GREMLIN Database
ROCR - Arginine utilization regulatory protein RocR
UniProt: P38022 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 461 (395)
Sequences: 11149 (8827)
Seq/√Len: 444.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
430_H440_E4.2701.00
289_A294_R3.9891.00
172_E314_R3.2421.00
229_L264_R3.1581.00
205_D249_S3.1031.00
330_K363_E2.9801.00
288_D292_G2.9631.00
216_K225_D2.9001.00
284_E289_A2.8231.00
262_K271_D2.8181.00
262_K273_P2.7191.00
231_E265_R2.7141.00
420_K424_E2.6511.00
263_I274_I2.5791.00
201_A252_A2.5531.00
264_R271_D2.5161.00
239_L281_T2.4991.00
159_R375_D2.4951.00
430_H437_A2.4871.00
157_A180_F2.4631.00
216_K268_S2.3781.00
429_K440_E2.3481.00
230_F257_A2.2991.00
285_D288_D2.1961.00
343_S380_T2.1911.00
419_E451_R2.1901.00
235_G275_D2.1371.00
436_K439_Q2.1341.00
355_W365_M2.1241.00
321_L351_L2.0881.00
321_L347_K2.0751.00
422_V426_V2.0691.00
217_K225_D2.0571.00
353_Y356_P1.9821.00
324_A366_I1.9731.00
190_R275_D1.9501.00
288_D291_A1.9351.00
146_T322_L1.9171.00
147_S318_E1.9081.00
341_H378_T1.8691.00
69_L76_G1.8631.00
324_A342_I1.8561.00
289_A292_G1.8431.00
180_F310_I1.8301.00
230_F238_L1.8061.00
158_K187_G1.8021.00
259_Q363_E1.7991.00
245_S284_E1.7841.00
416_E454_K1.7801.00
217_K224_V1.7741.00
268_S272_T1.7551.00
178_E256_R1.7491.00
170_A309_I1.7451.00
426_V430_H1.7431.00
345_D381_A1.7361.00
342_I366_I1.7321.00
170_A307_T1.7161.00
353_Y361_E1.7051.00
165_S367_E1.6901.00
426_V437_A1.6701.00
446_Q450_Y1.6531.00
145_G150_I1.6361.00
68_T71_Q1.6211.00
325_S347_K1.6201.00
231_E272_T1.6141.00
346_V381_A1.6041.00
317_K321_L1.5901.00
209_E253_K1.5841.00
153_V308_L1.5841.00
427_L437_A1.5701.00
349_F381_A1.5701.00
205_D247_N1.5641.00
346_V350_F1.5631.00
208_V250_L1.5551.00
435_S445_R1.5481.00
193_G235_G1.5421.00
326_E330_K1.5341.00
346_V379_I1.5301.00
380_T383_H1.5251.00
258_L278_I1.5191.00
286_P295_M1.5021.00
415_M418_F1.4981.00
287_I291_A1.4981.00
317_K320_I1.4891.00
436_K440_E1.4851.00
227_P231_E1.4781.00
348_Q352_S1.4771.00
414_K418_F1.4711.00
317_K354_D1.4681.00
153_V180_F1.4681.00
418_F422_V1.4591.00
343_S346_V1.4551.00
175_T310_I1.4531.00
145_G154_I1.4401.00
215_T220_F1.4241.00
444_S447_S1.4241.00
424_E428_R1.4221.00
343_S378_T1.4181.00
425_N429_K1.4141.00
57_D61_F1.3941.00
234_H275_D1.3921.00
164_S190_R1.3861.00
216_K265_R1.3731.00
144_L326_E1.3711.00
257_A263_I1.3651.00
435_S439_Q1.3591.00
234_H274_I1.3541.00
334_L367_E1.3521.00
160_A306_V1.3511.00
280_A303_L1.3441.00
164_S334_L1.3411.00
433_N436_K1.3391.00
434_I449_Q1.3321.00
