260.23
73_A83_E0.9240.23
85_R97_P0.9240.23
27_L48_A0.9210.23
83_E113_Y0.9190.23
43_D49_P0.9180.23
83_E99_F0.9070.23
26_L118_L0.8950.22
30_G47_Q0.8850.22
55_I87_K0.8740.21
14_K28_M0.8680.21
86_F117_T0.8650.21
52_Y150_T0.8560.21
39_E103_R0.8540.21
9_T80_P0.8460.21
16_I61_I0.8450.21
25_I35_I0.8400.20
12_F19_K0.8360.20
89_R128_W0.8360.20
12_F24_N0.8360.20
122_E158_Y0.8330.20
117_T138_H0.8260.20
24_N31_Q0.8180.20
55_I143_T0.8140.20
26_L34_A0.8040.19
67_A118_L0.7980.19
73_A76_Q0.7970.19
107_P113_Y0.7960.19
31_Q43_D0.7960.19
16_I123_S0.7950.19
93_V125_F0.7930.19
79_R112_T0.7600.18
8_G13_L0.7520.18
3_V61_I0.7440.18
32_E71_N0.7420.18
11_D21_P0.7330.17
72_I91_G0.7290.17
68_V138_H0.7280.17
18_Q66_F0.7230.17
68_V86_F0.7230.17
35_I97_P0.7210.17
38_H51_A0.7160.17
12_F43_D0.7150.17
15_T18_Q0.7110.17
66_F83_E0.7100.17
10_A29_Q0.7080.17
74_V78_G0.7080.17
86_F99_F0.7060.17
4_Y49_P0.7060.17
85_R132_G0.6990.16
41_N60_E0.6970.16
34_A126_Q0.6960.16
33_N158_Y0.6950.16
25_I41_N0.6930.16
3_V157_S0.6880.16
58_V94_E0.6860.16
36_L42_G0.6830.16
73_A107_P0.6820.16
90_A106_R0.6810.16
57_Q116_L0.6700.16
42_G84_N0.6670.16
82_F119_W0.6610.15
34_A39_E0.6590.15
71_N112_T0.6580.15
68_V89_R0.6560.15
12_F22_S0.6550.15
61_I116_L0.6550.15
24_N66_F0.6540.15
16_I161_T0.6440.15
72_I85_R0.6440.15
15_T19_K0.6400.15
90_A102_I0.6380.15
9_T20_H0.6360.15
90_A104_V0.6330.15
15_T28_M0.6270.15
40_T49_P0.6260.15
104_V148_D0.6260.15
77_E81_L0.6250.15
13_L46_F0.6240.15
53_E121_T0.6220.14
7_Y35_I0.6180.14
5_I109_D0.6180.14
67_A100_E0.6180.14
78_G112_T0.6170.14
77_E80_P0.6150.14
104_V115_I0.6130.14
74_V82_F0.6130.14
92_K116_L0.6090.14
155_R161_T0.6050.14
19_K43_D0.6020.14
34_A74_V0.5850.14
76_Q80_P0.5840.14
56_D85_R0.5820.14
61_I67_A0.5790.14
6_T80_P0.5770.13
48_A81_L0.5750.13
101_A125_F0.5730.13
128_W138_H0.5690.13
18_Q21_P0.5630.13
12_F130_Q0.5630.13
91_G104_V0.5630.13
44_T49_P0.5620.13
27_L62_K0.5560.13
67_A129_Q0.5550.13
4_Y69_L0.5530.13
17_V24_N0.5510.13
25_I38_H0.5510.13
101_A114_V0.5510.13
14_K21_P0.5480.13
74_V80_P0.5470.13
59_G77_E0.5470.13
116_L159_V0.5470.13
2_K152_I0.5450.13
43_D109_D0.5450.13
38_H46_F0.5420.13
89_R115_I0.5410.13
74_V103_R0.5340.13
70_N85_R0.5320.13
38_H80_P0.5310.12
60_E121_T0.5310.12
48_A122_E0.5190.12
23_E54_V0.5190.12
2_K44_T0.5160.12
3_V33_N0.5160.12
28_M121_T0.5150.12
108_L150_T0.5150.12
15_T101_A0.5140.12
22_S132_G0.5140.12
75_T90_A0.5130.12
14_K29_Q0.5060.12
61_I106_R0.5050.12
68_V72_I0.5030.12
36_L49_P0.5020.12
140_K148_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kiaA 1 0.9036 100 0.389 Contact Map
3fj2A 1 0.9578 100 0.458 Contact Map
4fvcA 1 0.9337 100 0.465 Contact Map
4ae5A 1 0.9699 100 0.469 Contact Map
1tz0A 3 0.5964 99 0.815 Contact Map
3hx9A 2 0.5663 99 0.817 Contact Map
1sqeA 2 0.5904 99 0.819 Contact Map
2zdoA 2 0.6145 99 0.819 Contact Map
2go8A 2 0.494 98.9 0.822 Contact Map
1iujA 4 0.5904 98.9 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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