327_F363_E1.3321.00
410_D413_E1.3301.00
446_Q449_Q1.3281.00
195_F236_G1.3231.00
152_D155_E1.3211.00
265_R268_S1.3181.00
226_Q269_T1.3101.00
143_I150_I1.3031.00
426_V441_L1.3011.00
149_A315_E1.2911.00
69_L72_A1.2881.00
244_N282_M1.2851.00
142_S186_N1.2831.00
140_F183_S1.2831.00
263_I273_P1.2701.00
331_N370_M1.2701.00
321_L324_A1.2571.00
328_I370_M1.2511.00
340_E377_Q1.2481.00
167_V184_I1.2461.00
182_Q197_S1.2461.00
423_I448_L1.2371.00
157_A308_L1.2341.00
234_H276_V1.2331.00
309_I315_E1.2291.00
165_S335_F1.2241.00
332_N338_N1.2211.00
162_R189_D1.2201.00
379_I384_L1.2181.00
88_N91_G1.2111.00
121_K125_L1.2091.00
118_D122_L1.2051.00
155_E158_K1.2051.00
131_N134_G1.2031.00
170_A287_I1.1931.00
374_T383_H1.1891.00
291_A297_K1.1861.00
143_I180_F1.1791.00
208_V212_L1.1681.00
323_L327_F1.1641.00
450_Y454_K1.1591.00
231_E263_I1.1581.00
347_K351_L1.1581.00
201_A245_S1.1531.00
183_S187_G1.1461.00
150_I154_I1.1451.00
150_I153_V1.1431.00
128_E133_K1.1431.00
129_N132_K1.1411.00
421_Y425_N1.1311.00
118_D125_L1.1271.00
332_N340_E1.1251.00
148_P152_D1.1201.00
287_I387_Q1.1191.00
328_I342_I1.1181.00
426_V440_E1.1121.00
331_N366_I1.1111.00
164_S189_D1.1091.00
265_R272_T1.1031.00
369_A379_I1.1011.00
411_L415_M1.1011.00
232_Q269_T1.1001.00
444_S450_Y1.0971.00
434_I445_R1.0951.00
230_F276_V1.0941.00
348_Q351_L1.0931.00
182_Q186_N1.0911.00
317_K351_L1.0891.00
114_E118_D1.0841.00
123_E126_I1.0811.00
211_I226_Q1.0811.00
126_I129_N1.0801.00
414_K422_V1.0751.00
421_Y424_E1.0731.00
385_P388_Y1.0691.00
71_Q75_E1.0691.00
244_N286_P1.0681.00
445_R449_Q1.0641.00
411_L414_K1.0591.00
327_F331_N1.0571.00
227_P269_T1.0561.00
443_I448_L1.0541.00
320_I324_A1.0511.00
304_S307_T1.0451.00
165_S305_V1.0431.00
430_H436_K1.0421.00
318_E351_L1.0391.00
261_R273_P1.0381.00
345_D380_T1.0361.00
433_N445_R1.0351.00
410_D442_G1.0351.00
332_N339_V1.0271.00
156_N373_M1.0201.00
447_S451_R1.0191.00
143_I179_L1.0181.00
169_L181_A1.0181.00
153_V157_A1.0111.00
149_A152_D1.0101.00
74_Q103_I1.0091.00
122_L125_L1.0081.00
172_E312_P1.0081.00
72_A76_G1.0061.00
449_Q453_K1.0051.00
325_S329_Q1.0051.00
154_I157_A1.0041.00
157_A183_S1.0041.00
146_T151_Q1.0011.00
197_S256_R0.9981.00
229_L232_Q0.9891.00
104_V109_I0.9731.00
172_E175_T0.9691.00
210_S215_T0.9661.00
342_I347_K0.9651.00
169_L180_F0.9641.00
230_F274_I0.9641.00
365_M369_A0.9641.00
178_E197_S0.9631.00
448_L452_L0.9631.00
122_L126_I0.9611.00
368_G373_M0.9601.00
109_I112_A0.9591.00
168_L280_A0.9561.00
434_I448_L0.9541.00
342_I379_I0.9481.00
423_I451_R0.9471.00
424_E457_H0.9461.00
129_N133_K0.9451.00
151_Q155_E0.9381.00
145_G322_L0.9371.00
329_Q333_H0.9361.00
127_R131_N0.9361.00
428_R432_H0.9351.00
123_E127_R0.9341.00
342_I346_V0.9281.00
227_P232_Q0.9251.00
427_L434_I0.9241.00
425_N428_R0.9221.00
284_E294_R0.9191.00
108_K111_G0.9191.00
434_I452_L0.9181.00
128_E132_K0.9161.00
53_K57_D0.9151.00
327_F366_I0.9131.00
153_V310_I0.9081.00
246_L250_L0.9051.00
151_Q154_I0.9021.00
126_I130_M0.9021.00
344_D348_Q0.9001.00
238_L278_I0.8991.00
443_I447_S0.8981.00
57_D60_M0.8901.00
152_D156_N0.8891.00
415_M422_V0.8871.00
115_I118_D0.8841.00
256_R260_E0.8791.00
244_N283_N0.8771.00
125_L129_N0.8741.00
332_N370_M0.8731.00
196_I233_A0.8701.00
169_L279_I0.8611.00
69_L80_K0.8601.00
57_D62_S0.8601.00
75_E78_T0.8601.00
154_I180_F0.8591.00
165_S306_V0.8551.00
116_A121_K0.8531.00
361_E387_Q0.8531.00
447_S450_Y0.8511.00
305_V364_H0.8501.00
181_A195_F0.8491.00
144_L322_L0.8491.00
215_T226_Q0.8471.00
245_S283_N0.8461.00
165_S372_F0.8461.00
118_D121_K0.8461.00
417_S421_Y0.8441.00
80_K83_K0.8441.00
385_P389_R0.8421.00
238_L257_A0.8401.00
69_L78_T0.8361.00
108_K112_A0.8301.00
56_M61_F0.8281.00
317_K352_S0.8281.00
140_F157_A0.8271.00
143_I154_I0.8271.00
451_R455_F0.8241.00
96_T108_K0.8231.00
427_L452_L0.8231.00
154_I158_K0.8231.00
321_L325_S0.8221.00
220_F223_A0.8221.00
232_Q268_S0.8201.00
437_A440_E0.8171.00
166_S261_R0.8151.00
215_T224_V0.8131.00
157_A184_I0.8121.00
420_K455_F0.8061.00
148_P151_Q0.8061.00
278_I303_L0.8041.00
234_H272_T0.8021.00
335_F370_M0.8021.00
414_K417_S0.8021.00
71_Q74_Q0.7971.00
67_S71_Q0.7951.00
196_I232_Q0.7941.00
199_N245_S0.7931.00
369_A374_T0.7931.00
331_N363_E0.7931.00
215_T219_A0.7921.00
434_I446_Q0.7911.00
331_N335_F0.7911.00
332_N337_M0.7911.00
422_V441_L0.7891.00
331_N367_E0.7881.00
75_E79_I0.7861.00
128_E131_N0.7841.00
99_H103_I0.7821.00
89_N92_Q0.7821.00
163_T372_F0.7821.00
130_M133_K0.7811.00
60_M63_K0.7801.00
313_L362_L0.7781.00
330_K334_L0.7751.00
116_A125_L0.7741.00
157_A187_G0.7731.00
363_E367_E0.7701.00
337_M370_M0.7701.00
169_L310_I0.7671.00
325_S341_H0.7651.00
204_P266_I0.7571.00
411_L418_F0.7571.00
287_I307_T0.7561.00
419_E423_I0.7491.00
140_F154_I0.7491.00
328_I332_N0.7471.00
121_K124_R0.7451.00
349_F388_Y0.7451.00
449_Q452_L0.7431.00
344_D347_K0.7431.00
349_F352_S0.7411.00
416_E455_F0.7401.00
166_S280_A0.7401.00
215_T266_I0.7401.00
320_I351_L0.7391.00
324_A347_K0.7331.00
140_F158_K0.7331.00
54_N57_D0.7321.00
312_P315_E0.7311.00
416_E420_K0.7291.00
369_A384_L0.7271.00
208_V246_L0.7271.00
120_T123_E0.7261.00
437_A448_L0.7241.00
136_T186_N0.7181.00
219_A223_A0.7171.00
340_E370_M0.7161.00
115_I122_L0.7161.00
159_R337_M0.7141.00
237_T279_I0.7101.00
230_F263_I0.7101.00
60_M72_A0.7081.00
317_K322_L0.7081.00
68_T72_A0.7081.00
145_G151_Q0.7081.00
322_L325_S0.7041.00
121_K126_I0.7041.00
160_A167_V0.7031.00
203_L212_L0.7021.00
127_R130_M0.7011.00
145_G319_D0.7001.00
409_A417_S0.7001.00
376_E383_H0.6951.00
227_P265_R0.6871.00
72_A75_E0.6861.00
190_R276_V0.6851.00
423_I437_A0.6831.00
219_A266_I0.6831.00
304_S368_G0.6811.00
368_G385_P0.6791.00
452_L457_H0.6771.00
438_A448_L0.6691.00
349_F385_P0.6671.00
244_N284_E0.6661.00
300_Y304_S0.6651.00
58_V76_G0.6641.00
287_I290_I0.6631.00
446_Q453_K0.6611.00
353_Y388_Y0.6611.00
69_L73_L0.6591.00
427_L432_H0.6581.00
190_R193_G0.6581.00
97_I100_T0.6561.00
226_Q229_L0.6561.00
444_S449_Q0.6561.00
70_V74_Q0.6521.00
423_I452_L0.6501.00
161_T187_G0.6480.99
324_A369_A0.6460.99
210_S220_F0.6460.99
435_S449_Q0.6450.99
76_G80_K0.6450.99
115_I119_V0.6390.99
138_Y142_S0.6370.99
320_I350_F0.6370.99
146_T318_E0.6350.99
55_L62_S0.6350.99
164_S335_F0.6350.99
287_I300_Y0.6340.99
116_A119_V0.6330.99
204_P207_L0.6310.99
124_R128_E0.6300.99
199_N246_L0.6300.99
125_L132_K0.6300.99
350_F355_W0.6290.99
248_L252_A0.6290.99
432_H452_L0.6280.99
434_I441_L0.6260.99
84_Q89_N0.6250.99
263_I272_T0.6250.99
185_H237_T0.6240.99
413_E421_Y0.6230.99
335_F372_F0.6230.99
116_A122_L0.6230.99
230_F278_I0.6220.99
141_D158_K0.6200.99
197_S262_K0.6200.99
102_P111_G0.6180.99
72_A78_T0.6160.99
338_N377_Q0.6160.99
125_L128_E0.6150.99
178_E260_E0.6130.99
329_Q339_V0.6130.99
159_R373_M0.6100.99
198_Q229_L0.6100.99
99_H102_P0.6090.99
322_L326_E0.6080.99
212_L250_L0.6080.99
203_L208_V0.6060.99
55_L61_F0.6060.99
182_Q260_E0.6060.99
155_E159_R0.6060.99
114_E117_K0.6050.99
140_F187_G0.6050.99
290_I300_Y0.6040.99
86_Y89_N0.6030.99
120_T124_R0.6030.99
138_Y141_D0.6030.99
263_I271_D0.6030.99
411_L422_V0.6010.99
69_L79_I0.6010.99
94_I98_N0.5990.99
119_V122_L0.5970.99
324_A328_I0.5960.99
434_I437_A0.5940.99
145_G149_A0.5930.99
170_A283_N0.5910.99
237_T277_R0.5910.99
119_V123_E0.5900.99
197_S260_E0.5890.99
105_Q108_K0.5880.99
368_G372_F0.5870.99
243_I303_L0.5850.99
413_E418_F0.5850.99
56_M62_S0.5850.99
419_E455_F0.5830.99
183_S186_N0.5820.99
199_N202_A0.5820.99
56_M60_M0.5810.99
416_E419_E0.5800.99
100_T112_A0.5800.99
326_E329_Q0.5800.99
69_L77_K0.5800.99
426_V429_K0.5790.99
118_D124_R0.5790.99
343_S381_A0.5780.99
130_M134_G0.5780.99
67_S72_A0.5780.99
413_E417_S0.5750.99
156_N368_G0.5750.99
450_Y453_K0.5740.99
268_S271_D0.5730.99
376_E380_T0.5730.99
261_R276_V0.5690.99
349_F384_L0.5690.99
204_P209_E0.5680.99
307_T368_G0.5670.99
299_L303_L0.5670.99
60_M87_F0.5670.99
168_L286_P0.5660.99
445_R450_Y0.5650.99
198_Q212_L0.5650.99
156_N306_V0.5640.99
198_Q238_L0.5640.99
149_A153_V0.5630.99
306_V372_F0.5630.99
346_V369_A0.5620.99
415_M419_E0.5620.99
337_M340_E0.5620.99
141_D186_N0.5610.99
423_I441_L0.5610.99
417_S420_K0.5590.99
293_E297_K0.5580.98
284_E293_E0.5570.98
257_A274_I0.5570.98
234_H261_R0.5560.98
117_K124_R0.5550.98
62_S96_T0.5540.98
145_G180_F0.5520.98
144_L179_L0.5520.98
155_E375_D0.5510.98
229_L269_T0.5500.98
109_I113_V0.5500.98
331_N334_L0.5480.98
235_G276_V0.5480.98
261_R274_I0.5470.98
85_S89_N0.5470.98
173_T297_K0.5460.98
121_K128_E0.5460.98
162_R188_S0.5450.98
150_I180_F0.5450.98
120_T126_I0.5440.98
339_V370_M0.5430.98
443_I451_R0.5420.98
412_K416_E0.5410.98
349_F353_Y0.5410.98
422_V425_N0.5410.98
435_S446_Q0.5400.98
412_K426_V0.5400.98
365_M368_G0.5390.98
203_L229_L0.5380.98
74_Q78_T0.5380.98
118_D123_E0.5380.98
164_S275_D0.5370.98
68_T76_G0.5370.98
226_Q232_Q0.5350.98
366_I369_A0.5330.98
55_L59_F0.5310.98
97_I104_V0.5300.98
72_A77_K0.5290.98
365_M388_Y0.5280.98
117_K120_T0.5280.98
215_T223_A0.5270.98
365_M384_L0.5260.98
434_I444_S0.5260.98
341_H377_Q0.5230.98
138_Y182_Q0.5220.98
234_H273_P0.5220.98
179_L183_S0.5210.98
188_S277_R0.5210.98
295_M299_L0.5200.98
444_S454_K0.5200.98
103_I111_G0.5200.98
290_I304_S0.5200.98
88_N92_Q0.5190.98
55_L60_M0.5180.98
434_I443_I0.5160.98
160_A308_L0.5140.97
444_S451_R0.5120.97
188_S237_T0.5110.97
257_A260_E0.5100.97
324_A350_F0.5100.97
139_T186_N0.5090.97
207_L221_T0.5090.97
52_N55_L0.5080.97
334_L363_E0.5070.97
87_F90_K0.5070.97
305_V367_E0.5070.97
246_L254_L0.5060.97
211_I229_L0.5060.97
87_F91_G0.5060.97
104_V111_G0.5060.97
117_K121_K0.5060.97
116_A120_T0.5040.97
194_P232_Q0.5030.97
200_C208_V0.5030.97
116_A123_E0.5020.97
193_G236_G0.5010.97
98_N104_V0.5010.97
225_D270_K0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.8048 100 0.194 Contact Map
3dzdA 2 0.7744 100 0.381 Contact Map
1ojlA 3 0.6508 100 0.409 Contact Map
4fwgA 3 0.6074 100 0.608 Contact Map
4qhsA 3 0.5271 100 0.639 Contact Map
4qosA 1 0.5184 100 0.642 Contact Map
1qvrA 3 0.7961 100 0.672 Contact Map
1r6bX 1 0.8243 100 0.677 Contact Map
1hqcA 1 0.59 100 0.679 Contact Map
1in4A 1 0.5727 100 0.682 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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